Faculty of Biological Sciences

Dr Steven Clapcote

BSc, Wales; MSc, Edinburgh; PhD 1999, Liverpool
Lecturer in Pharmacology
School of Biomedical Sciences

Background: Born and raised in Poole, Dorset. Studied Animal Science (BSc, Wales) and Animal Genetics (MSc, Edinburgh) before completing PhD work on the genetic basis of disease resistance at Liverpool. Subsequently worked with Prof. Chris Graham FRS (Oxford) on the genetic regulation of growth and with Dr John Roder (Mount Sinai Hospital, Toronto) on the molecular basis of mental disorders before joining the academic staff of Leeds in 2008.

Contact:  Garstang 6.31e | +44(0) 113 34 33041 | email address for  

Faculty Research and Innovation


Studentship information

See also:

Admin roles

FBS Faculty Board
FBS Purchasing Committee

Modules managed

BMSC2223 - Neuropharmacology

Modules taught

BMSC1103 - Basic Laboratory and Scientific Skills
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2120 - Scientific Skills
BMSC2222 - Mechanisms of Brain Function
BMSC2223/BMSC3302 - Neuropharmacology/Medical Pharmacology
BMSC2230 - Topics in Pharmacology
BMSC3101 - Inherited Disorders
BMSC3126 - Integrative Biomedical Sciences
BMSC3140 - Advanced Scientific Skills
BMSC3143/44/45/46/BIOL3112 b - ATU 12 - Epilepsy
BMSC3233/34/35/36/37 - ATUs - BMS specific
BMSC3301 - Research Proj: Biomed Sciences
DSUR1130 - Anxiety and Pain Management
MEDI - Medical teaching
MEDM5131M - Animal Models of Disease

Centre membership: Neuroscience Research at Leeds (NeuR@L)

Group Leader Dr Steven Clapcote  (Lecturer in Pharmacology)


Dr James Dachtler  (Wellcome Trust Junior Investigator Development Fellow)

Understanding the role of synaptic proteins in neurobehavioural disorders. 

Postgraduates

Ahmed Al-Amri  
Mohammad Alsaad  
Helena Briggs  

Kirshenbaum GS; Clapcote SJ; Duffy S; Burgess CR; Petersen J; Jarowek KJ; Yuecel YH; Cortez MA; III SOC; Vilsen B; Peever JH; Ralph MR; Roder JC Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase alpha 3 sodium pump PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108 18144-18149, 2011
DOI:10.1073/pnas.1108416108

Clapcote SJ; Duffy S; Xie G; Kirshenbaum G; Bechard AR; Schack VR; Petersen J; Sinai L; Saab BJ; Lerch JP; Minassian BA; Ackerley CA; Sled JG; Cortez MA; Henderson JT; Vilsen B; Roder JC Mutation I810N in the alpha 3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS P NATL ACAD SCI USA 106 14085-14090, 2009
DOI:10.1073/pnas.0904817106

Clapcote SJ; Lipina TV; Millar JK; Mackie S; Christie S; Ogawa F; Lerch JP; Trimble K; Uchiyama M; Sakuraba Y; Kaneda H; Shiroishi T; Houslay MD; Henkelman RM; Sled JG; Gondo Y; Porteous DJ; Roder JC Behavioral phenotypes of Disc1 missense mutations in mice NEURON 54 387-402, 2007
DOI:10.1016/j.neuron.2007.04.015

Heinzen EL; Arzimanoglou A; Brashear A; Clapcote SJ; Gurrieri F; Goldstein DB; Jóhannesson SH; Mikati MA; Neville B; Nicole S; Ozelius LJ; Poulsen H; Schyns T; Sweadner KJ; van den Maagdenberg A; Vilsen B; ATP1A3 Working Group Distinct neurological disorders with ATP1A3 mutations. Lancet Neurol 13 503-514, 2014
DOI:10.1016/S1474-4422(14)70011-0
View abstract

Porteous DJ; Thomson PA; Millar JK; Evans KL; Hennah W; Soares DC; McCarthy S; McCombie WR; Clapcote SJ; Korth C; Brandon NJ; Sawa A; Kamiya A; Roder JC; Lawrie SM; McIntosh AM; St Clair D; Blackwood DH DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan. Mol Psychiatry 19 141-143, 2014
DOI:10.1038/mp.2013.160

