Prof Nikita Gamper

MS, PhD 1998, St Petersburg
Professor of Neuroscience
School of Biomedical Sciences

Background: 1995-1998 PhD Physiology, Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia. 1999-2001 Postdoctral Fellow, Tuebingen University, Germany. 2001-2005 Postdoctoral Fellow, University of Texas Health Science Center at San Antonio, USA

Contact: Garstang 6.31d, +44(0) 113 34 37923, email address for  

Separation of electrical charges on the plasma membrane of the cell achieved by the complex balance of activities of different ion channels, transporters and pumps is a fundamental principle of life form organization. Dysfunctions of ion channels or their regulation causes a number of human diseases ranging from epilepsy to sudden cardiac death. We study function and regulation of ion channels and, in larger perspective, regulation of cellular excitability. Particular focus of the group is the regulation of excitability of peripheral pain-sensing (nociceptive) neurones in relation to pain signalling. We investigate the regulation of ion channels that control or influence excitability and synaptic transmission of nociceptors (e.g. KCNQ or M channels, Ca2+-activated Cl- channels, sensory TRP channels and voltage-gated Ca2+ channels). Our group is also interested in the modulation of different neuronal ion channels by G protein coupled receptors (GPSRs) and in GPCR signalling networks of sensory neurones. One of the latest projects is aimed at the investigation of the transcriptional regulation of neuronal K+ channels in chronic pain states.

We use a wide range of the cutting-edge methods and techniques which allow us to follow our research questions from the level of individual molecules and up to the whole-organism level. Thus we use biochemical and molecular biological approaches to study individual proteins and genes; we use electrophysiology (patch-clamp and voltage clamp) and bioimaging methods (including live confocal and TIRF microscopy) to study individual cells and, finally, we use various behavioural approaches to probe neuronal signalling in vivo.

Current and recent funding: MRC, BBSRC, Wellcome Trust

Industrial partners: Eli Lilly

Key recent publications:

Gao, H., Boillat, A., Huang, D., Liang, C., Peers, C., Gamper, N. (2017) Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1620598114

Du, X., Hao, H., Yang, Y., Huang, S., Wang, C., Gigout, S., Ramli, R., Li, X., Jaworska, E., Edwards, I., Deuchars, J., Yanagawa, Y., Qi, J., Guan, B., Jaffe, D.B., Zhang, H., Gamper, N. (2017) Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission. J Clin Invest. 127:1741-1756.

Huang, D., Huang, S., Gao, H., Liu, Y., Qi, J., Chen, P., Wang, C., Scragg, J.L., Vakurov, A., Peers, C., Du, X., Zhang, H., Gamper, N. (2016) Redox-dependent modulation of t-type Ca2+ channels in sensory neurons contributes to acute anti-nociceptive effect of substance P. Antioxid Redox Signal. 25:233-51.

Du, X., Hao, H., Gigout, S., Huang, D., Yang, Y., Li, L., Wang, C., Sundt, D., Jaffe, D.B., Zhang, H., Gamper, N. (2014) Control of Somatic Membrane Potential in Nociceptive Neurons and its Implications for Peripheral Nociceptive Transmission. PAIN 155:2306-22.

Jin, X., Shah, S., Liu, Y., Zhang, H., Lees, M., Fu, Z., Lippiat, J.D., Beech, D.J., Sivaprasadarao, A., Baldwin, S.A., Zhang, H., Gamper, N. (2013) Activation of the Cl- Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor. Science Signaling. 6(290):ra73.

Pettinger, L., Gigout, S., Linley, J.E., Gamper, N. (2013) Bradykinin controls pool size of sensory neurons expressing functional δ-opioid receptors. J Neurosci  33:10762-71.

Ooi, L., Gigout, S., Pettinger, L., Gamper, N. (2013) Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species. J Neurosci 33:6041-6.

Linley, J.E., Ooi, L., Pettinger, L., Kirton, H., Boyle, J.P., Peers, C., Gamper, N. (2012) Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons. Proc Natl Acad Sci U S A. 109, E1578-86.

Rose, K. Ooi, L., Dalle, C., Robertson, B., Wood, I.C., Gamper, N. (2011) Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury. PAIN 152,742-54.

Mucha, M., Ooi, L., Linley, J., Mordaka, P., Dalle, C., Robertson, B., Gamper, N., Wood, I. (2010) Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability. J Neurosci 30, 13235-45.

