Faculty of Biological Sciences

Dr Nikita Gamper

MS, PhD 1998, St Petersburg
Associate Professor in Neuroscience
School of Biomedical Sciences

Background: 1995-1998 PhD Physiology, Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia. 1999-2001 Postdoctral Fellow, Tuebingen University, Germany. 2001-2005 Postdoctoral Fellow, University of Texas Health Science Center at San Antonio, USA

Contact:  Garstang 6.31d | +44(0) 113 34 37923 | email address for Dr Nikita Gamper 

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Admin roles

FBS UGTSEC
UG Examinations Officer

Modules managed

BMSC2222 - Mechanisms of Brain Function

Modules taught

BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2118 - Neurobiology
BMSC2120 - Scientific Skills
BMSC2222 - Mechanisms of Brain Function
BMSC2223/BMSC3302 - Neuropharmacology/Medical Pharmacology
BMSC2231 - Topics in Neuroscience
BMSC3140 - Advanced Scientific Skills
BMSC3143/44/45/46 - ATUs - BMS specific
BMSC3301 - Research Proj: Biomed Sciences

Committees

Member of Undergraduate School Taught Student Education Committee

Centre membership: Neuroscience Research at Leeds (NeuR@L)

Mr Haixia Gao  (Research Fellow)

Dr Sylvain Gigout  (Research Fellow)

Miss Hannah Marie Kirton  (Research Fellow)

Mrs Katarzyna Marszalek  (Research Technician)


Postgraduates

Xin Jin  
Shihab Shah  

Rose KE; Gigout S; Gamper N M-Current Recording from Acute DRG Slices. Methods Mol Biol 998 311-320, 2013
DOI:10.1007/978-1-62703-351-0_25
View abstract

Kirton HM; Pettinger L; Gamper N Transient overexpression of genes in neurons using nucleofection. Methods Mol Biol 998 55-64, 2013
DOI:10.1007/978-1-62703-351-0_4
View abstract

Ooi L; Gigout S; Pettinger L; Gamper N Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species. J Neurosci 33 6041-6046, 2013
DOI:10.1523/JNEUROSCI.4275-12.2013
View abstract

Boycott HE; Dallas ML; Elies J; Pettinger L; Boyle JP; Scragg JL; Gamper N; Peers C Carbon monoxide inhibition of Cav3.2 T-type Ca2+ channels reveals tonic modulation by thioredoxin. FASEB J 27 3395-3407, 2013
DOI:10.1096/fj.13-227249
View abstract

Pettinger L; Gigout S; Linley JE; Gamper N Bradykinin controls pool size of sensory neurons expressing functionalδ-opioid receptors. J Neurosci 33 10762-10771, 2013
DOI:10.1523/JNEUROSCI.0123-13.2013
View abstract

Jin X; Shah S; Liu Y; Zhang H; Lees M; Fu Z; Lippiat JD; Beech DJ; Sivaprasadarao A; Baldwin SA; Zhang H; Gamper N Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor. Sci Signal 6 ra73-, 2013
DOI:10.1126/scisignal.2004184
View abstract

Du X; Gamper N Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential CURRENT NEUROPHARMACOLOGY 11 621-640, 2013

Linley JE; Pettinger L; Huang D; Gamper N M channel enhancers and physiological M channel block JOURNAL OF PHYSIOLOGY-LONDON 590 793-807, 2012
DOI:10.1113/jphysiol.2011.223404

Hettiarachchi NT; Boyle JP; Bauer CC; Dallas ML; Pearson HA; Hara S; Gamper N; Peers C Peroxynitrite mediates disruption of Ca2+ homeostasis by carbon monoxide via Ca2+ ATPase degradation. Antioxid Redox Signal 17 744-755, 2012
DOI:10.1089/ars.2011.4398
View abstract

Gamper N; Rohacs T Phosphoinositide sensitivity of ion channels, a functional perspective. Subcell Biochem 59 289-333, 2012
DOI:10.1007/978-94-007-3015-1_10
View abstract

Linley JE; Ooi L; Pettinger L; Kirton H; Boyle JP; Peers C; Gamper N Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons. Proc Natl Acad Sci U S A 109 E1578-E1586, 2012
DOI:10.1073/pnas.1201544109
View abstract

Jiang LH; Gamper N; Beech DJ Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1 CURR DRUG TARGETS 12 724-736, 2011

Rose K; Ooi L; Dalle C; Robertson B; Wood IC; Gamper N Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury PAIN 152 742-754, 2011
DOI:10.1016/j.pain.2010.12.028

Jopling HM; Howell GJ; Gamper N; Ponnambalam S The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling BIOCHEM BIOPH RES CO 410 170-176, 2011
DOI:10.1016/j.bbrc.2011.04.093

Linley JE; Rose K; Ooi L; Gamper N Understanding inflammatory pain: ion channels contributing to acute and chronic nociception PFLUG ARCH EUR J PHY 459 657-669, 2010
DOI:10.1007/s00424-010-0784-6

