Dr Steven Clapcote

BSc, Wales; MSc, Edinburgh; PhD 1999, Liverpool
Lecturer in Pharmacology
School of Biomedical Sciences

Background: Born and raised in Poole, Dorset. Studied Animal Science (BSc, Wales) and Animal Genetics (MSc, Edinburgh) before completing PhD work on the genetic basis of disease resistance at Liverpool. Subsequently worked with Prof. Chris Graham FRS (Oxford) on the genetic regulation of growth and with Dr John Roder (Mount Sinai Hospital, Toronto) on the molecular basis of mental disorders before joining the academic staff of Leeds in 2008.

Contact: Garstang 6.41a, +44(0) 113 34 33041, email address for  

Faculty Research and Innovation

Studentship information

See also:

Modules managed

BMSC2223 - Neuropharmacology
BMSC3398 - Practical Research Skills

Modules taught

BIOL5171M - Infectious & Non-infectious Diseases
BMSC1103 - Basic Laboratory and Scientific Skills
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2120 - Scientific Skills
BMSC2223 - Neuropharmacology
BMSC2223/BMSC3302 - Neuropharmacology/Medical Pharmacology
BMSC2230 - Topics in Pharmacology
BMSC2235 - Molecular Neuroscience
BMSC3101 - Inherited Disorders
BMSC3126/43/44/45/46 A - ATU - Integrative biomedical sciences
BMSC3140 - Advanced Scientific Skills
BMSC3143/44/45/46 B - ATU - Autism
BMSC3233/34/36 - Advanced Topics II
BMSC3301 - Research Project in Biomedical Sciences
BMSC3302 - Medical Pharmacology
BMSC3398 - Practical Research Skills
DSUR1130 - Anxiety and Pain Management
MEDI2201 - Control and Movement
MEDM5131M - Animal Models of Disease


Member of Undergraduate School Taught Student Education Committee

Centre membership: Neuroscience Research at Leeds (NeuR@L)

Group Leader Dr Steven Clapcote  (Lecturer in Pharmacology)


Abdulelah Alshawli (Co-supervisor) 10% FTE
Bethan Cole (Co-supervisor) 35% FTE

Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yuecel YH, Cortez MA, III SOC, Vilsen B, Peever JH, Ralph MR, Roder JC Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase alpha 3 sodium pump PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108 18144-18149, 2011

Clapcote SJ, Duffy S, Xie G, Kirshenbaum G, Bechard AR, Schack VR, Petersen J, Sinai L, Saab BJ, Lerch JP, Minassian BA, Ackerley CA, Sled JG, Cortez MA, Henderson JT, Vilsen B, Roder JC Mutation I810N in the alpha 3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS P NATL ACAD SCI USA 106 14085-14090, 2009

Clapcote SJ, Lipina TV, Millar JK, Mackie S, Christie S, Ogawa F, Lerch JP, Trimble K, Uchiyama M, Sakuraba Y, Kaneda H, Shiroishi T, Houslay MD, Henkelman RM, Sled JG, Gondo Y, Porteous DJ, Roder JC Behavioral phenotypes of Disc1 missense mutations in mice NEURON 54 387-402, 2007

Liu M, Fitzgibbon M, Wang Y, Reilly J, Qian X, O'Brien T, Clapcote S, Shen S, Roche M Ulk4 regulates GABAergic signaling and anxiety-related behavior Translational Psychiatry 8, 2018
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Al Amri A, Ivorra JL, Cardno AG, Logan C, Mullins J, Mahmood T, Nazar Q, Dachtler J, Abdelhamed Z, Khan S, Khan K, Johnson C, Ali M, Inglehearn CF, Clapcote SJ EVIDENCE FOR THE INVOLVEMENT OF DFNB31 VARIANTS IN PSYCHOTIC DISORDERS, 2017


McGirr A, Lipina TV, Mun H-S, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JGL, Liu F, Baillie GS, Clapcote SJ, Roder JC Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition (vol 41, pg 1080, 2016) NEUROPSYCHOPHARMACOLOGY 42 1178-1178, 2017