Liu, B., Linley, J.E., Du, X., Zhang, X., Ooi, L., Zhang, H., Gamper, N. (2010) The Acute Nociceptive Signals Induced by Bradykinin in Rat Sensory Neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels. J Clin Invest 120, 1240-52.

Milligan, C.J., Li, J., Sukumar, P., Majeed, Y., Dallas, M.L., English, A., Emery, P., Porter, K.E., Smith, A.M., McFadzean, I.,  Beccano-Kelly, D., Bahnasi, Y., Cheong, A., Naylor, J., Zeng, F., Liu, X., Gamper, N., Jiang, L.-H., Pearson, H.A., Peers, C., Robertson, B., Beech, D.J. (2009).  Robotic multi-well planar patch-clamp for native and primary mammalian cells. Nature Protocols 4, 244-55.

Linley, J.E., Rose, K., Patyl, M., Robertson, B., Akopian, A.N., Gamper, N. (2008) Inhibition of M Current in Sensory Neurons by Exogenous Proteases: a Signalling Pathway Mediating Inflammatory Nociception. J Neurosci 28, 11240-11249.

Gamper, N., Shapiro, M.S. (2007). Regulation of ion transport proteins by membrane phosphoinositides. Nat Rev Neurosci 8:921-934.

Gamper, N., Zaika, O., Li, Y., Martin, P., Hernandez, C.C., Perez, M.R., Wang, A.Y., Jaffe, D.B., Shapiro, M.S. (2006) Oxidative modification of M-type K+ channels as a mechanism of cytoprotective neuronal silencing. EMBO J 25, 4996-5004.

Patwardhan, A.M., Jeske, N.A., Price, T.J., Gamper, N., Akopian, A.N., Hargreaves, K.M. (2006) The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci U S A 103, 11393-8.





Faculty Research and Innovation

Studentship information

Postgraduate studentship areas:

  • Postgraduate studentship: strong candidates willing to do a PHD in the area of neuronal ion channel regulation are encouraged to apply

See also:

Modules managed

BMSC2235 - Molecular Neuroscience

Modules taught

BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2118 - Neurobiology
BMSC2118/2123 - Neurobiology and Sensorty and Motor Neuroscience
BMSC2120 - Scientific Skills
BMSC2223 - Neuropharmacology
BMSC2223/BMSC3302 - Neuropharmacology/Medical Pharmacology
BMSC2231 - Topics in Neuroscience
BMSC2235 - Molecular Neuroscience
BMSC3140 - Advanced Scientific Skills
BMSC3143/44/45/46 C - ATU - Experimental approaches in cellular neuroscience
BMSC3301 - Research Project in Biomedical Sciences
BMSC5382M - Extended Research Project

Centre membership: Neuroscience Research at Leeds (NeuR@L)

Dr Sylvain Gigout  (Research Fellow)

Dr Hannah Marie Kirton  (Research Fellow)

Mr Clement Nivet  (Visiting Research Assistant)


Alexandra-Silvia Hogea (Primary supervisor) 50% FTE
Frederick Jones (Primary supervisor) 50% FTE
Eleni Kyriakopoulou (Co-supervisor) 10% FTE
Rosmaliza Ramli (Primary supervisor) 75% FTE
Shihab Shah (Primary supervisor) 75% FTE
Ruth Butler-Ryan (Co-supervisor) 50% FTE
Cédric Stefens (Co-supervisor) 10% FTE

Zhang J, Chen X, Xue Y, Gamper N, Zhang X Beyond voltage-gated ion channels: Voltage-operated membrane proteins and cellular processes Journal of Cellular Physiology, 2018
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Shah S, Gamper N Fat nerves keep pain at bay EMBO Journal 37, 2018
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Gao H, Boillat A, Huang D, Liang C, Peers C, Gamper N Modulation of KCNQ Channels by Intracellular Zinc, 2018

