Faculty of Biological Sciences

Dr Simon Goodman

BSc, Sheffield, PhD 1996, Cambridge
Lecturer
School of Biology

Background: 2000-2004 Research Fellow, Institute of Zoology, Zoological Society of London

1996-2000 Post-doc, Institute of Cell, Animal and Population Biology, University of Edinburgh

1995-1996 Research Assistant, Dept. Genetics, University of Cambridge

1991-1995 PhD, Dept. Genetics, University of Cambridge

1988-1991 Honours degree, Dept. Genetics, University of Sheffield

Contact:  Manton 8.10 | +44(0) 113 34 32561 | email address for  

Research Interests

Population and conservation genetics, molecular ecology, disease ecology

Caspian
seal
Caspian seal (photo courtesy of Agip KCO)

My research focuses on investigating how patterns of genetic variation relate to disease susceptibility, and the mechanisms by which disease acts as major conservation threat. Pathogens are a major driving force in evolution and are intimately linked with much of the biological diversity we see around us. However, disease is now also a major global conservation threat, comparable in importance to other major factors such as habitat destruction, climate change, over exploitation and invasive species. Work in my group deals with investigating both the underlying evolutionary genetic interactions between hosts and pathogens, and developing ways to manage real world conservation disease threats.

We use a combination of theoretical and empirical approaches in our research, for example by using theoretical models to test hypotheses about the evolution of disease resistance, and comparative genomic techniques to examine genetic variation in host candidate genes in relation to specific wildlife diseases, e.g. Phocine distemper virus in seals, or links between the population genetics of vector populations and their ability to act as vectors for different diseases (e.g. mosquitoes in Galapagos). In recent work we showed that evolutionary feedback due to acquired immunity and stochasticity in epidemic intervals can impede the evolution of disease resistance, a finding that may have important implications for epidemiological models of human, agricultural and wildlife diseases (Harding et al. 2005).

Assessing the health of Galapagos giant tortoises
Assessing the health of Galapagos giant tortoises

In other work, together with Ecuadorian partners we recently established the first ever molecular genetic and pathology laboratory in the Galapagos islands (see http://www.galapagoslab.org). Galapagos is one of the most iconic places in the world for evolution and biodiversity, but many of the endemic species in the archipelago are now vulnerable to introduced diseases, or changes to the ecology of native diseases. We are using a range of genetic and pathology methods to determine what the current and future disease threats are, and to develop disease mitigation strategies for the Galapagos National Park Service. Our research here has already guided plans to reduce the risk of introduction of West Nile Virus to the archipelago (Kilpatrick et al. 2006).

We are also working with Institutions in the 5 Caspian states to develop solutions for conservation of the Caspian seal, which we recently demonstrated to have declined by more than 90% since the start of the 20th century.

 

Current funding for these projects comes from the Darwin Initiative (Galapagos disease threats, grant no: 162-12-17), The Caspian Environment Programme and Agip KCO (Caspian seal conservation), BBSRC and Marie Curie PhD studentships.

 

Faculty Research and Innovation


Studentship information

See also:

Modules managed

BLGY3133 - Advanced topics in Ecology
BLGY3246 - Evolution and Population Genetics
BLGY5104M - Conservation Genetics

Modules taught

BLGY1124 - The Diversity of Life
BLGY1303 - Tutorials: Biology & Genetics
BLGY2100 - Enhanced Study Skills for Biologists
BLGY2223 - Organismal Evolution
BLGY2275 - Human Populations
BLGY3021 - Research Project
BLGY3133 - Advanced topics in Ecology
BLGY3246 - Evolution and Population Genetics
BLGY3340 - Biology Research Projects
BLGY5104M - Conservation Genetics
BLGY5191M - Biodiversity and Conservation MSc and MRes Summer Project
BLGY5198M - Biodiversity and Conservation MRes Research Project 1

Dr Lilia Dmitrieva  (Research Fellow)

Dr Jenny Dunn  (Visiting Research Fellow)

