Faculty of Biological Sciences

Dr Harry Rossiter

BSc, Birmingham; MSc, PhD, London
Lecturer
School of Biomedical Sciences

Background: BSc (Birmingham), MSc (King's College, London), PhD (University of London). Postdoctoral research at University of London and University of California San Diego Lecturer in Exercise Physiology (2005?)

Contact:  Worsley 10.92 | +44(0) 113 34 37268 | email address for  

You can read more about Dr Rossiter's interests here:
http://community.frontiersin.org/people/HarryRossiter/25184
http://people.ctsi.ucla.edu/institution/personnel?personnel_id=2059926
http://scholar.google.com/citations?user=w90LxrEAAAAJ
http://www.perf2ndwind.org/

Research Interests

Exercise bioenergetics in health and disease

The mission of our lab is to improve function and quality of life in healthy elderly or patients with acute or chronic diseases where exercise intolerance is a major symptom. We aim to achieve this through improved understanding of the control and limitation of oxygen transport and utilization. As such, we investigate the effective integration of the cardio-pulmonary and neuromuscular systems that conflate to allow muscular exercise to be well sustained - with a special focus on the nonsteady-state. We use a multi-scale systems biology approach, incorporating:

  • Cardiopulmonary and neuromuscular exercise testing on healthy volunteers and patients with cardiovascular (CHF, PAH) and lung (COPD) disease
  • In vivo and in vitro investigation of skeletal muscle and mitochondrial bioenergetic control in health and disease
  • A systems-biology approach providing computational models to better understand physiological dynamics and systems integration during exercise
 

Current Projects

Current projects include:

  • The biological, behavioral, and genetic determinants of skeletal muscle dysfunction in chronic obstructive pulmonary disease (funded by Swiss National Foundation for Biology and Medicine; UCLA CTSI)
  • Assessment of central and peripheral fatigue during whole-body dynamic exercise in chronic obstructive pulmonary disease (funded by The Pulmonary Education and Research Foundation; CAPES, Brazil)
  • Muscle mitochondrial dysfunction and treatment in patients with pulmonary arterial hypertension (funded by LABioMed)
  • Quantitative non-invasive imaging of skeletal muscle: A Japan-Partnering project between Universities of Leeds, Liverpool, Kobe, Hiroshima, and Tsukuba (funded by BBSRC)
  • Integrative physiological determinants of exercise performance (funded by BBSRC)

External academic and industry collaborations include:

  • Non-invasive imaging of skeletal muscle vascular and mitochondrial function in chronic obstructive pulmonary disease and peripheral arterial disease (Novartis)
  • Exercise responses as an outcome for treatment of pulmonary arterial hypertension (Reata Pharma)
  • Non-invasive imaging of skeletal muscle vascular and mitochondrial function in chronic obstructive pulmonary disease and peripheral arterial disease (Hamamatsu Photonics, Japan)
  • Pulmonary vascular dysfunction in exercise intolerance in Fontans patients (collaboration with Gruschen Veltdman, Cincinnati Children's Hospital)
  • Endurance training in neo-adjuvant chemotherapy in patients with rectal cancer (collaboration with Sandy Jack and Mike Grocott, University of Southampton)
  • Effects of altered skeletal muscle calcium channel expression in heart failure (collaboration with Alex Lyon, Imperial College London)
 

Faculty Research and Innovation



Studentship information

See also:

Modules taught

BIOC2201/SPSC2201 - Exercise Biochemistry

Centre membership: The Multidisciplinary Cardiovascular Research Centre (MCRC)

Group Leader Dr Harry Rossiter  (Lecturer)

Exercise bioenergetics in health and disease 


Dr Scott Murgatroyd  (Visiting Lecturer (TO))