Berrout J, Kyriakopoulou E, Moparthi L, Hogea AS, Berrout L, Ivan C, Lorger M, Boyle J, Peers C, Muench S, Gomez JE, Hu X, Hurst C, Hall T, Umamaheswaran S, Wesley L, Gagea M, Shires M, Manfield I, Knowles MA, Davies S, Suhling K, Gonzalez YT, Carragher N, Macleod K, Abbott NJ, Calin GA, Gamper N, Zygmunt PM, Timsah Z TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p Nature Communications 8, 2017
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Li L, Sun H, Ding J, Niu C, Su M, Zhang L, Li Y, Wang C, Gamper N, Du X, Zhang H Selective targeting of M‐type potassium Kv7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression‐like behaviour British Journal of Pharmacology 174 4277-4294, 2017
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Du X, Gao H, Jaffe D, Zhang H, Gamper N M-type K(+) channels in peripheral nociceptive pathways. British Journal of Pharmacology, 2017
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Gao H, Boillat A, Huang D, Liang C, Peers C, Gamper N Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate Proceedings of the National Academy of Sciences of the United States of America 114 E6410-E6419, 2017
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Gamper N Itchy channels and where to find them The Journal of Physiology 595 3257-3259, 2017
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Chen K, Marsh BC, Cowan M, Al'Joboori YD, Gigout S, Smith CC, Messenger N, Gamper N, Schwab ME, Ichiyama RM Sequential therapy of anti-Nogo-A antibody treatment and treadmill training leads to cumulative improvements after spinal cord injury in rats Experimental Neurology 292 135-144, 2017
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Du X, Hao H, Yang Y, Huang S, Wang C, Gigout S, Ramli R, Li X, Jaworska E, Edwards I, Deuchars J, Yanagawa Y, Qi J, Guan B, Jaffe DB, Zhang H, Gamper N Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission Journal of Clinical Investigation 127 1741-1756, 2017
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Huang D, Huang S, Gao H, Liu Y, Qi J, Chen P, Wang C, Scragg JL, Vakurov A, Peers C, Du X, Zhang H, Gamper N Redox-Dependent Modulation of T-Type Ca<sup>2+</sup>Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P Antioxidants and Redox Signaling 25 233-251, 2016
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Elies J, Scragg JL, Boyle JP, Gamper N, Peers C Regulation of the T-type Ca<sup>2+</sup>channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H<inf>2</inf>S in nociception Journal of Physiology 594 4119-4129, 2016
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Huang D, Liang C, Zhang F, Men H, Du X, Gamper N, Zhang H Inflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca2+ channels Biochemical and Biophysical Research Communications 473 396-402, 2016
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Parry DA, Holmes TD, Gamper N, El-Sayed W, Hettiarachchi NT, Ahmed M, Cook GP, Logan CV, Johnson CA, Joss S, Peers C, Prescott K, Savic S, Inglehearn CF, Mighell AJ A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency Journal of Allergy and Clinical Immunology 137 955-957.e8, 2016

Jin X, Shah S, Du X, Zhang H, Gamper N Activation of Ca<sup>2+</sup>-activated Cl<sup>-</sup>channel ANO1 by localized Ca<sup>2+</sup>signals Journal of Physiology 594 19-30, 2016
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Gamper N Localised intracellular signalling in neurons JOURNAL OF PHYSIOLOGY-LONDON 594 7-8, 2016

Sundt D, Gamper N, Jaffe DB Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study Journal of Neurophysiology 114 3140-3153, 2015
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Huang D, Huang S, Peers C, Du X, Zhang H, Gamper N GABA&lt;inf&gt;B&lt;/inf&gt; receptors inhibit low-voltage activated and high-voltage activated Ca&lt;sup&gt;2+&lt;/sup&gt; channels in sensory neurons via distinct mechanisms Biochemical and Biophysical Research Communications 465 188-193, 2015
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Liu Y, Zhang H, Huang D, Qi J, Xu J, Gao H, Du X, Gamper N, Zhang H Characterization of the effects of Cl⁻ channel modulators on TMEM16A and bestrophin-1 Ca²⁺ activated Cl⁻ channels. Pflugers Arch 467 1417-1430, 2015
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Peers C, Boyle JP, Scragg JL, Dallas ML, Al-Owais MM, Hettiarachichi NT, Elies J, Johnson E, Gamper N, Steele DS Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. Br J Pharmacol 172 1546-1556, 2015
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Gamper N, Ooi L Redox and nitric oxide-mediated regulation of sensory neuron ion channel function. Antioxid Redox Signal 22 486-504, 2015
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Elies J, Scragg JL, Dallas ML, Huang D, Huang S, Boyle JP, Gamper N, Peers C Inhibition of t-type Ca<sup>2+</sup>channels by hydrogen sulfide, 2015
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Peers C, Elies J, Gamper N Novel ways to regulate T-type Ca<sup>2+</sup>channels Channels 9 68-69, 2015

