Faculty of Biological Sciences

Dr Thomas Edwards

BSc, PhD 1997, Bath
Associate Professor
School of Molecular and Cellular Biology

Contact:  Garstang 8.53d | +44(0) 113 34 33031 | email address for Dr Thomas Edwards 

You can read more about Dr Edwards's interests here:
http://www.fbs.leeds.ac.uk/staff/tae/
http://www.astbury.leeds.ac.uk/people/staffpage.php?StaffID=TE

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Admin roles

FBS Faculty Board

Modules managed

BIOL1112 - The Molecules of Life

Modules taught

BIOC1301 - Intro Inte Biochem Mol Process
BIOC1302 - Intro Biochem Practical Skills
BIOC1303 - Intro Biochem Problem Solving
BIOC2303 - Intermediate Biochem: Skills
BIOC3160 - Lab/Lit/Comp Research Project
BIOC3221/12/13/BIOL3210 a - ATU 15 - Genes and Development
BIOL1112 - The Molecules of Life
BIOL3306 - Biol Sciences Research Project
BIOL3399 - Extended Research Project Preparation
BIOL5292M - Bioscience MSc Research Proj
BIOL5294M - MSc Bioscience Res Project Pro
BIOW5901X - Foundation module
BIOW5903X - Structure/Function of Nucleic Acids
BMSC1103 - Basic Laboratory and Scientific Skills
BMSC2119 - Experimental Skills
MICR3110 - Microbiology Research Programme

Centre membership:

Group Leader Dr Thomas Edwards  (Associate Professor)

Structural Molecular Biology 


Dr Alice Bartlett  (Visiting Research Fellow)

Mrs Susan Matthews  (Research Technician)


Postgraduates

Stephen Carter  
Joel Dockray  
Rachel Dods  
Hannah Kyle  
Zoe Lear  
Emma Punch  
Liam Sharkey  
Rebecca Surtees  

Tanner SJ; Ariza A; Richard CA; Kyle HF; Dods RL; Blondot ML; Wu W; Trincão J; Trinh CH; Hiscox JA; Carroll MW; Silman NJ; Eléouët JF; Edwards TA; Barr JN Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. Proc Natl Acad Sci U S A 111 1580-1585, 2014
DOI:10.1073/pnas.1317262111
View abstract

Shepherd DA; Ariza A; Edwards TA; Barr JN; Stonehouse NJ; Ashcroft AE Probing Bunyavirus N protein oligomerisation using mass spectrometry Rapid Communications in Mass Spectrometry 28 793-800, 2014
DOI:10.1002/rcm.6841
View abstract

Long K; Edwards TA; Wilson AJ Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamideα-helix mimetics. Bioorg Med Chem 21 4034-4040, 2013
DOI:10.1016/j.bmc.2012.09.053
View abstract

Ariza A; Tanner SJ; Walter CT; Dent KC; Shepherd DA; Wu W; Matthews SV; Hiscox JA; Green TJ; Luo M; Elliott RM; Fooks AR; Ashcroft AE; Stonehouse NJ; Ranson NA; Barr JN; Edwards TA Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Research 41 5912-5926, 2013
DOI:10.1093/nar/gkt268
View abstract

Prabhakaran P; Barnard A; Murphy NS; Kilner CA; Edwards TA; Wilson AJ Aromatic Oligoamide Foldamers with a "Wet Edge" as Inhibitors of the -Helix-Mediated p53-hDM2 Protein-Protein Interaction EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 3504-3512, 2013
DOI:10.1002/ejoc.201300069

Cox G; Edwards TA; O'Neill AJ Mutagenesis Mapping of the Protein-Protein Interaction Underlying FusB-Type Fusidic Acid Resistance ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 57 4640-4644, 2013
DOI:10.1128/AAC.00198-13

Cox G; Thompson GS; Jenkins HT; Peske F; Savelsbergh A; Rodnina MV; Wintermeyer W; Homans SW; Edwards TA; O'Neill AJ Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proc Natl Acad Sci U S A 109 2102-2107, 2012
DOI:10.1073/pnas.1117275109
View abstract

Prabhakaran P; Azzarito V; Jacobs T; Hardie MJ; Kilner CA; Warriner SL; Wilson AJ; Edwards TA Conformational properties of O-alkylated benzamides Tetrahedron 68 4485-4491, 2012
DOI:10.1016/j.tet.2011.11.078
View abstract

Carter SD; Barr JN; Edwards TA Expression, purification and crystallization of the Crimean-Congo haemorrhagic fever virus nucleocapsid protein. Acta Crystallogr Sect F Struct Biol Cryst Commun 68 569-573, 2012
DOI:10.1107/S1744309112009736
View abstract

Azzarito V; Prabhakaran P; Bartlett AI; Murphy NS; Hardie MJ; Kilner CA; Edwards TA; Warriner SL; Wilson AJ 2-O-alkylated para-benzamideα-helix mimetics: the role of scaffold curvature. Org Biomol Chem 10 6469-6472, 2012
DOI:10.1039/c2ob26262b
View abstract

Roberts AJ; Malkova B; Walker ML; Sakakibara H; Numata N; Kon T; Ohkura R; Edwards TA; Knight PJ; Sutoh K; Oiwa K; Burgess SA ATP-driven remodeling of the linker domain in the dynein motor. Structure 20 1670-1680, 2012
DOI:10.1016/j.str.2012.07.003
View abstract

