Faculty of Biological Sciences

Prof Michelle Peckham

BA, York; PhD 1984, London.
Professor of Cell Biology
School of Molecular and Cellular Biology

Contact:  Astbury 8.106 | +44(0) 113 34 34348 | email address for  

You can read more about Prof Peckham's interests here:
www.contractility.org

Research Interests

Myosins, motors, and muscle in health and disease


 

Faculty Research and Innovation


Studentship information

Undergraduate project topics:

  • Structure and functions of myosins, roles of proteins in the Z-disc in muscle

Postgraduate studentship areas:

  • The structure and function of myosins and other molecular motors in muscle and non-muscle cells. Their roles in diseases. Super-resolution microscopy to obtain high resolution images of the cytoskeleton in muscle and non-muscle cells.

See also:

Admin roles

External Examiner (taught course): University College Dublin
Faculty Research & Innovation Committee
FBS Exective Committee
FBS Faculty Board
FBS Graduate School Committee (Chair)
FBS Promotions panel
FBS Student Recruitment Committee

Modules managed

BIOL2211 - Human Diseases

Modules taught

BIOC1301 - Intro Inte Biochem Mol Process
BIOC2201/SPSC2201 - Exercise Biochemistry
BIOC2301/MICR2120 - Integrated Biochemistry/Medical Bacteriology
BIOC3160 - Lab/Lit/Comp Research Project
BIOL1212 - Tissues, Organs & Processes
BIOL2211 - Human Diseases
BIOL3112/BMSC3143/44/45/46 - ATU 08 - Cell motility & trafficking
BIOL5212M/5321M - Bioimaging
BIOL5292M - Bioscience MSc Research Proj
BIOL5294M - MSc Bioscience Res Project Pro
BMSC1103 - Basic Laboratory and Scientific Skills
BMSC1110 - Foundations of Biomedical Sciences
BMSC1110/SPSC1220 - Foundation modules
BMSC3101 - Inherited Disorders
DSUR1127 - Health and Health promotion
MEDI1216 - Introduction to Medical Sciences
MICR3110 - Microbiology Research Programme
SPSC2201 - Exercise Biochemistry

Committees

Chair of Graduate School Committee

Centre membership:

Group Leader Prof Michelle Peckham  (Professor of Cell Biology)

Myosins, motors, and muscle in health and disease 


Dr Matthew Batchelor  (Research Fellow)

Dr Sally  Boxall  (Research Facility Manager)

Mr Alistair Curd  (Research Fellow)

Dr Marta Kurzawa  (Research Technician)

Dr Francine Parker  (Research Fellow)

Dr Kathryn White  (Research Fellow)

Dr Marcin Wolny  (Research Fellow)


Postgraduates

Christopher Bartlett  
Ruth Hughes  
Anna Lopata  
Katarzyna Makowska  

Yang Y; Baboolal TG; Siththanandan V; Chen M; Walker ML; Knight PJ; Peckham M; Sellers JR A FERM domain autoregulates Drosophila myosin 7a activity P NATL ACAD SCI USA 106 4189-4194, 2009
DOI:10.1073/pnas.0808682106

Baboolal TG; Sakamoto T; Forgacs E; White HD; Jackson SM; Takagi Y; Farrow RE; Molloy JE; Knight PJ; Sellers JR; Peckham M The SAH domain extends the functional length of the myosin lever P NATL ACAD SCI USA 106 22193-22198, 2009
DOI:10.1073/pnas.0909851106

Dunn S; Morrison EE; Liverpool TB; Molina-Paris C; Cross RA; Alonso MC; Peckham M Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells J CELL SCI 121 1085-1095, 2008
DOI:10.1242/jcs.026492

Soppina V; Norris SR; Dizaji AS; Kortus M; Verhey KJ; Veatch S; Peckham M Dimerization of mammalian kinesin-3 motors results in superprocessive motion Proceedings of the National Academy of Sciences of the United States of America 111 5562-5567, 2014
DOI:10.1073/pnas.1400759111
View abstract

