Faculty of Biological Sciences

Prof Stuart Egginton

BSc (Bangor), PhD (St Andrews), DSc (Birmingham)
Leadership Chair in Exercise Science
School of Biomedical Sciences

Background: BSc(Hons) Zoology, University of Wales, Bangor; PhD Physiology, University of St. Andrews, Fife; Postdoctoral Fellow at University of Maine, Orono (USA) and University of Birmingham; Lecturer, Senior Lecturer and Reader in Cardiovascular Physiology at University of Birmingham

Contact:  Worsley 10.100 | +44(0) 113 34 32264 | email address for  

Research Interests

Integrative cardiorespiratory and exercise physiology

My group studies the mechanisms of blood vessel growth, using physiological remodelling to devise targetted therapeutic repair of a pathologically damaged microcirculation, and interactions between the cardiovascular and respiratory systems in exercise and hypothermia, and how deleterious effects may be ameliorated e.g. using electrical stimulation or therapeutic bradycardia. The multidisciplinary approach ranges from mathematical modelling and bioinformatic network analysis, through cell and molecular assays, to in vivo tissue performance and integrative function in a range of animal species and man. These experiments explore the limits to physiological adaptation, and the origins of human morbidity.

 

Current Projects

1) Angiogenesis

The Angiogenesis Research Group is studying the mechanisms underlying growth of blood vessels in skeletal and cardiac muscle, with a particular emphasis on determining how mechanical factors (i.e. the local physical environment of endothelial cells) may initiate and control the proliferation of capillaries during in vivo angiogenesis. Currently under investigation is how increased blood flow (elevated shear stress) and muscle overload (increased longitudinal strain) lead to different patterns of growth originating at the inner (luminal) and outer (abluminal) surfaces, respectively. The combination of local factors invoked during muscle activity is compared with those seen during alterations in the external environment (e.g. hypoxia, hypothermia), including the differential influence of humoral and perivascular signals. These data are essential for the development of angiotherapies to promote regulated vascular growth or control vascular rarefaction, as required. This work has widespread implications - some estimates suggest 80% of NHS medical burden could benefit from targetted angiotherapy.

figure 1

Important developments include the observations that capillary growth can be induced with or without breakage of the basement membrane, endothelial proliferation may precede the formation of sprouts, the lack of involvement of FGF, and that VEGF, NO and metalloproteinases may differentially regulate physiological angiogenesis. These findings do not conform to the patterns established for pathological or in vitro models of angiogenesis. Further studies to elucidate this distinction include the role of stromal cells (pericytes, fibroblasts, macrophages) in controlling angiogenesis, and the link between small and large vessel growth. Exciting new avenues for angiotherapy being explored include manipulation of the HIF transcription pathway, the potential role for stem cells in treatment of muscle ischaemia (using endothelial progenitors), and how mobilisation of other blood components (platelets, leukocytes) may affect the angiogenic response to physiological or pathological stimuli.

figure 2

2) Oxygen transport

The responses to impaired blood flow or increased activity are used to examine how oxygen supply and demand are balanced. Analysis of capillary distribution within heterogeneous tissue (e.g. muscles with different fibre types) utilises morphometric quantification of capillary supply among fibres in terms of 'supply equivalents'. Scaling of capillary supply with respect to fibre size is the usual pattern observed in skeletal muscle of all vertebrates, and this basic growth process may be modified to a limited extent with training or under pathological conditions (see above). This work identifies the need for tight spatial organisation of adaptive angiogenesis. Complimentary to the extracellular diffusion distances described in this manner, changes to intracellular oxygen tension are examined using mathematical models to examine the relative efficiency of changes in different components within the pathway of oxygen transport to tissue. Bioinformatic analysis of complex diseases, those with central and peripheral components involving impaired oxygen transport, is used to explore the possibility of better targetted treatment for established co-morbidities (e.g. heart failure, respiratory disease).

figure 3

3) Muscle plasticity

The metabolic and ultrastructural responses of skeletal muscle to chronic reduction in blood flow or increased activity are followed in order to identify the range of strategies available to balance nutrient supply and demand. Work on chronic ischaemia is continuing to examine the apparent dissociation between structural and functional damage to the endothelium, and impairment of vascular reactivity liked with NO production. Glycolytic and oxidative muscles respond differently to similar stimuli, although metabolic and structural indices of aerobic capacity are closely related in most, but not all, cases (e.g. capillary supply and oxidative capacity may be varied independently, and localised interventions may have significant remote effects). Adaptations examined include myopathic and training responses in humans; electrical stimulation and ischaemia in mammals; steroid and overload hypertrophy in mammals; migratory fitness in a range of vertebrate species.

figure 4

4) Cardiorespiratory control

How well the cardiovascular system copes with reduced core temperature has major implications for survival in all animals, and use of clinically invoked hypothermia in humans. Using a specially designed environmental chamber (with photoperiod and temperature control), the strategies adopted by species that adapt to a cold environment are compared with the more limited tolerance of other mammals (including man). The cardiovascular response of hibernators to hypothermia examines angiogenic potential, vascular reactivity and cardiac autonomic control mechanisms; this has required development of new software (for power spectral analysis) and hardware (data loggers for long term storage), with potentially broad application. Ectotherms from polar & tropical environments provide additional insights into the physiological limits to life on the edge from an evolutionary perspective. Identifying the preserved or ancestral mechanisms will define the most robust, and therefore likely profitable, avenues for therapeutic intervention.

figure 5

 

Faculty Research and Innovation


Studentship information

Undergraduate project topics:

  • Angiogenesis and muscle activity

Postgraduate studentship areas:

  • Animal models of exercise
  • Translational benefits of muscle stimulation
  • Benefits of eccentric exercise

See also:

Modules managed

SPSC3328 - Sport Medicine, Health and Nutrition

Modules taught

BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC1215 - Life in the Extreme: Ultra Human Physiology
BMSC3233/34/35/36 - ATUs - BMS specific
SPSC1211 - Tutorial and Practical Skills in Sport and Exercise Science
SPSC2302 - Exercise Physiology in Sport, Health and Disease
SPSC3061 - Research Project in Sport and Exercise Science II
SPSC3321 - Advanced Exercise Physiology

Naylor AJ; McGettrick HM; Maynard WD; May P; Barone F; Croft AP; Egginton S; Buckley CD A differential role for CD248 (Endosialin) in PDGF-mediated skeletal muscle angiogenesis PLoS ONE 9 -, 2014
DOI:10.1371/journal.pone.0107146
View abstract

Packham IM; Watson SP; Bicknell R; Egginton S In vivo evidence for platelet-induced physiological angiogenesis by a COX driven mechanism PLoS ONE 9 -, 2014
DOI:10.1371/journal.pone.0107503
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Al-Shammari AA; Gaffney EA; Egginton S Modelling capillary oxygen supply capacity in mixed muscles: Capillary domains revisited Journal of Theoretical Biology 356 47-61, 2014
DOI:10.1016/j.jtbi.2014.04.016
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Davidsen PK; Herbert JM; Antczak P; Clarke K; Ferrer E; Peinado VI; Gonzalez C; Roca J; Egginton S; Barbera JA; Falciani F A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD Genome Medicine 6 -, 2014
DOI:10.1186/s13073-014-0059-5
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Egginton S; Brown MD In Memoriam: Olga Hudlicka (11.07.26-03.05.14). Microcirculation (New York, N.Y. : 1994) -, 2014
DOI:10.1111/micc.12151
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Egginton S; Birot O Angiogenesis: Growth points Microcirculation 21 276-277, 2014
DOI:10.1111/micc.12131
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Wragg JW; Durant S; Mcgettrick HM; Sample KM; Egginton S; Bicknell R Shear stress regulated gene expression and angiogenesis in vascular endothelium Microcirculation 21 290-300, 2014
DOI:10.1111/micc.12119
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Vornanen M; Haverinen J; Egginton S Acute heat tolerance of cardiac excitation in the brown trout (Salmo trutta fario) Journal of Experimental Biology 217 299-309, 2014
DOI:10.1242/jeb.091272
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Haverinen J; Egginton S; Vornanen M Electrical Excitation of the Heart in a Basal Vertebrate, the European River Lamprey (Lampetra fluviatilis). Physiological and biochemical zoology : PBZ 87 817-828, 2014
DOI:10.1086/678954
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Syeda F; Hauton D; Young S; Egginton S How ubiquitous is endothelial NOS? Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 166 207-214, 2013
DOI:10.1016/j.cbpa.2013.05.027
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Egginton S; May S; Deveci D; Hauton D Is cold acclimation of benefit to hibernating rodents? Journal of Experimental Biology 216 2140-2149, 2013
DOI:10.1242/jeb.079160
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Patel AS; Smith A; Nucera S; Biziato D; Saha P; Attia RQ; Humphries J; Mattock K; Grover SP; Lyons OT; Guidotti LG; Siow R; Ivetic A; Egginton S; Waltham M; Naldini L; De Palma M; Modarai B TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb EMBO Molecular Medicine 5 858-869, 2013
DOI:10.1002/emmm.201302752
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Patel AS; Smith A; Nucera S; Pucci F; Saha P; Humphries J; Mattock K; Attia RQ; Grover S; Lyons OTA; Egginton S; Siow R; Ivetic A; Waltham M; De Palma M; Modarai B TIE2-expressing monocytes are key regulators of revascularisation in the ischaemic limb, 2013