Liu BY; Linley JE; Du XN; Zhang X; Ooi L; Zhang HL; Gamper N The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels J CLIN INVEST 120 1240-1252, 2010
DOI:10.1172/JCI41084

Gamper N Osmosensitivity through the PIP2 availability: just add water J PHYSIOL-LONDON 588 3631-3632, 2010
DOI:10.1113/jphysiol.2010.197871

Mucha M; Ooi L; Linley JE; Mordaka P; Dalle C; Robertson B; Gamper N; Wood IC Transcriptional Control of KCNQ Channel Genes and the Regulation of Neuronal Excitability J NEUROSCI 30 13235-13245, 2010
DOI:10.1523/JNEUROSCI.1981-10.2010

Ooi L; Linley J; Gamper N Substance P triggers two different signaling pathways with opposing actions on M current mediated by intracellular Ca2+rises and oxidative modification FASEB JOURNAL 24 -, 2010

Shapiro MS; Gamper N Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons In Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels. , 2009

Milligan CJ; Li J; Sukumar P; Majeed Y; Dallas ML; English A; Emery P; Porter KE; Smith AM; McFadzean I; Beccano-Kelly D; Bahnasi Y; Cheong A; Naylor J; Zeng FN; Liu X; Gamper N; Jiang LH; Pearson HA; Peers C; Robertson B; Beech DJ Robotic multiwell planar patch-clamp for native and primary mammalian cells NAT PROTOC 4 244-255, 2009
DOI:10.1038/nprot.2008.230

Linley JE; Rose K; Patil M; Robertson B; Akopian AN; Gamper N Inhibition of M Current in Sensory Neurons by Exogenous Proteases: A Signaling Pathway Mediating Inflammatory Nociception J NEUROSCI 28 11240-11249, 2008
DOI:10.1523/JNEUROSCI.2297-08.2008

Gamper N; Shapiro MS Target-specific PIP2 signalling: how might it work? J PHYSIOL-LONDON 582 967-975, 2007
View abstract

Gamper N; Shapiro MS Regulation of ion transport proteins by membrane phosphoinositides NAT REV NEUROSCI 8 921-934, 2007
DOI:10.1038/nrn2257

Zaika O; Lara LS; Gamper N; Hilgemann D; Jaffe DB; Shapiro MS Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels J PHYSIOL-LONDON 575 49-67, 2006
DOI:10.1113/jphysiol.2006.114074

Pochynyuk O; Medina J; Gamper N; Genth H; Stockand JD; Staruschenko A Rapid translocation and insertion of the epithelial Na+ channel in response to RhoA signaling J BIOL CHEM 281 26520-26527, 2006
DOI:10.1074/jbc.M603716200

Patwardhan AM; Jeske NA; Price TJ; Gamper N; Akopian AN; Hargreaves KM The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin P NATL ACAD SCI USA 103 11393-11398, 2006
DOI:10.1073/pnas.0603861103

Jeske NA; Patwardhan AM; Gamper N; Price TJ; Akopian AN; Hargreaves KM Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons J BIOL CHEM 281 32879-32890, 2006
DOI:10.1074/jbc.M603220200

Gamper N; Shapiro MS Exogenous expression of proteins in neurons using the biolistic particle delivery system. Methods Mol Biol 337 27-38, 2006
DOI:10.1385/1-59745-095-2:27
View abstract

Gamper N; Zaika O; Li Y; Martin P; Hernandez CC; Perez MR; Wang AY; Jaffe DB; Shapiro MS Oxidative modification of M-type K+ channels as a mechanism of cytoprotective neuronal silencing EMBO J 25 4996-5004, 2006
DOI:10.1038/sj.emboj.7601374

Gamper N; Reznikov V; Yamada Y; Yang J; Shapiro MS Phosphatidylinositol 4,5-bisphosphate signals underlie receptor-specific G(q/11)-mediated modulation of N-type Ca2+ channels. (vol 24, pg 10980, 2004) J NEUROSCI 25 -, 2005

Gamper N; Li Y; Shapiro MS Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin MOL BIOL CELL 16 3538-3551, 2005
DOI:10.1091/mbc.E04-09-0849

Delmas P; Coste B; Gamper N; Shapiro MS Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation NEURON 47 179-182, 2005
DOI:10.1016/j.neuron.2005.07.001

Gamper N; Stockand JD; Shapiro MS The use of Chinese hamster ovary (CHO) cells in the study of ion channels. J Pharmacol Toxicol Methods 51 177-185, 2005
DOI:10.1016/j.vascn.2004.08.008
View abstract

Li Y; Gamper N; Hilgemann DW; Shapiro MS Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate J NEUROSCI 25 9825-9835, 2005
DOI:10.1523/JNEUROSCI.2597-05.2005

Patwardhan AM; Berg KA; Akopain AN; Jeske NA; Gamper N; Clarke WP; Hargreaves KM Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors J NEUROSCI 25 8825-8832, 2005
DOI:10.1523/JNEUROSCI.0160-05.2005