Farmland bird ecology and conservation 


Postgraduates

Judith Lane  
Leandro Patino Patino  
Rebecca Thomas  

Stockdale JE; Dunn JC; Goodman SJ; Morris AJ; Sheehan DK; Grice PV; Hamer KC The protozoan parasite Trichomonas gallinae causes adult and nestling mortality in a declining population of European Turtle Doves, Streptopelia turtur. Parasitology 1-9, 2014
DOI:10.1017/s0031182014001474
View abstract

Eastwood G; Cunningham AA; Goodman SJ; Cruz M; Hilgert N; Kramer LD Using avian surveillance in Ecuador to assess the imminence of West Nile virus incursion to Galápagos EcoHealth 11 53-62, 2014
DOI:10.1007/s10393-014-0911-5
View abstract

Dunn JC; Goodman SJ; Benton TG; Hamer KC Active blood parasite infection is not limited to the breeding season in a declining farmland bird Journal of Parasitology 100 260-266, 2014
DOI:10.1645/13-256.1
View abstract

Wilson SC; Eybatov TM; Amano M; Jepson PD; Goodman SJ The role of canine distemper virus and persistent organic pollutants in mortality patterns of Caspian seals (Pusa caspica). PLoS One 9 e99265-, 2014
DOI:10.1371/journal.pone.0099265
View abstract

Goodman SJ Phocine Distemper Virus In Mononegaviruses of Veterinary Importance, Volume 1: Pathobiology and Molecular Diagnosis , 2013

Dunn JC; Goodman SJ; Benton TG; Hamer KC Avian blood parasite infection during the non-breeding season: an overlooked issue in declining populations? BMC ECOLOGY 13 -, 2013
DOI:10.1186/1472-6785-13-30

Lennon RJ; Dunn JC; Stockdale JE; Goodman SJ; Morris AJ; Hamer KC Trichomonad parasite infection in four species of Columbidae in the UK. Parasitology 140 1368-1376, 2013
DOI:10.1017/S0031182013000887
View abstract

Whitlock R; Stewart GB; Goodman SJ; Piertney SB; Butlin RK; Pullin AS; Burke T A systematic review of phenotypic responses to between-population outbreeding Environmental Evidence 2 -, 2013
DOI:10.1186/2047-2382-2-13
View abstract

Cairns R; Sallu SM; Goodman S Questioning calls to consensus in conservation: a Q study of conservation discourses on Galápagos Environmental Conservation: an international journal of environmental science -, 2013
DOI:10.1017/S0376892913000131

Brock PM; Hall AJ; Goodman SJ; Cruz M; Acevedo-Whitehouse K Applying the tools of ecological immunology to conservation: A test case in the Galapagos sea lion Animal Conservation 16 19-31, 2013
DOI:10.1111/j.1469-1795.2012.00567.x
View abstract

Eastwood G; Goodman SJ; Cunningham AA; Kramer LD Aedes taeniorhynchus vectorial capacity informs a pre-emptive assessment of West Nile virus establishment in Galápagos. Sci Rep 3 1519-, 2013
DOI:10.1038/srep01519
View abstract

Brock PM; Hall AJ; Goodman SJ; Cruz M; Acevedo-Whitehouse K Immune activity, body condition and human-associated environmental impacts in a wild marine mammal. PLoS One 8 e67132-, 2013
DOI:10.1371/journal.pone.0067132
View abstract

Dmitrieva L; Kondakov AA; Oleynikov E; Kydyrmanov A; Karamendin K; Kasimbekov Y; Baimukanov M; Wilson S; Goodman SJ Assessment of Caspian Seal By-Catch in an Illegal Fishery Using an Interview-Based Approach. PLoS One 8 e67074-, 2013
DOI:10.1371/journal.pone.0067074
View abstract

Bataille A; Fournié G; Cruz M; Cedeño V; Parker PG; Cunningham AA; Goodman SJ Host selection and parasite infection in Aedes taeniorhynchus, endemic disease vector in the Galápagos Islands. Infect Genet Evol 12 1831-1841, 2012
DOI:10.1016/j.meegid.2012.07.019
View abstract