Dhillon SS; Dóró É; Magyary I; Egginton S; Sík A; Müller F Optimisation of Embryonic and Larval ECG Measurement in Zebrafish for Quantifying the Effect of QT Prolonging Drugs PLoS ONE 8 -, 2013
DOI:10.1371/journal.pone.0060552
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Egginton S Control of branchial artery tone in Antarctic fish, 2013

Egginton S; Hauton D; Winter J; Evans RD Individual microvascular units are critical to cardiac performance, 2013

Lotfi S; Patel AS; Mattock K; Egginton S; Smith A; Modarai B Towards a more relevant hind limb model of muscle ischaemia Atherosclerosis 227 1-8, 2013
DOI:10.1016/j.atherosclerosis.2012.10.060
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Patel AS; Smith A; Nucera S; Biziato D; Saha P; Attia RQ; Humphries J; Grover SP; Mattock K; Lyons OT; Guidotti LG; Siow R; Ivetic A; Egginton S; Waltham M; Naldini L; De Palma M; Modarai B TIE2-expressing monocytes regulate revascularisation of the ischaemic limb, 2013

Thin Luu N; Glen KE; Egginton S; Ed Rainger G; Nash GB Integrin-substrate interactions underlying shear-induced inhibition of the inflammatory response of endothelial cells Thrombosis and Haemostasis 109 298-308, 2013
DOI:10.1160/TH12-06-0400
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Hughes CE; Radhakrishnan UP; Lordkipanidzé M; Egginton S; Dijkstra JM; Jagadeeswaran P; Watson SP G6f-Like Is an ITAM-Containing Collagen Receptor in Thrombocytes PLoS ONE 7 -, 2012
DOI:10.1371/journal.pone.0052622
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Glen K; Luu NT; Ross E; Buckley CD; Rainger GE; Egginton S; Nash GB Modulation of functional responses of endothelial cells linked to angiogenesis and inflammation by shear stress: Differential effects of the mechanotransducer CD31 Journal of Cellular Physiology 227 2710-2721, 2012
DOI:10.1002/jcp.23015
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Hussain A; Steimle M; Hoppeler H; Baum O; Egginton S The Vascular-Disrupting Agent Combretastatin Impairs Splitting and Sprouting Forms of Physiological Angiogenesis Microcirculation 19 296-305, 2012
DOI:10.1111/j.1549-8719.2012.00160.x
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Cudmore MJ; Ahmad S; Sissaoui S; Ramma W; Ma B; Fujisawa T; Al-Ani B; Wang K; Cai M; Crispi F; Hewett PW; Gratacs E; Egginton S; Ahmed A Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: Identification of inter-dependency between Akt-1 and heme oxygenase-1 European Heart Journal 33 1150-1158, 2012
DOI:10.1093/eurheartj/ehr065
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Patel AS; Smith A; Saha P; Killough N; Mattock K; Humphries J; Waltham M; Siow R; Ivetic A; Egginton S; Modarai B Critical limb ischaemia promotes an angiogenic drive that is mediated by the angiopoietin/Tie2 axis, 2012

Patel AS; Smith A; Saha P; Killough N; Mattock K; Humphries J; Waltham M; Siow R; Ivetic A; Egginton S; Modarai B Critical limb ischaemia promotes an angiogenic drive in the circulation, 2012

Al-Shammari AA; Gaffney EA; Egginton S Re-evaluating the Use of Voronoi Tessellations in the Assessment of Oxygen Supply from Capillaries in Muscle Bulletin of Mathematical Biology 74 2204-2231, 2012
DOI:10.1007/s11538-012-9753-x
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Egginton S In vivo shear stress response Biochemical Society Transactions 39 1633-1638, 2011
DOI:10.1042/BST20110715
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Egginton S; Bicknell R Advances in the cellular and molecular biology of angiogenesis Biochemical Society Transactions 39 1551-1555, 2011
DOI:10.1042/BST20110749
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Patel AS; Smith A; Saha P; Mattock K; Humphries J; Waltham M; Siow R; Ivetic A; Egginton S; Modarai B Tie2-expressing Monocytes: An Angiogenic Target In Tissue Ischaemia, 2011

Egginton S; Kumar P HIGH ALTITUDE TOLERANCE IS NOT DETERMINED BY CLASS JOURNAL OF APPLIED PHYSIOLOGY 111 1524-1524, 2011

Egginton S; Kumar P Comments on point:counterpoint: High altitude is/is not for the birds! Journal of Applied Physiology 111 1524-1524, 2011
DOI:10.1152/japplphysiol.01117.2011

Young S; Egginton S Temperature acclimation of gross cardiovascular morphology in common carp (Cyprinus carpio) Journal of Thermal Biology 36 475-477, 2011
DOI:10.1016/j.jtherbio.2011.06.013
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Turan N; Kalko S; Stincone A; Clarke K; Sabah A; Howlett K; Curnow SJ; Rodriguez DA; Cascante M; O'Neill L; Egginton S; Roca J; Falciani F A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease PLoS Computational Biology 7 -, 2011
DOI:10.1371/journal.pcbi.1002129
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Hauton D; May S; Sabharwal R; Deveci D; Egginton S Cold-impaired cardiac performance in rats is only partially overcome by cold acclimation Journal of Experimental Biology 214 3021-3031, 2011
DOI:10.1242/jeb.053587
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Egginton S Physiological factors influencing capillary growth. Acta physiologica (Oxford, England) 202 225-239, 2011
DOI:10.1111/j.1748-1716.2010.02194.x
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Ormerod JOM; Ashrafian H; Maher AR; Arif S; Steeples V; Born GVR; Egginton S; Feelisch M; Watkins H; Frenneaux MP The role of vascular myoglobin in nitrite-mediated blood vessel relaxation Cardiovascular Research 89 560-565, 2011
DOI:10.1093/cvr/cvq299
View abstract

Egginton S; Badr I; Williams J; Hauton D; Baan GC; Jaspers RT Physiological angiogenesis is a graded, not threshold, response Journal of Physiology 589 195-206, 2011
DOI:10.1113/jphysiol.2010.194951
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Rae PC; Kelly RD; Egginton S; St John JC Angiogenic potential of endothelial progenitor cells and embryonic stem cells Vascular Cell 3 -, 2011
DOI:10.1186/2045-824X-3-11
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Scott GR; Schulte PM; Egginton S; Scott ALM; Richards JG; Milsom WK Molecular evolution of cytochrome c oxidase underlies high-altitude adaptation in the bar-headed goose Molecular Biology and Evolution 28 351-363, 2011
DOI:10.1093/molbev/msq205
View abstract

