Faculty of Biological Sciences

Prof G Eric Blair

BSc, Edinburgh; PhD 1974, Warwick
Professor in Molecular and Cellular Biology
School of Molecular and Cellular Biology

Background: Postdoctoral work in Aarhus, Denmark; Uppsala, Sweden and National Institute of Medical Research, London. Appointed Lecturer 1981, Senior Lecturer 1988, Reader 1996.

Contact:  Garstang 8.53f, +44(0) 113 34 33128, email address for  

Figure 1: Human adenovirus

Figure 2: MHC class I molecule

Research Interests

DNA tumour viruses: Entry into cells and evasion of the immune system

The small DNA tumour viruses (adenoviruses, papillomaviruses, SV40 and polyomaviruses) have proved to be important in the study of cell transformation, cell cycle control and tumour formation. In recent years, the adenoviruses have been exploited as potential vectors in gene therapy for inherited diseases such as cystic fibrosis and cancer. Human adenoviruses (see Figure 1) enter cells by attachment of the projecting fibre proteins to cell surface receptors. We have been studying the expression of a major cell surface receptor, CAR, that admits adenoviruses into susceptible cells. Engineering of CAR may improve entry of adenoviruses designed to deliver therapeutic genes into cells, providing benefits for gene therapy. We are also interested in using therapeutic adenoviruses to stimulate antigen-presenting cells (dendritic cells) in humans to reject cancer cells.

Although the adenoviruses can be harnessed to provide new treatments, in order to survive in humans, they must adopt mechanisms to avoid the immune system. We have shown that the adenoviruses and oncogenic human papillomaviruses (HPV16 and 18) subvert the process of antigen processing and presentation mediated by major histocompatibility complex (MHC) class I molecules. The class I molecules (see Figure 2) bind intracellularly processed peptides in the groove of the class I heavy chain molecule. Adenoviruses and oncogenic HPVs encode proteins (E1A and E7 respectively) that repress expression of many genes involved in the class I antigen presentation pathway. We aim to understand the biochemical mechanisms that underlie this immune evasion since this may reveal new targets to eradicate cancer-causing viruses.

 

Faculty Research and Innovation



Studentship information

Undergraduate project topics:

  • Construction of inducible cell lines expressing human adenovirus and papillomavirus oncoproteins
    Keywords: Adenoviruses, E1A oncogene, HPV, E7 oncogene, transformed cells, immunochemical detection of viral oncoproteins
    (Laboratory)
  • Target cellular genes for modulation by adenovirus and papillomarivus oncoproteins and the relationship to tumorigenicity
    Keywords: Adenoviruses, E1A and E1B oncogenes, HPV, E6 and E7 oncogenes, cellular gene expression
    (Literature)

Postgraduate studentship areas:

  • DNA tumour viruses: Entry into cells and evasion of the Immune system

See also:

Modules managed

BIOC3900 - Cancer Biology
BIOL3400 - Skills in the Cell Biology of Human Disease

Modules taught

BIOC2301 - Intermediate Integrated Biochemistry
BIOC2302 - Intermediate Biochemistry: Practicals
BIOC2303 - Intermediate Biochemistry: Skills
BIOC3160 - Laboratory/Literature/Computing Research Project
BIOC3231/32/3900/BIOL3211/MICR3212 - ATU - Molecular Oncology
BIOC3900 - Cancer Biology
BIOC3900/BIOL3211/BMSC3233/34/36 - ATU - Cancer Therapy/Biology
BIOL1302 - Introductory Skills for Biological Sciences
BIOL2111/BIOC2301 - Integrated Biochemistry/Genetic Engineering
BIOL2301 - Intermediate Skills for Biological Sciences
BIOL2301/03/05/MICR2320 - Skills for Biol Sci, Biosciences and Microbiology
BIOL2301/03/05/MICR2320/BIOL3400 - BIOL/BIOC/MICR advanced skills/Skills in the Cell Biology of Human Disease
BIOL2301/05 - Skills for Biol Sci & Biosciences
BIOL2305 - Integrated Skills for Biosciences 2
BIOL3305 - Advanced Skills in the Biosciences
BIOL3305/3400 - Advanced Skills in the Biosciences/Skills in the Cell Biology of Human Disease
BIOL3306 - Biological Sciences Research Project
BIOL3398 - Research Tools and Applications
BIOL3399 - Extended Research Project Preparation
BIOL3400 - Skills in the Cell Biology of Human Disease
BIOL5294M - MSc Bioscience Research Project Proposal
BIOL5296M - Treatment of Infectious Disease and Cancer
BIOL5382M - Extended Research Project
BIOL5392M - Bioscience MSc Research Project
BLGY3110 - Applied Genetics
BMSC1103 - Basic Laboratory and Scientific Skills
BMSC2210 - Chemotherapy
MICR2120/BIOC2301 - Integrated Biochemistry/Medical Bacteriology
MICR2221 - Medical Immunology

