Faculty of Biological Sciences

Prof Anne King

BSc, Aberdeen; PhD 1983, Southampton.
Chair of Translational Neuroscience
School of Biomedical Sciences

Contact:  Garstang G6.31f | +44(0) 113 34 34243 | email address for Prof Anne King 

please wait

Admin roles

FBS Equality and Diversity Committee
FBS Faculty Board
FBS UGTSEC
UG Programme Leader: Physiology

Modules taught

BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2229 - Exp Skills: Medical Sciences
BMSC2232 - Topics in Physiology
BMSC3233/34/35/36/37 - ATUs - BMS specific
BMSC3301 - Research Proj: Biomed Sciences

Committees

Member of Undergraduate School Taught Student Education Committee

Centre membership: Neuroscience Research at Leeds (NeuR@L)

Group Leader Prof Anne King  (Chair of Translational Neuroscience)

Spinal cord neurophysiology and neuropharmacology - molecular and cellular aspects of pain. 


Dr Tommaso Iannitti  (Research Fellow)

Dr Christopher Kay  (Postgraduate (BBSRC CASE funded))


Postgraduates

Natalie Griffiths  

Chapman RJ; Lall VK; Maxeiner S; Willecke K; Deuchars J; King AE Localization of neurones expressing the gap junction protein Connexin45 within the adult spinal dorsal horn: a study using Cx45-eGFP reporter mice. Brain Struct Funct 218 751-765, 2013
DOI:10.1007/s00429-012-0426-1
View abstract

Visockis V; King AE M-channels modulate network excitatory activity induced by 4-aminopyridine in immature rat substantia gelatinosa in vitro. Brain Res 1513 9-16, 2013
DOI:10.1016/j.brainres.2013.03.045
View abstract

Allen CE; Worsley MA; King AE; Boissonade FM Fos expression induced by activation of NMDA and neurokinin-1 receptors in the trigeminal subnucleus caudalis in vitro: Role of protein kinases BRAIN RES 1368 19-27, 2011
DOI:10.1016/j.brainres.2010.10.072

Nowak A; Mathieson HR; Chapman RJ; Janzso G; Yanagawa Y; Obata K; Szabo G; King AE Kv3.1b and Kv3.3 channel subunit expression in murine spinal dorsal horn GABAergic interneurones J CHEM NEUROANAT 42 30-38, 2011
DOI:10.1016/j.jchemneu.2011.02.003

Nowak A; Mathieson HR; Chapman RJ; King AE; Janzsó G; Yanagawa Y; Obata K; Szabo G Kv3.1b and Kv3.3 channel subunit expression in murine spinal dorsal horn GABAergic interneurones Journal of Chemical Neuroanatomy 42 30-38, 2011
DOI:10.1016/j.jchemneu.2011.02.003
View abstract

Chapman RJ; La Corte PFC; Asghar AUR; King AE Network-based activity induced by 4-aminopyridine in rat dorsal horn in vitro is mediated by both chemical and electrical synapses J PHYSIOL-LONDON 587 2499-2510, 2009
DOI:10.1113/jphysiol.2009.171777

Giles PA; Trezise DJ; King AE Differential activation of protein kinases in the dorsal horn in vitro of normal and inflamed rats by group I metabotropic glutamate receptor subtypes NEUROPHARMACOLOGY 53 58-70, 2007
DOI:10.1016/j.neuropharm.2007.04.003

Hilton KJ; Bateson AN; King AE Neurotrophin-induced preprotachykinin-A gene promoter modulation in organotypic rat spinal cord culture J NEUROCHEM 98 690-699, 2006
DOI:10.1111/j.1471-4159.2006.03910.x

King AE; Ackley MA; Cass CE; Young JD; Baldwin SA Nucleoside transporters: from scavengers to novel therapeutic targets TRENDS PHARMACOL SCI 27 416-425, 2006
DOI:10.1016/j.tips.2006.06.004

King AE The spinal cord in vitro: What can it tell us about nociception? Neurophysiology 38 410-420, 2006
DOI:10.1007/s11062-006-0079-x
View abstract