Egginton S Angiogenesis in vivo - the shear stress response, 2011

Robinson E; Egginton S; Davison W Warm-induced bradycardia and cold-induced tachycardia: Mechanisms of cardiac and ventilatory control in a warm-acclimated Antarctic fish Polar Biology 34 371-379, 2011
DOI:10.1007/s00300-010-0891-z
View abstract

Patel A; Smith A; Saha P; Killough N; Mattock K; Humphries J; Waltham M; Siow R; Ivetic A; Egginton S; Modarai B Critical limb ischaemia promotes an angiogenic phenotype in circulating monocytes, 2011

Egginton S; Syeda F Design and physiology of capillaries and secondary circulation | Capillaries, Capillarity, and Angiogenesis In Encyclopedia of Fish Physiology , 2011
DOI:10.1016/B978-0-12-374553-8.00049-6
View abstract

Egginton S Angiogenesis - may the force be with you! Journal of Physiology 588 4615-4616, 2010
DOI:10.1113/jphysiol.2010.201012

Egginton S Muscle capillary supply takes the load Journal of Physiology 588 4607-4608, 2010
DOI:10.1113/jphysiol.2010.200378

Luu N-T; Glen K; Egginton S; Rainger GE; Nash GB Suppression of inflammatory responses of endothelial cells by shear stress: Role of integrin signalling, 2010
DOI:10.1016/j.atherosclerosis.2010.08.030

Egginton S; Gaffney E Tissue capillary supply - It's quality not quantity that counts! Experimental Physiology 95 971-979, 2010
DOI:10.1113/expphysiol.2010.053421
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Hill JV; Egginton S Control of branchial artery tone in fish: Effects of environmental temperature and phylogeny Physiological and Biochemical Zoology 83 33-42, 2010
DOI:10.1086/648469
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Egginton S; White MJ 2010 winter games themed issue Experimental Physiology 95 402-403, 2010

Hauton D; Coney AM; Egginton S Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 154 514-522, 2009
DOI:10.1016/j.cbpa.2009.08.008
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Young S; Egginton S Allometry of skeletal muscle fine structure allows maintenance of aerobic capacity during ontogenetic growth Journal of Experimental Biology 212 3564-3575, 2009
DOI:10.1242/jeb.029512
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Herbert JMJ; Buffa FM; Vorschmitt H; Egginton S; Bicknell R A new procedure for determining the genetic basis of a physiological process in a non-model species, illustrated by cold induced angiogenesis in the carp BMC Genomics 10 490-490, 2009
DOI:10.1186/1471-2164-10-490
View abstract

Scott GR; Egginton S; Richards JG; Milsom WK Evolution of muscle phenotype for extreme high altitude flight in the bar-headed goose Proceedings of the Royal Society B: Biological Sciences 276 3645-3653, 2009
DOI:10.1098/rspb.2009.0947
View abstract

Ormerod JOM; Ashrafian H; Steeples V; Egginton S; Watkins H; Frenneaux MP Myoglobin is involved in vasodilatation by nitrite, 2009

Egginton S The influence of environmental temperature and phylogeny on cardiorespiratory control in fishes, 2009
DOI:10.1016/j.cbpa.2009.05.105

Clough GF; Egginton S Vasomotion and insulin-mediated capillary recruitment - Part of the explanation? Journal of Physiology 587 3407-3408, 2009
DOI:10.1113/jphysiol.2009.174557

Egginton S Invited review: Activity-induced angiogenesis Pflugers Archiv European Journal of Physiology 457 963-977, 2009
DOI:10.1007/s00424-008-0563-9
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Campbell H; Davison W; Fraser KPP; Peck LS; Egginton S Heart rate and ventilation in Antarctic fishes are largely determined by ecotype Journal of Fish Biology 74 535-552, 2009
DOI:10.1111/j.1095-8649.2008.02141.x
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Ahmed SK; Williams JL; Drake-Lee A; Egginton S Staining of nasal mucosa to examine remodelling Journal of Laryngology and Otology 123 234-237, 2009
DOI:10.1017/S0022215108003381
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Egginton S; May S; Deveci D; Hauton D HYPERTROPHIC HAMSTER HEARTS - A COMPROMISE FOR COLD ACCLIMATION?, 2009

Egginton S COLD CAPILLARIES - ANGIOGENESIS IN ECTO- AND ENDOTHERMS SUBJECTED TO LOW TEMPERATURES, 2009

Jetha KA; Nash GB; Egginton S Cooled neutrophils become deposited in the microcirculation after infusion: A potential mechanism for microvascular disruption following tissue hypothermia JOURNAL OF THERMAL BIOLOGY 33 451-458, 2008
DOI:10.1016/j.jtherbio.2008.08.004

Egginton S Optimising peripheral oxygen transport by means of microvascular remodelling, 2008
DOI:10.1016/j.cbpa.2008.04.262

Ross EA; Freeman S; Zhao Y; Dhanjal TS; Ross EJ; Lax S; Ahmed Z; Hou TZ; Kalia N; Egginton S; Nash G; Watson SP; Frampton J; Buckley CD A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow PLoS ONE 3 -, 2008
DOI:10.1371/journal.pone.0002338
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Campbell HA; Fraser KPP; Bishop CM; Peck LS; Egginton S Hibernation in an Antarctic fish: On ice for winter PLoS ONE 3 -, 2008
DOI:10.1371/journal.pone.0001743
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Egginton S In response to "Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise". Journal of applied physiology (Bethesda, Md. : 1985) 104 896-, 2008

Egginton S In response to Point: Counterpoint 'There is/is not capillary recruitment in active skeletal muscle during exercise', 2008

Ahmed SK; Williams JL; Drake-Lee A; Egginton S No significant role for angiogenesis in nasal polyposis American Journal of Rhinology 22 24-28, 2008
DOI:10.2500/ajr.2008.22.3124
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Hudlická O; Garnham A; Shiner R; Egginton S Attenuation of changes in capillary fine structure and leukocyte adhesion improves muscle performance following chronic ischaemia in rats Journal of Physiology 586 4961-4975, 2008
DOI:10.1113/jphysiol.2008.158055
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Facucho-Oliveira JM; Alderson J; Spikings EC; Egginton S; St John JC Mitochondrial DNA replication during differentiation of murine embryonic stem cells Journal of Cell Science 120 4025-4034, 2007
DOI:10.1242/jcs.016972
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Campbell HA; Fraser KPP; Peck LS; Bishop CM; Egginton S Life in the fast lane: The free-ranging activity, heart rate and metabolism of an Antarctic fish tracked in temperate waters Journal of Experimental Marine Biology and Ecology 349 142-151, 2007
DOI:10.1016/j.jembe.2007.05.009
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Nash GB; Egginton S Modelling the Effects of the Haemodynamic Environment on Endothelial Cell Responses Relevant to Angiogenesis In Angiogenesis Assays: A Critical Appraisal of Current Techniques , 2007
DOI:10.1002/9780470029350.ch5
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Campbell HA; Egginton S The vagus nerve mediates cardiorespiratory coupling that changes with metabolic demand in a temperate nototheniod fish Journal of Experimental Biology 210 2472-2480, 2007
DOI:10.1242/jeb.003822
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Hauton D; Egginton S Cold-induced cardiac hypertrophy does not preserve cardiac performance, 2007
DOI:10.1016/j.cbpa.2007.01.355

Taylor T; Campbell H; Egginton S; Skovgaard N Vagal tone determines the relative temperature dependency of heart rate in vertebrates, 2007
DOI:10.1016/j.cbpa.2007.01.353

Egginton S; Hauton D; Campbell H; May S; Young S Seasonal acclimation in cardiac activity: Mammals vs. fish, 2007
DOI:10.1016/j.cbpa.2007.01.354

