Faculty of Biological Sciences

Prof John Ladbury

Dean Faculty of Biological Sciences, Professor of Mechanistic Biology
School of Molecular and Cellular Biology

Background: Postdoctoral Research Fellow, Yale University, Harvard University Medical School, New York University Medical Center 1990-1994; Wellcome Trust Career Development Fellow, University of Oxford 1994; Wellcome Trust Senior Research Fellow & Honorary Senior Lecturer, 1996, Professor of Biophysics 2003, University College London; Endowed Chair in Cancer Research and Director of the Center for Biomolecular Structure and Function, UT MD Anderson Cancer Center, 2008.

Contact:  Miall 7.07, +44(0) 113 34 35669, email address for  

Research Interests

Mechanistic basis of pathological signal transduction

Current Projects

Focusing on early signalling events we are exploring the structural, biophysical, and cellular outcomes of protein complex formation at receptors. Perturbation of these complexes by inhibiting assembly or modifying the time course reveals how the exquisite sensitivity of early signalling complex formation can ensure specificity and lead to disease.

Fig1

Current major projects include:

  • Aberrancies in signaling lead to cancer
  • Signaling in growth factor-deprived cells
  • Biophysical characterization of complex formation
  • Thermodynamics in drug development
 
Professor Ladbury's independent research is strongly influenced by his background in biophysical chemistry. He has published seminal investigations on the application of biophysical data to the understanding of signal transduction and in drug development. This experience was also exploited for investigating the mechanisms by which proteins are able to propagate and maintain mutually exclusive signals in mammalian cells. This work questioned existing dogma regarding specificity in interactions involved in tyrosine kinase-mediated signal transduction. His observations in this area led him to investigate the role of multi-protein complexes in signalling pathways. This has culminated in the development of a probabilistic view of signalling regulated by control and switching mechanisms, perturbation of which can lead to disease states such as cancer. 
 
The Ladbury laboratory adopts methods including cell biology, biophysical instrumental techniques and high resolution structure determination. He has combined the use of cell-based fluorescent life time imaging microscopy with in vitro measurement of biomolecular interactions to investigate the formation protein ensembles on plasma membrane receptors. 
 
Professor Ladbury has also maintained an interest in the area of structure-based drug design and has pioneered approaches to integrate thermodynamic parameterisation into this process. Professor Ladbury has always been an enthusiastic collaborator and has published with many of the leading scientists in his field. 
 
He has also worked closely with industrial partners and has received research funding from UCB/Celltech and AstraZeneca. In his previous role in the USA he successfully developed the interface between biophysics/structural biology and clinical scientists at MDACC. This activity in which researchers are encouraged to include biophysical/structural data in their interpretation of clinical outcomes will continue at the University of Leeds.
 

Faculty Research and Innovation

Modules taught

BIOW5902X - Medicinal Chemistry and Drug Design
BIOW5907X - Biocatalysis

Committees

Member of Faculty Taught Student Education Committee (Dean, Faculty of Biological Sciences)
Member of Masters Taught Student Education Committee (Dean FBS (ex officio))

Dr Jonathan Berrout  (Research Fellow)

Dr Sabine Knipp  (Research Fellow)

Dr Chi-Chuan Lin  (Research Fellow)


Postgraduates

Dovile Milonaityte (Primary supervisor) 75% FTE
Janne Darell (Primary supervisor) 34% FTE
Caroline Seiler (Primary supervisor) 50% FTE
Amy Stainthorp (Primary supervisor) 50% FTE
Sophie Taylor (Co-supervisor) 25% FTE

Taylor S, Ladbury J, Short S, Bruning-Richardson A ARHGAP gene expression in established glioma cell lines and glioma tumour samples and their association with cell migration, 2017

Kim JY, Kinoshita M, Kume S, Hanke GT, Sugiki T, Ladbury JE, Kojima C, Ikegami T, Kurisu G, Goto Y, Hase T, Lee YH Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity. Biochemical Journal 473 3837-3854, 2016
DOI:10.1042/BCJ20160658
View abstract

Belousova N, Mikheeva G, Xiong C, Stagg LJ, Gagea M, Fox PS, Bassett RL, Ladbury JE, Braun MB, Stehle T, Li C, Krasnykh V Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43 Oncotarget 7 53414-53429, 2016
DOI:10.18632/oncotarget.10800
View abstract

Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GNA, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer Oncogene 35 2186-2196, 2016
DOI:10.1038/onc.2015.279
View abstract

Carter BZ, Mak PY, Chen Y, Mak DH, Mu H, Jacamo R, Ruvolo V, Arold ST, Ladbury JE, Burks JK, Kornblau S, Andreeff M Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network Oncotarget 7 20054-20067, 2016
DOI:10.18632/oncotarget.7911
View abstract

Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim C Structural basis of cyclic nucleotide selectivity in cGMP-dependent Protein Kinase II Journal of Biological Chemistry 291 5623-5633, 2016
DOI:10.1074/jbc.M115.691303
View abstract

Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response Journal of Clinical Investigation 125 4529-4543, 2015
DOI:10.1172/JCI82826
View abstract

Mandal PK, Morlacchi P, Knight JM, Link TM, Lee GR, Nurieva R, Singh D, Dhanik A, Kavraki L, Corry DB, Ladbury JE, McMurray JS Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity Journal of Medicinal Chemistry 58 8970-8984, 2015
DOI:10.1021/acs.jmedchem.5b01321
View abstract

Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Armaiz-Peña GN, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung MC, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK Erythropoietin Stimulates Tumor Growth via EphB4 Cancer Cell 28 610-622, 2015
DOI:10.1016/j.ccell.2015.09.008
View abstract