Asghar AU; Cilia La Corte PF; LeBeau FE; Al Dawoud M; Reilly SC; Buhl EH; Whittington MA; King AE Oscillatory activity within rat substantia gelatinosa in vitro: a role for chemical and electrical neurotransmission. J Physiol 562 183-198, 2005
DOI:10.1113/jphysiol.2004.076398
View abstract

Worsley MA; Todd AJ; King AE Serotoninergic-mediated inhibition of substance P sensitive deep dorsal horn neurons: a combined electrophysiological and morphological study in vitro Experimental Brain Research 160 360-367, 2005
DOI:10.1007/s00221-004-2018-7
View abstract

Governo RJM; Deuchars J; Baldwin SA; King AE Localization of the NBMPR-sensitive equilibrative nucleoside transporter, ENT1, in the rat dorsal root ganglion and lumbar spinal cord BRAIN RES 1059 129-138, 2005
DOI:10.1016/j.brainres.2005.08.017

Ackley MA; Baldwin SA; King AE Adenosine contributes to mu-opioid synaptic inhibition in rat substantia gelatinosa in vitro NEUROSCI LETT 376 102-106, 2005
DOI:10.1016/j.neulet.2004.11.034

Hilton KJ; Bateson AN; King AE A model of organotypic rat spinal slice culture and biolistic transfection to elucidate factors that drive the preprotachykinin-A promoter Brain Research Reviews 46 191-203, 2004
DOI:10.1016/j.brainresrev.2004.07.016
View abstract

Baldwin SA; Beal PR; Yao SYM; King AE; Cass CE; Young JD The equilibrative nucleoside transporter family, SLC29. Pflugers Archiv: European Journal of Physiology 447 735-743, 2004
DOI:10.1007/s00424-003-1103-2

Ackley MA; Governo RJ; Cass CE; Young JD; Baldwin SA; King AE Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1 Journal of Physiology 548 507-517, 2003
DOI:10.1113/jphysiol.2002.038091
View abstract

Hilton KJ; Ackley MA; Bateson AN; King AE The use of organotypic slice cultures for the biolistic transfection of cells in the dorsal horn, 2002

Asghar AUR; Al Dawoud M; LeBeau FEN; Buhl EH; King AE The role of GABA(A) and glycine receptor-mediated inhibition on theta frequency oscillations in substantia gelatinosa neurones of the rat spinal cord in vitro, 2002

Asghar AUR; LeBeau FEN; Buhl EH; King AE Potassium-induced theta oscillations in rat substantia gelatinosa neurones of the spinal cord in vitro J PHYSIOL-LONDON 539 152P-153P, 2002

Asghar AUR; Bird GC; King AE Glutamate uptake inhibition modulates dorsal horn neurotransmission: a comparison between normal and arthritic rats NEUROREPORT 12 4061-4064, 2001

Bird G; Asghar AU; Ackley MA; King AE Modulation of primary afferent-mediated neurotransmission and Fos expression by glutamate uptake inhibition in rat spinal neurones in vitro Neuropharmacology 41 581-591, 2001
DOI:10.1016/S0028-3908(01)00111-3
View abstract

Badie-Mahdavi H; Worsley MA; Ackley MA; Asghar AUR; Slack JR; King AE A role for protein kinase intracellular messengers in substance P- and nociceptor afferent-mediated excitation and expression of the transcription factor Fos in rat dorsal horn neurons in vitro EUR J NEUROSCI 14 426-434, 2001

Bird GC; Asghar AUR; Ackley MA; King AE Modulation of primary afferent-mediated neurotransmission and Fos expression by glutamate uptake inhibition in rat spinal neurones in vitro NEUROPHARMACOLOGY 41 582-591, 2001

Ackley MA; Asghar AU; Worsley M; King AE Peripheral inflammation reduces the response of spinal dorsal horn neurons to an NK3 receptor agonist Neuroscience Letters 308 13-16, 2001
View abstract

Asghar AU; Hasan SS; King AE Actions of the anticonvulsant remacemide metabolic AR-R12495AA on afferent-evoked spinal synaptic transmission in vitro and on models of acute and chronic inflammation in the rat. Journal of Pharmacology and Experimental Therapeutics 294 876-883, 2000