Li Y; Langlais P; Gamper N; Liu F; Shapiro MS Dual phosphorylations underlie modulation of unitary KCNQ K+ channels by Src tyrosine kinase J BIOL CHEM 279 45399-45407, 2004
DOI:10.1074/jbc.M408410200

Li Y; Gamper N; Shapiro MS Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent J NEUROSCI 24 5079-5090, 2004
DOI:10.1523/JNEUROSCI.0882-04.2004

Gamper N; Reznikov V; Yamada Y; Yang J; Shapiro MS Phosphatidylinositol [correction] 4,5-bisphosphate signals underlie receptor-specific Gq/11-mediated modulation of N-type Ca2+ channels. J Neurosci 24 10980-10992, 2004
DOI:10.1523/JNEUROSCI.3869-04.2004
View abstract

Tong Q; Gamper N; Medina JL; Shapiro MS; Stockand JD Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase. J Biol Chem 279 22654-22663, 2004
DOI:10.1074/jbc.M401004200
View abstract

Gamper N; Shapiro MS Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels. J Gen Physiol 122 17-31, 2003
DOI:10.1085/jgp.200208783
View abstract

Gamper N; Stockand JD; Shapiro MS Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase. J Neurosci 23 84-95, 2003
View abstract

Braĭlovskaia IV; Gamper NL; Savina MV [External pathway of NADH oxidation in the liver of lamprey Lampetra fluviatilis]. Zh Evol Biokhim Fiziol 39 201-204, 2003

Bock J; Szabo I; Gamper N; Adams C; Gulbins E Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms BIOCHEM BIOPH RES CO 305 890-897, 2003
DOI:10.1016/S0006-291X(03)00763-0

Gamper N; Shapiro MS Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels J GEN PHYSIOL 122 17-31, 2003
DOI:10.1085/gp.200208783

Huber S; Uhlemann A; Gamper N; Duranton C; Lang F; Kremsner P Oxidative permeabilization? Trends Parasitol 18 346-, 2002

Huber SM; Uhlemann AC; Gamper NL; Duranton C; Kremsner PG; Lang F Plasmodium falciparum activates endogenous Cl(-) channels of human erythrocytes by membrane oxidation. EMBO J 21 22-30, 2002
DOI:10.1093/emboj/21.1.22
View abstract

Gamper N; Fillon S; Huber SM; Feng Y; Kobayashi T; Cohen P; Lang F IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1. Pflugers Arch 443 625-634, 2002
DOI:10.1007/s00424-001-0741-5
View abstract

Tanneur V; Ilgaz D; Duranton C; Fillon S; Gamper N; Huber SM; Lang F Time-dependent regulation of capacitative Ca2+ entry by IGF-1 in human embryonic kidney cells. Pflugers Arch 445 74-79, 2002
DOI:10.1007/s00424-002-0859-0
View abstract

Gamper N; Fillon S; Feng Y; Friedrich B; Lang PA; Henke G; Huber SM; Kobayashi T; Cohen P; Lang F K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. Pflugers Arch 445 60-66, 2002
DOI:10.1007/s00424-002-0873-2
View abstract

Hendron E; Patel P; Hausenfluke M; Gamper N; Shapiro MS; Booth RE; Stockand JD Identification of cytoplasmic domains within the epithelial Na+ channel reactive at the plasma membrane J BIOL CHEM 277 34480-34488, 2002
DOI:10.1074/jbc.M204615200

Gamper N; Savina MV; Brailovskaja IV; Vereninov AA Respiration rates, ATP content and ionic regulation in hepatocytes of starving lamprey during the pre-spawning period of their life cycle Journal of Fish Biology 58 230-239, 2001
DOI:10.1111/j.1095-8649.2001.tb00510.x
View abstract

Fillon S; Warntges S; Matskevitch J; Moschen I; Setiawan I; Gamper N; Feng YX; Stegen C; Friedrich B; Waldegger S; Broer S; Wagner CA; Huber SM; Klingel K; Vereninov A; Lang F Serum- and glucocorticoid-dependent kinase, cell volume, and the regulation of epithelial transport COMP BIOCHEM PHYS A 130 367-376, 2001
View abstract

Huber SM; Gamper N; Lang F Chloride conductance and volume-regulatory nonselective cation conductance in human red blood cell ghosts PFLUG ARCH EUR J PHY 441 551-558, 2001

Gamper N; Huber SM; Badawi K; Lang F Cell volume-sensitive sodium channels unregulated by glucocorticoids in U937 macrophages PFLUG ARCH EUR J PHY 441 281-286, 2000

Lang F; Ritter M; Gamper N; Huber S; Fillon S; Tanneur V; Lepple-Wienhues A; Szabo I; Gulbins E Cell volume in the regulation of cell proliferation and apoptotic cell death CELL PHYSIOL BIOCHEM 10 417-428, 2000