Dr Juan Fontana

University Academic Fellowship in Correlative Light and Electron Microscopy
School of Molecular and Cellular Biology

Contact: Astbury 8.109, +44(0) 113 34 34170, email address for  

You can read more about Dr Fontana's interests here:

Faculty Research and Innovation

Modules taught

BIOC3303 - Advanced Biochemistry: Skills
BIOL3399 - Extended Research Project Preparation
BIOL5382M - Extended Research Project
BIOL5394M - Specialised Research Topics and Skills
BIOW5907X - Biocatalysis
MICR3211 - Advanced Topics in Microbiology 2


Benjamin Chadwick (Primary supervisor) 35% FTE
Oliver Debski-Antoniak (Primary supervisor) 60% FTE
Lorelai Vennard (Primary supervisor) 50% FTE

Punch EK, Hover S, Blest HTW, Fuller J, Hewson R, Fontana J, Mankouri J, Barr JN Potassium is a trigger for conformational change in the fusion spike of an enveloped RNA virus. The Journal of biological chemistry 293 9937-9944, 2018
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Hover S, Foster B, Fontana J, Kohl A, Goldstein SAN, Barr JN, Mankouri J Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection PLoS Pathogens 14, 2018
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Vennard LM, Atanasiu D, Saw WT, Eisenberg RJ, Cohen GH, Fontana J Recent insights into the structural characterization of herpes simplex virus fusion protein, gB Future Virology 13 5-7, 2018

Fontana J, Atanasiu D, Saw WT, Gallagher JR, Cox RG, Whitbeck JC, Brown LM, Eisenberg RJ, Cohen GH The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane mBio 8, 2017
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Newcomb WW, Fontana J, Winkler DC, Cheng N, Heymann JB, Steven AC The Primary Enveloped Virion of Herpes Simplex Virus 1: Its Role in Nuclear Egress mBio 8 e00825-17-e00825-17, 2017
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Fontana J, Keller PW, Urano E, Ablan SD, Steven AC, Freed EO Identification of an HIV-1 mutation in spacer peptide 1 that stabilizes the immature CA-SP1 lattice Journal of Virology 90 972-978, 2016
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Aksyuk AA, Newcomb WW, Cheng N, Winkler DC, Fontana J, Bernard Heymann J, Steven AC Subassemblies and Asymmetry in Assembly of Herpes Simplex Virus Procapsid mBio 6, 2015
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Fontana J, Jurado KA, Cheng N, Ly NL, Fuchs JR, Gorelick RJ, Engelman AN, Steven AC Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation Journal of Virology 89 9765-9780, 2015
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Fontana J, Steven AC Influenza virus-mediated membrane fusion: Structural insights from electron microscopy Archives of Biochemistry and Biophysics 581 86-97, 2015
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McHugh CA, Fontana J, Nemecek D, Cheng N, Aksyuk AA, Heymann JB, Winkler DC, Lam AS, Wall JS, Steven AC, Hoiczyk E A virus capsid-like nanocompartment that stores iron and protects bacteria from oxidative stress EMBO Journal 33 1896-1911, 2014
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Cairns TM, Fontana J, Huang Z-Y, Whitbeck JC, Atanasiu D, Rao S, Shelly SS, Lou H, Ponce de Leon M, Steven AC, Eisenberg RJ, Cohen GH Mechanism of Neutralization of Herpes Simplex Virus by Antibodies Directed at the Fusion Domain of Glycoprotein B Journal of Virology 88 2677-2689, 2014
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Cheng N, Wu W, Watts NR, Fontana J, Steven AC Turning a liability into an asset: Radiation damage as a cytochemical marker, 2014

Fontana J, Steven AC At Low pH, influenza virus matrix protein M1 undergoes a conformational change prior to dissociating from the membrane Journal of Virology 87 5621-5628, 2013
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Cardone G, Brecher M, Fontana J, Winkler DC, Butan C, White JM, Steven AC Visualization of the two-step fusion process of the retrovirus avian sarcoma/leukosis virus by cryo-electron tomography Journal of Virology 86 12129-12137, 2012
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Verma S, Dimitrova M, Munjal A, Fontana J, Crevar CJ, Carter DM, Ross TM, Khurana S, Goldinga H Oligomeric recombinant H5 HA1 vaccine produced in bacteria protects ferrets from homologous and heterologous wild-type H5N1 influenza challenge and controls viral loads better than subunit h5n1 vaccine by eliciting high-affinity antibodies Journal of Virology 86 12283-12293, 2012
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Fontana J, Cardone G, Heymann JB, Winkler DC, Steven AC Structural changes in influenza virus at low ph characterized by cryo-electron tomography Journal of Virology 86 2919-2929, 2012
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Winkler DC, Fontana J, Cardone G, Heymann JB, Steven AC Cryo-Electron Tomographic Characterization of Structural Changes in Influenza Virus at Low pH Microscopy and Microanalysis 18 108-109, 2012

Khurana S, Larkin C, Verma S, Joshi MB, Fontana J, Steven AC, King LR, Manischewitz J, McCormick W, Gupta RK, Golding H Recombinant HA1 produced in E. coli forms functional oligomers and generates strain-specific SRID potency antibodies for pandemic influenza vaccines Vaccine 29 5657-5665, 2011
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Fontana J, López-Iglesias C, Tzeng WP, Frey TK, Fernández JJ, Risco C Three-dimensional structure of Rubella virus factories Virology 405 579-591, 2010
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Diestra E, Fontana J, Guichard P, Marco S, Risco C Visualization of proteins in intact cells with a clonable tag for electron microscopy Journal of Structural Biology 165 157-168, 2009
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Fontana J, López-Montero N, Elliott RM, Fernández JJ, Risco C The unique architecture of Bunyamwera virus factories around the Golgi complex Cellular Microbiology 10 2012-2028, 2008
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Fontana J, Tzeng WP, Calderita G, Fraile-Ramos A, Frey TK, Risco C Novel replication complex architecture in rubella replicon-transfected cells Cellular Microbiology 9 875-890, 2007
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Novoa RR, Calderita G, Arranz R, Fontana J, Granzow H, Risco C Virus factories: Associations of cell organelles for viral replication and morphogenesis Biology of the Cell 97 147-172, 2005
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