Asghar AUR; Bird GC; King AE Glutamate transporters and modulation of primary afferent-mediated synaptic transmission in spinal dorsal horn neurones from normal and arthritic rats in vitro BRIT J PHARMACOL 131 U7-U7, 2000

Worsley MA; Badie-Mahdavi H; King AE Protein kinase a involvement in neurokinin- and nociceptive afferent- induced slow depolarisations and fos expression in rat spinal cord dorsal horn in vitro BRIT J PHARMACOL 131 U8-U8, 2000

Asghar AU; Hasan SS; King AE The anticonvulsant remacemide and its metabolite AR-R12495AA attenuate spinal synaptic transmission and carrageenan-induced inflammation in the young rat. European Journal of Pain 4 97-106, 2000

Khasabov SG; Lopez-Garcia JA; Asghar AU; King AE Modulation of afferent-evoked neurotransmission by 5-HT3 receptors in young rat dorsal horn neurones in vitro: a putative mechanism of 5-HT3 induced anti-nociception British Journal of Pharmacology 127 843-852, 1999

Khasabov SG; Lopez-Garcia JA; King AE; Asghar AU The role of 5-HT3 receptors in dorsal horn neurotransmission: mechanisms of endogenous analgesia. British Journal of Pharmacology 127 843-852, 1999

Chiter A; Blair GE; King AE The production of a transgenic rat expressing nerve growth factor using cell-type specific keratin promoters. Biochem Soc Trans 26 S144-, 1998

Khasabov SG; Lopez-Garcia JA; King AE Serotonin-induced population primary afferent depolarisation in vitro: the effects of neonatal capsaicin treatment. Brain Res 789 339-342, 1998
View abstract

King AE; Slack JR; Lopez-Garcia JA; Ackley MA Tachykinin actions on deep dorsal horn neurons in vitro: an electrophysiological and morphological study in the immature rat. European Journal of Neuroscience 9 1037-1046, 1997

Chiter A; King AE; Blair GE The role of neurotrophins in pathological pain states: a novel transgenic rat model of hyperalgesia. Biochem Soc Trans 25 209S-, 1997

Norris SK; King AE The stereo-isomers of the anticonvulsant ARL 12495AA limit sustained repetitive firing and modify action potential properties of rat hippocampal neurons in vitro. J Pharmacol Exp Ther 281 1191-1198, 1997
View abstract

Norris SK; King AE Electrophysiological effects of the anticonvulsant remacemide hydrochloride and its metabolite ARL 12495AA on rat CA1 hippocampal neurons in vitro. Neuropharmacology 36 951-959, 1997
View abstract

King AE; Ackley MA; Slack JR Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro. Brain Res 767 55-63, 1997
View abstract

BadieMahdavi H; Withington DJ; McCrossan D; King AE Induction of c-fos in the auditory pathway following pure-tone or broadband noise stimulation., 1997

King AE; Liu XH Dual action metabotropic glutamate receptor agonists on neuronal excitability and synaptic transmission in spinal ventral horn neurons in vitro Neuropharmacology 35 1673-1680, 1996

Lopez-Garcia JA; King AE Pre- and post-synaptic actions of 5-HT in the rat lumbar dorsal horn in vitro: implications for somatosensory transmission. European Journal of Neuroscience 8 2188-2197, 1996

Lopez-Garcia JA; King AE A novel methodology for simultaneous assessment of the effects of 5-hydroxytryptamine on primary afferent polarisation and synaptic transmission in rat dorsal horn neurones in vitro. J Neurosci Methods 68 1-6, 1996
View abstract

KING AE; THOMPSON SWN BRIEF AND PROLONGED CHANGES IN SPINAL-INJURY EXCITABILITY FOLLOWING PERIPHERAL INJURY SEMIN NEUROSCI 7 233-243, 1995

Lopez-Garcia JA; King AE Membrane properties of physiologically classified rat dorsal horn neurons in vitro: correlation with cutaneous sensory afferent input. Eur J Neurosci 6 998-1007, 1994
View abstract

King AE; Lopez-Garcia JA Intracellular analysis of cutaneous afferent-induced excitation and inhibition in rat dorsal horn neurones in vitro. J Neurosci Methods 52 61-68, 1994
View abstract

