Faculty of Biological Sciences

Dr Neil Ranson

BSc, PhD 1997, Bristol
Associate Professor
School of Molecular and Cellular Biology

Contact:  Astbury 8.108 | +44(0) 113 34 37065 | email address for  

You can read more about Dr Ranson's interests here:
http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=NAR

Faculty Research and Innovation


Studentship information

See also:

Admin roles

School Director of Student Education

Modules managed

BIOC2303 - Intermediate Biochem: Skills

Modules taught

BIOC1301 - Intro Inte Biochem Mol Process
BIOC1302 - Intro Biochem Practical Skills
BIOC1303 - Intro Biochem Problem Solving
BIOC2301 - Interm Integrated Biochemistry
BIOC2302 - Intermediate Biochem: Prac
BIOC2303 - Intermediate Biochem: Skills
BIOC3111/12/13 b - ATU 02 - Structural & MS techniques
BIOC3111/12/13/BIOL3112/MICR3120 - ATU 36 - Visualising viruses
BIOC3160 - Lab/Lit/Comp Research Project
BIOC3303 - Advanced Biochem: Skills
BIOL1112 - The Molecules of Life
BIOL3112 - Adv Topics for Biol Sciences 1
BIOL5212M/5321M - Bioimaging
BIOL5272M - Advanced Biomolecular Technologies
BIOW5901X - Foundation module
BIOW5904X - Folding and Assembly
BMSC2120 - Scientific Skills

Centre membership: The Astbury Centre for Structural Molecular Biology

Group Leader Dr Neil Ranson  (Associate Professor)


Dr Matthew Iadanza  (Research Fellow)


Postgraduates

Brendan Rogers  
Rebecca Thompson  

Bakker SE; Groppelli E; Pearson AR; Stockley PG; Rowlands DJ; Ranson NA Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle. J Virol 88 6093-6099, 2014
DOI:10.1128/JVI.01979-13
View abstract

Goodchild SC; Sheynis T; Thompson R; Tipping KW; Xue WF; Ranson NA; Beales PA; Hewitt EW; Radford SE β2-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH. PLoS One 9 e104492-, 2014
DOI:10.1371/journal.pone.0104492
View abstract

Dent K; Thompson R; Barker A; Hiscox J; Barr J; Stockley P; Ranson N The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release Structure 21 1225-1234, 2013
DOI:10.1016/j.str.2013.05.012
View abstract

Stockley PG; Ranson NA; Twarock R A new paradigm for the roles of the genome in ssRNA viruses FUTURE VIROLOGY 8 531-543, 2013
DOI:10.2217/FVL.12.84

Ariza A; Tanner SJ; Walter CT; Dent KC; Shepherd DA; Wu W; Matthews SV; Hiscox JA; Green TJ; Luo M Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Research 41 5912-5926, 2013
DOI:10.1093/nar/gkt268
View abstract

Ford RJ; Barker AM; Bakker SE; Coutts RH; Ranson NA; Phillips SE; Pearson AR; Stockley PG Sequence-specific, RNA-protein interactions overcome electrostatic barriers preventing assembly of satellite tobacco necrosis virus coat protein. J Mol Biol 425 1050-1064, 2013
DOI:10.1016/j.jmb.2013.01.004
View abstract

Keef T; Wardman JP; Twarock R; Ranson NA; Stockley PG Structural constraints on the three-dimensional geometry of simple viruses: Case studies of a new predictive tool Acta Crystallographica Section A: Foundations of Crystallography 69 140-150, 2013
DOI:10.1107/S0108767312047150
View abstract

Stockley PG; Barker AM; Borodavka A; Ford RJ; Pearson AR; Ranson NA; Tuma R; Twarock R; Dykeman E; Phillips SEV Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism Journal of Biological Physics 1-11, 2013
DOI:10.1007/s10867-013-9313-0
View abstract

Bakker SE; Ford RJ; Barker AM; Robottom J; Saunders K; Pearson AR; Ranson NA; Stockley PG Isolation of an asymmetric RNA uncoating intermediate for a single-stranded RNA plant virus. J Mol Biol 417 65-78, 2012
DOI:10.1016/j.jmb.2012.01.017
View abstract

