Faculty of Biological Sciences

Dr Stacy-Paul Wilshaw

BSc, PhD Oct 2006, Leeds
Senior Translational Research Fellow in Cardiovascular Tissue Engineering
School of Biomedical Sciences

Contact:  Other/Unknown, +44(0) 113 34 35619, email address for  

You can read more about Dr Wilshaw's interests here:
www.imbe.org.uk/


Research Interests

Tissue Replacement and Regeneration, Cardiovascular Tissue Engineering

    Tissue Engineering and Wound Healing

   Biomaterials and Biomaterial/Tissue interactions

   Vascular Biology and the Cardiovascular system

My research is mainly focused on the production and characterisation of acellular immunocompatible soft tissue matrices.  Our group has developed patented methods for the decellularisation of allogeneic and xenogeneic tissues including, aortic roots, pericardium, amniotic membrane and arteries.  These matrices have been extensively characterised and are being evaluated for their ability to regenerate into functional living tissues.  These tissue matrices are currently being seeded with cells to determine the biocompatibility and potential for regeneration.

Further research is focused on the creation of novel in vitro models of healthy and diseased arteries, which may be used to evaluate novel grafts or therapeutics.

 

 

Faculty Research and Innovation



Studentship information

Undergraduate project topics:

  • Cardiovascular Tissue engineering, wound healing, immunological reactions to biomaterials.

Postgraduate studentship areas:

  • Tissue Engineering and Regenerative Medicine

See also:

Modules taught

BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2233 - Topics in Medical Sciences
BMSC3126/43/44/45/46 - Integrative Biomedical Sciences/Advanced Topics I
MECH5003M - CDT External Placement
MECH5008M - Cross displine lab placeement
MECH5490M - Biomaterials (Short Course)
MECH5564M - Medical Engineering Experimental Design and Analysis
MICR2221 - Medical Immunology
MICR5100M/BIOL5245M - Tissue Engineering

Centre memberships:

Dr Paul Rooney  (Visiting Associate Professor)

Postgraduates

Laura Edwards (Primary supervisor) 50% FTE
James Holland (Primary supervisor) 40% FTE
Rupaly Pande (Primary supervisor) 80% FTE
Georgina Webster (Primary supervisor) 70% FTE
Abdul Hakeem (Co-supervisor) 33% FTE
Jayna Patel (Co-supervisor) 33% FTE
Fatimah Samman (Co-supervisor) 25% FTE
Eirini Tsagkaraki (Co-supervisor) 25% FTE

Zilic L, Wilshaw SP, Haycock JW Decellularisation and histological characterisation of porcine peripheral nerves Biotechnology and Bioengineering 113 2041-2053, 2016
DOI:10.1002/bit.25964
View abstract

Zilic L, Garner PE, Yu T, Roman S, Haycock JW, Wilshaw SP An anatomical study of porcine peripheral nerve and its potential use in nerve tissue engineering Journal of Anatomy 227 302-314, 2015
DOI:10.1111/joa.12341
View abstract

Lewis DI, Byrne A, Choppin C, Davies D, Watkins C, Chakrabarty S, McBurney S, Volz V, Wilshaw S Creating Xerte e-learning resources: An easy to use student guide, 2015

Luo J, Korossis SA, Wilshaw SP, Jennings LM, Fisher J, Ingham E Development and characterization of acellular porcine pulmonary valve scaffolds for tissue engineering. Tissue Eng Part A 20 2963-2974, 2014
DOI:10.1089/ten.TEA.2013.0573
View abstract

Luo J, Ingham E, Fisher J, Homer-Vanniasinkam S, Wilshaw S-P The development of an acellular porcine carotid artery, 2014

Owen K, Wilshaw SP, Homer-Vanniasinkam S, Bojar RA, Berry H, Ingham E Assessment of the antimicrobial activity of acellular vascular grafts. Eur J Vasc Endovasc Surg 43 573-581, 2012
DOI:10.1016/j.ejvs.2012.01.027
View abstract

