Faculty of Biological Sciences

Dr Ian Wood

BSc, Imperial; PhD 1992, University College, London.
Senior Lecturer in Neuroscience
School of Biomedical Sciences

Background: Postdoctoral work at Scripps Research Institute and University College, London. Joined the School of Biochemistry and Molecular Biology at Leeds in October, 1999.

Contact:  Garstang G6.41c | +44(0) 113 34 37922 | email address for Dr Ian Wood 

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Admin roles

FBS Faculty Board
School Director of Student Education

Modules taught

BMSC1103 - Basic Laboratory and Scientific Skills
BMSC1110/SPSC1220 - Foundation modules
BMSC1210/SPSC1222 - Biology of the Mind/Neuroscience for Exercise Science
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2118 - Neurobiology
BMSC2120 - Scientific Skills
BMSC2222 - Mechanisms of Brain Function
BMSC2224 - Principles of Drug Discovery
BMSC2231 - Topics in Neuroscience
BMSC3140 - Advanced Scientific Skills
BMSC3143/44/45/46 - ATUs - BMS specific
BMSC3301 - Research Proj: Biomed Sciences


Member of Faculty Taught Student Education Committee
Member of Undergraduate School Taught Student Education Committee

Centre membership:

Group Leader Dr Ian Wood  (Senior Lecturer in Neuroscience)

Uncovering the molecular mechanisms that control the gene expression in human disease 


Aliah Alshanwani  
Benjamin Durham  

Murrell A; Hurd PJ; Wood IC Epigenetic Mechanisms in Development and Disease BIOCHEMICAL SOCIETY TRANSACTIONS 41 697-699, 2013

Bowater RP; Wood IC; Luisi BF From beads on a string to the pearls of regulation: The structure and dynamics of chromatin Biochemical Society Transactions 40 331-334, 2012
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Hatano N; Itoh Y; Suzuki H; Muraki Y; Hayashi H; Onozaki K; Wood IC; Beech DJ; Muraki K Hypoxia-inducible Factor-1 alpha (HIF1 alpha) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release JOURNAL OF BIOLOGICAL CHEMISTRY 287 31962-31972, 2012

Cheong A; Li J; Sukumar P; Kumar B; Zeng F; Riches K; Munsch C; Wood IC; Porter KE; Beech DJ Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by K(V)1.3 channel blockers CARDIOVASC RES 89 282-289, 2011

Rose K; Ooi L; Dalle C; Robertson B; Wood IC; Gamper N Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury PAIN 152 742-754, 2011

Stead LF; Wood IC; Westhead DR KvSNP: accurately predicting the effect of genetic variants in voltage-gated potassium channels BIOINFORMATICS 27 2181-2186, 2011

Wood IC Uncovering combinatorial interactions in chromatin Epigenomics-UK 3 371-379, 2011
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Stead LF; Wood IC; Westhead DR KvDB; Mining and Mapping Sequence Variants in Voltage-Gated Potassium Channels HUM MUTAT 31 908-917, 2010

Mucha M; Ooi L; Linley JE; Mordaka P; Dalle C; Robertson B; Gamper N; Wood IC Transcriptional Control of KCNQ Channel Genes and the Regulation of Neuronal Excitability Journal of Neuroscience 30 13235-13245, 2010
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Wood IC; Gray NK; Jones L Gene Expression in Neuronal Disease BIOCHEM SOC T 37 1261-1262, 2009

Johnson R; Samuel J; Ng CKL; Jauch R; Stanton LW; Wood IC Evolution of the Vertebrate Gene Regulatory Network Controlled by the Transcriptional Repressor REST Molecular Biology and Evolution 26 1491-1507, 2009
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Ooi L; Wood IC Chromatin switching and transcriptional regulation in disease BIOCHEM SOC T 36 599-602, 2008

Ooi L; Wood IC Regulation of gene expression in the nervous system BIOCHEM J 414 327-341, 2008

Bingham AJ; Ooi L; Wood IC Multiple chromatin modifying complexes are required for REST to regulate cardiac specific gene expression Molecular and Cellular Biology 1138-1140, 2007

Ooi L; Wood IC Chromatin crosstalk in development and disease: lessons from REST NAT REV GENET 8 544-554, 2007

Turner NA; Aley PK; Hall KT; Warburton P; Galloway S; Midgley L; O'Regan DJ; Wood IC; Ball SG; Porter KE Simvastatin inhibits TNF alpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms J MOL CELL CARDIOL 43 168-176, 2007

Fountain SJ; Cheong A; Li J; Dondas NY; Zeng F; Wood IC; Beech DJ K(V)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress American Journal of Physiology: Heart and Circulatory Physiology 293 2719-2725, 2007
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Fountain SJ; Cheong A; Li J; Dondas NY; Zeng F; Wood IC; Beech DJ K(V)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress AM J PHYSIOL-HEART C 293 H2719-H2725, 2007

Bingham AJ; Ooi L; Kozera L; White E; Wood IC The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes MOL CELL BIOL 27 4082-4092, 2007

Johnson R; Gamblin RJ; Ooi L; Bruce AW; Donaldson IJ; Westhead DR; Wood IC; Jackson RM; Buckley NJ Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication NUCLEIC ACIDS RES 34 3862-3877, 2006

Ooi L; Belyaev ND; Miyake K; Wood IC; Buckley NJ BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression J BIOL CHEM 281 38974-38980, 2006

Bingham AJ; Ooi L; Wood IC Multiple chromatin modifications important for gene expression changes in cardiac hypertrophy BIOCHEM SOC T 34 1138-1140, 2006
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Cheong A; Wood IC; Beech DJ Less REST, more vascular disease? CELL CYCLE 5 129-131, 2006