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee Iv GR, Lin CC, Gagea M, Marti AA, Ladbury JE Erratum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function (Nature Communications (2015) 6:7354 DOI:10.1038/ncomms8354) Nature Communications 6 -, 2015
DOI:10.1038/ncomms9007

Vohidov F, Knudsen SE, Leonard PG, Ohata J, Wheadon MJ, Popp BV, Ladbury JE, Ball ZT Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors Chemical Science 6 4778-4783, 2015
DOI:10.1039/c5sc01602a
View abstract

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee GR, Lin C-C, Gagea M, Marti AA, Ladbury JE Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nat Commun 6 7354-, 2015
DOI:10.1038/ncomms8354
View abstract

Bagheri-Yarmand R, Sinha KM, Gururaj AE, Ahmed Z, Rizvi YQ, Huang SC, Ladbury JE, Bogler O, Williams MD, Cote GJ, Gagel RF A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis Journal of Biological Chemistry 290 11749-11761, 2015
DOI:10.1074/jbc.M114.619833
View abstract

Davlieva M, Shi Y, Leonard PG, Johnson TA, Zianni MR, Arias CA, Ladbury JE, Shamoo Y A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin Nucleic Acids Research 43 4758-4773, 2015
DOI:10.1093/nar/gkv321
View abstract

Poncet-Montange G, Zhan Y, Bardenhagen JP, Petrocchi A, Leo E, Shi X, Lee IV GR, Leonard PG, Geck Do MK, Cardozo MG, Andersen JN, Palmer WS, Jones P, Ladbury JE Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2. Biochemical Journal 466 337-346, 2015
DOI:10.1042/BJ20140933
View abstract

Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, Esteva FJ HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer Molecular Oncology 9 586-600, 2015
DOI:10.1016/j.molonc.2014.10.011
View abstract

Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M T<inf>H</inf>17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26 Nature Immunology 16 970-979, 2015
DOI:10.1038/ni.3211
View abstract

Timsah Z, Berrout J, Suraokar M, Behrens C, Song J, Lee JJ, Ivan C, Gagea M, Shires M, Hu X, Vallien C, Kingsley CV, Wistuba II, Ladbury JE Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma American Journal of Cancer Research 5 3135-3148, 2015
View abstract

Drake M, Furuta T, Suen KM, Gonzalez G, Liu B, Kalia A, Ladbury JE, Fire AZ, Skeath JB, Arur S A Requirement for ERK-Dependent Dicer Phosphorylation in Coordinating Oocyte-to-Embryo Transition in C. elegans DEVELOPMENTAL CELL 31 614-628, 2014
DOI:10.1016/j.devcel.2014.11.004

Dudutiene V, Matuliene J, Smirnov A, Timm DD, Zubriene A, Baranauskiene L, Morkunaite V, Smirnoviene J, Michailoviene V, Juozapaitiene V, Mickevičiute A, Kazokaite J, Bakšyte S, Kasiliauskaite A, Jachno J, Revuckiene J, Kišonaite M, Pilipuityte V, Ivanauskaite E, Milinavičiute G, Smirnovas V, Petrikaite V, Kairys V, Petrauskas V, Norvaišas P, Linge D, Gibieža P, Čapkauskaite E, Zakšauskas A, Kazlauskas E, Manakova E, Gražulis S, Ladbury JE, Matulis D Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX Journal of Medicinal Chemistry 57 9435-9446, 2014
DOI:10.1021/jm501003k
View abstract

Ladbury JE, Hall A, Skidmore J The toolbox is open, but who should pay for the job? Nat Rev Drug Discov 13 479-480, 2014
DOI:10.1038/nrd4367

Aramini JM, Hamilton K, Ma LC, Swapna GVT, Leonard PG, Ladbury JE, Krug RM, Montelione GT 19F NMR Reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus Structure 22 515-525, 2014
DOI:10.1016/j.str.2014.01.010
View abstract

Timsah Z, Ahmed Z, Lin CC, Melo FA, Stagg LJ, Leonard PG, Jeyabal P, Berrout J, O'Neil RG, Bogdanov M, Ladbury JE Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion Nature Structural and Molecular Biology 21 180-188, 2014
DOI:10.1038/nsmb.2752
View abstract

Munoz WA, Lee M, Miller RK, Ahmed Z, Ji H, Link TM, Lee GR, Kloc M, Ladbury JE, McCrea PD Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. PLoS One 9 e86784-, 2014
DOI:10.1371/journal.pone.0086784
View abstract

Liu H, Thaker YR, Stagg L, Schneider H, Ladbury JE, Rudd CE SLP-76 sterileα motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation Journal of Biological Chemistry 288 29539-29549, 2013
DOI:10.1074/jbc.M112.424846
View abstract

Cimo AM, Ahmed Z, Mcintyre BW, Lewis DE, Ladbury JE CD25 and CD69 induction byα4β1 outside-in signalling requires TCR early signalling complex proteins Biochemical Journal 454 109-121, 2013
DOI:10.1042/BJ20130485
View abstract

Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression Cell 154 556-568, 2013
DOI:10.1016/j.cell.2013.06.048
View abstract

Kanakaraj I, Chen WH, Poongavanam M, Dhamane S, Stagg LJ, Ladbury JE, Kourentzi K, Strych U, Willson RC Biophysical characterization of VEGF-aHt DNA aptamer interactions International Journal of Biological Macromolecules 57 69-75, 2013
DOI:10.1016/j.ijbiomac.2013.02.016
View abstract

