Dr Thomas Edwards

BSc, PhD 1997, Bath
Associate Professor
School of Molecular and Cellular Biology

Background: Dr Edwards is an Associate Professor in the School of Molecular and Cell Biology at the University of Leeds and is Deputy Director of the Astbury Centre for Structural Molecular Biology. He obtained a BSc (Hons) in Biochemistry at the University of Bath in 1992, and a Ph.D. in Biology also from Bath in 1996. Dr Edwards worked as a postdoctoral fellow in the laboratory of Professor Aneel Aggarwal at the Mount Sinai School of Medicine in New York (1997-2003) in the Structural Biology Program, and was promoted to the faculty in 2003. Dr Edwards joined the University of Leeds in April 2005.

Contact: Garstang 8.53d, +44(0) 113 34 33031, email address for  

You can read more about Dr Edwards's interests here:


PoPPI - Perturbation of Protein-Protein Interactions:

Research Interests

Structural Molecular Biology



Current Projects

Structural Biology

RNA:Protein Interactions

RNA viruses and viral RNA binding proteins

Protein-protein interactions

Molecular Control of Embryogenesis

Mechanisms of antibiotic resistance. 



Faculty Research and Innovation

Studentship information

Undergraduate project topics:

  • Biochemistry, Microbiology & Biological Sciences

Postgraduate studentship areas:

  • RNA binding proteins; protein-protein interactions; RNA viruses; molecular embryogenesis

See also:

Modules taught

BIOC1302 - Introductory Biochemistry: Practical Skills
BIOC1303 - Introductory Biochemistry: Problem Solving and Data Handling
BIOC2301 - Intermediate Integrated Biochemistry
BIOC2303 - Intermediate Biochemistry: Skills
BIOC2303/BIOL2303 - Skills
BIOC3160 - Laboratory/Literature/Computing Research Project
BIOC3221/22/BIOL3210/MICR3211 D - ATU - RNA binding proteins
BIOL1302/1303/MICR1320 - Intro skills - Biological Science and Microbiology
BIOL3306 - Biological Sciences Research Project
BIOL3399 - Extended Research Project Preparation
BIOW5902X - Medicinal Chemistry and Drug Design
BMSC1103 - Basic Laboratory and Scientific Skills
FOBS1135/BIOL1112 - The Basis of Life/The molecules of life
FOBS1201/BIOL1214 - Molecular Physiology/Multicellular Systems

Academic roles

School Director of Research and Innovation

Centre memberships:

Group Leader Dr Thomas Edwards  (Associate Professor)

Structural Molecular Biology 

Mrs Susan Matthews  (Research Technician)

Dr Jennifer Tomlinson  (Research Fellow)


Francis Hopkins (Primary supervisor) 34% FTE
Georgia Pangratiou (Primary supervisor) 50% FTE
Amelia Shaw (Primary supervisor) 34% FTE
Michaela Agapiou (Co-supervisor) 25% FTE
Beatriz Álvarez Rodriguez (Co-supervisor) 33% FTE
Katherine Davies (Co-supervisor) 40% FTE
Katarzyna Haza (Co-supervisor) 30% FTE
Emily Levitt (Co-supervisor) 35% FTE
David Nicholson (Co-supervisor) 33% FTE
Timen Passchier (Co-supervisor) 50% FTE
Ajinkya Rao (Co-supervisor) 50% FTE
Brendan Rogers (Co-supervisor) 33% FTE
Jaskiran Sabharwal (Co-supervisor) 10% FTE
Sophie Saunders (Co-supervisor) 30% FTE
Gemma Swinscoe (Co-supervisor) 33% FTE

