Admin roles

Wellcome Trust Module Manager

Modules taught

BIOL3305 - Adv Skills in the Biosciences
MICR3120 - Adv Topics: Microbiology 1  Module manager
BLGY3110 - Applied Genetics
BIOC311*/BIOL3112/MICR3120 - ATU 36 - Visualising viruses
BIOL3306 - Biol Sciences Research Project
BIOL5292M - Bioscience MSc Research Proj
BIOC2303 - Intermediate Biochem: Skills
BIOL2301 - Intermediate Skills for BioSci
BIOC1301 - Intro Inte Biochem Mol Process
BIOL1302 - Intro Skills - Biological Sci
MICR1120/3342 - Introduction to Microbiology
BIOC3160 - Lab/Lit/Comp Research Project
MICR2222 - Medical Virology
MICR3110 - Microbiology Research Programme
MICR2121 - Molecular Virology
BIOL5294M - MSc Bioscience Res Project Pro
BMSC2120 - Scientific Skills
BIOL5243M - Topics in Cancer Biology

Committees

Member of Graduate School Committee

Centre membership: The Astbury Centre for Structural Molecular Biology

Leader of the Nicola Stonehouse group

Postgraduates

Oluwapelumi Adeyemi  
Ozlem Cesur  
Julian Crandall Hollick  
Kristopher Holmes  
James Kelly  
Marietta Mueller  
Anusha Panjwani  

Ariza A; Tanner SJ; Walter CT; Dent KC; Shepherd DA; Wu W; Matthews SV; Hiscox JA; Green TJ; Luo M; Elliott RM; Fooks AR; Ashcroft AE; Stonehouse NJ; Ranson NA; Barr JN; Edwards TA Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Res -, 2013
DOI:10.1093/nar/gkt268
View abstract

Bentham M; Holmes K; Forrest S; Rowlands DJ; Stonehouse NJ Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activity. J Virol 86 2371-2374, 2012
DOI:10.1128/JVI.05696-11
View abstract

Nicol C; Bunka DH; Blair GE; Stonehouse NJ Effects of single nucleotide changes on the binding and activity of RNA aptamers to human papillomavirus 16 E7 oncoprotein. Biochem Biophys Res Commun 405 417-421, 2011
DOI:10.1016/j.bbrc.2011.01.044
View abstract

Foster TL; Gallay P; Stonehouse NJ; Harris M Cyclophilin A Interacts with Domain II of Hepatitis C Virus NS5A and Stimulates RNA Binding in an Isomerase-Dependent Manner J VIROL 85 7460-7464, 2011
DOI:10.1128/JVI.00393-11

Foster TL; Belyaeva T; Stonehouse NJ; Pearson AR; Harris M All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding J VIROL 84 9267-9277, 2010
DOI:10.1128/JVI.00616-10

Basnak G; Morton VL; Rolfsson O; Stonehouse NJ; Ashcroft AE; Stockley PG Viral Genomic Single-Stranded RNA Directs the Pathway Toward a T=3 Capsid J MOL BIOL 395 924-936, 2010
DOI:10.1016/j.jmb.2009.11.018

Knapman TW; Morton VL; Stonehouse NJ; Stockley PG; Ashcroft AE Determining the topology of virus assembly intermediates using ion mobility spectrometry-mass spectrometry RAPID COMMUN MASS SP 24 3033-3042, 2010
DOI:10.1002/rcm.4732

Morton VL; Burkitt W; O'Connor G; Stonehouse NJ; Stockley PG; Ashcroft AE RNA-induced conformational changes in a viral coat protein studied by hydrogen/deuterium exchange mass spectrometry PHYS CHEM CHEM PHYS 12 13468-13475, 2010
DOI:10.1039/c0cp00817f

Morton VL; Dykeman EC; Stonehouse NJ; Ashcroft AE; Twarock R; Stockley PG The Impact of Viral RNA on Assembly Pathway Selection J MOL BIOL 401 298-308, 2010
DOI:10.1016/j.jmb.2010.05.059