Morlacchia P, Mandal PK, Knight JM, Corry DB, Link T, Ladbury JE, McMurray JS Phosphopeptidomimetic Prodrugs Targeting STAT6 Inhibit Asthma Symptoms in a Mouse Model, 2013
DOI:10.1002/bip.22277

Cheng X, Veverka V, Radhakrishnan A, Waters LC, Muskett FW, Morgan SH, Huo J, Yu C, Evans EJ, Leslie AJ, Griffiths M, Stubberfield C, Griffin R, Henry AJ, Jansson A, Ladbury JE, Ikemizu S, Carr MD, Davis SJ Structure and interactions of the human programmed cell death 1 receptor Journal of Biological Chemistry 288 11771-11785, 2013
DOI:10.1074/jbc.M112.448126
View abstract

Suen KM, Lin CC, George R, Melo FA, Biggs ER, Ahmed Z, Drake MN, Arur S, Arold ST, Ladbury JE Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nature Structural and Molecular Biology 20 620-627, 2013
DOI:10.1038/nsmb.2557
View abstract

Seidel SAI, Dijkman PM, Lea WA, van den Bogaart G, Jerabek-Willemsen M, Lazic A, Joseph JS, Srinivasan P, Baaske P, Simeonov A, Katritch I, Melo FA, Ladbury JE, Schreiber G, Watts A, Braun D, Duhr S Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions Methods 59 301-315, 2013
DOI:10.1016/j.ymeth.2012.12.005
View abstract

Ahmed Z, Lin CC, Suen KM, Melo FA, Levitt JA, Suhling K, Ladbury JE Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity Journal of Cell Biology 200 493-504, 2013
DOI:10.1083/jcb.201204106
View abstract

Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Chong K, Morton DL, Stemke-Hale K, Chen G, Noble M, Meyerson M, Ladbury JE, Davies MA, Gershenwald JE, Wagner SN, Hoon DSB, Schadendorf D, Lander ES, Gabriel SB, Getz G, Garraway LA, Chin L A landscape of driver mutations in melanoma Cell 150 251-263, 2012
DOI:10.1016/j.cell.2012.06.024
View abstract

Ramakrishnan M, de Melo FA, Kinsey BM, Ladbury JE, Kosten TR, Orson FM Probing cocaine-antibody interactions in buffer and human serum PLoS ONE 7 -, 2012
DOI:10.1371/journal.pone.0040518
View abstract

Lin CC, Melo FA, Ghosh R, Suen KM, Stagg LJ, Kirkpatrick J, Arold ST, Ahmed Z, Ladbury JE Inhibition of basal FGF receptor signaling by dimeric Grb2 Cell 149 1514-1524, 2012
DOI:10.1016/j.cell.2012.04.033
View abstract

Chen Z, Vohidov F, Coughlin JM, Stagg LJ, Arold ST, Ladbury JE, Ball ZT Catalytic protein modification with dirhodium metallopeptides: Specificity in designed and natural systems Journal of the American Chemical Society 134 10138-10145, 2012
DOI:10.1021/ja302284p
View abstract

Ladbury JE, Arold ST Noise in cellular signaling pathways: Causes and effects Trends in Biochemical Sciences 37 173-178, 2012
DOI:10.1016/j.tibs.2012.01.001
View abstract

Rodriguez UT, Oyola-Robles D, Arold S, De Melo FA, Ladbury JE, Vazquez E, Vega IE, Baerga-Ortiz A Biophysical Characterization of Acyl Carrier Protein Domains from a Polyunsaturated Fatty Acid Synthase, 2012

Domizio JD, Zhang R, Stagg LJ, Gagea M, Zhuo M, Ladbury JE, Cao W Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid Journal of Biological Chemistry 287 736-747, 2012
DOI:10.1074/jbc.M111.238477
View abstract

Noble M, Ladbury JE Catalysis and regulation Current Opinion in Structural Biology 21 775-776, 2011
DOI:10.1016/j.sbi.2011.10.007

Frenkel M, Chirico RD, Diky V, Brown PL, Dymond JH, Goldberg RN, Goodwin ARH, Heerklotz H, Königsberger E, Ladbury JE, Marsh KN, Remeta DP, Stein SE, Wakeham WA, Williams PA Extension of ThermoML: The IUPAC standard for thermodynamic data communications (IUPAC Recommendations 2011) Pure and Applied Chemistry 83 1937-1969, 2011
DOI:10.1351/PAC-REC-11-05-01
View abstract

Olsson TSG, Ladbury JE, Pitt WR, Williams MA Extent of enthalpy-entropy compensation in protein-ligand interactions Protein Science 20 1607-1618, 2011
DOI:10.1002/pro.692
View abstract

Philippe D, Ababou A, Yang X, Ghosh R, Daviter T, Ladbury JE, Pfuhl M Making ends meet: The importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85 Biochemistry 50 3649-3659, 2011
DOI:10.1021/bi1019644
View abstract

Di Domizio J, Zhang R, Zhuo M, Stagg L, Ladbury J, Gilliet M, Cao W A novel class of host-derived etiological agent for autoimmunity: oligomers of endogenous proteins bind to self-nucleic acids and trigger type I IFN production by plasmacytoid dendritic cells JOURNAL OF IMMUNOLOGY 186 -, 2011

Yu C, Sonnen AFP, George R, Dessailly BH, Stagg LJ, Evans EJ, Orengo CA, Stuart DI, Ladbury JE, Ikemizu S, Gilbert RJC, Davis SJ Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering Journal of Biological Chemistry 286 6685-6696, 2011
DOI:10.1074/jbc.M110.182394
View abstract