Easton V, McPhillie M, Garcia-Dorival I, Barr JN, Edwards TA, Foster R, Fishwick C, Harris M Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening Antiviral Research 156 46-54, 2018
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Muniyandi S, Pangratiou G, Edwards TA, Barr JN Structure and function of the human respiratory syncytial virus M2–1 protein Subcellular Biochemistry 88 245-260, 2018
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Hughes DJ, Tiede C, Penswick N, Tang AAS, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology Science Signaling 10, 2017
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Burslem GM, Kyle HF, Nelson A, Edwards TA, Wilson AJ Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions Chemical Science 8 4188-4202, 2017
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Stevenson SR, Kamisugi Y, Trinh CH, Schmutz J, Jenkins JW, Grimwood J, Muchero W, Tuskan GA, Rensing SA, Lang D, Reski R, Melkonian M, Rothfels CJ, Li F-W, Larsson A, Wong GK-S, Edwards TA, Cuming AC Genetic Analysis of Physcomitrella patens Identifies ABSCISIC ACID NON-RESPONSIVE, a Regulator of ABA Responses Unique to Basal Land Plants and Required for Desiccation Tolerance. Plant Cell 28 1310-1327, 2016
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Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ Towards "bionic" proteins: Replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics Chemical Communications 52 5421-5424, 2016
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Azzarito V, Rowell P, Barnard A, Edwards TA, Macdonald A, Warriner SL, Wilson AJ Probing Protein Surfaces: QSAR Analysis with Helix Mimetics ChemBioChem 17 768-773, 2016
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Sharkey LKR, Edwards TA, O Neill AJ ABC-F proteins mediate antibiotic resistance through ribosomal protection mBio 7, 2016
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Burslem GM, Kyle HF, Prabhakaran P, Breeze AL, Edwards TA, Warriner SL, Nelson A, Wilson AJ Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups Organic and Biomolecular Chemistry 14 3782-3786, 2016
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Miles JA, Yeo DJ, Rowell P, Rodriguez-Marin S, Pask CM, Warriner SL, Edwards TA, Wilson AJ Hydrocarbon constrained peptides-understanding preorganisation and binding affinity Chemical Science 7 3694-3702, 2016
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Surtees R, Dowall SD, Shaw A, Armstrong S, Hewson R, Carroll MW, Mankouri J, A Edwards T, Hiscox JA, Barr JN Heat shock protein 70 family members interact with Crimean-Congo hemorrhagic fever virus and Hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle Journal of Virology 90 9305-9316, 2016
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Haywood NJ, Wolny M, Rogers B, Trinh CH, Shuping Y, Edwards TA, Peckham M Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation Biochemical Journal 473 2485-2493, 2016
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Surtees R, Ariza A, Punch EK, Trinh CH, Dowall SD, Hewson R, Hiscox JA, Barr JN, Edwards TA The crystal structure of the Hazara virus nucleocapsid protein BMC Structural Biology 15, 2015
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Edwards TA Bespoke RNA recognition by Pumilios Biochemical Society Transactions 43 801-806, 2015
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Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies Molecular BioSystems 11 2738-2749, 2015
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Azzarito V, Miles JA, Fisher J, Edwards TA, Warriner SL, Wilson AJ Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers Chemical Science 6 2434-2443, 2015
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Barnard A, Long K, Martin HL, Miles JA, Edwards TA, Tomlinson DC, Macdonald A, Wilson AJ Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions Angewandte Chemie - International Edition 54 2960-2965, 2015
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Barnard A, Long K, Yeo DJ, Miles JA, Azzarito V, Burslem GM, Prabhakaran P, A Edwards T, Wilson AJ Orthogonal functionalisation ofα-helix mimetics. Org Biomol Chem 12 6794-6799, 2014
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Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction. Chembiochem 15 1083-1087, 2014
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Shepherd DA, Ariza A, Edwards TA, Barr JN, Stonehouse NJ, Ashcroft AE Probing bunyavirus N protein oligomerisation using mass spectrometry. Rapid Commun Mass Spectrom 28 793-800, 2014
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Tanner SJ, Ariza A, Richard C-A, Kyle HF, Dods RL, Blondot M-L, Wu W, Trincão J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eléouët J-F, Edwards TA, Barr JN Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. Proc Natl Acad Sci U S A 111 1580-1585, 2014
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Cox G, Edwards TA, O'Neill AJ Mutagenesis Mapping of the Protein-Protein Interaction Underlying FusB-Type Fusidic Acid Resistance ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 57 4640-4644, 2013

Long K, Edwards TA, Wilson AJ Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamideα-helix mimetics. Bioorg Med Chem 21 4034-4040, 2013
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Prabhakaran P, Barnard A, Murphy NS, Kilner CA, Edwards TA, Wilson AJ Aromatic Oligoamide Foldamers with a "Wet Edge" as Inhibitors of the -Helix-Mediated p53-hDM2 Protein-Protein Interaction EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 3504-3512, 2013

Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M, Elliott RM, Fooks AR, Ashcroft AE, Stonehouse NJ, Ranson NA, Barr JN, Edwards TA Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Research 41 5912-5926, 2013
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Roberts AJ, Malkova B, Walker ML, Sakakibara H, Numata N, Kon T, Ohkura R, Edwards TA, Knight PJ, Sutoh K, Oiwa K, Burgess SA ATP-driven remodeling of the linker domain in the dynein motor. Structure 20 1670-1680, 2012
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Carter SD, Surtees R, Walter CT, Ariza A, BergeronÉ, Nichol ST, Hiscox JA, Edwards TA, Barr JN Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein. J Virol 86 10914-10923, 2012
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Azzarito V, Prabhakaran P, Bartlett AI, Murphy NS, Hardie MJ, Kilner CA, Edwards TA, Warriner SL, Wilson AJ 2-O-alkylated para-benzamideα-helix mimetics: the role of scaffold curvature. Org Biomol Chem 10 6469-6472, 2012
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Prabhakaran P, Azzarito V, Jacobs T, Hardie MJ, Kilner CA, Edwards TA, Warriner SL, Wilson AJ Conformational properties of O-alkylated benzamides Tetrahedron 68 4485-4491, 2012
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Carter SD, Barr JN, Edwards TA Expression, purification and crystallization of the Crimean-Congo haemorrhagic fever virus nucleocapsid protein. Acta Crystallogr Sect F Struct Biol Cryst Commun 68 569-573, 2012
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Cox G, Thompson GS, Jenkins HT, Peske F, Savelsbergh A, Rodnina MV, Wintermeyer W, Homans SW, Edwards TA, O'Neill AJ Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proc Natl Acad Sci U S A 109 2102-2107, 2012
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Fuller JC, Jackson RM, Edwards TA, Wilson AJ, Shirts MR Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable. PLoS One 7 e43253-, 2012
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Jenkins HT, Malkova B, Edwards TA Kinkedβ-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL. Proc Natl Acad Sci U S A 108 18266-18271, 2011
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East DA, Sousa D, Martin SR, Edwards TA, Lehman W, Mulvihill DP Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin BIOCHEM J 438 265-273, 2011

Edwards TA, Wilson AJ Helix-mediated protein-protein interactions as targets for intervention using foldamers AMINO ACIDS 41 743-754, 2011

Walden M, Jenkins HT, Edwards TA Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun 67 744-748, 2011
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Campbell F, Plante JP, Edwards TA, Warriner SL, Wilson AJ N-alkylated oligoamide alpha-helical proteomimetics ORG BIOMOL CHEM 8 2344-2351, 2010

Jenkins HT, Baker-Wilding R, Edwards TA Structure and RNA binding of the mouse Pumilio-2 Puf domain J STRUCT BIOL 167 271-276, 2009

Gupta YK, Lee TH, Edwards TA, Escalante CR, Kadyrova LY, Wharton RP, Aggarwal AK Co-occupancy of two Pumilio molecules on a single hunchback NRE RNA 15 1029-1035, 2009

Plante JP, Burnley T, Malkova B, Webb ME, Warriner SL, Edwards TA, Wilson AJ Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction CHEM COMMUN 5091-5093, 2009

Stead MA, Trinh CH, Garnett JA, Carr SB, Baron AJ, Edwards TA, Wright SC A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain J MOL BIOL 373 820-826, 2007

Edwards TA, Butterwick JA, Zeng L, Gupta YK, Wang X, Wharton RP, Palmer AG, Aggarwal AK Solution structure of the Vts1 SAM domain in the presence of RNA. J Mol Biol 356 1065-1072, 2006
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Uljon SN, Johnson RE, Edwards TA, Prakash S, Prakash L, Aggarwal AK Crystal structure of the catalytic core of human DNA polymerase kappa. Structure 12 1395-1404, 2004
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Townson SA, Samuelson JC, Vanamee ES, Edwards TA, Escalante CR, Xu S-Y, Aggarwal AK Crystal structure of BstYI at 1.85A resolution: a thermophilic restriction endonuclease with overlapping specificities to BamHI and BglII. J Mol Biol 338 725-733, 2004
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Edwards TA, Wilkinson BD, Wharton RP, Aggarwal AK Model of the brain tumor-Pumilio translation repressor complex. Genes Dev 17 2508-2513, 2003
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James JA, Escalante CR, Yoon-Robarts M, Edwards TA, Linden RM, Aggarwal AK Crystal structure of the SF3 helicase from adeno-associated virus type 2. Structure 11 1025-1035, 2003
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Green JB, Edwards TA, Trincao J, Escalante CR, Wharton RP, Aggarwal AK Crystallization and characterization of Smaug: a novel RNA-binding motif. Biochem Biophys Res Commun 297 1085-1088, 2002
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Kumar V, Carlson JE, Ohgi KA, Edwards TA, Rose DW, Escalante CR, Rosenfeld MG, Aggarwal AK Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase MOL CELL 10 857-869, 2002

Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK Crystallization and characterization of PU.1/IRF-4/DNA ternary complex. J Struct Biol 139 55-59, 2002
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Alloush HM, Edwards TA, Valle-Lisboa V, Wheals AE Disruption of six Saccharomyces cerevisiae ORFs on chromosome XII results in three lethal disruptants. Yeast 19 79-86, 2002
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Edwards TA, Pyle SE, Wharton RP, Aggarwal AK Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Cell 105 281-289, 2001
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Edwards TA, Trincao J, Escalante CR, Wharton RP, Aggarwal AK Crystallization and characterization of Pumilo: a novel RNA binding protein. J Struct Biol 132 251-254, 2000
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