Ritchie DJ; Clapcote SJ Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Laboratory Animals 47 162-167, 2013
DOI:10.1177/0023677213478299
View abstract

Edwards IJ; Bruce G; Lawrenson C; Howe L; Clapcote SJ; Deuchars SA; Deuchars J Na+/K+ ATPaseα1 and α3 isoforms are differentially expressed in α- and γ-motoneurons. J Neurosci 33 9913-9919, 2013
DOI:10.1523/JNEUROSCI.5584-12.2013
View abstract

McGirr A; Lipina T; Mun H-S; Georgiou J; Zhai D; Liu F; Clapcote S; Roder J The Phosphodiesterase 4B Mutant: Cognitive Enhancement and a Novel Therapeutic Approach to PTSD, 2013

Kirshenbaum GS; Dawson N; Mullins JG; Johnston TH; Drinkhill MJ; Edwards IJ; Fox SH; Pratt JA; Brotchie JM; Roder JC; Clapcote SJ Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPaseα3 missense mutant mice. PLoS One 8 e60141-, 2013
DOI:10.1371/journal.pone.0060141
View abstract

Kirshenbaum GS; Clapcote SJ; Petersen J; Vilsen B; Ralph MR; Roder JC Genetic suppression of agrin reduces mania-like behavior in Na+ , K+ -ATPaseα3 mutant mice. Genes Brain Behav 11 436-443, 2012
DOI:10.1111/j.1601-183X.2012.00800.x
View abstract

Reichelt AC; Rodgers RJ; Clapcote SJ The role of neurexins in schizophrenia and autistic spectrum disorder. Neuropharmacology 62 1519-1526, 2012
DOI:10.1016/j.neuropharm.2011.01.024
View abstract

Sha L; MacIntyre L; Machell JA; Kelly MP; Porteous DJ; Brandon NJ; Muir WJ; Blackwood DH; Watson DG; Clapcote SJ; Pickard BS Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3. Mol Psychiatry 17 267-279, 2012
DOI:10.1038/mp.2011.73
View abstract

Zhang L; Fu D; Belichenko PV; Liu C; Kleschevnikov AM; Pao A; Liang P; Clapcote SJ; Mobley WC; Yu YE Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs 3 8-12, 2012
DOI:10.4161/bbug.3.1.17696
View abstract

d'Isa R; Clapcote SJ; Voikar V; Wolfer DP; Giese KP; Brambilla R; Fasano S Mice lacking Ras-GRF1 show contextual fear conditioning but not spatial memory impairments: convergent evidence from two independently generated mouse mutant lines FRONTIERS IN BEHAVIORAL NEUROSCIENCE 5 1-11, 2011
DOI:10.3389/fnbeh.2011.00078

Lazar NL; Singh S; Paton T; Clapcote SJ; Gondo Y; Fukumura R; Roder JC; Cain DP Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice BEHAV BRAIN RES 224 73-79, 2011
DOI:10.1016/j.bbr.2011.05.020

Brown SM; Clapcote SJ; Millar JK; Torrance HS; Anderson SM; Walker R; Rampino A; Roder JC; Thomson PA; Porteous DJ; Evans KL Synaptic modulators Nrxn1 and Nrxn3 are disregulated in a Disc1 mouse model of schizophrenia. Mol Psychiatry 16 585-587, 2011
DOI:10.1038/mp.2010.134

Lee FHF; Fadel MP; Preston-Maher K; Cordes SP; Clapcote SJ; Price DJ; Roder JC; Wong AHC Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex J NEUROSCI 31 3197-3206, 2011
DOI:10.1523/JNEUROSCI.4219-10.2011

Lipina TV; Kaidanovich-Beilin O; Patel S; Wang M; Clapcote SJ; Liu F; Woodgett JR; Roder JC Genetic and Pharmacological Evidence for Schizophrenia-Related Disc1 Interaction With GSK-3 SYNAPSE 65 234-248, 2011
DOI:10.1002/syn.20839

Yu T; Liu CH; Belichenko P; Clapcote SJ; Li SM; Pao AN; Kleschevnikov A; Bechard AR; Asrar S; Chen RQ; Fan N; Zhou ZY; Jia ZP; Chen C; Roder JC; Liu B; Baldini A; Mobley WC; Yu YE Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice BRAIN RES 1366 162-171, 2010
DOI:10.1016/j.brainres.2010.09.107