Carter SD; Surtees R; Walter CT; Ariza A; BergeronÉ; Nichol ST; Hiscox JA; Edwards TA; Barr JN Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein. J Virol 86 10914-10923, 2012
DOI:10.1128/JVI.01555-12
View abstract

Fuller JC; Jackson RM; Edwards TA; Wilson AJ; Shirts MR Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable. PLoS One 7 e43253-, 2012
DOI:10.1371/journal.pone.0043253
View abstract

Edwards TA; Wilson AJ Helix-mediated protein-protein interactions as targets for intervention using foldamers AMINO ACIDS 41 743-754, 2011
DOI:10.1007/s00726-011-0880-8

Walden M; Jenkins HT; Edwards TA Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun 67 744-748, 2011
DOI:10.1107/S1744309111017453
View abstract

East DA; Sousa D; Martin SR; Edwards TA; Lehman W; Mulvihill DP Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin BIOCHEM J 438 265-273, 2011
DOI:10.1042/BJ20101316

Jenkins HT; Malkova B; Edwards TA Kinkedβ-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL. Proc Natl Acad Sci U S A 108 18266-18271, 2011
DOI:10.1073/pnas.1105211108
View abstract

Campbell F; Plante JP; Edwards TA; Warriner SL; Wilson AJ N-alkylated oligoamide alpha-helical proteomimetics ORG BIOMOL CHEM 8 2344-2351, 2010
DOI:10.1039/c001164a

Jenkins HT; Baker-Wilding R; Edwards TA Structure and RNA binding of the mouse Pumilio-2 Puf domain J STRUCT BIOL 167 271-276, 2009
DOI:10.1016/j.jsb.2009.06.007

Plante JP; Burnley T; Malkova B; Webb ME; Warriner SL; Edwards TA; Wilson AJ Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction CHEM COMMUN 5091-5093, 2009
DOI:10.1039/b908207g

Gupta YK; Lee TH; Edwards TA; Escalante CR; Kadyrova LY; Wharton RP; Aggarwal AK Co-occupancy of two Pumilio molecules on a single hunchback NRE RNA 15 1029-1035, 2009
DOI:10.1261/rna.1327609

Stead MA; Trinh CH; Garnett JA; Carr SB; Baron AJ; Edwards TA; Wright SC A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain J MOL BIOL 373 820-826, 2007
DOI:10.1016/j.jmb.2007.08.026

Edwards TA; Butterwick JA; Zeng L; Gupta YK; Wang X; Wharton RP; Palmer AG; Aggarwal AK Solution structure of the Vts1 SAM domain in the presence of RNA. J Mol Biol 356 1065-1072, 2006
DOI:10.1016/j.jmb.2005.12.004
View abstract

Townson SA; Samuelson JC; Vanamee ES; Edwards TA; Escalante CR; Xu SY; Aggarwal AK Crystal structure of BstYI at 1.85A resolution: a thermophilic restriction endonuclease with overlapping specificities to BamHI and BglII. J Mol Biol 338 725-733, 2004
DOI:10.1016/j.jmb.2004.02.074
View abstract

Uljon SN; Johnson RE; Edwards TA; Prakash S; Prakash L; Aggarwal AK Crystal structure of the catalytic core of human DNA polymerase kappa. Structure 12 1395-1404, 2004
DOI:10.1016/j.str.2004.05.011
View abstract

Edwards TA; Wilkinson BD; Wharton RP; Aggarwal AK Model of the brain tumor-Pumilio translation repressor complex. Genes Dev 17 2508-2513, 2003
DOI:10.1101/gad.1119403
View abstract

James JA; Escalante CR; Yoon-Robarts M; Edwards TA; Linden RM; Aggarwal AK Crystal structure of the SF3 helicase from adeno-associated virus type 2. Structure 11 1025-1035, 2003
View abstract

Alloush HM; Edwards TA; Valle-Lisboa V; Wheals AE Disruption of six Saccharomyces cerevisiae ORFs on chromosome XII results in three lethal disruptants. Yeast 19 79-86, 2002
DOI:10.1002/yea.808
View abstract

Kumar V; Carlson JE; Ohgi KA; Edwards TA; Rose DW; Escalante CR; Rosenfeld MG; Aggarwal AK Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase MOL CELL 10 857-869, 2002

Escalante CR; Shen L; Escalante MC; Brass AL; Edwards TA; Singh H; Aggarwal AK Crystallization and characterization of PU.1/IRF-4/DNA ternary complex. J Struct Biol 139 55-59, 2002
View abstract

Green JB; Edwards TA; Trincao J; Escalante CR; Wharton RP; Aggarwal AK Crystallization and characterization of Smaug: a novel RNA-binding motif. Biochem Biophys Res Commun 297 1085-1088, 2002
View abstract

Edwards TA; Pyle SE; Wharton RP; Aggarwal AK Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Cell 105 281-289, 2001
View abstract

Edwards TA; Trincao J; Escalante CR; Wharton RP; Aggarwal AK Crystallization and characterization of Pumilo: a novel RNA binding protein. J Struct Biol 132 251-254, 2000
View abstract

DEADWYLER SA; HAMPSON RE; BENNETT BA; EDWARDS TA; MU J; PACHECO MA; WARD SJ; CHILDERS SR CANNABINOIDS MODULATE POTASSIUM CURRENT IN CULTURED HIPPOCAMPAL-NEURONS RECEPTOR CHANNEL 1 121-134, 1993