Elies J, Scragg JL, Huang S, Dallas ML, Huang D, MacDougall D, Boyle JP, Gamper N, Peers C Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels. FASEB J 28 5376-5387, 2014
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Du X, Hao H, Gigout S, Huang D, Yang Y, Li L, Wang C, Sundt D, Jaffe DB, Zhang H, Gamper N Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission. Pain 155 2306-2322, 2014
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Vakurov A, Galluzzi M, Podesta A, Gamper N, Nelson AL, Connell SDA Direct Characterization of Fluid Lipid Assemblies on Mercury in Electric Fields ACS NANO 8 3242-3250, 2014

Du X, Gamper N Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential CURRENT NEUROPHARMACOLOGY 11 621-640, 2013

Jin X, Shah S, Liu Y, Zhang H, Lees M, Fu Z, Lippiat JD, Beech DJ, Sivaprasadarao A, Baldwin SA, Zhang H, Gamper N Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor. Sci Signal 6 ra73-, 2013
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Boycott HE, Dallas ML, Elies J, Pettinger L, Boyle JP, Scragg JL, Gamper N, Peers C Carbon monoxide inhibition of Cav3.2 T-type Ca2+ channels reveals tonic modulation by thioredoxin. FASEB J 27 3395-3407, 2013
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Pettinger L, Gigout S, Linley JE, Gamper N Bradykinin controls pool size of sensory neurons expressing functionalδ-opioid receptors. J Neurosci 33 10762-10771, 2013
View abstract

Ooi L, Gigout S, Pettinger L, Gamper N Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species. J Neurosci 33 6041-6046, 2013
View abstract

Kirton HM, Pettinger L, Gamper N Transient overexpression of genes in neurons using nucleofection. Methods Mol Biol 998 55-64, 2013
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Rose KE, Gigout S, Gamper N M-Current Recording from Acute DRG Slices. Methods Mol Biol 998 311-320, 2013
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Hettiarachchi NT, Boyle JP, Bauer CC, Dallas ML, Pearson HA, Hara S, Gamper N, Peers C Peroxynitrite mediates disruption of Ca2+ homeostasis by carbon monoxide via Ca2+ ATPase degradation. Antioxid Redox Signal 17 744-755, 2012
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Linley JE, Ooi L, Pettinger L, Kirton H, Boyle JP, Peers C, Gamper N Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons. Proc Natl Acad Sci U S A 109 E1578-E1586, 2012
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Linley JE, Pettinger L, Huang D, Gamper N M channel enhancers and physiological M channel block JOURNAL OF PHYSIOLOGY-LONDON 590 793-807, 2012

Gamper N, Rohacs T Phosphoinositide sensitivity of ion channels, a functional perspective. Subcell Biochem 59 289-333, 2012
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Jopling HM, Howell GJ, Gamper N, Ponnambalam S The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling BIOCHEM BIOPH RES CO 410 170-176, 2011

Jiang LH, Gamper N, Beech DJ Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1 CURR DRUG TARGETS 12 724-736, 2011

Rose K, Ooi L, Dalle C, Robertson B, Wood IC, Gamper N Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury PAIN 152 742-754, 2011

Mucha M, Ooi L, Linley JE, Mordaka P, Dalle C, Robertson B, Gamper N, Wood IC Transcriptional Control of KCNQ Channel Genes and the Regulation of Neuronal Excitability J NEUROSCI 30 13235-13245, 2010

Gamper N Osmosensitivity through the PIP2 availability: just add water J PHYSIOL-LONDON 588 3631-3632, 2010

Linley JE, Rose K, Ooi L, Gamper N Understanding inflammatory pain: ion channels contributing to acute and chronic nociception PFLUG ARCH EUR J PHY 459 657-669, 2010

Ooi L, Linley J, Gamper N Substance P triggers two different signaling pathways with opposing actions on M current mediated by intracellular Ca2+rises and oxidative modification FASEB JOURNAL 24, 2010

Liu BY, Linley JE, Du XN, Zhang X, Ooi L, Zhang HL, Gamper N The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels J CLIN INVEST 120 1240-1252, 2010

Linley JE, Gamper N Can Pharmacological Openers Of M-type Potassium Channels Overcome Receptor-mediated Channel Inhibition?, 2009