Timothy JWS, Klas N, Sanghani HR, Al-Mansouri T, Hughes ATL, Kirshenbaum GS, Brienza V, Belle MDC, Ralph MR, Clapcote SJ, Piggins HD Circadian Disruptions in the Myshkin Mouse Model of Mania Are Independent of Deficits in Suprachiasmatic Molecular Clock Function Biological Psychiatry, 2017
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Clapcote SJ Phosphodiesterase-4B as a therapeutic target for cognitive impairment and obesity-related metabolic diseases In Advances in Neurobiology, 2017
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Al-Amri A, Saegh AA, Al-Mamari W, El-Asrag ME, Ivorra JL, Cardno AG, Inglehearn CF, Clapcote SJ, Ali M Homozygous single base deletion in TUSC3 causes intellectual disability with developmental delay in an Omani family American Journal of Medical Genetics Part A 170 1826-1831, 2016
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Mcgirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition Neuropsychopharmacology 41 1080-1092, 2016
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Dachtler J, Elliott C, Rodgers RJ, Baillie GS, Clapcote SJ Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice Scientific Reports 6, 2016
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Kirshenbaum GS, Idris NF, Dachtler J, Roder JC, Clapcote SJ Deficits in social behavioral tests in a mouse model of alternating hemiplegia of childhood Journal of Neurogenetics 30 42-49, 2016
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Kirshenbaum GS, Dachtler J, Roder JC, Clapcote SJ Transgenic rescue of phenotypic deficits in a mouse model of alternating hemiplegia of childhood Neurogenetics 17 57-63, 2016
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Dachtler J, Ivorra JL, Rowland TE, Lever C, John Rodgers R, Clapcote SJ Heterozygous deletion ofα-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia Behavioral Neuroscience 129 765-776, 2015
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Kirshenbaum GS, Dachtler J, Roder JC, Clapcote SJ Characterization of cognitive deficits in mice with an alternating hemiplegia-linked mutation Behavioral Neuroscience 129 822-831, 2015
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Chandran JS, Kazanis I, Clapcote SJ, Ogawa F, Millar JK, Porteous DJ, Ffrench-Constant C Disc1 variation leads to specific alterations in adult neurogenesis PLoS ONE 9, 2014
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Heinzen EL, Arzimanoglou A, Brashear A, Clapcote SJ, Gurrieri F, Goldstein DB, Jóhannesson SH, Mikati MA, Neville B, Nicole S, Ozelius LJ, Poulsen H, Schyns T, Sweadner KJ, van den Maagdenberg A, Vilsen B, ATP1A3 Working Group Distinct neurological disorders with ATP1A3 mutations. Lancet Neurol 13 503-514, 2014
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Porteous DJ, Thomson PA, Millar JK, Evans KL, Hennah W, Soares DC, McCarthy S, McCombie WR, Clapcote SJ, Korth C, Brandon NJ, Sawa A, Kamiya A, Roder JC, Lawrie SM, McIntosh AM, St Clair D, Blackwood DH DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan. Mol Psychiatry 19 141-143, 2014