Rolfsson O; Toropova K; Morton V; Francese S; Basnak G; Thompson GS; Homans SW; Ashcroft AE; Stonehouse NJ; Ranson NA; Stockley PG RNA packing specificity and folding during assembly of the bacteriophage MS2 COMPUT MATH METHOD M 9 339-349, 2008
DOI:10.1080/17486700802168445

Morton VL; Stockley PG; Stonehouse NJ; Ashcroft AE INSIGHTS INTO VIRUS CAPSID ASSEMBLY FROM NON-COVALENT MASS SPECTROMETRY MASS SPECTROM REV 27 575-595, 2008
DOI:10.1002/mas.20176

Tolley AC; Stonehouse NJ Conformational changes in the connector protein complex of the bacteriophage phi 29 DNA packaging motor COMPUT MATH METHOD M 9 327-337, 2008
DOI:10.1080/17486700802168486

Stockley PG; Rolfsson O; Thompson GS; Basnak G; Francese S; Stonehouse NJ; Homans SW; Ashcroft AE A simple, RNA-mediated allosteric switch controls the pathway to formation of a T=3 viral capsid J MOL BIOL 369 541-552, 2007
DOI:10.1016/j.jmb.2007.03.020

Horn WT; Tars K; Grahn E; Heigstrand C; Baron AJ; Lago H; Adams CJ; Peabody DS; Phillips SEV; Stonehouse NJ; Liljas L; Stockley PG Structural basis of RNA binding discrimination between bacteriophages Q beta and MS2 STRUCTURE 14 487-495, 2006
DOI:10.1016/j.str.2005.12.006

Ellingham M; Bunka DHJ; Rowlands DJ; Stonehouse NJ Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus RNA 12 1970-1979, 2006
DOI:10.1261/rna.161006

Robinson MA; Wood JPA; Capaldi SA; Baron AJ; Gell C; Smith DA; Stonehouse NJ Affinity of molecular interactions in the bacteriophage phi 29 DNA packaging motor NUCLEIC ACIDS RES 34 2698-2709, 2006
DOI:10.1093/nar/gkl318

Wood JPA; Capaldi SA; Robinson MA; Baron AJ; Stonehouse NJ RNA multimerisation in the DNA packaging motor of bacteriophage phi29 Journal of Theoretical Medicine 6 127-134, 2005
DOI:10.1080/10273660500149802

Stockley PG; Ashcroft AE; Francese S; Thompson GS; Ranson NA; Smith AM; Homans SW; Stonehouse NJ Dissecting the fine details of assembly of a T=3 capsid Journal of Theoretical Medicine 6 119-125, 2005
DOI:10.1080/10273660500149869

Hall J; Moll D; Zhang W; Guo P; Stonehouse N; Urquidi-Macdonald M Determination of molecular size, distance and stochiometry of bionanoparticles using nanoscale measurement techniques In Handbook of nanostructured biomaterials and their applications in nanobiotechnology , 2005

Ashcroft AE; Lago H; Macedo JMB; Horn WT; Stonehouse NJ; Stockley PG Engineering thermal stability in RNA phage capsids via disulphide bonds J NANOSCI NANOTECHNO 5 2034-2041, 2005
DOI:10.1166/jnn.2005.507

Horn WT; Convery MA; Stonehouse NJ; Adams CJ; Liljas L; Phillips SEV; Stockley PG The crystal structure of a high affinity RNA stem-loop complexed with the bacteriophage MS2 capsid: Further challenges in the modeling of ligand-RNA interactions RNA 10 1776-1782, 2004
DOI:10.1261/rna.7710304

Helgstrand C; Grahn E; Moss T; Stonehouse NJ; Tars K; Stockley PG; Liljas L Investigating the structural basis of purine specificity in the structures of MS2 coat protein RNA translational operator hairpins NUCLEIC ACIDS RES 30 2678-2685, 2002

Lago H; Parrott AM; Moss T; Stonehouse NJ; Stockley PG Probing the kinetics of formation of the bacteriophage MS2 translational operator complex: Identification of a protein conformer unable to bind RNA J MOL BIOL 305 1131-1144, 2001

