Faculty of Biological Sciences

Prof Eileen Ingham

BSc, PhD 1979, Leeds.
Professor of Medical Immunology
School of Biomedical Sciences

Background: BSc (Leeds), PhD (Leeds). Professor of Medical Immunology (2000-); Deputy Director iMBE; Deputy Director of WELMEC; member of EPSRC College and EPSRC Engineering SAT.

Contact:  Garstang 7.60a, +44(0) 113 34 35691, email address for  

You can read more about Prof Ingham's interests here:
http://www.imbe.leeds.ac.uk/people/imbe/staff/e.ingham

Figure 1: (EI)

Figure 2: (EI)

Research Interests

Tissue replacement and regeneration, joint prostheses, tissue engineering

Research is conducted through the multidisciplinary Institute of Medical & Biological Engineering (iMBE) in collaboration with John Fisher (Bioengineer).  I am actively engaged in translational research in three major areas.

(1) Acellular biological scaffolds for tissue repair and regeneration

Firstly, research towards clinical and commercial translation of biological scaffolds in musculoskeletal and cardiovascular applications. Investigations include:  the effects of different sterilisation techniques on the structure and function of acellular biological scaffolds; gaining insight into the regenerative potential of these scaffolds and elucidation of the role of macrophages in the regenerative process. The developments in musculoskeletal include novel composite scaffolds of bone and soft tissues. This research is supported by the Leeds Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC, WT088908/z/09/z, an ERC Advanced investigator award, NIHR Leeds Musculoskeletal Biomedical Research Unit (LMBRU), NHS Blood & Transplant and also supported through co-development and proof of concept awards through the IKC in Medical Technologies.

Fundamental studies of the regeneration of acellular cardiovascular and musculoskeletal tissues by adult multipotential stromal cells (MSC) are in progress. This research aims to better understand the role of the micro to macro level strains experienced by MSC in biological scaffolds on their differentiation towards different lineages and to understand the mechanisms by which the acellular biological scaffolds regenerate in vivo. We have developed a unique series of in vitro physiological physically interactive bioreactors that deliver cyclic tensile, compressive and biaxial strain to cell-seeded scaffolds in vitro to support this exciting area of research.

(2) Whole natural joint simulations

I am also actively engaged in research, unique to iMBE, to develop model simulations for whole joint natural joints, focussing initially in the knee. The vision is that these models will be used for the pre-clinical testing of the safety and efficacy of novel tissue substitution therapies including our unique biological scaffolds. This research is supported through EPSRC, LMBRU and the ERC Advanced Investigator award and builds upon our recent developments in this area. My contribution is to develop methods for maintaining the viability of the tissues in short and longer term and  development of novel methods of non-invasive assessment of the viability and function of the tissue.

(3) Biological consequence of exposure to prosthetic wear particles

Elucidation of the biological consequences of exposure to prosthetic wear debris remains a key area of research, currently building upon recent research which demonstrated the propensity of micron sized metal particles to induce type IV hypersensitivity in vivo. I have recently extended studies of wear particle interactions with cells to spinal tissues, in light of the advent of total disc replacements. I have an ongoing collaboration with Tom Brown from the University of Iowa, USA, funded by NIH (USA) on the isolation and characterisation of third body particles generated in hip replacement surgery.

More information: http://www.imbe.leeds.ac.uk
Institute of Medical and Biological Engineering

 

Faculty Research and Innovation



Studentship information

Undergraduate project topics:

  • Organ culture of musculoskeletal tissues, methods for analysis of acellular biological scaffolds for tissue repair and replacement, biological reactions to prosthetic wear particles.

Postgraduate studentship areas:

  • Biological reactions to prosthetic wear particles, development of acellular biological scaffolds for tissue repair and replacement, biological reactions to prosthetic wear particles, effects of physiological mechanical stimulation on the differentiation of adult stem cells, maintaining musculoskeletal tissues in vitro.

See also:

Modules taught

MICR1220 - Introduction to Immunology
MICR3080/3110/3190/3370/BIOL3306 - MICR/BIOL projects

Centre memberships:

Group Leader Prof Eileen Ingham  (Professor of Medical Immunology)

Tissue replacement and regeneration, joint prostheses, tissue engineering 

Dr Helen Berry  (UAF in Cardiovascular Regenerative Therapies & Devices)

Elucidating the Mechanisms Underpinning the Immunomodulation and Regenerative Properties of Acellular Scaffolds 

Mrs Fiona Walker  (Research Technician)

Dr Jennifer Edwards  (Research Fellow)

Dr Hazel Fermor  (Lecturer in Musculoskeletal Regenerative Medicine )

Dr Daniel Thomas  (Laboratory Manager)

Prof Joanne Tipper  (Professor of Medical and Biological Engineering)

Host cell responses to periprosthetic wear products 

Dr Stacy-Paul Wilshaw  (Senior Translational Research Fellow in Cardiovascular Tissue Engineering)

Tissue Replacement and Regeneration, Cardiovascular Tissue Engineering 


Postgraduates

Andres Barco (Primary supervisor) 34% FTE
Vaia Papathanasiou (Primary supervisor) 50% FTE
Lindsey Parker (Primary supervisor) 34% FTE
Normalina Sandora (Primary supervisor) 55% FTE
Ashley Ward (Primary supervisor) 50% FTE
Divya Baji (Co-supervisor) 25% FTE
Philippa Bowland (Co-supervisor) 25% FTE
Amisha Desai (Co-supervisor) 25% FTE
Abdul Hakeem (Co-supervisor) 33% FTE
Taha Khan (Co-supervisor) 33% FTE
Halina Norbertczak (Co-supervisor) 50% FTE
Fatimah Samman (Co-supervisor) 25% FTE
Eirini Tsagkaraki (Co-supervisor) 25% FTE
Fiona Walker (Co-supervisor) 50% FTE
James Warren (Co-supervisor) 33% FTE