Dachtler J, Glasper J, Cohen RN, Ivorra JL, Swiffen DJ, Jackson AJ, Harte MK, Rodgers RJ, Clapcote SJ Deletion ofα-neurexin II results in autism-related behaviors in mice Translational Psychiatry 4, 2014
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Ritchie DJ, Clapcote SJ Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Laboratory Animals 47 162-167, 2013
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Edwards IJ, Bruce G, Lawrenson C, Howe L, Clapcote SJ, Deuchars SA, Deuchars J Na+/K+ ATPaseα1 and α3 isoforms are differentially expressed in α- and γ-motoneurons. J Neurosci 33 9913-9919, 2013
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Kirshenbaum GS, Dawson N, Mullins JGL, Johnston TH, Drinkhill MJ, Edwards IJ, Fox SH, Pratt JA, Brotchie JM, Roder JC, Clapcote SJ Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPaseα3 missense mutant mice. PLoS One 8 e60141-, 2013
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Kirshenbaum GS, Clapcote SJ, Petersen J, Vilsen B, Ralph MR, Roder JC Genetic suppression of agrin reduces mania-like behavior in Na+ , K+ -ATPaseα3 mutant mice. Genes Brain Behav 11 436-443, 2012
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Sha L, MacIntyre L, Machell JA, Kelly MP, Porteous DJ, Brandon NJ, Muir WJ, Blackwood DH, Watson DG, Clapcote SJ, Pickard BS Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3. Mol Psychiatry 17 267-279, 2012
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Reichelt AC, Rodgers RJ, Clapcote SJ The role of neurexins in schizophrenia and autistic spectrum disorder. Neuropharmacology 62 1519-1526, 2012
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Zhang L, Fu D, Belichenko PV, Liu C, Kleschevnikov AM, Pao A, Liang P, Clapcote SJ, Mobley WC, Yu YE Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs 3 8-12, 2012
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d'Isa R, Clapcote SJ, Voikar V, Wolfer DP, Giese KP, Brambilla R, Fasano S Mice lacking Ras-GRF1 show contextual fear conditioning but not spatial memory impairments: convergent evidence from two independently generated mouse mutant lines FRONTIERS IN BEHAVIORAL NEUROSCIENCE 5 1-11, 2011

Lazar NL, Singh S, Paton T, Clapcote SJ, Gondo Y, Fukumura R, Roder JC, Cain DP Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice BEHAV BRAIN RES 224 73-79, 2011

Brown SM, Clapcote SJ, Millar JK, Torrance HS, Anderson SM, Walker R, Rampino A, Roder JC, Thomson PA, Porteous DJ, Evans KL Synaptic modulators Nrxn1 and Nrxn3 are disregulated in a Disc1 mouse model of schizophrenia. Mol Psychiatry 16 585-587, 2011

Lee FHF, Fadel MP, Preston-Maher K, Cordes SP, Clapcote SJ, Price DJ, Roder JC, Wong AHC Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex J NEUROSCI 31 3197-3206, 2011

Lipina TV, Kaidanovich-Beilin O, Patel S, Wang M, Clapcote SJ, Liu F, Woodgett JR, Roder JC Genetic and Pharmacological Evidence for Schizophrenia-Related Disc1 Interaction With GSK-3 SYNAPSE 65 234-248, 2011

Yu T, Liu CH, Belichenko P, Clapcote SJ, Li SM, Pao AN, Kleschevnikov A, Bechard AR, Asrar S, Chen RQ, Fan N, Zhou ZY, Jia ZP, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice BRAIN RES 1366 162-171, 2010

Xie G, Harrison J, Clapcote SJ, Huang Y, Zhang JY, Wang LY, Roder JC A New Kv1.2 Channelopathy Underlying Cerebellar Ataxia J BIOL CHEM 285 32160-32173, 2010

Clapcote SJ, Lipina TV, Roder JC Endophenotypes of Disc1 missense mutations in mice, 2010

Yu T, Li ZY, Jia ZP, Clapcote SJ, Liu CH, Li SM, Asrar S, Pao A, Chen RQ, Fan N, Carattini-Rivera S, Bechard AR, Spring SS, Henkelman RM, Stoica G, Matsui SI, Nowak NJ, Roder JC, Chen C, Bradley A, Yu YE A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions HUM MOL GENET 19 2780-2791, 2010

Yu T, Clapcote SJ, Li ZY, Liu CH, Pao A, Bechard AR, Carattini-Rivera S, Matsui SI, Roder JC, Baldini A, Mobley WC, Bradley A, Yu YE Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice MAMM GENOME 21 258-267, 2010

Ng D, Pitcher GM, Szilard RK, Sertie A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR Neto1 Is a Novel CUB-Domain NMDA Receptor-Interacting Protein Required for Synaptic Plasticity and Learning PLOS BIOL 7 278-300, 2009

Labrie V, Clapcote SJ, Roder JC Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors PHARMACOL BIOCHEM BE 91 610-620, 2009

Young EJ, Lipina T, Tam E, Mandel A, Clapcote SJ, Bechard AR, Chambers J, Mount HTJ, Fletcher PJ, Roder JC, Osborne LR Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice GENES BRAIN BEHAV 7 224-234, 2008