Grahn E; Moss T; Helgstrand C; Fridborg K; Sundaram M; Tars K; Lago H; Stonehouse NJ; Davis DR; Stockley PG; Liljas L Structural basis of pyrimidine specificity in the MS2 RNA hairpin-coat-protein complex RNA 7 1616-1627, 2001

Grahn E; Stonehouse NJ; Adams CJ; Fridborg K; Beigelman L; Matulic-Adamic J; Warriner SL; Stockley PG; Liljas L Deletion of a single hydrogen bonding atom from the MS2 RNA operator leads to dramatic rearrangements at the RNA-coat protein interface Nucleic Acids Research 28 4611-4616, 2000
View abstract

Stonehouse NJ; Fonseca SA; Wood JPA RNA-protein interactions in the assembly of bacteriophage phi 29 (Abstract), 2000

Parrott A; Lago-Zarrilli HAH; Adams CJ; Ashcroft AE; Stonehouse NJ; Stockley PG RNA aptamers for the MS2 bacteriophage coat protein have similar solution conformations and dynamics to the wild-type RNA translational operator Nucleic Acids Research 28 489-497, 2000
View abstract

Grahn E; Stonehouse NJ; Murray JB; van den Worm SHE; Valegard K; Fridborg K; Stockley PG; Lijas L Crystallographic studies of RNA hairpins in complexes with recombinant MS2 capsids: Implications for binding requirements. RNA 5 131-138, 1999
View abstract

Stockley PG; Stonehouse NJ Virus Assembly and Morphogenesis In Development-genetics, epigentics and environmental regulation , 1999

Stonehouse NJ Dissecting the key recognition features of the MS2 bacteriophage translational repression complex Nucleic Acids Research 26 1337-1344, 1998

van den Worm SHE; Stonehouse NJ; Valegard K; Murray JB; Walton C; Fridborg K; Stockley PG Crystal structures of MS2 coat protein mutants in complex with wild-type RNA operator fragments Nucleic Acids Research 26 1345-1351, 1998

Stonehouse NJ; Phillips SEV; Stockley PG; Convery MA; Rowsell S; Murray JB; Hirao I; Ellington AD; Peabody DS Crystal structure of an RNA aptamer protein complex at 2.8 angstrom resolution Nature Structural Biology 5 133-139, 1998
View abstract

Stonehouse NJ The three-dimensional structures of two complexes between recombinant MS2 capsids and RNA operator fragments reveal sequence-specific protein-RNA interactions Journal of Molecular Biology 270 724-738, 1997

Stonehouse NJ; Valegard K; Golmohammadi R; van den Worm SHE; Walton C; Stockley PG; Liljas L Crystal-structures of MS2 capsids with mutations in the subunit FG loop Journal of Molecular Biology 256 330-339, 1996

Stonehouse NJ Molecular-interactions in the RNA bacteriophage MS2 Biochemical Society Transactions 24 412-412, 1996

Stockley PG; Stonehouse NJ; Walton C Molecular mechanism of RNA Phage Morphogenesis Biochemical Society Transactions 21 627-633, 1993

Robinson C; Kirkham J; Brookes SJ; Stonehouse NJ Growth of Fluorosed Rat Enamel Crystals in vitro Journal of Dental Research 71 696-696, 1992

Shore RC; Robinson C; Kirkham J; Stonehouse NJ Development of Crystal Morphology in Rat Incisor Enamel Journal of Dental Research 71 728-728, 1992

Robinson C; Kirkham J; Shore RC; Stonehouse NJ Extracellular matrix enzymes and the control of enamel crystal growth Journal of Dental Research 70 350-350, 1991

Robinson C; Kirkham J; Shore RC; Stonehouse NJ Degradative activity in the developing tooth Journal of Dental Research 70 683-683, 1991

Robinson C; Shore RC; Kirkham J; Stonehouse NJ Extracellular processing of enamel matrix proteins and the control of crystal growth Journal de Biologie Buccale 18 355-361, 1990

Robinson C; Stonehouse NJ; Shore RC; Kirkham J Porous enamel hypoplasia: A new hypopthesis - the role of serum proteins Journal of Dental Research 69 967-967, 1990

Stonehouse NJ Using RNA aptamers as a research tool,