Faculty of Biological Sciences

Dr Neil Ranson

BSc, PhD 1997, Bristol
Associate Professor
School of Molecular and Cellular Biology

Contact:  Astbury 8.108 | +44(0) 113 34 37065 | email address for  

You can read more about Dr Ranson's interests here:
http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=NAR

Faculty Research and Innovation


Studentship information

See also:

Admin roles

School Director of Student Education

Modules managed

BIOC2303 - Intermediate Biochem: Skills

Modules taught

BIOC1301 - Intro Inte Biochem Mol Process
BIOC1302 - Intro Biochem Practical Skills
BIOC1303 - Intro Biochem Problem Solving
BIOC2301 - Interm Integrated Biochemistry
BIOC2302 - Intermediate Biochem: Prac
BIOC2303 - Intermediate Biochem: Skills
BIOC3111/12/13 b - ATU 02 - Structural & MS techniques
BIOC3111/12/13/BIOL3112/MICR3120 - ATU 36 - Visualising viruses
BIOC3160 - Lab/Lit/Comp Research Project
BIOC3303 - Advanced Biochem: Skills
BIOL1112 - The Molecules of Life
BIOL3112 - Adv Topics for Biol Sciences 1
BIOL5212M/5321M - Bioimaging
BIOL5272M - Advanced Biomolecular Technologies
BIOW5901X - Foundation module
BIOW5904X - Folding and Assembly
BMSC2120 - Scientific Skills

Centre membership: The Astbury Centre for Structural Molecular Biology

Group Leader Dr Neil Ranson  (Associate Professor)


Dr Emma Hesketh  (Research Fellow)

Dr Matthew Iadanza  (Research Fellow)


Postgraduates

Brendan Rogers  
Rebecca Thompson  

Bakker SE; Groppelli E; Pearson AR; Stockley PG; Rowlands DJ; Ranson NA Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle. J Virol 88 6093-6099, 2014
DOI:10.1128/JVI.01979-13
View abstract

Goodchild SC; Sheynis T; Thompson R; Tipping KW; Xue WF; Ranson NA; Beales PA; Hewitt EW; Radford SE β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH. PLoS One 9 e104492-, 2014
DOI:10.1371/journal.pone.0104492
View abstract

Dent K; Thompson R; Barker A; Hiscox J; Barr J; Stockley P; Ranson N The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release Structure 21 1225-1234, 2013
DOI:10.1016/j.str.2013.05.012
View abstract

Stockley PG; Ranson NA; Twarock R A new paradigm for the roles of the genome in ssRNA viruses FUTURE VIROLOGY 8 531-543, 2013
DOI:10.2217/FVL.12.84

Ariza A; Tanner SJ; Walter CT; Dent KC; Shepherd DA; Wu W; Matthews SV; Hiscox JA; Green TJ; Luo M; Elliott RM; Fooks AR; Ashcroft AE; Stonehouse NJ; Ranson NA; Barr JN; Edwards TA Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Research 41 5912-5926, 2013
DOI:10.1093/nar/gkt268
View abstract

Ford RJ; Barker AM; Bakker SE; Coutts RH; Ranson NA; Phillips SE; Pearson AR; Stockley PG Sequence-specific, RNA-protein interactions overcome electrostatic barriers preventing assembly of satellite tobacco necrosis virus coat protein. J Mol Biol 425 1050-1064, 2013
DOI:10.1016/j.jmb.2013.01.004
View abstract

Keef T; Wardman JP; Ranson NA; Stockley PG; Twarock R Structural constraints on the three-dimensional geometry of simple viruses: Case studies of a new predictive tool Acta Crystallographica Section A: Foundations of Crystallography 69 140-150, 2013
DOI:10.1107/S0108767312047150
View abstract

Stockley PG; Barker AM; Borodavka A; Ford RJ; Pearson AR; Ranson NA; Tuma R; Twarock R; Dykeman E; Phillips SEV; Bakker SE Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism Journal of Biological Physics 1-11, 2013
DOI:10.1007/s10867-013-9313-0
View abstract