Ooi L, Rose KE, Linley JE, Mucha M, Wood IC, Gamper N Regulation Of Kcnq2/3 Channels By The Transcriptional Repressor REST In Nociception, 2009

Shapiro MS, Gamper N Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons In Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels., 2009

Milligan CJ, Li J, Sukumar P, Majeed Y, Dallas ML, English A, Emery P, Porter KE, Smith AM, McFadzean I, Beccano-Kelly D, Bahnasi Y, Cheong A, Naylor J, Zeng FN, Liu X, Gamper N, Jiang LH, Pearson HA, Peers C, Robertson B, Beech DJ Robotic multiwell planar patch-clamp for native and primary mammalian cells NAT PROTOC 4 244-255, 2009

Linley JE, Rose K, Patil M, Robertson B, Akopian AN, Gamper N Inhibition of M Current in Sensory Neurons by Exogenous Proteases: A Signaling Pathway Mediating Inflammatory Nociception J NEUROSCI 28 11240-11249, 2008

Gamper N, Shapiro MS Regulation of ion transport proteins by membrane phosphoinositides NAT REV NEUROSCI 8 921-934, 2007

Gamper N, Shapiro MS Target-specific PIP2 signalling: how might it work? J PHYSIOL-LONDON 582 967-975, 2007
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Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons J BIOL CHEM 281 32879-32890, 2006

Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, Wang AY, Jaffe DB, Shapiro MS Oxidative modification of M-type K+ channels as a mechanism of cytoprotective neuronal silencing EMBO J 25 4996-5004, 2006

Pochynyuk O, Medina J, Gamper N, Genth H, Stockand JD, Staruschenko A Rapid translocation and insertion of the epithelial Na+ channel in response to RhoA signaling J BIOL CHEM 281 26520-26527, 2006

Zaika O, Lara LS, Gamper N, Hilgemann D, Jaffe DB, Shapiro MS Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels J PHYSIOL-LONDON 575 49-67, 2006

Patwardhan AM, Jeske NA, Price TJ, Gamper N, Akopian AN, Hargreaves KM The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin P NATL ACAD SCI USA 103 11393-11398, 2006

Gamper N, Shapiro MS Exogenous expression of proteins in neurons using the biolistic particle delivery system. Methods Mol Biol 337 27-38, 2006
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Li Y, Gamper N, Hilgemann DW, Shapiro MS Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate J NEUROSCI 25 9825-9835, 2005

Patwardhan AM, Berg KA, Akopain AN, Jeske NA, Gamper N, Clarke WP, Hargreaves KM Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors J NEUROSCI 25 8825-8832, 2005

Gamper N, Li Y, Shapiro MS Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin MOL BIOL CELL 16 3538-3551, 2005

Delmas P, Coste B, Gamper N, Shapiro MS Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation NEURON 47 179-182, 2005

Gamper N, Stockand JD, Shapiro MS The use of Chinese hamster ovary (CHO) cells in the study of ion channels. J Pharmacol Toxicol Methods 51 177-185, 2005
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Gamper N, Reznikov V, Yamada Y, Yang J, Shapiro MS Phosphatidylinositol 4,5-bisphosphate signals underlie receptor-specific G(q/11)-mediated modulation of N-type Ca2+ channels. (vol 24, pg 10980, 2004) J NEUROSCI 25, 2005

Gamper N, Reznikov V, Yamada Y, Yang J, Shapiro MS Phosphatidylinositol [correction] 4,5-bisphosphate signals underlie receptor-specific Gq/11-mediated modulation of N-type Ca2+ channels. J Neurosci 24 10980-10992, 2004
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Li Y, Langlais P, Gamper N, Liu F, Shapiro MS Dual phosphorylations underlie modulation of unitary KCNQ K+ channels by Src tyrosine kinase J BIOL CHEM 279 45399-45407, 2004

Li Y, Gamper N, Shapiro MS Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent J NEUROSCI 24 5079-5090, 2004

Tong Q, Gamper N, Medina JL, Shapiro MS, Stockand JD Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase. J Biol Chem 279 22654-22663, 2004
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Gamper N, Shapiro MS Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels. J Gen Physiol 122 17-31, 2003
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Bock J, Szabo I, Gamper N, Adams C, Gulbins E Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms BIOCHEM BIOPH RES CO 305 890-897, 2003

Braĭlovskaia IV, Gamper NL, Savina MV [External pathway of NADH oxidation in the liver of lamprey Lampetra fluviatilis]. Zh Evol Biokhim Fiziol 39 201-204, 2003