Tatterton M, Wilshaw SP, Ingham E, Homer-Vanniasinkam S The use of antithrombotic therapies in reducing synthetic small-diameter vascular graft thrombosis. Vasc Endovascular Surg 46 212-222, 2012
DOI:10.1177/1538574411433299
View abstract

Wilshaw SP, Rooney P, Berry H, Kearney JN, Homer-Vanniasinkam S, Fisher J, Ingham E Development and characterization of acellular allogeneic arterial matrices. Tissue Eng Part A 18 471-483, 2012
DOI:10.1089/ten.tea.2011.0287
View abstract

Owen K, Wilshaw SP, Homer-Vanniasinkam S, Bojar R, Berry H, Ingham E Assessment of the antimicrobial activity of acellular vascular grafts, 2011

Khan TH, Wilshaw SP, Korossis SA, Ingham E, Homer-Vanniasinkam S Biocompatibility of acellular porcine ureteric scaffold for tissue engineering small diameter vessels European Cells and Materials 22 55-, 2011

Hogg P, Rooney P, Wilshaw S, Ingham E, Kearney J Development of an acellular dermis European Cells and Materials 22 89-, 2011

Guilliatt RS, Davies RPW, Wilshaw SP, Aggeli A, Ingham E Peptideβ-sheet self-assembly for the modification of acellular vascular grafts European Cells and Materials 22 57-, 2011

Wilshaw SP, Berry H, Rooney P, Kearney JN, Homer-Vanniasinkam S, Fisher J, Ingham E Biocompatibility and immunoreactivity of acellular xenogeneic and allogeneic arteries, 2011

Wang L, Wilshaw SP, Korossis S, Fisher J, Jin ZM, Ingham E Factors Influencing the Oxygen Consumption Rate of Aortic Valve Interstitial Cells: Application to Tissue Engineering TISSUE ENG PART C-ME 15 355-363, 2009
DOI:10.1089/ten.tec.2008.0415

Rimmer S, Wilshaw SP, Pickavance P, Ingham E Cytocompatibility of poly(1,2 propandiol methacrylate) copolymer hydrogels and conetworks with or without alkyl amine functionality BIOMATERIALS 30 2468-2478, 2009
DOI:10.1016/j.biomaterials.2009.01.041

Shortt AJ, Secker GA, Lomas RJ, Wilshaw SP, Kearney JN, Tuft SJ, Daniels JT The effect of amniotic membrane preparation method on its ability to serve as a substrate for the ex-vivo expansion of limbal epithelial cells BIOMATERIALS 30 1056-1065, 2009
DOI:10.1016/j.biomaterials.2008.10.048

Wilshaw SP, Burke D, Fisher J, Ingham E Investigation of the Antiadhesive Properties of Human Mesothelial Cells Cultured In Vitro on Implantable Surgical Materials J BIOMED MATER RES B 88B 49-60, 2009
DOI:10.1002/jbm.b.31148

Wilshaw SP, Aggeli A, Fisher J, Ingham E In vivo assessment of the immunogenicity of self-assembling peptides for use in regenerative applications European Cells and Materials 16 97-, 2008

Wilshaw SP, Kearney J, Fisher J, Ingham E Biocompatibility and potential of acellular human amniotic membrane to support the attachment and proliferation of allogeneic cells TISSUE ENG PT A 14 463-472, 2008
DOI:10.1089/tea.2007.0145

Bolland F, Korossis S, Wilshaw SP, Ingham E, Fisher J, Kearney JN, Southgate J Development and characterisation of a full-thickness acellular porcine bladder matrix for tissue engineering BIOMATERIALS 28 1061-1070, 2007
DOI:10.1016/j.biomaterials.2006.10.005

Wilshaw SP, Kearney JN, Fisher J, Ingham E Production of an acellular amniotic membrane matrix for use in tissue engineering TISSUE ENG 12 2117-2129, 2006

Wilshaw S, Fisher J, Kearney J, Ingham E Biocompatibility of decellularised human amniotic membrane European Cells and Materials 11 18-, 2006