Xie G; Harrison J; Clapcote SJ; Huang Y; Zhang JY; Wang LY; Roder JC A New Kv1.2 Channelopathy Underlying Cerebellar Ataxia J BIOL CHEM 285 32160-32173, 2010
DOI:10.1074/jbc.M110.153676

Clapcote SJ; Lipina TV; Roder JC Endophenotypes of Disc1 missense mutations in mice, 2010

Yu T; Li ZY; Jia ZP; Clapcote SJ; Liu CH; Li SM; Asrar S; Pao A; Chen RQ; Fan N; Carattini-Rivera S; Bechard AR; Spring SS; Henkelman RM; Stoica G; Matsui SI; Nowak NJ; Roder JC; Chen C; Bradley A; Yu YE A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions HUM MOL GENET 19 2780-2791, 2010
DOI:10.1093/hmg/ddq179

Yu T; Clapcote SJ; Li ZY; Liu CH; Pao A; Bechard AR; Carattini-Rivera S; Matsui SI; Roder JC; Baldini A; Mobley WC; Bradley A; Yu YE Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice MAMM GENOME 21 258-267, 2010
DOI:10.1007/s00335-010-9262-x

Ng D; Pitcher GM; Szilard RK; Sertie A; Kanisek M; Clapcote SJ; Lipina T; Kalia LV; Joo D; McKerlie C; Cortez M; Roder JC; Salter MW; McInnes RR Neto1 Is a Novel CUB-Domain NMDA Receptor-Interacting Protein Required for Synaptic Plasticity and Learning PLOS BIOL 7 278-300, 2009
DOI:10.1371/journal.pbio.1000041

Labrie V; Clapcote SJ; Roder JC Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors PHARMACOL BIOCHEM BE 91 610-620, 2009
DOI:10.1016/j.pbb.2008.09.016

Young EJ; Lipina T; Tam E; Mandel A; Clapcote SJ; Bechard AR; Chambers J; Mount HTJ; Fletcher PJ; Roder JC; Osborne LR Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice GENES BRAIN BEHAV 7 224-234, 2008
DOI:10.1111/j.1601-183X.2007.00343.x

Xie G; Clapcote SJ; Nieman BJ; Tallerico T; Huang Y; Vukobradovic I; Cordes SP; Osborne LR; Rossant J; Sled JG; Henderson JT; Roder JC Forward genetic screen of mouse reveals dominant missense mutation in the P/Q-type voltage-dependent calcium channel, CACNA1A GENES BRAIN BEHAV 6 717-727, 2007
DOI:10.1111/j.1601-183X.2007.00302.x

Millar JK; Mackie S; Clapcote SJ; Murdoch H; Pickard BS; Christie S; Muir WJ; Blackwood DH; Roder JC; Houslay MD; Porteous DJ Disrupted in schizophrenia 1 and phosphodiesterase 413: towards an understanding of psychiatric illness JOURNAL OF PHYSIOLOGY-LONDON 584 401-405, 2007
DOI:10.1113/jphysiol.2007.140210

Ishizuka K; Chen J; Taya S; Li W; Millar JK; Xu Y; Clapcote S; Hookway C; Morita M; Kamiya A; Tomoda T; Lipska B; Roder J; Pletnikov M; Porteous D; Silva A; Cannon T; Kaibuchi K; Brandon N; Weinberger D; Sawa A Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice MOL PSYCHIATR 12 897-899, 2007
DOI:10.1038/sj.mp.4002024

Lipina TV; Clapcote SJ; Lerch JP; Sled JG; Uchiyama M; Gondo Y; Roder JC The point mutation in disc1 gene is associated with schizophrenia-like behavior and neuroanatomical abnormalities in mice, 2007

Clapcote SJ; Roder JC Deletion polymorphism of Disc1 is common to all 129 mouse substrains: Implications for gene-targeting studies of brain function GENETICS 173 2407-2410, 2006
DOI:10.1534/genetics.106.060749

Abramow-Newerly W; Lipina T; Abramow-Newerly M; Kim D; Bechard AR; Xie G; Clapcote SJ; Roder JC Methods to rapidly and accurately screen a large number of ENU mutagenized mice for abnormal motor phenotypes AMYOTROPH LATERAL SC 7 112-118, 2006
DOI:10.1080/14660820500443000