Deveci D; Egginton S Effects of acute and chronic cooling on cardiorespiratory depression in rodents Journal of Physiological Sciences 57 73-79, 2007
DOI:10.2170/physiolsci.RP005906
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Jetha KA; Egginton S; Nash GB Changes in the integrin-mediated adhesion of human neutrophils in the cold and after rewarming Biorheology 44 37-49, 2007
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Milkiewicz M; Hudlicka O; Shiner R; Egginton S; Brown MD Vascular endothelial growth factor mRNA and protein do not change in parallel during non-inflammatory skeletal muscle ischaemia in rat Journal of Physiology 577 671-678, 2006
DOI:10.1113/jphysiol.2006.113357
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Whiteley NM; Christiansen JS; Egginton S Polar cod, Boreogadus saida (Gadidae), show an intermediate stress response between Antarctic and temperate fishes Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 145 493-501, 2006
DOI:10.1016/j.cbpa.2006.08.023
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Taylor EW; Campbell HA; Levings JJ; Young MJ; Butler PJ; Egginton S Coupling of the respiratory rhythm in fish with activity in hypobranchial nerves and with heartbeat Physiological and Biochemical Zoology 79 1000-1009, 2006
DOI:10.1086/507663
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Degens H; Deveci D; Botto-Van Bemden A; Hoofd LJC; Egginton S Maintenance of heterogeneity of capillary spacing is essential for adequate oxygenation in the soleus muscle of the growing rat Microcirculation 13 467-476, 2006
DOI:10.1080/10739680600776286
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Williams JL; Cartland D; Rudge JS; Egginton S VEGF trap abolishes shear stress- and overload-dependent angiogenesis in skeletal muscle Microcirculation 13 499-509, 2006
DOI:10.1080/10739680600785717
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Campbell HA; Klepacki JZ; Egginton S A new method in applying power spectral statistics to examine cardio-respiratory interactions in fish Journal of Theoretical Biology 241 410-419, 2006
DOI:10.1016/j.jtbi.2005.12.005
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Hauton D; Richards SB; Egginton S The role of the liver in lipid metabolism during cold acclimation in non-hibernator rodents Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology 144 372-381, 2006
DOI:10.1016/j.cbpb.2006.03.013
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Campbell HA; Leite CAC; Wang T; Skals M; Abe AS; Egginton S; Rantin FT; Bishop CM; Taylor EW Evidence for a respiratory component, similar to mammalian respiratory sinus arrhythmia, in the heart rate variability signal from the rattlesnake, Crotalus durissus terrificus Journal of Experimental Biology 209 2628-2636, 2006
DOI:10.1242/jeb.02278
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Williams JL; Weichert A; Zakrzewicz A; Da Silva-Azevedo L; Pries AR; Baum O; Egginton S Differential gene and protein expression in abluminal sprouting and intraluminal splitting forms of angiogenesis Clinical Science 110 587-595, 2006
DOI:10.1042/CS20050185
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Egginton S; Campbell H; Davison W Cardiovascular control in Antarctic fish Deep-Sea Research Part II: Topical Studies in Oceanography 53 1115-1130, 2006
DOI:10.1016/j.dsr2.2006.03.007
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Campbell H; Egginton S; Peck L; Fraser K Vagally mediated heart rates in fish: an evolutionary flexible strategy, 2006

Egginton S; Campbell H; Axelsson M; Davison W Baroreceptor sensitivity of Antarctic fishes-cardiovascular control in extreme hypothermia, 2006

Williams JL; Cartland D; Hussain A; Egginton S A differential role for nitric oxide in two forms of physiological angiogenesis in mouse Journal of Physiology 570 445-454, 2006
DOI:10.1113/jphysiol.2005.095596
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Campbell HA; Taylor EW; Egginton S Does respiratory sinus arrhythmia occur in fishes? Biology Letters 1 484-487, 2005
DOI:10.1098/rsbl.2005.0365
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Campbell HA; Bishop CM; Davies DA; Egginton S Recording long-term heart rate in Paranotothenia angustata using an electronic datalogger Journal of Fish Biology 67 1150-1156, 2005
DOI:10.1111/j.0022-1112.2005.00793.x
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Richards SB; Egginton S; Hauton D Effect of cold acclimation and hypothermia on rat hepatic lipid metabolism, 2005

Campbell HA; Taylor EW; Egginton S Does respiratory sinus arrhythmia occur in fishes?, 2005

Young S; Egginton S Temperature acclimation of branchial vascular control in carp, 2005

Ramsden JD; Buchanan MA; Egginton S; Watkinson JC; Mautner V; Eggo MC Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling Endocrinology 146 2895-2902, 2005
DOI:10.1210/en.2005-0168
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Sänger AM; Davison W; Egginton S Muscle fine structure reflects ecotype in two nototheniids Journal of Fish Biology 66 1371-1386, 2005
DOI:10.1111/j.1095-8649.2005.00689.x
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Milkiewicz M; Pugh CW; Egginton S Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice Journal of Physiology 560 21-26, 2004
DOI:10.1113/jphysiol.2004.069757
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McKenzie DJ; Wong S; Randall DJ; Egginton S; Taylor EW; Farrell AP The effects of sustained exercise and hypoxia upon oxygen tensions in the red muscle of rainbow trout Journal of Experimental Biology 207 3629-3637, 2004
DOI:10.1242/jeb.01199
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Sabharwal R; Johns EJ; Egginton S The influence of acute hypothermia on renal function of anaesthetized euthermic and acclimatized rats Experimental Physiology 89 455-463, 2004
DOI:10.1113/expphysiol.2004.027904
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Sabharwal R; Coote JH; Johns EJ; Egginton S Effect of hyporthermia on baroreflex control of heart rate and renal sympathetic nerve activity in anaesthesized rats Journal of Physiology 557 247-259, 2004
DOI:10.1113/jphysiol.2003.059444
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Campbell HA; Taylor EW; Egginton S The use of power spectral analysis to determine cardiorespiratory control in the short-horned sculpin Myoxocephalus scorpius Journal of Experimental Biology 207 1969-1976, 2004
DOI:10.1242/jeb.00972
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Weichert A; Williams J; da Silva-Azevedo L; Pries AR; Egginton S; Zakrzewicz A; Baum O Restin, PECAM-1, Ang-2, midkine, SPARC, HIF-1alpha and MMP-2 are involved in angiogenesis in skeletal muscles, 2004

Deveci D; Egginton S Cold exposure differentially stimulates angiogenesis in glycolytic and oxidative muscles of rats and hamsters Experimental Physiology 88 741-746, 2003
DOI:10.1113/eph8802630
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Milkiewicz M; Hudlicka O; Verhaeg J; Egginton S; Brown MD Differential expression of Flk-1 and Flt-1 in rat skeletal muscle in response to chronic ischaemia: Favourable effect of muscle activity Clinical Science 105 473-482, 2003
DOI:10.1042/CS20030035
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Badr I; Brown MD; Egginton S; Hudlická O; Milkiewicz M; Verhaeg J Differences in local environment determine the site of physiological angiogenesis in rat skeletal muscle Experimental Physiology 88 565-568, 2003
DOI:10.1113/eph8802601
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Sabharwal R; Johns EJ; Egginton S Baroreflex control of heart rate (HR) and renal sympathetic nerve activity (RSNA) in anaesthetised rats during hypothermia, 2003

Williams J; Baum O; Zakrzewicz A; Egginton S Changes in gene expression in response to different experimental stimuli of angiogenesis in mouse skeletal muscle, 2003

Hudlicka O; Graciotti L; Fulgenzi G; Brown MD; Egginton S; Milkiewics M; Granata A-L The effect of chronic skeletal muscle stimulation on capillary growth in the rat: Are sensory nerve fibres involved? Journal of Physiology 546 813-822, 2003
DOI:10.1113/jphysiol.2002.030569
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Jetha KA; Egginton S; Nash GB Increased resistance of neutrophils to deformation upon cooling and rate of recovery on rewarming Biorheology 40 567-576, 2003
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Egginton S; Gerritsen M Lumen formation. In vivo versus in vitro observations Microcirculation 10 45-61, 2003
DOI:10.1038/sj.mn.7800174
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O'Brien KM; Skilbeck C; Sidell BD; Egginton S Muscle fine structure may maintain the function of oxidative fibres in haemoglobinless Antarctic fishes Journal of Experimental Biology 206 411-421, 2003
DOI:10.1242/jeb.00088
View abstract