Xie G, Clapcote SJ, Nieman BJ, Tallerico T, Huang Y, Vukobradovic I, Cordes SP, Osborne LR, Rossant J, Sled JG, Henderson JT, Roder JC Forward genetic screen of mouse reveals dominant missense mutation in the P/Q-type voltage-dependent calcium channel, CACNA1A GENES BRAIN BEHAV 6 717-727, 2007

Millar JK, Mackie S, Clapcote SJ, Murdoch H, Pickard BS, Christie S, Muir WJ, Blackwood DH, Roder JC, Houslay MD, Porteous DJ Disrupted in schizophrenia 1 and phosphodiesterase 413: towards an understanding of psychiatric illness JOURNAL OF PHYSIOLOGY-LONDON 584 401-405, 2007

Ishizuka K, Chen J, Taya S, Li W, Millar JK, Xu Y, Clapcote S, Hookway C, Morita M, Kamiya A, Tomoda T, Lipska B, Roder J, Pletnikov M, Porteous D, Silva A, Cannon T, Kaibuchi K, Brandon N, Weinberger D, Sawa A Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice MOL PSYCHIATR 12 897-899, 2007

Lipina TV, Clapcote SJ, Lerch JP, Sled JG, Uchiyama M, Gondo Y, Roder JC The point mutation in disc1 gene is associated with schizophrenia-like behavior and neuroanatomical abnormalities in mice, 2007

Clapcote SJ, Roder JC Deletion polymorphism of Disc1 is common to all 129 mouse substrains: Implications for gene-targeting studies of brain function GENETICS 173 2407-2410, 2006

Abramow-Newerly W, Lipina T, Abramow-Newerly M, Kim D, Bechard AR, Xie G, Clapcote SJ, Roder JC Methods to rapidly and accurately screen a large number of ENU mutagenized mice for abnormal motor phenotypes AMYOTROPH LATERAL SC 7 112-118, 2006

Snead OC, Clapcote SJ, Roder JC, Boulianne GL Novel strategies for the development of animal models of refractory epilepsy. Adv Neurol 97 155-171, 2006

Clapcote SJ, Lazar NL, Bechard AR, Roder JC Effects of the rd1 mutation and host strain on hippocampal learning in mice BEHAV GENET 35 591-601, 2005

Clapcote SJ, Lazar NL, Bechard AR, Wood GA, Roder JC NIH Swiss and Black Swiss mice have retinal degeneration and performance deficits in cognitive tests. Comp Med 55 310-316, 2005
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Clapcote SJ, Roder JC Simplex PCR assay for sex determination in mice. Biotechniques 38 702-706, 2005

Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu H-C, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle J-M, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan H-J, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck H-W, Spearow JL, Svenson K, and 15 other authors The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet 36 1133-1137, 2004
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Clapcote SJ, Roder JC Survey of embryonic stem cell line source strains in the water maze reveals superior reversal learning of 129S6/SvEvTac mice BEHAV BRAIN RES 152 35-48, 2004

Ng D, Sertie A, Szilard RK, Pitcher GM, Clapcote S, Kalia LV, Salter MW, Roder JC, Cortez MA, McInnes RR Loss of Neto1, a component of the NMDA receptor complex, is associated with decreased synaptic plasticity and impaired extinction of memories., 2003

Clapcott SJ, Peters J, Orban PC, Brambilla R, Graham CF Two ENU-induced mutations in Rasgrf1 and early mouse growth retardation. Mamm Genome 14 495-505, 2003
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Iraqi F, Clapcott SJ, Kumari P, Haley CS, Kemp SJ, Teale AJ Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Mamm Genome 11 645-648, 2000
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Clapcott SJ, Teale AJ, Kemp SJ Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice PARASITE IMMUNOL 22 259-263, 2000

Teale A, Agaba M, Clapcott S, Gelhaus A, Haley C, Hanotte O, Horstmann R, Iraqi F, Kemp S, Nilsson P, Schwerin M, Sekikawa K, Soller M, Sugimoto Y, Womack J Resistance to trypanosomosis: of markers, genes and mechanisms ARCH TIERZUCHT 42 36-41, 1999