Snead OC; Clapcote SJ; Roder JC; Boulianne GL Novel strategies for the development of animal models of refractory epilepsy. Adv Neurol 97 155-171, 2006

Clapcote SJ; Lazar NL; Bechard AR; Roder JC Effects of the rd1 mutation and host strain on hippocampal learning in mice BEHAV GENET 35 591-601, 2005
DOI:10.1007/s10519-005-5634-5

Clapcote SJ; Lazar NL; Bechard AR; Wood GA; Roder JC NIH Swiss and Black Swiss mice have retinal degeneration and performance deficits in cognitive tests. Comp Med 55 310-316, 2005
View abstract

Clapcote SJ; Roder JC Simplex PCR assay for sex determination in mice. Biotechniques 38 702-706, 2005

Churchill GA; Airey DC; Allayee H; Angel JM; Attie AD; Beatty J; Beavis WD; Belknap JK; Bennett B; Berrettini W; Bleich A; Bogue M; Broman KW; Buck KJ; Buckler E; Burmeister M; Chesler EJ; Cheverud JM; Clapcote S; Cook MN; Cox RD; Crabbe JC; Crusio WE; Darvasi A; Deschepper CF; Doerge RW; Farber CR; Forejt J; Gaile D; Garlow SJ; Geiger H; Gershenfeld H; Gordon T; Gu J; Gu W; de Haan G; Hayes NL; Heller C; Himmelbauer H; Hitzemann R; Hunter K; Hsu HC; Iraqi FA; Ivandic B; Jacob HJ; Jansen RC; Jepsen KJ; Johnson DK; Johnson TE; Kempermann G; Kendziorski C; Kotb M; Kooy RF; Llamas B; Lammert F; Lassalle JM; Lowenstein PR; Lu L; Lusis A; Manly KF; Marcucio R; Matthews D; Medrano JF; Miller DR; Mittleman G; Mock BA; Mogil JS; Montagutelli X; Morahan G; Morris DG; Mott R; Nadeau JH; Nagase H; Nowakowski RS; O'Hara BF; Osadchuk AV; Page GP; Paigen B; Paigen K; Palmer AA; Pan HJ; Peltonen-Palotie L; Peirce J; Pomp D; Pravenec M; Prows DR; Qi Z; Reeves RH; Roder J; Rosen GD; Schadt EE; Schalkwyk LC; Seltzer Z; Shimomura K; Shou S; Sillanpää MJ; Siracusa LD; Snoeck HW; Spearow JL; Svenson K; Tarantino LM; Threadgill D; Toth LA; Valdar W; de Villena FP; Warden C; Whatley S; Williams RW; Wiltshire T; Yi N; Zhang D; Zhang M; Zou F; Complex Trait Consortium The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet 36 1133-1137, 2004
DOI:10.1038/ng1104-1133
View abstract

Clapcote SJ; Roder JC Survey of embryonic stem cell line source strains in the water maze reveals superior reversal learning of 129S6/SvEvTac mice BEHAV BRAIN RES 152 35-48, 2004
DOI:10.1016/j.bbr.2003.09.030

Ng D; Sertie A; Szilard RK; Pitcher GM; Clapcote S; Kalia LV; Salter MW; Roder JC; Cortez MA; McInnes RR Loss of Neto1, a component of the NMDA receptor complex, is associated with decreased synaptic plasticity and impaired extinction of memories., 2003

Clapcott SJ; Peters J; Orban PC; Brambilla R; Graham CF Two ENU-induced mutations in Rasgrf1 and early mouse growth retardation. Mamm Genome 14 495-505, 2003
DOI:10.1007/s00335-002-2258-4
View abstract

Iraqi F; Clapcott SJ; Kumari P; Haley CS; Kemp SJ; Teale AJ Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Mamm Genome 11 645-648, 2000
View abstract

Clapcott SJ; Teale AJ; Kemp SJ Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice PARASITE IMMUNOL 22 259-263, 2000

Teale A; Agaba M; Clapcott S; Gelhaus A; Haley C; Hanotte O; Horstmann R; Iraqi F; Kemp S; Nilsson P; Schwerin M; Sekikawa K; Soller M; Sugimoto Y; Womack J Resistance to trypanosomosis: of markers, genes and mechanisms ARCH TIERZUCHT 42 36-41, 1999