Centre membership: The Antimicrobial Research Centre

Group Leader Prof G Eric Blair  (Professor in Molecular and Cellular Biology)

DNA tumour viruses: Entry into cells and evasion of the immune system 

Postgraduates

Muhammad Abdullah (Primary supervisor) 50% FTE
Reem Elghazawy (Primary supervisor) 90% FTE
Magdalena Karwatka (Primary supervisor) 90% FTE
Abigail Bloy (Co-supervisor) 20% FTE
Anthony Chan (Co-supervisor) 30% FTE
Sian Drake (Co-supervisor) 40% FTE

Dallaire F, Schreiner S, Blair GE, Dobner T, Branton PE, Blanchette P The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F MSPHERE 1 -, 2016
DOI:10.1128/mSphere.00014-15

Dallaire F, Schreiner S, Blair GE, Dobner T, Branton PE, Blanchette P The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity mSphere 1 -, 2016
DOI:10.1128/msphere.00015-15
View abstract

Richards KH, Wasson CW, Watherston O, Doble R, Eric Blair G, Wittmann M, Macdonald A The human papillomavirus (HPV) E7 protein antagonises an Imiquimod-induced inflammatory pathway in primary human keratinocytes Scientific Reports 5 -, 2015
DOI:10.1038/srep12922
View abstract

CesurÖ, Nicol C, Groves H, Mankouri J, Blair GE, Stonehouse NJ The subcellular localisation of the human papillomavirus (HPV) 16 E7 protein in cervical cancer cells and its perturbation by RNA aptamers Viruses 7 3443-3461, 2015
DOI:10.3390/v7072780
View abstract

Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Chakraborty JB, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA NFκ B1 is a suppressor of neutrophil-driven hepatocellular carcinoma Nature Communications 6 -, 2015
DOI:10.1038/ncomms7818
View abstract

Knight LM, Stakaityte G, Wood JJ, Abdul-Sada H, Griffiths DA, Howell GJ, Wheat R, Blair GE, Steven NM, Macdonald A, Blackbourn DJ, Whitehouse A Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration Journal of Virology 89 35-47, 2015
DOI:10.1128/JVI.02317-14
View abstract

Orchard-Webb DJ, Lee TC, Cook GP, Blair GE CUB Domain Containing Protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells BMC CANCER 14 -, 2014
DOI:10.1186/1471-2407-14-754
View abstract

Belyaeva TA, Nicol C, Cesur O, Travé G, Blair GE, Stonehouse NJ An RNA Aptamer Targets the PDZ-Binding Motif of the HPV16 E6 Oncoprotein. Cancers (Basel) 6 1553-1569, 2014
DOI:10.3390/cancers6031553
View abstract

El-Jawhari JJ, El-Sherbiny YM, Scott GB, Morgan RSM, Prestwich R, Bowles PA, Blair GE, Tanaka T, Rabbitts TH, Meade JL, Cook GP Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytes. Mol Immunol 58 160-168, 2014
DOI:10.1016/j.molimm.2013.11.020
View abstract

Richards KH, Doble R, Wasson CW, Haider M, Blair GE, Wittmann M, Macdonald A Human papillomavirus E7 oncoprotein increases production of the anti-inflammatory interleukin-18 binding protein in keratinocytes. J Virol 88 4173-4179, 2014
DOI:10.1128/JVI.02546-13
View abstract