Gamper N, Stockand JD, Shapiro MS Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase. J Neurosci 23 84-95, 2003
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Tanneur V, Ilgaz D, Duranton C, Fillon S, Gamper N, Huber SM, Lang F Time-dependent regulation of capacitative Ca2+ entry by IGF-1 in human embryonic kidney cells. Pflugers Arch 445 74-79, 2002
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Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. Pflugers Arch 445 60-66, 2002
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Hendron E, Patel P, Hausenfluke M, Gamper N, Shapiro MS, Booth RE, Stockand JD Identification of cytoplasmic domains within the epithelial Na+ channel reactive at the plasma membrane J BIOL CHEM 277 34480-34488, 2002

Huber S, Uhlemann A, Gamper N, Duranton C, Lang F, Kremsner P Oxidative permeabilization? Trends Parasitol 18 346-, 2002

Gamper N, Fillon S, Huber SM, Feng Y, Kobayashi T, Cohen P, Lang F IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1. Pflugers Arch 443 625-634, 2002
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Huber SM, Uhlemann A-C, Gamper NL, Duranton C, Kremsner PG, Lang F Plasmodium falciparum activates endogenous Cl(-) channels of human erythrocytes by membrane oxidation. EMBO J 21 22-30, 2002
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Fillon S, Warntges S, Matskevitch J, Moschen I, Setiawan I, Gamper N, Feng YX, Stegen C, Friedrich B, Waldegger S, Broer S, Wagner CA, Huber SM, Klingel K, Vereninov A, Lang F Serum- and glucocorticoid-dependent kinase, cell volume, and the regulation of epithelial transport COMP BIOCHEM PHYS A 130 367-376, 2001
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Gamper N, Savina MV, Brailovskaja IV, Vereninov AA Respiration rates, ATP content and ionic regulation in hepatocytes of starving lamprey during the pre-spawning period of their life cycle Journal of Fish Biology 58 230-239, 2001
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Huber SM, Gamper N, Lang F Chloride conductance and volume-regulatory nonselective cation conductance in human red blood cell ghosts PFLUG ARCH EUR J PHY 441 551-558, 2001

Gamper N, Huber SM, Badawi K, Lang F Cell volume-sensitive sodium channels unregulated by glucocorticoids in U937 macrophages PFLUG ARCH EUR J PHY 441 281-286, 2000

Gamper NL, Savina MV Reversible metabolic depression in hepatocytes of lamprey (Lampetra fluviatilis) during pre-spawning: regulation by substrate availability. Comparative biochemistry and physiology. Part B, Biochemistry&molecular biology 127 147-154, 2000
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Dubinina EE, Morozova MG, Leonova NV, Gamper NL, Soliternova IB, Nuller IUL, Butoma GB, Kovrugina SV [Oxidative modification of blood proteins in patients with psychiatric disorders (depression, depersonalization)] Voprosy meditsinskoi khimii 46 398-409, 2000
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Wagner CA, Bröer A, Albers A, Gamper N, Lang F, Bröer S The heterodimeric amino acid transporter 4F2hc/LAT1 is associated in Xenopus oocytes with a non-selective cation channel that is regulated by the serine/threonine kinase sgk-1. The Journal of physiology 526 Pt 1 35-46, 2000
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Morozova MG, Gamper NL, Dubinina EE, Nuller IUL, Lebedev AV [High performance liquid chromatography of corticosteroids in patients with depression and depersonalization] Klinicheskaia laboratornaia diagnostika 14-16, 2000
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Lang F, Ritter M, Gamper N, Huber S, Fillon S, Tanneur V, Lepple-Wienhues A, Szabo I, Gulbins E Cell volume in the regulation of cell proliferation and apoptotic cell death CELL PHYSIOL BIOCHEM 10 417-428, 2000

Gamper NL, Saar VG, Koroleva EM, Savina MV [The determination of free nucleotides in tissue, cellular and mitochondrial extracts by microcolumn high-performance liquid chromatography] Zhurnal evoliutsionnoi biokhimii i fiziologii 34 178-184, 1998

Savina MV, Gamper NL, Braĭlovskaia IV [Relationship between the rate of hepatocyte respiration and body mass in the poikilothermic vertebrates] Zhurnal evoliutsionnoi biokhimii i fiziologii 33 392-397, 1997