Dykeman EC; Grayson NE; Toropova K; Ranson NA; Stockley PG; Twarock R Simple Rules for Efficient Assembly Predict the Layout of a Packaged Viral RNA J MOL BIOL 408 399-407, 2011
DOI:10.1016/j.jmb.2011.02.039

Toropova K; Stockley PG; Ranson NA Visualising a Viral RNA Genome Poised for Release from Its Receptor Complex J MOL BIOL 408 408-419, 2011
DOI:10.1016/j.jmb.2011.02.040

Rolfsson O; Toropova K; Ranson NA; Stockley PG Mutually-induced conformational switching of RNA and coat protein underpins efficient assembly of a viral capsid. J Mol Biol 401 309-322, 2010
DOI:10.1016/j.jmb.2010.05.058
View abstract

Rolfsson O; Toropova K; Ranson NA; Stockley PG Mutually-induced Conformational Switching of RNA and Coat Protein Underpins Efficient Assembly of a Viral Capsid J MOL BIOL 401 309-322, 2010
DOI:10.1016/j.jmb.2010.05.058

Carter SD; Dent KC; Atkins E; Foster TL; Verow M; Gorny P; Harris M; Hiscox JA; Ranson NA; Griffin S Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability FEBS LETT 584 2786-2790, 2010
DOI:10.1016/j.febslet.2010.05.006

Toropova K; Basnak G; Twarock R; Stockley PG; Ranson NA The three-dimensional structure of genomic RNA in bacteriophage MS2: Implications for assembly J MOL BIOL 375 824-836, 2008
DOI:10.1016/j.jmb.2007.08.067

Rolfsson O; Toropova K; Morton V; Francese S; Basnak G; Thompson GS; Homans SW; Ashcroft AE; Stonehouse NJ; Ranson NA RNA packing specificity and folding during assembly of the bacteriophage MS2 COMPUT MATH METHOD M 9 339-349, 2008
DOI:10.1080/17486700802168445

Toropova K; Basnak G; Twarock R; Stockley PG; Ranson NA The three-dimensional structure of genomic RNA in bacteriophage MS2: Implications for assembly, 2007
DOI:10.1016/j.jmb.2007.08.067

Ranson NA; Stromer T; Bousset L; Melki R; Serpell LC Insights into the architecture of the Ure2p yeast protein assemblies from helical twisted fibrils Protein Science 15 2481-2487, 2006
DOI:10.1110/ps.062215206
View abstract

Ranson NA; Clare DK; Farr GW; Houldershaw D; Horwich AL; Saibil HR Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes NAT STRUCT MOL BIOL 13 147-152, 2006
DOI:10.1038/nsmb1046

Stockley PG; Ashcroft AE; Francese S; Thompson GS; Ranson NA; Smith AM; Homans SW; Stonehouse NJ Dissecting the fine details of assembly of a T=3 capsid Journal of Theoretical Medicine 6 119-125, 2005
DOI:10.1080/10273660500149869

Saibil HR; Ranson NA The chaperonin folding machine TRENDS BIOCHEM SCI 27 627-632, 2002

Ranson NA; Farr GW; Roseman AM; Gowen B; Fenton WA; Horwich AL; Saibil HR ATP-Bound States of GroEL Captured by Cryo-Electron Microscopy Cell 107 869-879, 2001
DOI:10.1016/S0092-8674(01)00617-1

Roseman AM; Ranson NA; Gowen BT; Fuller SD; Saibil HR Structures of Unliganded and ATP-Bound States of the Escherichia coli Chaperonin GroEL by Cryoelectron Microscopy Journal of Structural Biology 135 115-125, 2001
DOI:10.1006/jsbi.2001.4374
View abstract

Roseman AM; Ranson NA; Gowen B; Fuller SD; Saibil HR The ATP-bound state of the E Coli Chaperonin GroEL studied by Cryo-Electron Microscopy Journal of Structural Biology 135 115-125, 2001
DOI:10.1006/jsbi.2001.4374