Frenkel M, Diky V, Chirico RD, Goldberg RN, Heerklotz H, Ladbury JE, Remeta DP, Dymond JH, Goodwin ARH, Marsh KN, Wakeham WA, Stein SE, Brown PL, Königsberger E, Williams PA ThermoML: An XML-based approach for storage and exchange of experimental and critically evaluated thermophysical and thermochemical property data. 5. Speciation and complex equilibria Journal of Chemical and Engineering Data 56 307-316, 2011
DOI:10.1021/je100999j
View abstract

Ladbury JE, Arold ST Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling Methods in Enzymology 488 147-183, 2011
DOI:10.1016/B978-0-12-381268-1.00007-0
View abstract

Arold ST, Leonard PG, Parkinson GN, Ladbury JE H-NS forms a superhelical protein scaffold for DNA condensation Proceedings of the National Academy of Sciences of the United States of America 107 15728-15732, 2010
DOI:10.1073/pnas.1006966107
View abstract

Ladbury JE Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design Biochemical Society Transactions 38 888-893, 2010
DOI:10.1042/BST0380888
View abstract

Stevens CN, Simeone AM, John S, Ahmed Z, Lucherini OM, Baldari CT, Ladbury JE T-cell receptor early signalling complex activation in response to interferon-α receptor stimulation Biochemical Journal 428 429-437, 2010
DOI:10.1042/BJ20091660
View abstract

Leonard PG, Parkinson GN, Gor J, Perkins SJ, Ladbury JE The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66 421-425, 2010
DOI:10.1107/S1744309110004574
View abstract

Chirico RD, Frenkel M, Diky V, Goldberg RN, Heerklotz H, Ladbury JE, Remeta DP, Dymond JH, Goodwin ARH, Marsh KN, Wakeham WA ThermoML -An XML-based approach for storage and exchange of experimental and critically evaluated thermophysical and thermochemical property data. 4. biomaterials Journal of Chemical and Engineering Data 55 1564-1572, 2010
DOI:10.1021/je900685d
View abstract

Raab M, Wang H, Lu Y, Smith X, Wu Z, Strebhardt K, Ladbury JE, Rudd CE T Cell Receptor "Inside-Out" Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes Immunity 32 541-556, 2010
DOI:10.1016/j.immuni.2010.03.007
View abstract

Ahmed Z, George R, Lin CC, Suen KM, Levitt JA, Suhling K, Ladbury JE Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function Cellular Signalling 22 23-33, 2010
DOI:10.1016/j.cellsig.2009.08.011
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Ladbury JE, Klebe G, Freire E Adding calorimetric data to decision making in lead discovery: A hot tip Nature Reviews Drug Discovery 9 23-27, 2010
DOI:10.1038/nrd3054
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Nilapwar S, Williams E, Fu C, Prodromou C, Pearl LH, Williams MA, Ladbury JE Structural-Thermodynamic Relationships of Interactions in the N-Terminal ATP-Binding Domain of Hsp90 Journal of Molecular Biology 392 923-936, 2009
DOI:10.1016/j.jmb.2009.07.041
View abstract

Leonard PG, Ono S, Gor J, Perkins SJ, Ladbury JE Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria Molecular Microbiology 73 165-179, 2009
DOI:10.1111/j.1365-2958.2009.06754.x
View abstract

Ababou A, Pfuhl M, Ladbury JE Novel Insights into the Mechanisms of CIN85 SH3 Domains Binding to Cbl Proteins: Solution-Based Investigations and In Vivo Implications Journal of Molecular Biology 387 1120-1136, 2009
DOI:10.1016/j.jmb.2009.02.061
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Zhou L, Li J, George R, Ruchaud S, Zhou HG, Ladbury JE, Earnshaw WC, Yuan X Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex Biochemistry 48 1156-1161, 2009
DOI:10.1021/bi801298j
View abstract

George R, Chan HL, Ahmed Z, Suen KM, Stevens CN, Levitt JA, Suhling K, Timms J, Ladbury JE A complex of Shc and Ran-GTPase localises to the cell nucleus Cellular and Molecular Life Sciences 66 711-720, 2009
DOI:10.1007/s00018-009-8667-8
View abstract

Olsson TSG, Williams MA, Pitt WR, Ladbury JE The Thermodynamics of Protein-Ligand Interaction and Solvation: Insights for Ligand Design Journal of Molecular Biology 384 1002-1017, 2008
DOI:10.1016/j.jmb.2008.09.073
View abstract

Taylor JD, Ababou A, Fawaz RR, Hobbs CJ, Williams MA, Ladbury JE Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design Proteins: Structure, Function and Genetics 73 929-940, 2008
DOI:10.1002/prot.22119
View abstract

Patel S, George R, Autore F, Fraternali F, Ladbury JE, Nikolova PV Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax Nucleic Acids Research 36 5139-5151, 2008
DOI:10.1093/nar/gkn490
View abstract

Ababou A, Pfuhl M, Ladbury JE The binding stoichiometry of CIN85 SH3 domain A and Cbl-b Nature Structural and Molecular Biology 15 890-891, 2008
DOI:10.1038/nsmb0908-890

Ahmed Z, Schüller AC, Suhling K, Tregidgo C, Ladbury JE Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling Biochemical Journal 413 37-49, 2008
DOI:10.1042/BJ20071594
View abstract