Griffiths DA, Abdul-Sada H, Knight LM, Jackson BR, Richards K, Prescott EL, Peach AHS, Blair GE, Macdonald A, Whitehouse A Merkel Cell Polyomavirus Small T Antigen Targets the NEMO Adaptor Protein To Disrupt Inflammatory Signaling JOURNAL OF VIROLOGY 87 13853-13867, 2013
DOI:10.1128/JVI.02159-13

Blair GE Analysis of the role of the immune response in human cancers mediated by small DNA tumour viruses, 2013

Nicol C, CesurÖ, Forrest S, Belyaeva TA, Bunka DHJ, Blair GE, Stonehouse NJ An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein. PLoS One 8 e64781-, 2013
DOI:10.1371/journal.pone.0064781
View abstract

Fender P, Hall K, Schoehn G, Blair GE Impact of Human Adenovirus Type 3 Dodecahedron on Host Cells and Its Potential Role in Viral Infection JOURNAL OF VIROLOGY 86 5380-5385, 2012
DOI:10.1128/JVI.07127-11

Wetherill LF, Holmes KK, Verow M, Müller M, Howell G, Harris M, Fishwick C, Stonehouse N, Foster R, Blair GE, Griffin S, Macdonald A High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors. J Virol 86 5341-5351, 2012
DOI:10.1128/JVI.06243-11
View abstract

Caygill RL, Hodges CS, Holmes JL, Higson SPJ, Blair GE, Millner PA Novel impedimetric immunosensor for the detection and quantitation of Adenovirus using reduced antibody fragments immobilized onto a conducting copolymer surface. Biosens Bioelectron 32 104-110, 2012
DOI:10.1016/j.bios.2011.11.041
View abstract

White L, Blair GE Adenoviruses and Gene Therapy: The Role of the Immune System SMALL DNA TUMOUR VIRUSES 281-319, 2012

Hamdan S, Verbeke CS, Fox N, Booth J, Bottley G, Pandha HS, Blair GE The roles of cell surface attachment molecules and coagulation Factor X in adenovirus 5-mediated gene transfer in pancreatic cancer cells CANCER GENE THER 18 478-488, 2011
DOI:10.1038/cgt.2011.17

Nicol C, Bunka DHJ, Blair GE, Stonehouse NJ Effects of single nucleotide changes on the binding and activity of RNA aptamers to human papillomavirus 16 E7 oncoprotein. Biochem Biophys Res Commun 405 417-421, 2011
DOI:10.1016/j.bbrc.2011.01.044
View abstract

Holmes TD, El-Sherbiny YM, Davison A, Clough SL, Blair GE, Cook GP A Human NK Cell Activation/Inhibition Threshold Allows Small Changes in the Target Cell Surface Phenotype To Dramatically Alter Susceptibility to NK Cells J IMMUNOL 186 1538-1545, 2011
DOI:10.4049/jimmunol.1000951

Caygill RL, Blair GE, Millner PA A review on viral biosensors to detect human pathogens ANAL CHIM ACTA 681 8-15, 2010
DOI:10.1016/j.aca.2010.09.038

Scott GB, Bowles PA, Wilson EB, Meade JL, Low BC, Davison A, Blair GE, Cook GP Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing BIOCHEM J 431 423-431, 2010
DOI:10.1042/BJ20091073

Hall K, Zajdel MEB, Blair GE Unity and diversity in the human adenoviruses: exploiting alternative entry pathways for gene therapy BIOCHEM J 431 321-336, 2010
DOI:10.1042/BJ20100766

James NJ, Howell GJ, Walker JH, Blair GE The role of Cajal bodies in the expression of late phase adenovirus proteins VIROLOGY 399 299-311, 2010
DOI:10.1016/j.virol.2010.01.013

Hall K, Zajdel MEB, Blair GE Defining the role of CD46, CD80 and CD86 in mediating adenovirus type 3 fiber interactions with host cells VIROLOGY 392 222-229, 2009
DOI:10.1016/j.virol.2009.07.010

Strath J, Georgopoulos LJ, Kellam P, Blair GE Identification of genes differentially expressed as result of adenovirus type 5-and adenovirus type 12-transformation BMC GENOMICS 10 -, 2009
DOI:10.1186/1471-2164-10-67