Harkonen T; Harding KC; Svensson CJ; Wilson S; Baimukanov M; Dmitrieva L; Goodman SJ Collapse of a Marine Mammal Species Driven by Human Impacts PLoS ONE 7 -, 2012
DOI:10.1371/journal.pone.0043130
View abstract

Niedziałkowska M; Jȩdrzejewska B; Wójcik JM; Goodman SJ Genetic structure of red deer population in northeastern poland in relation to the history of human interventions Journal of Wildlife Management 76 1264-1276, 2012
DOI:10.1002/jwmg.367
View abstract

De Luna CJ; Goodman SJ; Thatcher O; Jepson PD; Andersen L; Tolley K; Hoelzel AR Phenotypic and genetic divergence among harbour porpoise populations associated with habitat regions in the North Sea and adjacent seas. J Evol Biol 25 674-681, 2012
DOI:10.1111/j.1420-9101.2012.02461.x
View abstract

Taype CA; Agapito JC; Accinelli RA; Espinoza JR; Godreuil S; Goodman SJ; Bañuls AL; Shaw MA Genetic diversity, population structure and drug resistance of Mycobacterium tuberculosis in Peru. Infect Genet Evol 12 577-585, 2012
DOI:10.1016/j.meegid.2012.02.002
View abstract

Cruz LL; McGill RAR; Goodman SJ; Hamer KC Stable isotope ratios of a tropical marine predator: Confounding effects of nutritional status during growth Marine Biology 159 873-880, 2012
DOI:10.1007/s00227-011-1864-7
View abstract

Kovacs KM; Aguilar A; Aurioles D; Burkanov V; Campagna C; Gales N; Gelatt T; Goldsworthy SD; Goodman SJ; Hofmeyr GJG; Härkönen T; Lowry L; Lydersen C; Schipper J; Sipilä T; Southwell C; Stuart S; Thompson D; Trillmich F Global threats to pinnipeds Marine Mammal Science 28 414-436, 2012
DOI:10.1111/j.1748-7692.2011.00479.x

Bataille A; Cunningham AA; Cruz M; Cedeño V; Goodman SJ Adaptation, isolation by distance and human-mediated transport determine patterns of gene flow among populations of the disease vector Aedes taeniorhynchus in the Galapagos Islands. Infect Genet Evol 11 1996-2003, 2011
DOI:10.1016/j.meegid.2011.09.009
View abstract

McCarthy AJ; Shaw MA; Jepson PD; Brasseur SM; Reijnders PJ; Goodman SJ Variation in European harbour seal immune response genes and susceptibility to phocine distemper virus (PDV). Infect Genet Evol 11 1616-1623, 2011
DOI:10.1016/j.meegid.2011.06.002
View abstract

Eastwood G; Kramer LD; Goodman SJ; Cunningham AA West Nile Virus Vector Competency of Culex quinquefasciatus Mosquitoes in the Galapagos Islands AM J TROP MED HYG 85 426-433, 2011
DOI:10.4269/ajtmh.2011.10-0739

Bataille A; Cunningham AA; Cruz M; Cedeno V; Goodman SJ Seasonal effects and fine-scale population dynamics of Aedes taeniorhynchus, a major disease vector in the Galapagos Islands MOL ECOL 19 4491-4504, 2010
DOI:10.1111/j.1365-294X.2010.04843.x

Senn HV; Barton NH; Goodman SJ; Swanson GM; Abernethy KA; Pemberton JM Investigating temporal changes in hybridization and introgression in a predominantly bimodal hybridizing population of invasive sika (Cervus nippon) and native red deer (C-elaphus) on the Kintyre Peninsula, Scotland MOL ECOL 19 910-924, 2010
DOI:10.1111/j.1365-294X.2009.04497.x

Senn HV; Swanson GM; Goodman SJ; Barton NH; Pemberton JM Phenotypic correlates of hybridisation between red and sika deer (genus Cervus) J ANIM ECOL 79 414-425, 2010
DOI:10.1111/j.1365-2656.2009.01633.x