George R, Schuller AC, Harris R, Ladbury JE A Phosphorylation-Dependent Gating Mechanism Controls the SH2 Domain Interactions of the Shc Adaptor Protein Journal of Molecular Biology 377 740-747, 2008
DOI:10.1016/j.jmb.2007.12.040
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Schüller AC, Ahmed Z, Ladbury JE Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation Biochemical Journal 410 205-211, 2008
DOI:10.1042/BJ20070859
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Taylor JD, Gilbert PJ, Williams MA, Pitt WR, Ladbury JE Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation Proteins: Structure, Function and Genetics 67 981-990, 2007
DOI:10.1002/prot.21369
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Zavaleta J, Chinchilla DB, Ramirez A, Pao A, Martinez K, Nilapwar S, Ladbury JE, Mallik S, Gomez FA Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands Talanta 71 192-201, 2007
DOI:10.1016/j.talanta.2006.03.039
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Impagliazzo A, Blok AJ, Cliff MJ, Ladbury JE, Ubbink M Redox-state-dependent complex formation between pseudoazurin and nitrite reductase Journal of the American Chemical Society 129 226-233, 2007
DOI:10.1021/ja0659830
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Ababou A, Ladbury JE Survey of the year 2005: Literature on applications of isothermal titration calorimetry Journal of Molecular Recognition 20 4-14, 2007
DOI:10.1002/jmr.803
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Ladbury JE Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction, 2006
DOI:10.1107/S0907444906046373
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Evans EJ, Castro MAA, O'Brien R, Kearney A, Walsh H, Sparks LM, Tucknott MG, Davies EA, Carmo AM, Van Der Merwe PA, Stuart DI, Jones EY, Ladbury JE, Ikemizu S, Davis SJ Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48 Journal of Biological Chemistry 281 29309-29320, 2006
DOI:10.1074/jbc.M601314200
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Beuron F, Dreveny I, Yuan X, Pye VE, Mckeown C, Briggs LC, Cliff MJ, Kaneko Y, Wallis R, Isaacson RL, Ladbury JE, Matthews SJ, Kondo H, Zhang X, Freemont PS Conformational changes in the AAA ATPase p97-p47 adaptor complex EMBO Journal 25 1967-1976, 2006
DOI:10.1038/sj.emboj.7601055
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Cliff MJ, Harris R, Barford D, Ladbury JE, Williams MA Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90 Structure 14 415-426, 2006
DOI:10.1016/j.str.2005.12.009
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Grunau A, Paine MJ, Ladbury JE, Gutierrez A Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase Biochemistry 45 1421-1434, 2006
DOI:10.1021/bi052115r
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Ababou A, Ladbury JE Survey of the year 2004: Literature on applications of isothermal titration calorimetry Journal of Molecular Recognition 19 79-89, 2006
DOI:10.1002/jmr.750
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Zavaleta J, Chinchilla DB, Kaddis CF, Martinez K, Brown A, Gomez A, Pao A, Ramirez A, Nilapwar S, Ladbury JE, Gomez FA Partial-filling affinity capillary electrophoresis techniques to probe the binding of glycopeptide antibiotics to D-Ala-D-Ala terminus peptides Journal of Capillary Electrophoresis and Microchip Technology 9 101-117, 2005
View abstract

Keatch SA, Leonard PG, Ladbury JE, Dryden DTF StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI Nucleic Acids Research 33 6540-6546, 2005
DOI:10.1093/nar/gki951
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Ahmed Z, Beeton CA, Williams MA, Clements D, Baldari CT, Ladbury JE Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors Journal of Molecular Biology 353 1001-1010, 2005
DOI:10.1016/j.jmb.2005.09.024
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Erra E, Petraccone L, Esposito V, Randazzo A, Mayol L, Ladbury J, Barone G, Giancola C Interaction of porphyrin with G-quadruplex structures, 2005
DOI:10.1081/NCN-200060070
View abstract

Ono S, Goldberg MD, Olsson T, Esposito D, Hinton JCD, Ladbury JE H-NS is a part of a thermally controlled mechanism for bacterial gene regulation Biochemical Journal 391 203-213, 2005
DOI:10.1042/BJ20050453
View abstract

Taylor JD, Fawaz RR, Ababou A, Williams MA, Ladbury JE NMR assignment of the apo and peptide-bound SH2 domain from the Rous sarcoma viral protein Src [9] Journal of Biomolecular NMR 32 339-, 2005
DOI:10.1007/s10858-005-0471-7

Cliff MJ, Williams MA, Brooke-Smith J, Barford D, Ladbury JE Molecular recognition via coupled folding and binding in a TPR domain Journal of Molecular Biology 346 717-732, 2005
DOI:10.1016/j.jmb.2004.12.017
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Yang J, Roe SM, Cliff MJ, Williams MA, Ladbury JE, Cohen PTW, Barford D Molecular basis for TPR domain-mediated regulation of protein phosphatase 5 EMBO Journal 24 1-10, 2005
DOI:10.1038/sj.emboj.7600496
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Ladbury JE Application of isothermal titration calorimetry in the biological sciences: Things are heating up! BioTechniques 37 885-887, 2004

Lachenmann MJ, Ladbury JE, Qian X, Huang K, Singh R, Weiss MA Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice Protein Science 13 3115-3126, 2004
DOI:10.1110/ps.04866404
View abstract