Blair GE, Cook GP Cancer and the immune system: an overview - Introduction ONCOGENE 27 5868-5868, 2008
DOI:10.1038/onc.2008.277

Oikarinen M, Tauriainen S, Honkanen T, Vuori K, Karhunen P, Vasama-Nolvi C, Oikarinen S, Verbeke C, Blair GE, Rantala I, Ilonen J, Simell O, Knip M, Hyoty H Analysis of pancreas tissue in a child positive for islet cell antibodies DIABETOLOGIA 51 1796-1802, 2008
DOI:10.1007/s00125-008-1107-8

Franqueville L, Henning P, Magnusson M, Vigne E, Schoehn G, Blair-Zajdel ME, Habib N, Lindholm L, Blair GE, Hong SS, Boulanger P Protein Crystals in Adenovirus Type 5-Infected Cells: Requirements for Intranuclear Crystallogenesis, Structural and Functional Analysis PLOS ONE 3 -, 2008
DOI:10.1371/journal.pone.0002894

Bottley G, Watherston OG, Hiew YL, Norrild B, Cook GP, Blair GE High-risk human papillomavirus E7 expression reduces cell-surface MHC class I molecules and increases susceptibility to natural killer cells ONCOGENE 27 1794-1799, 2008
DOI:10.1038/sj.onc.1210798

Hodrien AJ, Waigh TA, Voice AM, Blair GE, Clarke SM Adsorption of DNA onto positively charged amidine colloidal spheres and the resultant bridging interaction INT J BIOL MACROMOL 41 146-153, 2007
DOI:10.1016/j.ijbiomac.2007.01.009

Perry SE, Robinson P, Melcher A, Quirke P, Bühring H-J, Cook GP, Blair GE Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. FEBS Lett 581 1137-1142, 2007
DOI:10.1016/j.febslet.2007.02.025
View abstract

Bottley G, Holt JR, James NJ, Blair GE Flow cytometric detection of adenoviruses and intracellular adenovirus proteins. Methods Mol Med 130 205-213, 2007
View abstract

Bottley G, Cook GP, Blair GE A flow cytometric assay for analysis of natural-killer cell-mediated cytolysis of adenovirus-transformed cells. Methods Mol Med 131 221-230, 2007
View abstract

Strath J, Blair GE Adenovirus subversion of immune surveillance, apoptotic and growth regulatory pathways: a model for tumorigenesis. Acta Microbiol Immunol Hung 53 145-169, 2006
DOI:10.1556/AMicr.53.2006.2.3
View abstract

Bottley G, Cook GP, Meade JL, Holt JR, Hoeben RC, Blair GE Differential expression of LFA-3, Fas and MHC Class I on Ad5- and Ad12-transformed human cells and their susceptibility to lymphokine-activated killer (LAK) cells. Virology 338 297-308, 2005
DOI:10.1016/j.virol.2005.05.017
View abstract

Lee TWR, Matthews DA, Blair GE Novel molecular approaches to cystic fibrosis gene therapy BIOCHEM J 387 1-15, 2005
DOI:10.1042/BJ20041923

Gedge LJE, Morrison EE, Blair GE, Walker JH Nuclear actin is partially associated with Cajal bodies in human cells in culture and relocates to the nuclear periphery after infection of cells by adenovirus 5. Exp Cell Res 303 229-239, 2005
DOI:10.1016/j.yexcr.2004.06.034
View abstract

Yusof R, Yong HY, Ali Mohd M, Blair GE Modulation of major histocompatibility complex (MHC) class I heavy chain gene expression by Naringenin in cells that express Human Papillomavirus (HPV) E6 and E7 genes Asia-Pacific Journal of Molecular Biology and Biotechnology 12 33-38, 2004
View abstract

Blair GE Adenoviral vectors - Adenoviral vectors, breaking a barrier to gene therapy? GENE THER 11 229-230, 2004
DOI:10.1038/sj.gt.3302168

Blair GE, Blair Zajdel ME Evasion of the immune system by adenoviruses Current Topics in Microbiology and Immunology 273 3-28, 2004