Deveci D; Egginton S The effects of reduced temperature and photoperiod on body composition in hibernator and non-hibernator rodents Journal of Thermal Biology 27 467-478, 2002
DOI:10.1016/S0306-4565(02)00019-0
View abstract

Sabharwal R; Johns EJ; Egginton S Effects of hypothermia on renal function in normothermic and cold-acclimated anaesthetised rats, 2002

Rivilis I; Milkiewicz M; Boyd P; Goldstein J; Brown MD; Egginton S; Hansen FM; Hudlicka O; Haas TL Differential involvement of MMP-2 and VEGF during muscle stretch-versus shear stress-induced angiogenesis American Journal of Physiology - Heart and Circulatory Physiology 283 -, 2002
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Schovan L; Egginton S; Hudlicka O; Hansen-Smith F Role of TGF beta and PDGF-B in arteriolar and capillary proliferation in stretched rat extensor digitorum longus (EDL) muscle., 2002

Deveci D; Egginton S Overload-induced angiogenesis is effective during chronic skeletal muscle ischaemia in rats, 2002

Aston S; Hill JV; Egginton S Effects of hypothermia on reactivity of isolated vessels from normothermic and cold-acclimated rats, 2002

Deveci D; Egginton S Differing mechanisms of cold-induced changes in capillary supply in m. tibialis anterior of rats and hamsters Journal of Experimental Biology 205 829-840, 2002
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Egginton S; Skilbeck C; Hoofd L; Calvo J; Johnston IA Peripheral oxygen transport in skeletal muscle of Antarctic and sub-Antarctic notothenioid fish Journal of Experimental Biology 205 769-779, 2002
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Deveci D; Egginton S Muscle ischaemia in rats may be relieved by overload-induced angiogenesis Experimental Physiology 87 479-488, 2002
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Deveci D; Marshall JM; Egginton S Chronic hypoxia induces prolonged angiogenesis in skeletal muscles of rat Experimental Physiology 87 287-291, 2002
DOI:10.1113/eph8702377
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Egginton S Temperature and angiogenesis: The possible role of mechanical factors in capillary growth Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 132 773-787, 2002
DOI:10.1016/S1095-6433(02)00047-8
View abstract

Hudlicka O; Brown MD; Egginton S; Zhou AL; Milkiewicz M Growth patterns in physiological angiogenesis, 2001

Brown MD; Milkiewicz M; Kent J; Egginton S; Hudlicka O The effect of chronic ischemia on eNos in rat skeletal muscle, 2001

Hankins TM; Morris LW; Hudlicka O; Egginton S; Hansen-Smith FM Sequelae and locus of cell proliferation during stretch-induced angiogenesis muscle., 2001

Egginton S; Zhou A-L; Brown MD; Hudlická O Unorthodox angiogenesis in skeletal muscle Cardiovascular Research 49 634-646, 2001
DOI:10.1016/S0008-6363(00)00282-0
View abstract

Egginton S; Fairney J; Bratcher J Differential effects of cold exposure on muscle fibre composition and capillary supply in hibernator and non-hibernator rodents Experimental Physiology 86 629-639, 2001
DOI:10.1113/eph8602260
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Milkiewicz M; Brown MD; Egginton S; Hudlicka O Association between shear stress, angiogenesis, and VEGF in skeletal muscles in vivo Microcirculation 8 229-241, 2001
DOI:10.1038/sj.mn.7800074
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Nash GB; Abbitt KB; Tate K; Jetha KA; Egginton S Changes in the mechanical and adhesive behaviour of human neutrophils on cooling in vitro Pflugers Archiv European Journal of Physiology 442 762-770, 2001
DOI:10.1007/s004240100598
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Deveci D; Marshall JM; Egginton S Relationship between capillary angiogenesis, fiber type, and fiber size in chronic systemic hypoxia American Journal of Physiology - Heart and Circulatory Physiology 281 -, 2001
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Hansen-Smith F; Egginton S; Zhou A-L; Hudlicka O Growth of arterioles precedes that of capillaries in stretch-induced angiogenesis in skeletal muscle Microvascular Research 62 1-14, 2001
DOI:10.1006/mvre.2001.2308
View abstract

Egginton S; Forster ME; Davison W Control of vascular tone in notothenioid fishes is determined by phylogeny, not environmental temperature American Journal of Physiology - Regulatory Integrative and Comparative Physiology 280 -, 2001
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Deveci D; Stone PCW; Egginton S Differential effect of cold acclimation on blood composition in rats and hamsters Journal of Comparative Physiology - B Biochemical, Systemic, and Environmental Physiology 171 135-143, 2001
DOI:10.1007/s003600000156
View abstract

Hudlicka O; Brown D; Egginton S; Milkiewicz M Shear modulation of angiogenesis, 2000

Hansen-Smith; Hudlicka O; Egginton S Muscle capillary branching patterns elicited during physiological angiogenesis vary qualitatively and quantitatively depending on stimulus, 2000

Whiteley NM; Egginton S Adrenergic responses of Antarctic fishes to extreme trauma, 2000

Deveci D; Ambrose N; Egginton S Telemetric recording of heart rate, motor activity and body temperature in a hibernator and nonhibernator during chronic cold exposure, 2000

Egginton S; Fairney JA; Bratcher J Effect of acute and chronic cooling on cardiorespiratory integration in rodents, 2000

Deveci D; Marshall JM; Egginton S Six weeks of chronic hypoxia induces angiogenesis in skeletal muscles of rats, 2000

Egginton S; Hudlicka O Selective long-term electrical stimulation of fast glycolytic fibres increases capillary supply but not oxidative enzyme activity in rat skeletal muscles Experimental Physiology 85 567-574, 2000
View abstract

Egginton S; Zhou A-L; Brown MD; Hudlická O The role of pericytes in controlling angiogenesis in vivo Advances in Experimental Medicine and Biology 476 81-99, 2000
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Haas TL; Milkiewicz M; Davis SJ; Zhou AL; Egginton S; Brown MD; Madri JA; Hudlicka O Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle American Journal of Physiology - Heart and Circulatory Physiology 279 -, 2000
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Egginton S; Cordiner S; Skilbeck C Thermal compensation of peripheral oxygen transport in skeletal muscle of seasonally acclimatized trout American Journal of Physiology - Regulatory Integrative and Comparative Physiology 279 -, 2000
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Whiteley NM; Egginton S Antarctic fishes have a limited capacity for catecholamine synthesis Journal of Experimental Biology 202 3623-3629, 1999
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Hawker MJ; Egginton S The effect of stimulation frequency on blood flow in rat fast skeletal muscles Experimental Physiology 84 941-946, 1999
DOI:10.1017/S095806709901845X
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Deveci D; Egginton S Development of the fluorescent microsphere technique for quantifying regional blood flow in small mammals EXPERIMENTAL PHYSIOLOGY 84 615-630, 1999
DOI:10.1111/j.1469-445X.1999.01852.x

Taylor SE; Egginton S; Taylor EW; Franklin CE; Johnston IA Estimation of intracellular pH in muscle of fishes from different thermal environments Journal of Thermal Biology 24 199-208, 1999
DOI:10.1016/S0306-4565(99)00013-3
View abstract

Egginton S The influence of environmental temperature on microvascular development in fish Zoology 102 164-172, 1999
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Haas TL; Davis SJ; Zhou AL; Egginton S; Brown MD; Milkiewicz M; Hudlicka O; Madri JA Increased matrix metalloproteinases MMP-2 and MT1-MMP mRNA correlates with disturbances in capillary basement membrane in chronically stimulated rat skeletal muscle., 1999

Hansen-Smith F; Hudlicka O; Zhou A; Egginton S Recruitment of fibroblasts to pericyte position in capillaries during stretch-induced angiogenesis in rat skeletal muscle., 1999