Lachenmann MJ, Ladbury JE, Dong J, Huang K, Carey P, Weiss MA Why zinc fingers prefer zinc: Ligand-field symmetry and the hidden thermodynamics of metal ion selectivity Biochemistry 43 13910-13925, 2004
DOI:10.1021/bi0491999
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Cliff MJ, Gutierrez A, Ladbury JE A survey of the year 2003 literature on applications of isothermal titration calorimetry Journal of Molecular Recognition 17 513-523, 2004
DOI:10.1002/jmr.714
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Bergqvist S, Williams MA, O'Brien R, Ladbury JE Heat Capacity Effects of Water Molecules and Ions at a Protein-DNA Interface Journal of Molecular Biology 336 829-842, 2004
DOI:10.1016/j.jmb.2003.12.061
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Cliff MJ, Ladbury JE A survey of the year 2002 literature on applications of isothermal titration calorimetry Journal of Molecular Recognition 16 383-391, 2003
DOI:10.1002/jmr.648
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Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors Journal of Biological Chemistry 278 39735-39746, 2003
DOI:10.1074/jbc.M304541200
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Bergqvist S, Williams MA, O'Brien R, Ladbury JE Halophilic adaptation of protein-DNA interactions, 2003
DOI:10.1042/BST0310677
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O'Rourke L, Ladbury JE Specificity is complex and time consuming: Mutual exclusivity in tyrosine kinase-mediated signaling Accounts of Chemical Research 36 410-416, 2003
DOI:10.1021/ar020167s
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Esposito D, Petrovic A, Harris R, Ono S, Eccleston JF, Mbabaali A, Haq I, Higgins CF, Hinton JCD, Driscoll PC, Ladbury JE H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein Journal of Molecular Biology 324 841-850, 2002
DOI:10.1016/S0022-2836(02)01141-5
View abstract

Salek RM, Williams MA, Prodromou C, Pearl LH, Ladbury JE Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone [3] Journal of Biomolecular NMR 23 327-328, 2002
DOI:10.1023/A:1020268712347

Low LY, Hernández H, Robinson CV, O'Brien R, Grossmann JG, Ladbury JE, Luisi B Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains Journal of Molecular Biology 319 87-106, 2002
DOI:10.1016/S0022-2836(02)00236-X
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Bergqvist S, Williams MA, O'Brien R, Ladbury JE Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy Structure 10 629-637, 2002
DOI:10.1016/S0969-2126(02)00749-9
View abstract

Ladbury JE Isothermal titration calorimetry: Application to structure-based drug design Thermochimica Acta 380 209-215, 2001
DOI:10.1016/S0040-6031(01)00674-8
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Haq I, O'Brien R, Lagunavicius A, Siksnys V, Ladbury JE Specific DNA recognition by the type II restriction endonuclease MunI: The effect of pH Biochemistry 40 14960-14967, 2001
DOI:10.1021/bi0113566
View abstract

Henriques DA, Ladbury JE Inhibitors to the Src SH2 domain: A lesson in structure-thermodynamic correlation in drug design Archives of Biochemistry and Biophysics 390 158-168, 2001
DOI:10.1006/abbi.2001.2334
View abstract

Lee L, Stollar E, Chang JF, Günter Grossmann J, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator Biochemistry 40 6580-6588, 2001
DOI:10.1021/bi010095x
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Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble MEM The Role of the Src Homology 3-Src Homology 2 Interface in the Regulation of Src Kinases Journal of Biological Chemistry 276 17199-17205, 2001
DOI:10.1074/jbc.M011185200
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Joseph C, Stier G, O'Brien R, Politou AS, Atkinson RA, Bianco A, Ladbury JE, Martin SR, Pastore A A structural characterization of the interactions between titin Z-repeats and theα-actinin C-terminal domain Biochemistry 40 4957-4965, 2001
DOI:10.1021/bi002739r
View abstract

Renzoni D, Esposito D, Pfuhl M, Hinton JCD, Higgins CF, Driscoll PC, Ladbury JE Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS H-NS Journal of Molecular Biology 306 1127-1137, 2001
DOI:10.1006/jmbi.2001.4471
View abstract

Bergqvist S, O'Brien R, Ladbury JE Site-specific cation binding mediates TATA binding protein - DNA interaction from a hyperthermophilic archaeon Biochemistry 40 2419-2425, 2001
DOI:10.1021/bi002488m
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Payne JW, Grail BM, Gupta S, Ladbury JE, Marshall NJ, O Brien R, Payne GM Structural basis for recognition of dipeptides by peptide transporters Archives of Biochemistry and Biophysics 384 9-23, 2000
DOI:10.1006/abbi.2000.2084
View abstract

Pacini S, Valensin S, Telford JL, Ladbury J, Baldari CT Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR European Journal of Immunology 30 2620-2631, 2000
DOI:10.1002/1521-4141(200009)30:9<2620::AID-IMMU2620>3.0.CO;2-Q
View abstract

Prodromou C, Panaretou B, Chohan S, Siligardi G, O'Brien R, Ladbury JE, Roe SM, Piper PW, Pearl LH The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the hi-terminal domains EMBO Journal 19 4383-4392, 2000
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Kahmann JD, O'Brien R, Werner JM, Heinegård D, Ladbury JE, Campbell ID, Day AJ Localization and characterization of the hyaluronan-binding site on the Link module from human TSG-6 Structure 8 763-774, 2000
DOI:10.1016/S0969-2126(00)00163-5
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Ihtshamul H, Ladbury J Drug-DNA recognition: Energetics and implications for design Journal of Molecular Recognition 13 188-197, 2000
DOI:10.1002/1099-1352(200007/08)13:4<188::AID-JMR503>3.0.CO;2-1
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Lundbäck T, Chang JF, Phillips K, Luisi B, Ladbury JE Characterization of sequence-specific DNA binding by the transcription factor Oct-1 Biochemistry 39 7570-7579, 2000
DOI:10.1021/bi000377h
View abstract

