Dr Brian Jackson

BSc, PhD East Anglia
Research Facility Manager for Protein Production
School of Molecular and Cellular Biology

Background: BSc(Hons) 2000-2004; PhD 2004-2008, University of East Anglia. Postdoctoral Research Fellow 2008-2012; Wellcome Trust ISSF Junior Independent Research Fellow 2012-2014; Research Facility Manager for Bioimaging and Flow Cytometry 2015-2016; Research Facility Manager for Protein Production 2016-present, Faculty of Biological Sciences, University of Leeds.

Contact: Astbury 9.108f, +44(0) 113 34 37369 (Lab: +44(0) 113 34 31253), email address for  

You can read more about Dr Jackson's interests here:

Research Interests

Protein Production Facility Manager

I trained as a Molecular Microbiologist, gaining my PhD in 2008 from the University of East Anglia. I gained substantial experience in recombinant DNA and protein technology throughout my PhD and postdoctoral positions, including the expression of archaeal, bacterial, mammalian and viral proteins. I moved from my own independent reserarch to Facility Management in 2015 when I took over management of the Bioimaging and Flow Cytometry Facilities at the University of Leeds. Now, with major investments in structural biology at Leeds, I have been appointed Facility Manager of the new Protein Production Facility (PPF).


Current Projects

We anticipate construction work to begin on the PPF in July 2016, with completion of the facility by Autumn 2016.

The Leeds PPF will offer the following services:

  • Vector design and cloning strategies
  • Protein expression optimisation
  • Protein purification from bacterial, insect or mammalian cells

Whilst the PPF is still in the design/construction stage, I am happy to discuss potential projects and can help with design, advice and small-scale lab work in the short term. Please get in touch for all your protein needs.


Faculty Research and Innovation

Modules taught

BIOL2211 - Human Diseases
BIOL5371M - Research Planning and Scientific Communication
SPSC2203 - Exercise Biochemistry

Centre membership: The Astbury Centre for Structural Molecular Biology

Group Leader Dr Brian Jackson  (Research Facility Manager for Protein Production )

Protein Production Facility Manager 

Miss Fatima Nadat  (Research Technician)

Mr David Sharples  (Technician)

Mrs Laura Wilkinson Hewitt  (Research Technician)

Research Facility Manager for Protein Production

Schumann S, Jackson BR, Yule I, Whitehead SK, Revill C, Foster R, Whitehouse A Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach Nature Microbiology 2, 2016
View abstract

Jackson BR, Noerenberg M, Whitehouse A A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells. PLoS Pathog 10 e1004098-, 2014
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Jackson BR, Boyne JR, Noerenberg M, Taylor A, Hautbergue GM, Walsh MJ, Wheat R, Blackbourn DJ, Wilson SA, Whitehouse A An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export. PLoS Pathog 7 e1002138-, 2011
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Tunnicliffe RB, Hautbergue GM, Kalra P, Jackson BR, Whitehouse A, Wilson SA, Golovanov AP Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57 PLOS PATHOG 7, 2011

Boyne JR, Jackson BR, Taylor A, Macnab SA, Whitehouse A Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs. EMBO J 29 1851-1864, 2010
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Rout SP, Payne L, Walker S, Scott T, Heard P, Eccles H, Bond G, Shah P, Bills P, Jackson BR, Boxall SA, Laws AP, Charles C, Williams SJ, Humphreys PN The Impact of Alkaliphilic Biofilm Formation on the Release and Retention of Carbon Isotopes from Nuclear Reactor Graphite Scientific Reports 8, 2018
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Charles CJ, Rout SP, Laws AP, Jackson BR, Boxall SA, Humphreys PN The impact of biofilms upon surfaces relevant to an intermediate level radioactive waste geological disposal facility under simulated near-field conditions Geosciences (Switzerland) 7, 2017
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Charles CJ, Rout SP, Patel KA, Akbar S, Laws AP, Jackson BR, Boxall SA, Humphreys PN Floc formation reduces the pH stress experienced by microorganisms living in alkaline environments Applied and Environmental Microbiology 83, 2017
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Wood JJ, Boyne JR, Paulus C, Jackson BR, Nevels MM, Whitehouse A, Hughes DJ ARID3B: A novel regulator of the Kaposi's sarcoma-associated herpesvirus lytic cycle Journal of Virology 90 9543-9555, 2016
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Hughes DJ, Wood JJ, Jackson BR, Baquero-Pérez B, Whitehouse A NEDDylation Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus Latency and Lytic Reactivation and Represents a Novel Anti-KSHV Target PLoS Pathogens 11, 2015
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Owen CB, Hughes DJ, Baquero-Perez B, Berndt A, Schumann S, Jackson BR, Whitehouse A Utilising proteomic approaches to understand oncogenic human herpesviruses Molecular and Clinical Oncology 2 891-903, 2014
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Griffiths D, Abdul-Sada H, Knight L, Jackson BR, Richards K, Prescott E, Peach H, Blair GE, Macdonald A, Whitehouse A Merkel cell polyomavirus small T antigen targets the NEMO adaptor protein to disrupt inflammatory signaling Journal of Virology 87 13853-13867, 2013
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Cobb AM, Jackson BR, Kim E, Bond PL, Bowater RP Sequence-specific and DNA structure-dependent interactions of Escherichia coli MutS and human p53 with DNA. Anal Biochem 442 51-61, 2013
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Schumann S, Jackson BR, Baquero-Perez B, Whitehouse A Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing Viruses 5 1901-1923, 2013
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Jackson BR, Noerenberg M, Whitehouse A The Kaposi's sarcoma-associated herpesvirus ORF57 protein and its multiple roles in mRNA biogenesis FRONTIERS IN MICROBIOLOGY 3, 2012

Taylor A, Jackson BR, Noerenberg M, Hughes DJ, Boyne JR, Verow M, Harris M, Whitehouse A Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization. J Virol 85 7881-7891, 2011
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Boyne JR, Jackson BR, Whitehouse A ORF57: Master regulator of KSHV mRNA biogenesis. Cell Cycle 9 2702-2703, 2010

Jackson BR, Noble C, Lavesa-Curto M, Bond PL, Bowater RP Characterization of an ATP-dependent DNA ligase from the acidophilic archaeon "Ferroplasma acidarmanus" Fer1. Extremophiles 11 315-327, 2007
View abstract