Faculty of Biological Sciences

Prof Elwyn Isaac

BSc, PhD 1978, Wales.
Professor of Comparative Biochemistry
School of Biology

Background: Senior Research Fellow in the Department of Biochemistry, University of Liverpool, Liverpool, UK, 1977-1983. Visiting Scientist in the Department of Entomolgy, Texas A&M University, College Station, Texas, USA, 1991 and at the Department d'Etudes et d'Ingéniérie des Protéins, Commissariat à l'Energie Atomique, CE-Saclay, Gif-Sur-Yvette, France, 1998-1999. Visiting Lecturer in the Department of Biological Sciences, University of Lancaster, Lancaster, UK, 2000-2003.

Contact:  Miall 8.15, +44(0) 113 34 32903, email address for  

Disrupting the expression of a C. elegans peptidase gene results in failure to replace old cuticle with new during a larval moult.

Research Interests

Comparative biochemistry and functional genomics of neuropeptides and peptidases

Our research exploits the amenable genetics and the sequenced genomes of the nematode, C. elegans, and the fly, D. melanogaster, to understand biochemical mechanisms of behaviour, development and reproduction.? We are particularly interested in the role of neuropeptides and peptidases in controlling the behaviour and sex-life of insects and in understanding the various physiological roles of members of large metallopeptidase and nucleoside transporter gene families in nematodes. We are also interested in the development of novel strategies to control parasitic nematodes and insect pests by identifying target proteins for inhibitors and vaccines.


Faculty Research and Innovation

Studentship information

Postgraduate studentship areas:

  • Structure and function of peptide hormones in Drosophila

See also:

Modules managed

BLGY2253 - Animals as Pests
BLGY3021 - Research Project
BLGY3340 - Biology Research Projects
BLGY3395 - Advanced Research Skills and Experience
BLGY3396 - Research Literature Review
BLGY5380M - Extended Research Project

Modules taught

BLGY1125 - Biology Practicals and Data Analysis
BLGY2100/2301 - Level 2 Tutorials
BLGY2253 - Animals as Pests
BLGY3021 - Research Project
BLGY3021/3396 - BLGY projects
BLGY3340 - Biology Research Projects
BLGY3340/3021/3396 - BLGY projects
BLGY3340/3395 - BLGY projects

Centre membership: Neuroscience Research at Leeds (NeuR@L)

Group Leader Prof Elwyn Isaac  (Professor of Comparative Biochemistry)

Comparative biochemistry and functional genomics of neuropeptides and peptidases 


Zatul-'Iffah Abu Hasan (Primary supervisor) 90% FTE
Petra Bell (Primary supervisor) 50% FTE
Calum Ferguson (Primary supervisor) 50% FTE
Jaida Begum (Co-supervisor) 50% FTE
Matthew Dooley (Co-supervisor) 20% FTE
James Rouse (Co-supervisor) 10% FTE