Lee TWR, Lawrence FJ, Dauksaite V, Akusjarvi G, Blair GE, Matthews DA Precursor of human adenovirus core polypeptide Mu targets the nucleolus and modulates the expression of E2 proteins J GEN VIROL 85 185-196, 2004
DOI:10.1099/vir.0.19352-0

Lee TWR, Blair GE, Matthews DA Adenovirus core protein VII contains distinct sequences that mediate targeting to the nucleus and nucleolus, and colocalization with human chromosomes J GEN VIROL 84 3423-3428, 2003
DOI:10.1099/vir.0.19546-0

Matheus L, Blair GE Identification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic protein. Biochim Biophys Acta 1630 47-53, 2003
View abstract

Pandha HS, Stockwin LH, Eaton J, Clarke IA, Dalgleish AG, Todryk SM, Blair GE Coxsackie B and adenovirus receptor, integrin and major histocompatibility complex class I expression in human prostate cancer cell lines: implications for gene therapy strategies PROSTATE CANCER P D 6 6-11, 2003
DOI:10.1038/sj.pcan.4500611

Stockwin LH, Matzow T, Georgopoulos NT, Stanbridge LJ, Jones SV, Martin IG, Blair-Zajdel ME, Blair GE Engineered expression of the Coxsackie B and adenovirus receptor (CAR) in human dendritic cells enhances recombinant adenovirus-mediated gene transfer. J Immunol Methods 259 205-215, 2002
View abstract

Philpott N, Blair GE Evasion of the immune system by tumor viruses Perspectives in Medical Virology 5 413-449, 2001

Asipu A, Mellor AL, Blair GE The specificity of the myelin basic protein gene promoter studied in transgenic mice. Biochem Biophys Res Commun 288 809-818, 2001
DOI:10.1006/bbrc.2001.5837
View abstract

Stockwin LH, McGonagle D, Martin IG, Blair GE Dendritic cells: immunological sentinels with a central role in health and disease. Immunol Cell Biol 78 91-102, 2000
DOI:10.1046/j.1440-1711.2000.00888.x
View abstract

Georgopoulos N, Proffitt JL, Blair GE Transcriptional regulation of the major histocompatibility complex (MHC) class I heavy chain, TAP1 and LMP2 genes by the human papillomavirus (HPV) type 6b, 16 and 18 E7 oncoproteins Oncogene 19 4930-4935, 2000

Chiter A, Forbes JM, Blair GE DNA stability in plant tissues: Implications for the possible transfer of genes from genetically-modified foods FEBS Letters 481 164-168, 2000

McDonald D, Stockwin L, Matzow T, Blair Zajdel ME, Blair GE Coxsackie and adenovirus receptor (CAR)-dependent and major histocompatibility complex (MHC) class I-independent uptake of recombinant adenoviruses into human tumour cells. Gene Ther 6 1512-1519, 1999
DOI:10.1038/sj.gt.3301006
View abstract

Chiter A, Blair GE, King AE The production of a transgenic rat expressing nerve growth factor using cell-type specific keratin promoters. Biochem Soc Trans 26 S144-, 1998

Blair GE, Hall KT Human adenoviruses: Evading detection by cytotoxic T lymphocytes SEMIN VIROL 8 387-397, 1998

Asipu A, Blair GE Cell-type specific factors bind to regulatory elements located downstream of the TATA-box element in the mouse myelin basic protein (MBP) gene promoter BBA-GENE STRUCT EXPR 1395 127-134, 1998

Forbes JM, Blair GE Effect of feed processing conditions on DNA fragmentation, 1998

Mavria G, Hall KT, Jones RA, Blair GE Transcriptional regulation of MHC class I gene expression in rat oligodendrocytes Biochemical Journal 330 155-161, 1998

Philpott NJ, Proffitt JA, Blair GE Studies on the down-regulation of major histocompatibility complex class I gene expression in adenovirus-transformed cells. Biochem Soc Trans 25 352S-, 1997

Hall KT, Blair GE The mechanism of down-regulation of major histocompatibility complex (MHC) class I antigens in highly oncogenic adenovirus 12-transformed cells. Biochem Soc Trans 25 353S-, 1997