Wolny M; Batchelor M; Parker F; Baboolal T; Mashanov G; Molloy J; Paci E; Dougan L; Knight PJ; Peckham M Unravelling the Properties of Single alpha-Helical Domains in Myosin and other Proteins, 2014

Stones R; Benoist D; Peckham M; White E Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension. J Mol Cell Cardiol 56 91-96, 2013
DOI:10.1016/j.yjmcc.2012.12.010
View abstract

Riches K; Franklin L; Maqbool A; Peckham M; Adams M; Bond J; Warburton P; Feric NT; Koschinsky ML; O'Regan DJ; Ball SG; Turner NA; Porter KE Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin alpha(v)beta(3) and RhoA/ROCK-mediated mechanisms INTERNATIONAL JOURNAL OF BIOCHEMISTRY&CELL BIOLOGY 45 1776-1783, 2013
DOI:10.1016/j.biocel.2013.05.021

Sevdali M; Kumar V; Peckham M; Sparrow J Human congenital myopathy actin mutants cause myopathy and alter Z-disc structure in Drosophila flight muscle. Neuromuscular disorders : NMD 23 243-255, 2013
View abstract

Wolny M; Colegrave M; Colman L; White E; Knight P; Peckham M Cardiomyopathy mutations in the tail of beta cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes. Journal of Biological Chemistry 288 31952-31962, 2013
DOI:10.1074/jbc.M113.513291
View abstract

Mashanov GI; Nenasheva TA; Peckham M; Molloy JE Myosin-6 Mobility at the Plasma Membrane of Cultured Mammalian Cells, 2012

Peckham M Histology at a Glance, 2011
View abstract

Allsop G; Peckham M Cytoskeleton and Cell Motility In Comprehensive Biotechnology , 2011

Yoon JR; Whipple RA; Balzer EM; Cho EH; Matrone MA; Peckham M; Martin SS Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor cells BREAST CANCER RES TR 129 691-701, 2011
DOI:10.1007/s10549-010-1239-7

Peckham M Coiled coils and SAH domains in cytoskeletal molecular motors BIOCHEM SOC T 39 1142-1148, 2011
DOI:10.1042/BST0391142

Nenasheva TA; Mashanov GI; Peckham M; Molloy JE Imaging Individual Myosin Molecules Within Living Cells In Single Molecule Enzymology , 2011
DOI:10.1007/978-1-61779-261-8_9
View abstract

Thompson O; Moore CJ; Hussaina SA; Kleino I; Peckham M; Hohenester E; Ayscough KR; Saksela K; Winder SJ Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan J CELL SCI 123 118-127, 2010
DOI:10.1242/jcs.047902

Peckham M Journal club. A cell biologist ponders an outstanding mystery in muscle formation. Nature 458 1081-, 2009
DOI:10.1038/4581081e

Peckham M; Knight PJ When a predicted coiled coil is really a single alpha-helix, in myosins and other proteins SOFT MATTER 5 2493-2503, 2009
DOI:10.1039/b822339d

Peltzer J; Colman L; Cebrian J; Musa H; Peckham M; Keller A Novel murine clonal cell lines either express slow or mixed (fast and slow) muscle markers following differentiation in vitro DEV DYNAM 237 1412-1423, 2008
DOI:10.1002/dvdy.21543

Ridley A; Peckham M; Clark P Introduction Journal of Microscopy 231 440-440, 2008
DOI:10.1111/j.1365-2818.2008.02067.x

Domazetovska A; Ilkovski B; Kumar V; Valova VA; Vandebrouck A; Hutchinson DO; Robinson PJ; Cooper ST; Sparrow JC; Peckham M; North KN Intranuclear rod myopathy: Molecular pathogenesis and mechanisms of weakness ANN NEUROL 62 597-608, 2007
DOI:10.1002/ana.21200