McCarthy AJ; Goodman SJ Reassessing conflicting evolutionary histories of the Paramyxoviridae and the origins of respiroviruses with Bayesian multigene phylogenies INFECT GENET EVOL 10 97-107, 2010
DOI:10.1016/j.meegid.2009.11.002

Bataille A; Cunningham AA; Cedeno V; Cruz M; Eastwood G; Fonseca DM; Causton CE; Azuero R; Loayza J; Martinez JDC; Goodman SJ Evidence for regular ongoing introductions of mosquito disease vectors into the Galapagos Islands P R SOC B 276 3769-3775, 2009
DOI:10.1098/rspb.2009.0998

Ruiz-Garcia M; Martinez-Aguero M; Alvarez D; Goodman S Genetic variability in Neotropical deer genera (Mammalia: Cervidae) according to DNA microsatellite loci REV BIOL TROP 57 879-904, 2009

Bataille A; Horsburgh GJ; Dawson DA; Cunningham AA; Goodman SJ Microsatellite markers characterized in the mosquito Aedes taeniorhynchus (Diptera, Culicidae), a disease vector and major pest on the American coast and the Galapagos Islands INFECT GENET EVOL 9 971-975, 2009
DOI:10.1016/j.meegid.2009.04.003

Bataille A; Cunningham AA; Cedeno V; Patino L; Constantinou A; Kramer LD; Goodman SJ Natural colonization and adaptation of a mosquito species in Galapagos and its implications for disease threats to endemic wildlife P NATL ACAD SCI USA 106 10230-10235, 2009
DOI:10.1073/pnas.0901308106

Harkonen T; Jussi M; Baimukanov M; Bignert A; Dmitrieva L; Kasimbekov Y; Verevkin M; Wilson S; Goodman S Pup production and breeding distribution of the Caspian seal (Phoca caspica) in relation to human impacts AMBIO 37 356-361, 2008

McCarthy AJ; Shaw MA; Goodman SJ Pathogen evolution and disease emergence in carnivores P R SOC B 274 3165-3174, 2007
DOI:10.1098/rspb.2007.0884

Schaschl H; Wandeler P; Suchentrunk F; Obexer-Ruff G; Goodman SJ Selection and recombination drive the evolution of MHC class II DRB diversity in ungulates HEREDITY 97 427-437, 2006
DOI:10.1038/sj.hdy.6800892

Hall AJ; Jepson PD; Goodman SJ; Harkonen T Phocine distemper virus in the North and European Seas - Data and models, nature and nurture BIOL CONSERV 131 221-229, 2006
DOI:10.1016/j.biocon.2006.04.008

Kilpatrick AM; Daszak P; Goodman SJ; Rogg H; Kramer LD; Cedeno V; Cunningham AA Predicting pathogen introduction: West Nile virus spread to Galapagos CONSERV BIOL 20 1224-1231, 2006
DOI:10.1111/j.1523-1739.2006.00423.x

Lopez-Vaamonde C; Wikstrom N; Labandeira C; Godfray HCJ; Goodman SJ; Cook JM Fossil-calibrated molecular phylogenies reveal that leaf-mining moths radiated millions of years after their host plants J EVOLUTION BIOL 19 1314-1326, 2006
DOI:10.1111/j.1420-9101.2005.01070.x

Harkonen T; Dietz R; Reijnders P; Teilmann J; Harding K; Hall A; Brasseur S; Siebert U; Goodman SJ; Jepson PD; Rasmussen TD; Thompson P The 1988 and 2002 phocine distemper virus epidemics in European harbour seals DIS AQUAT ORGAN 68 115-130, 2006

Harding KC; Hansen BJL; Goodman SJ Acquired immunity and stochasticity in epidemic intervals impede the evolution of host disease resistance AM NAT 166 722-730, 2005

Whiteman NK; Goodman SJ; Sinclair BJ; Walsh T; Cunningham AA; Kramer LD; Parker PG Establishment of the avian disease vector Culex quinquefasciatus Say, 1823 (Diptera : Culicidae) on the Galapagos Islands, Ecuador Ibis 147 844-847, 2005
DOI:10.1111/j.1474-919X.2005.00468.x