Smyth CP, Lundbäck T, Renzoni D, Siligardi G, Beavil R, Layton M, Sidebotham JM, Hinton JCD, Driscoll PC, Higgins CF, Ladbury JE Oligomerization of the chromatin-structuring protein H-NS Molecular Microbiology 36 962-972, 2000
DOI:10.1046/j.1365-2958.2000.01917.x
View abstract

O'Brien R, Rugman P, Renzoni D, Layton M, Handa R, Hilyard K, Waterfield MD, Driscoll PC, Ladbury JE Alternative modes of binding of proteins with tandem SH2 domains Protein Science 9 570-579, 2000
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Rostom AA, Tame JRH, Ladbury JE, Robinson CV Specificity and interactions of the protein OppA: Partitioning solvent binding effects using mass spectrometry Journal of Molecular Biology 296 269-279, 2000
DOI:10.1006/jmbi.1999.3431
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Ladbury JE, Arold S Searching for specificity in SH domains Chemistry and Biology 7 -, 2000
DOI:10.1016/S1074-5521(00)00067-3
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Chung EW, Henriques DA, Renzoni D, Morton CJ, Mulhern TD, Pitkeathly MC, Ladbury JE, Robinson CV Probing the nature of interactions in SH2 binding interfaces - Evidence from electrospray ionization mass spectrometry Protein Science 8 1962-1970, 1999
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Sleigh SH, Seavers PR, Wilkinson AJ, Ladbury JE, Tame JRH Crystallographic and calorimetric analysis of peptide binding to OppA protein Journal of Molecular Biology 291 393-415, 1999
DOI:10.1006/jmbi.1999.2929
View abstract

Chang JF, Phillips K, Lundbäck T, Gstaiger M, Ladbury JE, Luisi B Oct-1 POU and octamer DNA co-operate to recognise the bob-1 transcription co-activator via induced folding Journal of Molecular Biology 288 941-952, 1999
DOI:10.1006/jmbi.1999.2711
View abstract

Baraldi E, Carugo KD, Hyvönen M, Surdo PL, Riley AM, Potter BVL, O'Brien R, Ladbury JE, Saraste M Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate Structure 7 449-460, 1999
DOI:10.1016/S0969-2126(99)80057-4
View abstract

Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin Journal of Medicinal Chemistry 42 260-266, 1999
DOI:10.1021/jm980403y
View abstract

Prodromou C, Siligardi G, O'Brien R, Woolfson DN, Regan L, Panaretou B, Ladbury JE, Piper PW, Pearl LH Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones EMBO Journal 18 754-762, 1999
DOI:10.1093/emboj/18.3.754
View abstract

Willcox BE, Gao GF, Wyer JR, Ladbury JE, Bell JI, Jakobsen BK, Van der Merwe PA TCR binding to peptide-MHC stabilizes a flexible recognition interface Immunity 10 357-365, 1999
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Arold S, O'Brien R, Franken P, Strub MP, Hoh F, Dumas C, Ladbury JE RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef Biochemistry 37 14683-14691, 1998
DOI:10.1021/bi980989q
View abstract

Chung E, Henriques D, Renzoni D, Zvelebil M, Bradshaw JM, Waksman G, Robinson CV, Ladbury JE Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides Structure 6 1141-1151, 1998
View abstract

Panaretou B, Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo EMBO Journal 17 4829-4836, 1998
DOI:10.1093/emboj/17.16.4829
View abstract

Bradshaw JM, Grucza RA, Ladbury JE, Waksman G Probing the 'two-pronged plug two-holed socket' model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: A thermodynamic study Biochemistry 37 9083-9090, 1998
DOI:10.1021/bi973147k
View abstract

O'Brien R, Dedecker B, Fleming KG, Sigler PB, Ladbury JE The effects of salt on the TATA binding Protein-DNA interaction from a hyperthermophilic archaeon Journal of Molecular Biology 279 117-125, 1998
DOI:10.1006/jmbi.1998.1743
View abstract

Garratt PJ, Ibbett AJ, Ladbury JE, O'Brien R, Hursthouse MB, Malik KMA Molecular design using electrostatic interactions. Part 1. Synthesis and properties of flexible tripodand tri- and hexa-cations with restricted conformations. Molecular selection of ferricyanide from ferrocyanide Tetrahedron 54 949-968, 1998
DOI:10.1016/S0040-4020(97)10351-9
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Haq I, Ladbury JE, Chowdhry BZ, Jenkins TC, Chaires JB Specific binding of Hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: Calorimetric and spectroscopic studies Journal of Molecular Biology 271 244-257, 1997
DOI:10.1006/jmbi.1997.1170
View abstract

Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone Cell 90 65-75, 1997
DOI:10.1016/S0092-8674(00)80314-1
View abstract

O'Brien R, Wynn R, Driscoll PC, Davis B, Plaxco KW, Sturtevant JM, Ladbury JE The adaptability of Escherichia coli thioredoxin to non-conservative amino acid substitutions Protein Science 6 1325-1332, 1997
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Lemmon MA, Bu Z, Ladbury JE, Zhou M, Pinchasi D, Lax I, Engelman DM, Schlessinger J Two EGF molecules contribute additively to stabilization of the EGFR dimer EMBO Journal 16 281-294, 1997
DOI:10.1093/emboj/16.2.281
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Tsai FTF, Singh OMP, Skarzynski T, Wonacott AJ, Weston S, Tucker A, Pauptit RA, Breeze AL, Poyser JP, O'Brien R, Ladbury JE, Wigley DB The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin Proteins: Structure, Function and Genetics 28 41-52, 1997
DOI:10.1002/(SICI)1097-0134(199705)28:1<41::AID-PROT4>3.0.CO;2-M
View abstract