Peckham M Research Highlights: Journal Club Nature pp.895-, 2006

Swailes NT; Colegrave M; Knight PJ; Peckham M Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse J CELL SCI 119 3561-3570, 2006
DOI:10.1242/jcs.03096

Mashanov GI; Nenasheva TA; Peckham M; Molloy JE Cell biochemistry studied by single-molecule imaging BIOCHEM SOC T 34 983-988, 2006

Musa H; Meek S; Gautel M; Peddie D; Smith AJH; Peckham M Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation J CELL SCI 119 4322-4331, 2006
DOI:10.1242/jcs.03198

Murphy JE; Tacon D; Tedbury PR; Hadden JM; Knowling S; Sawamura T; Peckham M; Phillips SEV; Walker JH; Ponnambalam S LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells BIOCHEM J 393 107-115, 2006

Knight PJ; Thirumurugan K; Xu YH; Wang F; Kalverda AP; Stafford WF; Sellers JR; Peckham M The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head J BIOL CHEM 280 34702-34708, 2005
DOI:10.1074/jbc.M504887200

Ridley A; Clark P; Peckham M Cell Motility, from molecules to organisms, 2004

Tacon D; Knight PJ; Peckham M Imaging myosin 10 in cells BIOCHEMICAL SOCIETY TRANSACTIONS 32 689-693, 2004

Swailes NT; Knight PJ; Peckham M Actin filament organization in aligned prefusion myoblasts J ANAT 205 381-391, 2004

Mashanov GI; Tacon D; Peckham M; Molloy JE The spatial and temporal dynamics of pleckstrin homology domain binding at the plasma membrane measured by Imaging single molecules in live mouse myoblasts J BIOL CHEM 279 15274-15280, 2004
DOI:10.1074/jbc.M312140200

Mashanov GI; Tacon DS; Knight AE; Peckham M; Molloy JE Visualizing single molecules inside living cells using total internal reflection fluorescence microscopy. Methods: A Companion to Methods in Enzymology 29 142-152, 2003
DOI:10.1016/S1046-2023(02)00305-5

Miller G; Maycock J; White E; Peckham M; Calaghan S Heterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes. J Physiol 548 167-174, 2003
DOI:10.1113/jphysiol.2002.031922
View abstract

Musa H; Orton C; Morrison EE; Peckham M Microtubule assembly in cultured myoblasts and myotubes following nocodazole induced microtubule depolymerisation. J Muscle Res Cell Motil 24 301-308, 2003
View abstract

Miller G; Musa H; Gautel M; Peckham M A targeted deletion of the C-terminal end of titin, including the titin kinase domain, impairs myofibrillogenesis J CELL SCI 116 4811-4819, 2003
DOI:10.1242/jcs.00768

Dobrzynski H; Musa H; Claydon TW; Coppen SR; Dupont E; Severs NJ; Peckham M; Billeter-Clark R; Boyett MR Different distribution and cellular localisation of connexin43 and a-myosin heavy chain mRNA in the sinoatrial node. Pflugers Archiv: European Journal of Physiology 443 pp.208-, 2002

Natali AJ; Wilson LA; Peckham M; Turner DL; Harrison SM; White E Different regional effects of voluntary exercise on the mechanical and electrical properties of rat ventricular myocytes Journal of Physiology 541 863-875, 2002
DOI:10.1113/jphysiol.2001.013415

Clark P; Dunn GA; Knibbs A; Peckham M Alignment of myoblasts on ultrafine gratings inhibits fusion in vitro INT J BIOCHEM CELL B 34 816-825, 2002

Peckham M; Miller G; Wells C; Zicha D; Dunn GA Specific changes to the mechanism of cell locomotion induced by overexpression of beta-actin J CELL SCI 114 1367-1377, 2001

Miller G; Colegrave M; Peckham M N232S, G741R and D778G beta-cardiac myosin mutants, implicated in familial hypertrophic cardiomyopathy, do not disrupt myofibrillar organisation in cultured myotubes FEBS LETT 486 325-327, 2000