Bakker SE; Ford RJ; Barker AM; Robottom J; Saunders K; Pearson AR; Ranson NA; Stockley PG Isolation of an asymmetric RNA uncoating intermediate for a single-stranded RNA plant virus. J Mol Biol 417 65-78, 2012
DOI:10.1016/j.jmb.2012.01.017
View abstract

Dykeman EC; Grayson NE; Toropova K; Ranson NA; Stockley PG; Twarock R Simple Rules for Efficient Assembly Predict the Layout of a Packaged Viral RNA J MOL BIOL 408 399-407, 2011
DOI:10.1016/j.jmb.2011.02.039

Toropova K; Stockley PG; Ranson NA Visualising a Viral RNA Genome Poised for Release from Its Receptor Complex J MOL BIOL 408 408-419, 2011
DOI:10.1016/j.jmb.2011.02.040

Rolfsson O; Toropova K; Ranson NA; Stockley PG Mutually-induced conformational switching of RNA and coat protein underpins efficient assembly of a viral capsid. J Mol Biol 401 309-322, 2010
DOI:10.1016/j.jmb.2010.05.058
View abstract

Rolfsson O; Toropova K; Ranson NA; Stockley PG Mutually-induced Conformational Switching of RNA and Coat Protein Underpins Efficient Assembly of a Viral Capsid J MOL BIOL 401 309-322, 2010
DOI:10.1016/j.jmb.2010.05.058

Carter SD; Dent KC; Atkins E; Foster TL; Verow M; Gorny P; Harris M; Hiscox JA; Ranson NA; Griffin S; Barr JN Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability FEBS LETT 584 2786-2790, 2010
DOI:10.1016/j.febslet.2010.05.006

Toropova K; Basnak G; Twarock R; Stockley PG; Ranson NA The three-dimensional structure of genomic RNA in bacteriophage MS2: Implications for assembly J MOL BIOL 375 824-836, 2008
DOI:10.1016/j.jmb.2007.08.067

Rolfsson O; Toropova K; Morton V; Francese S; Basnak G; Thompson GS; Homans SW; Ashcroft AE; Stonehouse NJ; Ranson NA; Stockley PG RNA packing specificity and folding during assembly of the bacteriophage MS2 COMPUT MATH METHOD M 9 339-349, 2008
DOI:10.1080/17486700802168445

Toropova K; Basnak G; Twarock R; Stockley PG; Ranson NA The three-dimensional structure of genomic RNA in bacteriophage MS2: Implications for assembly, 2007
DOI:10.1016/j.jmb.2007.08.067

Ranson NA; Stromer T; Bousset L; Melki R; Serpell LC Insights into the architecture of the Ure2p yeast protein assemblies from helical twisted fibrils Protein Science 15 2481-2487, 2006
DOI:10.1110/ps.062215206
View abstract

Ranson NA; Clare DK; Farr GW; Houldershaw D; Horwich AL; Saibil HR Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes NAT STRUCT MOL BIOL 13 147-152, 2006
DOI:10.1038/nsmb1046

Stockley PG; Ashcroft AE; Francese S; Thompson GS; Ranson NA; Smith AM; Homans SW; Stonehouse NJ Dissecting the fine details of assembly of a T=3 capsid Journal of Theoretical Medicine 6 119-125, 2005
DOI:10.1080/10273660500149869

Saibil HR; Ranson NA The chaperonin folding machine TRENDS BIOCHEM SCI 27 627-632, 2002

Ranson NA; Farr GW; Roseman AM; Gowen B; Fenton WA; Horwich AL; Saibil HR ATP-Bound States of GroEL Captured by Cryo-Electron Microscopy Cell 107 869-879, 2001
DOI:10.1016/S0092-8674(01)00617-1

Roseman AM; Ranson NA; Gowen BT; Fuller SD; Saibil HR Structures of Unliganded and ATP-Bound States of the Escherichia coli Chaperonin GroEL by Cryoelectron Microscopy Journal of Structural Biology 135 115-125, 2001
DOI:10.1006/jsbi.2001.4374
View abstract

Roseman AM; Ranson NA; Gowen B; Fuller SD; Saibil HR The ATP-bound state of the E Coli Chaperonin GroEL studied by Cryo-Electron Microscopy Journal of Structural Biology 135 115-125, 2001
DOI:10.1006/jsbi.2001.4374