King AE; Lopez-Garcia JA Excitatory amino acid receptor-mediated neurotransmission from cutaneous afferents in rat dorsal horn in vitro. J Physiol 472 443-457, 1993
View abstract

King AE; Lopez-Garcia JA; Cumberbatch M Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br J Pharmacol 107 375-381, 1992
View abstract

Thompson SW; King AE; Woolf CJ Activity-Dependent Changes in Rat Ventral Horn Neurons in vitro; Summation of Prolonged Afferent Evoked Postsynaptic Depolarizations Produce a d-2-Amino-5-Phosphonovaleric Acid Sensitive Windup. Eur J Neurosci 2 638-649, 1990
View abstract

King AE; Thompson SW; Woolf CJ Characterization of the cutaneous input to the ventral horn in vitro using the isolated spinal cord-hind limb preparation. J Neurosci Methods 35 39-46, 1990
View abstract

Woolf CJ; King AE Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord. J Neurosci 10 2717-2726, 1990
View abstract

King AE; Thompson SW Characterization of deep dorsal horn neurones in the rat spinal cord in vitro: synaptic and excitatory amino acid induced excitations. Comp Biochem Physiol A Comp Physiol 93 171-175, 1989
View abstract

Woolf CJ; King AE Subthreshold components of the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat lumbar spinal cord. J Neurophysiol 62 907-916, 1989
View abstract

King AE; Thompson SW; Urban L; Woolf CJ An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice. Neurosci Lett 89 286-292, 1988
View abstract

King AE; Thompson SW; Urban L; Woolf CJ The responses recorded in vitro of deep dorsal horn neurons to direct and orthodromic stimulation in the young rat spinal cord. Neuroscience 27 231-242, 1988
View abstract

Woolf CJ; Thompson SW; King AE Prolonged primary afferent induced alterations in dorsal horn neurones, an intracellular analysis in vivo and in vitro. J Physiol (Paris) 83 255-266, 1988
View abstract

Woolf CJ; King AE Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord. J Neurophysiol 58 460-479, 1987
View abstract

KING AE; THOMPSON SWN; URBAN L; WOOLF CJ RESPONSE PROPERTIES OF NEURONS RECORDED FROM THE DEEP DORSAL HORN OF 14-16 DAY OLD RATS INVITRO J PHYSIOL-LONDON 390 P39-P39, 1987

FITZGERALD M; KING AE; THOMPSON SWN; WOOLF CJ THE POSTNATAL-DEVELOPMENT OF THE VENTRAL ROOT REFLEX IN THE RAT - A COMPARATIVE INVIVO AND INVITRO STUDY NEUROSCI LETT 78 41-45, 1987

KING AE; CHERUBINI E; NISTRI A A STUDY OF AMINO ACID-ACTIVATED CURRENTS RECORDED FROM FROG MOTONEURONS INVITRO NEUROSCI LETT 76 179-184, 1987

CORRADETTI R; KING AE; NISTRI A; ROVIRA C; SIVILOTTI L PHARMACOLOGICAL CHARACTERIZATION OF D-AMINOPHOSPHONOVALERIC ACID ANTAGONISM OF AMINO-ACID AND SYNAPTICALLY EVOKED EXCITATIONS ON FROG MOTONEURONES INVITRO - AN INTRACELLULAR STUDY BRIT J PHARMACOL 86 19-25, 1985

KING AE; NISTRI A; ROVIRA C THE EXCITATION OF FROG MOTONEURONES INVITRO BY THE GLUTAMATE ANALOG, DL-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE-PROPIONIC ACID (AMPA), AND THE EFFECT OF AMINO-ACID ANTAGONISTS NEUROSCI LETT 55 77-82, 1985

ARENSON MS; BERTI C; KING AE; NISTRI A THE EFFECT OF D-ALPHA-AMINOADIPATE ON EXCITATORY AMINO-ACID RESPONSES RECORDED INTRACELLULARLY FROM MOTONEURONES OF THE FROG SPINAL-CORD NEUROSCI LETT 49 99-104, 1984