Egginton S; Hudlická O Early changes in performance, blood flow and capillary fine structure in rat fast muscles induced by electrical stimulation Journal of Physiology 515 265-275, 1999
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Egginton S; Forster M; Davison W How is vascular tone maintained in the cold?, 1999

Egginton S; Hudlická O; Brown MD; Walter H; Weiss JB; Bate A Capillary growth in relation to blood flow and performance in overloaded rat skeletal muscle Journal of Applied Physiology 85 2025-2032, 1998
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Moerland TS; Egginton S Intracellular pH of muscle and temperature: Insight from in vivo 31P NMR measurements in a stenothermal antarctic teleost (Harpagifer antarcticus) Journal of Thermal Biology 23 275-282, 1998
DOI:10.1016/S0306-4565(98)00016-3
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Zhou A-L; Egginton S; Brown MD; Hudlická O Capillary growth in overloaded, hypertrophic adult rat skeletal muscle: An ultrastructural study Anatomical Record 252 49-63, 1998
DOI:10.1002/(SICI)1097-0185(199809)252:1<49::AID-AR6>3.0.CO;2-9
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Deveci D; Egginton S The effects of prolonged cold exposure on angiogenesis in skeletal and cardiac muscle of hamsters, 1998

Brown MD; Hudlicka O; Egginton S; Hansen-Smith F Sequence of vascular growth induced by intense activity in rat skeletal muscle, 1998

Brown MD; Zhou AL; Egginton S; Hudlicka O Endothelial glycocalyx, blood flow and angiogenesis, 1998

Tuurala H; Egginton S; Soivio A Cold exposure increases branchial water-blood barrier thickness in the eel Journal of Fish Biology 53 451-455, 1998
DOI:10.1006/jfbi.1998.0712
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Egginton S Anatomical adaptations for peripheral oxygen transport at high and low temperatures South African Journal of Zoology 33 119-128, 1998
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Brown MD; Hudlická O; Egginton S; Milkiewicz M Capillary proliferation in overloaded rat skeletal muscle, 1998
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Hansen-Smith F; Hudlicka O; Egginton S Growth of terminal arterioles in overloaded extensor muscles., 1998

Bishop CM; Butler PJ; El Haj AJ; Egginton S Comparative development in captive and migratory populations of the barnacle goose Physiological Zoology 71 198-207, 1998
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Deveci D; Egginton S Use of fluorescent microspheres to determine regional blood flow in small tissue samples, 1998

Abbitt KB; Nash GB; Egginton S Effects of exposure to the cold on flow resistance of individual human neutrophils, 1998

Zhou AL; Egginton S Immunogold labelling of proliferating cells during skeletal muscle angiogenesis, 1998

Hudlicka O; Egginton S; Brown MD Angiogenesis in the heart and skeletal muscle - Models for capillary growth, 1998

Zhou A-L; Egginton S; Hudlická O; Brown MD Internal division of capillaries in rat skeletal muscle in response to chronic vasodilator treatment withα1-antagonist prazosin Cell and Tissue Research 293 293-303, 1998
DOI:10.1007/s004410051121
View abstract

Hansen-Smith F; Egginton S; Hudlicka O Growth of arterioles in chronically stimulated adult rat skeletal muscle Microcirculation 5 49-59, 1998
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Brown MD; Walter H; Hansen-Smith FM; Hudlická O; Egginton S Lack of involvement of basic fibroblast growth factor (FGF-2) in capillary growth in skeletal muscles exposed to long-term contractile activity Angiogenesis 2 81-91, 1998
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Egginton S Control of tissue blood flow at very low temperatures Journal of Thermal Biology 22 403-407, 1997
DOI:10.1016/S0306-4565(97)00059-4
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Egginton S; Cordiner S Cold-induced angiogenesis in seasonally acclimatized rainbow trout (Oncorhynchus Mykiss) Journal of Experimental Biology 200 2263-2268, 1997
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Hoofd L; Egginton S The possible role of intracellular lipid in determining oxygen delivery to fish skeletal muscle Respiration Physiology 107 191-202, 1997
DOI:10.1016/S0034-5687(96)02519-4
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Egginton S A comparison of the response to induced exercise in red- and white-blooded Antarctic fishes Journal of Comparative Physiology - B Biochemical, Systemic, and Environmental Physiology 167 129-134, 1997
DOI:10.1007/s003600050056
View abstract

Hawker MJ; Egginton S The effect of stimulation frequency on skeletal muscle blood flow in the anaesthetized rat, 1997

Jeal S; Brown MD; Hudlicka O; Egginton S Involvement of vascular endothelial growth factor in capillary growth as a result of chronic electrical stimulation of skeletal muscle in conscious rats, 1997

Zhou AL; Egginton S Capillary growth in overloaded rat skeletal muscle: An ultrastructural study, 1997

Zhou A-L; Egginton S; Hudlicka O Ultrastructural study of three types of physiological angiogenesis in adult rat skeletal muscle FASEB Journal 11 -, 1997
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Cordiner S; Egginton S Effects of seasonal temperature acclimatization on muscle metabolism in rainbow trout, Oncorhynchus mykiss Fish Physiology and Biochemistry 16 333-343, 1997
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Ahmed SK; Egginton S; Jakeman PM; Mannion AF; Ross HF Is human skeletal muscle capillary supply modelled according to fibre size or fibre type? Experimental Physiology 82 231-234, 1997
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Egginton S The physiological response of Antarctic fishes to environmental and experimental stress Cybium 21 415-421, 1997
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Thomson IA; Egginton S; Simms MH; Hudlická O Effect of muscle ischaemia and iloprost during femorodistal reconstruction on capillary endothelial swelling. International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation 16 284-290, 1996
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Egginton S Effect of temperature on the optimal substrate forβ-oxidation Journal of Fish Biology 49 753-758, 1996
DOI:10.1006/jfbi.1996.0206
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Bishop CM; Butler PJ; El Haj AJ; Egginton S; Loonen MJJE The morphological development of the locomotor and cardiac muscles of the migratory barnacle goose (Branta leucopsis) Journal of Zoology 239 1-15, 1996
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Taylor SE; Egginton S; Taylor EW Seasonal temperature acclimatisation of rainbow trout: Cardiovascular and morphometric influences on maximal sustainable exercise level Journal of Experimental Biology 199 835-845, 1996
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Egginton S Blood rheology of Antarctic fishes: Viscosity adaptations at very low temperatures Journal of Fish Biology 48 513-521, 1996
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Egginton S; Hudlicka O; Brown MD; Graciotti L; Granata AL In vivo pericyte-endothelial cell interaction during angiogenesis in adult cardiac and skeletal muscle Microvascular Research 51 213-228, 1996
DOI:10.1006/mvre.1996.0022
View abstract

Zhou AL; Egginton S; Hudlicka O Ultrastructural evidence for a novel mechanism of capillary growth in rat skeletal muscle, 1996

Hudlicka O; Brown MD; Egginton S Angiogenesis in skeletal muscle, 1996

Hansen-Smith FM; Hudlicka O; Egginton S In vivo angiogenesis in adult rat skeletal muscle: Early changes in capillary network architecture and ultrastructure Cell and Tissue Research 286 123-136, 1996
DOI:10.1007/s004410050681
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Brown MD; Egginton S; Hudlicka O; Zhou A-L Appearance of the capillary endothelial glycocalyx in chronically stimulated rat skeletal muscles in relation to angiogenesis Experimental Physiology 81 1043-1046, 1996
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Lecklin T; Egginton S; Nash GB Effect of temperature on the resistance of individual red blood cells to flow through capillary sized apertures Pflugers Archiv European Journal of Physiology 432 753-759, 1996
DOI:10.1007/s004240050195
View abstract

HANSENSMITH F; EGGINTON S; OWENS G; HUDLICKA O GROWTH OF ARTERIOLES IN CHRONICALLY STIMULATED RAT FAST MUSCLES, 1995

LECKLIN T; NASH G; EGGINTON S DO FISH ACCLIMATED TO LOW-TEMPERATURE IMPROVE MICROCIRCULATORY PERFUSION BY ADAPTING RED-CELL RHEOLOGY JOURNAL OF EXPERIMENTAL BIOLOGY 198 1801-1808, 1995