Bruce AW; Krejci A; Ooi L; Deuchars J; Wood IC; Dolezal V; Buckley NJ The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype J NEUROCHEM 98 1828-1840, 2006

Cheong A; Bingham AJ; Li J; Kumar B; Sukumar P; Munsch C; Buckley NJ; Neylon CB; Porter KE; Beech DJ; Wood IC Downregulated REST Transcription Factor Is a Switch Enabling Critical Potassium Channel Expression and Cell Proliferation Molecular Cell 20 45-52, 2005
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Bruce AW; Donaldson IJ; Wood IC; Yerbury SA; Sadowski MI; Chapman M; Gottgens B; Buckley NJ Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes P NATL ACAD SCI USA 101 10458-10463, 2004

Pais I; Monyer H; Traub RD; Wood IC; Whittington MA; Buhl EH; Le Beau FEN Sharp-wave burst discharges in the hippocampus in vitro in mice lacking the gap junction protein connexin 36. Journal of Neurophysiology 89 2046-2054, 2003

Belyaev ND; Wood IC; Bruce AW; Street M; Trinh JB; Buckley NJ Distinct RE-1 Silencing Transcription Factor-containing Complexes Interact with Different Target Genes Journal of Biological Chemistry 279 556-561, 2003
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Pais I; Hormuzdi SG; Monyer H; Traub RD; Wood IC; Buhl EH; Whittington MA; LeBeau FE Sharp wave-like activity in the hippocampus in vitro in mice lacking the gap junction protein connexin 36. J Neurophysiol 89 2046-2054, 2003
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Wood IC; Belyaev ND; Bruce AW; Jones C; Mistry M; Roopra A; Buckley NJ Interaction of the Repressor Element 1-silencing Transcription Factor (REST) with Target Genes Journal of Molecular Biology 334 863-874, 2003
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Selyanko AA; Delmas P; Hadley JK; Tatulian L; Wood IC; Mistry M; London B; Brown DA Dominant-Negative Subunits Reveal Potassium Channel Families That Contribute to M-Like Potassium Currents Journal of Neuroscience 22 pp.RC212-, 2002

Wood IC Regulation of gene expression by the anticonvulsant VPA suggests potential new uses Trends in Pharmacological Sciences 23 pp.10-, 2002

Wood IC Transcription factors move with the glow Trends in Pharmacological Sciences 22 pp.166-, 2001

Wood IC The real fat controller? A glucose-responsive transcription factor Trends in Pharmacological Sciences 22 pp.499-, 2001

Wood IC How can anti-diabetics suppress tumours? Trends in Pharmacological Sciences 22 pp.399-, 2001

Roopra A; Sharling L; Wood IC; Briggs T; Bachfischer U; Paquette AJ; Buckley NJ Transcriptional repression by neuron-restrictive silence factor is mediated via the sin3-histone deacetylase complex Molecular and Cellular Biology 20 2147-2157, 2000
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Selyanko AA; Hadley JK; Wood IC; Abogadie FC; Jentsch TJ; Brown DA Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors Journal of Physiology 522 349-355, 2000

Hadley JK; Noda M; Selyanko AA; Wood IC; Abogadie FC; Brown DA Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. Br J Pharmacol 129 413-415, 2000
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Tatulian L; Selyanko AA; Wood I; Abogadie FC; Buckley NJ; Delmas P; Brown DA Dominant negative KCNQ4 blocks M-current in sympathetic neurones EUROPEAN JOURNAL OF NEUROSCIENCE 12 453-453, 2000

Selyanko AA; Hadley JK; Wood IC; Abogadie FC; Delmas P; Buckley NJ; London B; Brown DA Two types of K+ channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell Journal of Neuroscience 19 7742-7756, 1999

Wood IC; Garriga M; Palmer CL; Pepitoni S; Buckley NJ Neuronal expression of the rat M1 mucarinic acetylcholine receptor gene is regulated by elements in the first exon Biochemical Journal 1:340 475-483, 1999

Pepitoni S; Wood IC; Buckley NJ Structure of the m1 muscarinic acetylcholine receptor gene and its promoter Journal of Biological Chemistry 272 17112-17117, 1997

Wood IC; Roopra A; Buckley NJ Neural specific expression of the m4 muscarinic acetylcholine receptor gene is mediated by a RE1/NRSE-type silencing element Journal of Biological Chemistry 271 14221-14225, 1996

Wood IC; Roopra A; Harrington C; Buckley NJ Structure of the m4 cholinergic muscarinic receptor gene and its promoter J BIOL CHEM 270 30933-30940, 1995

Goomer RS; Holst BD; Wood IC; Jones FS; Edelman GM Regulation in vitro of an L-CAM enhancer by homeobox genes HoxD9 and HNF-1. Proc Natl Acad Sci U S A 91 7985-7989, 1994
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Holst BD; Goomer RS; Wood IC; Edelman GM; Jones FS Binding and activation of the promoter for the neural cell adhesion molecule by Pax-8. J Biol Chem 269 22245-22252, 1994
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Mauro VP; Wood IC; Krushel L; Crossin KL; Edelman GM Cell adhesion alters gene transcription in chicken embryo brain cells and mouse embryonal carcinoma cells. Proc Natl Acad Sci U S A 91 2868-2872, 1994
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Ooi L; Wood IC Identifying Transcriptional Regulatory Regions Using Reporter Genes and DNA-Protein Interactions by Chromatin Immunoprecipitation. In Potassium Channels ,
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