Renzoni DA, Pugh DJR, Siligardi G, Das P, Morton CJ, Rossi C, Waterfield MD, Campbell ID, Ladbury JE Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase Biochemistry 35 15646-15653, 1996
DOI:10.1021/bi9620969
View abstract

Ladbury JE Just add water! The effect of water on the specificity of protein- ligand binding sites and its potential application to drug design Chemistry and Biology 3 973-980, 1996
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Tame JRH, Sleigh SH, Wilkinson AJ, Ladbury JE The role of water in sequence-independent ligand binding by an oligopeptide transporter protein NATURE STRUCTURAL BIOLOGY 3 998-1001, 1996
DOI:10.1038/nsb1296-998

Haq I, Ladbury JE, Chowdhry BZ, Jenkins TC Molecular anchoring of duplex and triplex DNA by disubstituted anthracene-9,10-diones: Calorimetric, UV melting, and competition dialysis studies Journal of the American Chemical Society 118 10693-10701, 1996
DOI:10.1021/ja961907t
View abstract

Ladbury JE, Chowdhry BZ Sensing the heat: The application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions Chemistry and Biology 3 791-801, 1996
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Morton CJ, Ladbury JE Water mediated protein-DNA interactions: The relationship of thermodynamics to structural detail Protein Science 5 2115-2118, 1996
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Ladbury JE, Hensmann M, Panayotou G, Campbell ID Alternative modes of tyrosyl phosphopeptide binding to a Src family SH2 domain: Implications for regulation of tyrosine kinase activity Biochemistry 35 11062-11069, 1996
DOI:10.1021/bi960543e
View abstract

LEMMON MA, LADBURY JE, ZHOU M, PINCHASE D, ULLRICH A, LAX I, SCHLESSINGER J DIMERIZATION OF THE EGB RECEPTOR BYU A SINGLE-MOLECULE OF EGF JOURNAL OF CELLULAR BIOCHEMISTRY 20-20, 1995

Ladbury JE, Lemmon MA, Zhou M, Green J, Botfield MC, Schlessinger J Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: A reappraisal Proceedings of the National Academy of Sciences of the United States of America 92 3199-3203, 1995
View abstract

Ladbury JE Counting the calories to stay in the groove Structure 3 635-639, 1995
DOI:10.1016/S0969-2126(01)00197-6
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Ladbury JE, Wynn R, Thomson JA, Sturtevant JM Substitution of Charged Residues into the Hydrophobic Core of Escherichia coli Thioredoxin Results in a Change in Heat Capacity of the Native Protein Biochemistry 34 2148-2152, 1995
DOI:10.1021/bi00007a007
View abstract

Lemmon MA, Ladbury JE, Mandiyan V, Zhou M, Schlessinger J Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2 Journal of Biological Chemistry 269 31653-31658, 1994
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Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, Jaye M, Crumley G, Schlessinger J, Lax I Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation Cell 79 1015-1024, 1994
DOI:10.1016/0092-8674(94)90032-9
View abstract

Ladbury J, Peters R Turning up the heat on rational drug design Nature Biotechnology 12 1083-1085, 1994

Ladbury JE, Sturtevant JM, Leontis NB The Thermodynamics of Formation of a Three-Strand, DNA Three-Way Junction Complex Biochemistry 33 6828-6833, 1994
DOI:10.1021/bi00188a011
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Ladbury JE, Wright JG, Sturtevant JM, Sigler PB A thermodynamic study of the trp repressor-operator interaction Journal of Molecular Biology 238 669-681, 1994
DOI:10.1006/jmbi.1994.1328
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Lemmon MA, Ladbury JE Thermodynamic Studies of Tyrosyl-Phosphopeptide Binding to the SH2 Domain of p56<sup>lck</sup> Biochemistry 33 5070-5076, 1994
DOI:10.1021/bi00183a010
View abstract

Ladbury JE, Kishore N, Sturtevant JM, Hellinga HW, Wynn R Thermodynamic Effects of Reduction of the Active-Site Disulfide of Escherichia coli Thioredoxin Explored by Differential Scanning Calorimetry Biochemistry 33 3688-3692, 1994
DOI:10.1021/bi00178a027
View abstract

Ladbury J, Peters R Turning up the heat on rational drug design Bio/Technology 12 1083-1085, 1994
DOI:10.1038/nbt1194-1083
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Smith GP, Schultz DA, Ladbury JE A ribonuclease S-peptide antagonist discovered with a bacteriophage display library Gene 128 37-42, 1993
DOI:10.1016/0378-1119(93)90150-2
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Ladbury JE, Wynn R, Hellinga HW, Sturtevant JM Stability of Oxidized Escherichia coli Thioredoxin and Its Dependence on Protonation of the Aspartic Acid Residue in the 26 Position Biochemistry 32 7526-7530, 1993
DOI:10.1021/bi00080a026
View abstract

Hua QX, Weiss MA, Ladbury JE Dynamics of a Monomeric Insulin Analogue: Testing the Molten-Globule Hypothesis Biochemistry 32 1433-1442, 1993
DOI:10.1021/bi00057a006
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Ladbury JE, Sturtevant JM, Hu CQ A Differential Scanning Calorimetric Study of the Thermal Unfolding of Mutant Forms of Phage T4 Lysozyme Biochemistry 31 10699-10702, 1992
DOI:10.1021/bi00159a009
View abstract

Henriques DA, Ladbury JE Inhibitors to the Src SH2 domain: A lesson in structure-thermodynamic correlation in drug design Archives of Biochemistry and Biophysics 290 158-168, 1991
DOI:10.1006/abbi.2001.2334
View abstract