MOERLAND T; EGGINTON S INTRACELLULAR PH OF SKELETAL-MUSCLE FROM THE ANTARCTIC TELEOST HARPAGIFER ANTARCTICUS, 1995

PEARCE S; HUDLICKA O; EGGINTON S EARLY STAGES IN ACTIVITY-INDUCED ANGIOGENESIS IN RAT SKELETAL-MUSCLES - INCORPORATION OF BROMODEOXYURIDINE INTO CELLS OF THE INTERSTITIUM, 1995

BROWN M; DAVIES M; HUDLICKA O; TOWNSEND P; EGGINTON S CARDIAC-PERFORMANCE IN THE ANESTHETIZED PIG AFTER LONG-TERM PACING-INDUCED BRADYCARDIA, 1995

RIVAS M; SKRONE J; CLARIDGE E; JAKEMAN P; EGGINTON S GASPAR - TASK-SPECIFIC IMAGE-ANALYSIS SOFTWARE FOR USE WITH HUMAN MUSCLE HISTOLOGY, 1995

BRATCHER J; EGGINTON S THE EFFECT OF COLD-ACCLIMATION ON SKELETAL-MUSCLE OF THE LABORATORY RAT, 1995

AHMED S; EGGINTON S; ROSS H; MANNION A; JAKEMAN P SCALING OF MUSCLE CAPILLARY SUPPLY IN HUMANS - EFFECT OF STRENGTH TRAINING, 1995

Egginton S; Cordiner S Effect of fixation protocols on muscle preservation and in situ diffusion distances Journal of Fish Biology 47 59-69, 1995
DOI:10.1006/jfbi.1995.0111

Bishop CM; Butler PJ; Egginton S; El Haj AJ; Gabrielsen GW Development of metabolic enzyme activity in locomotor and cardiac muscles of the migratory barnacle goose American Journal of Physiology - Regulatory Integrative and Comparative Physiology 269 -, 1995
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EGGINTON S; HOOFD L EFFECTS OF LOW-TEMPERATURE ON CALCULATED INTRACELLULAR OXYGEN-TENSIONS IN FISH SKELETAL-MUSCLE, 1994

HUDLICKA O; EGGINTON S EARLY CHANGES IN MUSCLE BLOOD-FLOW AND PERFORMANCE INDUCED BY CHRONIC ELECTRICAL-STIMULATION OF RAT FAST MUSCLES, 1994

FAIRNEY J; EGGINTON S THE EFFECT OF COLD-ACCLIMATION ON MUSCLE CAPILLARY SUPPLY IN THE SYRIAN-HAMSTER (MESOCRICETUS-AURATUS), 1994

Wilson RW; Egginton S Assessment of maximum sustainable swimming performance in rainbow trout (Oncorhynchus mykiss) Journal of Experimental Biology 192 299-305, 1994

Egginton S Stress response in two Antarctic teleosts (Notothenia coriiceps Richardson and Chaenocephalus aceratus Lönnberg) following capture and surgery Journal of Comparative Physiology B 164 482-491, 1994
DOI:10.1007/BF00714586
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Hudlicka O; Brown MD; Egginton S; Dawson JM Effect of long-term electrical stimulation on vascular supply and fatigue in chronically ischemic muscles Journal of Applied Physiology 77 1317-1324, 1994
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Thomson IA; Egginton S; Hudlická O; Sims MH Iloprost reduces leukocyte adhesion in skeletal muscle venules following ischaemia in a rat model of femorodistal bypass European Journal of Vascular Surgery 8 335-341, 1994
DOI:10.1016/S0950-821X(05)80152-5
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Hudlicka O; Egginton S; Brown MD Effect of torbafylline on muscle blood flow, performance, and capillary supply in ischemic muscles subjected to varying levels of activity Canadian Journal of Physiology and Pharmacology 72 811-817, 1994
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Egginton S; Hudlicka O; Glover M Fine structure of capillaries in ischaemic and non ischaemic rat striated muscle. Effect of torbafylline. International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation 12 33-44, 1993
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Nash GB; Egginton S Comparative rheology of human and trout red blood cells. Journal of Experimental Biology 174 109-122, 1993
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Lecklin T; Nash GB; Egginton S Effects of acute temperature change and thermal acclimation on membrane rigidity of fish erythrocytes, 1993

Egginton S; Moerland TS Intracellular pH of fast muscle from an Antarctic teleost (Harpagifer antarcticus) estimated in vivo by 31P NMR, 1993

Egginton S; Hudlicka O; Brown MD The possible role in angiogenesis of pericytes from chronically stimulated rat skeletal muscles, 1993

BROWN M; GEAL C; EGGINTON S THE EFFECT OF ACUTE AND CHRONIC COOLING ON THE CHEEK POUCH MICROCIRCULATION IN ANESTHETIZED HAMSTERS, 1993

EGGINTON S CHANGES IN BLOOD-CHEMISTRY OF ANTARCTIC TELEOSTS DURING RECOVERY FROM CAPTURE AND SURGERY, 1993

TAYLOR S; EGGINTON S; TAYLOR E RESPIRATORY AND CARDIOVASCULAR-RESPONSES IN RAINBOW-TROUT (ONCORHYNCHUS-MYKISS) TO AEROBIC EXERCISE OVER A RANGE OF ACCLIMATION TEMPERATURES, 1993

Egginton S; Hudlicka O Regional capillary perfusion in muscles with limited blood supply: effects of torbafylline Pflügers Archiv European Journal of Physiology 421 336-342, 1992
DOI:10.1007/BF00374221
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Hudlicka O; Brown M; Egginton S Angiogenesis in skeletal and cardiac muscle Physiological Reviews 72 369-417, 1992

EGGINTON S ADAPTABILITY OF THE ANATOMICAL CAPILLARY SUPPLY TO SKELETAL-MUSCLE OF FISHES JOURNAL OF ZOOLOGY 226 691-698, 1992

HUDLICKA O; EGGINTON S; BROWN M; DAWSON J; HICKEY N MUSCLE ISCHEMIA - EFFECT OF CHRONIC STIMULATION ON CAPILLARY ULTRASTRUCTURE AND CIRCULATION, 1992

EGGINTON S; HUDLICKA O EFFECT OF LONG-TERM MUSCLE OVERLOAD ON CAPILLARY SUPPLY, BLOOD-FLOW AND PERFORMANCE IN RAT FAST MUSCLE, 1992

Egginton S Acid-base status of Antarctic teleosts in response to exercise-induced stress, 1992

Egginton S; Fisher AC; Nash GB Comparative studies on thermal sensitivity of haemorheology; Use of human and fish red blood cells Clinical Hemorheology 12 677-687, 1992

Wilson R; Egginton S Cardiovascular responses in rainbow trout (Oncorhynchus mykiss) to aerobic exercise, 1992

Egginton S; Taylor EW; Wilson RW; Johnston IA; Moon TW Stress response in the Antarctic teleosts (Notothenia neglecta Nybelin and N. rossii Richardson) Journal of Fish Biology 38 225-235, 1991
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Hudlicka O; Egginton S; Brown MD; Dawson JM Blood flow, performance and capillary ultrastructure in ischaemic rat fast muscles: Effect of chronic electrical stimulation, 1991

Egginton S; Hudlicka O Stimulation of skeletal muscle can induce systemic changes in capillary fine structure in the rat, 1991

Egginton S; Hudlická O The effect of torbafylline on enzyme activities in fast and slow muscles with limited blood supply Comparative Biochemistry and Physiology. Part C, Comparative 99 163-168, 1991
DOI:10.1016/0742-8413(91)90094-A
View abstract

Hargreaves D; Egginton S; Hudlická O Changes in capillary perfusion induced by different patterns of activity in rat skeletal muscle Microvascular Research 40 14-28, 1990
DOI:10.1016/0026-2862(90)90003-A
View abstract