Maggs AM; Taylor-Harris P; Peckham M; Hughes SM Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development. J Muscle Res Cell Motil 21 101-113, 2000
View abstract

Peckham M; Wells C; Taylor-Harris P; Coles D; Zicha D; Dunn GA Using molecular genetics as a tool in understanding crawling cell locomotion in myoblasts Biochemical Society Symposium 65 281-299, 1999

Harris JM; Morgan JE; Rosenblatt JD; Rosenblatt D; Peckham M; Partridge T Forced MyHCIIB expression following targeted genetic manipulation of conditionally immortalized muscle precursor cells Experimental Cell Research 253 523-532, 1999

Peckham M; Young P; Gautel M Constitutive and variable regions of Z-disk titin/connectin in myofibril formation: A dominant-negative screen Cell Structure and Function 22 95-101, 1997

Clark P; Coles D; Peckham M Preferential adhesion to and survival on patterned laminin organizes myogenesis in vitro EXP CELL RES 230 275-283, 1997

Wells C; Coles D; Entwistle A; Peckham M Myogenic cells express multiple myosin isoforms J MUSCLE RES CELL M 18 501-515, 1997

PECKHAM M; FERENCZI MA; IRVING M A BIREFRINGENCE STUDY OF CHANGES IN MYOSIN ORIENTATION DURING RELAXATION OF SKINNED MUSCLE-FIBERS INDUCED BY PHOTOLYTIC ATP RELEASE BIOPHYS J 67 1141-1148, 1994

MORGAN JE; BEAUCHAMP JR; PAGEL CN; PECKHAM M; ATALIOTIS P; JAT PS; NOBLE MD; FARMER K; PARTRIDGE TA MYOGENIC CELL-LINES DERIVED FROM TRANSGENIC MICE CARRYING A THERMOLABILE T-ANTIGEN - A MODEL SYSTEM FOR THE DERIVATION OF TISSUE-SPECIFIC AND MUTATION-SPECIFIC CELL-LINES DEV BIOL 162 486-498, 1994

PECKHAM M; CRIPPS R; WHITE D; BULLARD B MECHANICS AND PROTEIN-CONTENT OF INSECT FLIGHT MUSCLES J EXP BIOL 168 57-76, 1992

Sparrow J; Drummond D; Peckham M; Hennessey E; White D Protein engineering and the study of muscle contraction in Drosophila flight muscles. J Cell Sci Suppl 14 73-78, 1991
View abstract

PECKHAM M; WHITE DCS MECHANICAL-PROPERTIES OF DEMEMBRANATED FLIGHT-MUSCLE FIBERS FROM A DRAGONFLY J EXP BIOL 159 135-147, 1991

Peckham M; Molloy JE; Sparrow JC; White DC Physiological properties of the dorsal longitudinal flight muscle and the tergal depressor of the trochanter muscle of Drosophila melanogaster. J Muscle Res Cell Motil 11 203-215, 1990
View abstract

DRUMMOND DR; PECKHAM M; SPARROW JC; WHITE DCS ALTERATION IN CROSSBRIDGE KINETICS CAUSED BY MUTATIONS IN ACTIN NATURE 348 440-442, 1990

PECKHAM M; IRVING M MYOSIN CROSSBRIDGE ORIENTATION IN DEMEMBRANATED MUSCLE-FIBERS STUDIED BY BIREFRINGENCE AND X-RAY-DIFFRACTION MEASUREMENTS J MOL BIOL 210 113-126, 1989

PECKHAM M; WOLEDGE RC LABILE HEAT AND CHANGES IN RATE OF RELAXATION OF FROG MUSCLES J PHYSIOL-LONDON 374 123-135, 1986

ELZINGA G; PECKHAM M; WOLEDGE RC THE SARCOMERE-LENGTH DEPENDENCE OF THE RATE OF HEAT-PRODUCTION DURING ISOMETRIC TETANIC CONTRACTION OF FROG MUSCLES J PHYSIOL-LONDON 357 495-504, 1984