Harkonen T; Harding KC; Goodman SJ; Johannesson K Colonization history of the baltic harbor seals: Integrating archaeological, behavioral, and genetic data Marine Mammal Science 21 695-716, 2005
DOI:10.1111/j.1748-7692.2005.tb01260.x
View abstract

Schaschl H; Suchentrunk F; Hammer S; Goodman SJ Recombination and the origin of sequence diversity in the DRB MHC class II locus in chamois (Rupicapra spp.) Immunogenetics 57 108-115, 2005
DOI:10.1007/s00251-005-0784-4
View abstract

Schaschl H; Goodman SJ; Suchentrunk F Sequence analysis of the MHC class II DRB alleles in Alpine chamois (Rupicapra r. rupicapra) Developmental and Comparative Immunology 28 265-277, 2004
DOI:10.1016/j.dci.2003.08.003
View abstract

Goodman SJ Linkage In Encyclopedia of Evolution , 2002

Lowden S; Finlayson HA; MacDonald AA; Downing AC; Goodman SJ; Leus K; Kaspe L; Wahyuni E; Archibald AL Application of Sus scrofa microsatellite markers to wild suiformes Conservation Genetics 3 347-350, 2002
DOI:10.1023/A:1019989432176

Goodman SJ Genetic Polymorphism In Encyclopedia of Evolution , 2002

Coltman DW; Goodman SJ; Bowen WD Molecular ecology of Atlantic harbour seals (Phoca vitulina) In Cellular and Molecular Biology of Marine Mammals , 2002

Goodman SJ; Tamate HB; Wilson R; Nagata J; Tatsuzawa S; Swanson GM; Pemberton JM; McCullough DR Bottlenecks, drift and differentiation: the population structure and demographic history of sika deer (Cervus nippon) in the Japanese archipelago Molecular Ecology 10 1357-1370, 2001
DOI:10.1046/j.1365-294X.2001.01277.x
View abstract

Goodman SJ; Barton NH; Swanson G; Abernethey K; Pemberton JM Introgression through rare hybridization: A genetic study of a hybrid zone between red and sika deer (genus Cervus) in Argyll, Scotland. Genetics 152 355-371, 1999
View abstract

Goodman SJ Patterns of extensive genetic differentiation and variation among European harbor seals (Phoca vitulina vitulina) revealed using microsatellite DNA polymorphisms. Molecular Biology and Evolution 15 104-118, 1998
View abstract

Slate J; Coltman DW; Goodman SJ; MacLean I; Pemberton JM; Williams JL Bovine microsatellite loci are highly conserved in red deer (Cervus elaphus), sika deer (Cervus nippon) and Soay sheep (Ovis aries). Animal Genetics 29 307-315, 1998
View abstract

Goodman SJ R-ST Calc: a collection of computer programs for calculating estimates of genetic differentiation from microsatellite data and determining their significance MOLECULAR ECOLOGY 6 881-885, 1997
DOI:10.1111/j.1365-294X.1997.tb00143.x

Thompson PM; Goodman S Direct and indirect estimates of dispersal distances TRENDS IN ECOLOGY&EVOLUTION 12 195-196, 1997
DOI:10.1016/S0169-5347(97)84095-5

Goodman SJ Dinucleotide repeat polymorphisms at seven anonymous microsatellite loci cloned from the European harbour seal (Phoca vitulina vitulina). Animal Genetics 28 310-311, 1997

Gemmell NJ; Allen P; Goodman SJ; Reed JZ Interspecific microsatellite markers for the study of pinniped populations. Molecular Ecology 6 661-666, 1997
View abstract

Stanley HF; Casey S; Carnahan JM; Goodman S; Harwood J; Wayne RK Worldwide patterns of mitochondrial DNA differentiation in the harbor seal (Phoca vitulina) MOL BIOL EVOL 13 368-382, 1996