Egginton S Numerical and areal density estimates of fibre type composition in a skeletal muscle (rat extensor digitorum longus) Journal of Anatomy 168 73-80, 1990
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Egginton S; Turek Z Comparative distributions of numerical and areal indices of tissue capillarity Advances in Experimental Medicine and Biology 277 161-169, 1990

Hoofd L; Turek Z; Egginton S Concentric oxygen diffusion in tissue with heterogeneous permeability and consumption Advances in Experimental Medicine and Biology 277 13-20, 1990

EGGINTON S; ROSS H PLANAR ANALYSIS OF TISSUE CAPILLARY SUPPLY, 1989

BROWN M; EGGINTON S PHYSIOLOGICAL CONSEQUENCES OF AN INCREASED CAPILLARY BARRIER THICKNESS IN RABBIT HEARTS DAMAGED BY A HIGH-DOSE OF NORADRENALINE, 1989

Turek Z; Olders J; Hoofd L; Egginton S; Kreuzer F; Rakusan K PO2 histograms in various models of tissue oxygenation in skeletal muscle. Advances in Experimental Medicine and Biology 248 227-237, 1989

Egginton S; Sidell BD Thermal acclimation induces adaptive changes in subcellular structure of fish skeletal muscle American Journal of Physiology - Regulatory Integrative and Comparative Physiology 256 -, 1989
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Egginton S; Ross HF Influence of muscle phenotype on local capillary supply. Advances in Experimental Medicine and Biology 248 281-291, 1989
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Egginton S; Ross HF Quantifying capillary distribution in four dimensions. Advances in Experimental Medicine and Biology 248 271-280, 1989
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HUDLICKA O; EGGINTON S CAPILLARY MORPHOLOGY IN RAT MUSCLES WITH LIMITED BLOOD-SUPPLY, 1988

EGGINTON S; HARGREAVES D; HUDLICKA O; ROSS H; TUREK Z EFFECT OF SPATIAL AND TEMPORAL HETEROGENEITY IN CAPILLARY SUPPLY ON MUSCLE OXYGENATION, 1988

TUREK Z; HOOFD L; EGGINTON S; RAKUSAN K EFFECTS OF HETEROGENEITY IN CAPILLARY SPACING ON THE CALCULATED PO2 DISTRIBUTION IN SKELETAL-MUSCLE, 1988

HUDLICKA O; EGGINTON S; BROWN M CAPILLARY DIFFUSION DISTANCES - THEIR IMPORTANCE FOR CARDIAC AND SKELETAL-MUSCLE PERFORMANCE NEWS IN PHYSIOLOGICAL SCIENCES 3 134-138, 1988

Brown MD; Egginton S Capillary density and fine structure in rabbit papillary muscles after a high dose of norepinephrine Microvascular Research 36 1-12, 1988
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EGGINTON S; HARGREAVES D; HUDLICKA O CHANGES IN CAPILLARY PERFUSION INDUCED BY DIFFERENT PATTERNS OF ACTIVITY IN RAT SKELETAL-MUSCLE, 1988

EGGINTON S; HUDLICKA O SPECIFIC ACTIVATION OF GLYCOLYTIC FIBERS IN RAT SKELETAL-MUSCLE, 1988

Egginton S; Turek Z; Hoofd LJC Differing patterns of capillary distribution in fish and mammalian skeletal muscle Respiration Physiology 74 383-396, 1988
DOI:10.1016/0034-5687(88)90045-X
View abstract

Egginton S Effect of inter-animal variation of a nested sampling design for stereological analysis of skeletal muscle Acta Stereologica 7 81-89, 1988
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Egginton S Effects of an anabolic hormone on striated muscle growth and performance Pflügers Archiv European Journal of Physiology 410 349-355, 1987
DOI:10.1007/BF00586510
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Egginton S Effects of an anabolic hormone on aerobic capacity of rat striated muscle Pflügers Archiv European Journal of Physiology 410 356-361, 1987
DOI:10.1007/BF00586511
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EGGINTON S; HUDLICKA O DEVELOPMENT OF FATIGUE AND RELATIVE FIBER GLYCOGEN-CONTENT IN RAT SKELETAL-MUSCLE, 1987

EGGINTON S METAMORPHOSIS OF THE AMERICAN EEL, ANGUILLA-ROSTRATA LESEUR .3. CONTRACTILE CHARACTERISTICS OF SKELETAL-MUSCLE JOURNAL OF EXPERIMENTAL ZOOLOGY 243 39-50, 1987
DOI:10.1002/jez.1402430107

Egginton S; Turek Z; Hoofd L Morphometric analysis of sparse capillary networks. Advances in Experimental Medicine and Biology 215 1-12, 1987
View abstract

BROWN M; EGGINTON S ULTRASTRUCTURAL-CHANGES IN CAPILLARIES OF HEARTS WITH MYOCARDIAL NECROSIS DUE TO A HIGH-DOSE OF NORADRENALINE, 1987

BROWN M; EGGINTON S EFFECT OF NORADRENALINE ON RABBIT LEFT-VENTRICULAR CAPILLARIZATION, 1987

EGGINTON S THE CAPILLARY SUPPLY TO FISH SKELETAL-MUSCLE IS BOTH ANISOTROPIC AND HIGHLY VARIABLE, 1987

EGGINTON S DIFFERENTIAL-EFFECTS OF AN ANABOLIC HORMONE ON AEROBIC CAPACITY OF RAT STRIATED-MUSCLE, 1987

EGGINTON S; HARGREAVES D; HUDLICKA O IS CAPILLARY PERFUSION IN SKELETAL-MUSCLE LINKED TO A SPECIFIC PATTERN OF ACTIVITY, 1987

EGGINTON S; SIDELL B CHANGES IN MITOCHONDRIAL SPACING IN FISH SKELETAL-MUSCLE INDUCED BY ENVIRONMENTAL-TEMPERATURE, 1986

EGGINTON S EFFECTS OF AN ANABOLIC HORMONE ON PERFORMANCE AND COMPOSITION OF RAT SKELETAL-MUSCLE, 1986

EGGINTON S; JOHNSTON I PERIPHERAL INNERVATION PATTERN IN MYOTOMAL MUSCLE OF 2 TELEOSTS AS REVEALED BY INTRACELLULAR MARKING JOURNAL OF ZOOLOGY 208 379-394, 1986

EGGINTON S METAMORPHOSIS OF THE AMERICAN EEL, ANGUILLA-ROSTRATA LESEUR .1. CHANGES IN METABOLISM OF SKELETAL-MUSCLE JOURNAL OF EXPERIMENTAL ZOOLOGY 237 173-184, 1986
DOI:10.1002/jez.1402370204

Egginton S Metamorphosis of the American eel, Anguilla rostrata Le Seur: II. Structural reorganisation of the locomotory musculature Journal of Experimental Zoology 238 297-309, 1986

Egginton S Is this science? Nature 321 806-806, 1986
DOI:10.1038/321806b0

Egginton S; Johnston IA Effects of acclimation temperature on routine metabolism muscle mitrochondrial volume density and capillary supply in the elver (Anguilla anguilla L.) Journal of Thermal Biology 9 165-170, 1984
DOI:10.1016/0306-4565(84)90016-0
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Egginton S; Johnston IA An estimate of capillary anisotropy and determination of surface and volume densities of capillaries in skeletal muscles of the conger eel (Conger conger L.) Quarterly Journal of Experimental Physiology 68 603-617, 1983
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Egginton S; Johnston IA A morphometric analysis of regional differences in myotomal muscle ultrastructure in the juvenile eel (Anguilla anguilla L.) Cell and Tissue Research 222 579-596, 1982

Egginton S; Johnston IA Muscle fibre differentiation and vascularisation in the juvenile European eel (Anguilla anguilla L.) Cell and Tissue Research 222 563-577, 1982
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EGGINTON S; JOHNSTON I ULTRASTRUCTURAL HETEROGENEITY OF FISH FAST MUSCLE-FIBERS JOURNAL OF PHYSIOLOGY-LONDON 310 P28-P28, 1981