Keynan S, Asipu A, Hooper NM, Turner AJ, Blair GE Stable and temperature sensitive transformation of baby rat kidney cells by SV40 suppresses expression of membrane dipeptidase Oncogene 15 1241-1245, 1997

Asipu A, Blair GE Cell specifc factors bind to regulatory elements located downstream of the TATA box element in the mouse myelin basic protein (MBP) promoter In Cell Biology and Pathology of Myelin: Evolving biological concepts and Theraputic approaches , 1997

Asipu A, Blair GE Homologous insertion of a myelin basic protein promoter - beta-galactosidase transgene into the germ line of mice Multiple Sclerosis -, 1997

Proffitt JA, Blair GE The MHC-encoded TAP1/LMP2 bidirectional promoter is down-regulated in highly oncogenic adenovirus type 12 transformed cells FEBS Letters 400 141-144, 1997

Blair GE, Hall KA, Philpott N, Proffitt JA Modulation of expression of genes in the major histocompatibility complex in adenovirus infection and transformation IMMUNOLOGY 89 SE108-SE108, 1996

Philpott NJ, Proffitt JA, Blair GE Studies on the down-regulation of major histocompatibility complex class I gene expression in adenovirus-transformed cells., 1996

Hall K, Blair GE The mechanism of down-regulation of major histocompatibility complex class I antigens in highly oncogenic adenovirus transformed cells. IMMUNOLOGY 89 EE359-EE359, 1996

Abdalla EE, Adam IJ, Blair GE, Boylston A, Sue-Ling HM, Finan P, Johnston D The immunomodulatory effect of levamisole is influenced by postoperative changes and type of lymphocyte stimulant. Cancer Immunol Immunother 41 193-198, 1995
View abstract

ABDALLA EE, BLAIR GE RE - MECHANISM OF SYNERGY OF LEVAMISOLE AND FLUOROURACIL - INDUCTION OF HUMAN-LEUKOCYTE ANTIGEN CLASS-I IN A COLORECTAL-CANCER CELL-LINE - RESPONSE J NATL CANCER I 87 1182-1183, 1995

Osbaldeston NJ, Lee DM, Cox VM, Hesketh JE, Morrison JF, Blair GE, Goldspink DF The temporal and cellular expression of c-fos and c-jun in mechanically stimulated rabbit latissimus dorsi muscle. Biochem J 308 ( Pt 2) 465-471, 1995
View abstract

AbdAlla EE, Blair GE, Jones RA, Sue-Ling HM, Johnston D Mechanism of synergy of levamisole and fluorouracil: induction of human leukocyte antigen class I in a colorectal cancer cell line. J Natl Cancer Inst 87 489-496, 1995
View abstract

Asipu A, Blair GE Regulation of myelin basic protein-encoding gene transcription in rat oligodendrocytes. Gene 150 227-234, 1994

Proffitt JL, Sharma E, Blair GE Adenovirus 12-mediated down-regulation of the major histocompatibility complex (MHC) class I promoter: identification of a negative regulatory element responsive to Ad12 E1A. Nucleic Acids Res 22 4779-4788, 1994
View abstract

GILLESPIE CS, SHERMAN DL, BLAIR GE, BROPHY PJ PERIAXIN, A NOVEL PROTEIN OF MYELINATING SCHWANN-CELLS WITH A POSSIBLE ROLE IN AXONAL ENSHEATHMENT NEURON 12 497-508, 1994

Rousell J, Zajdel ME, Howdle PD, Blair GE Rapid detection of enteric adenoviruses by means of the polymerase chain reaction. J Infect 27 271-275, 1993
View abstract

Scott N, Bell SM, Sagar P, Blair GE, Dixon MF, Quirke P p53 expression and K-ras mutation in colorectal adenomas. Gut 34 621-624, 1993
View abstract

Bell SM, Scott N, Cross D, Sagar P, Lewis FA, Blair GE, Taylor GR, Dixon MF, Quirke P Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterology 104 57-64, 1993
View abstract

Howdle PD, Blair GE Molecular biology and coeliac disease. Gut 33 573-575, 1992

BLAIR GE, ZAJDEL MEB THE POLYMERASE CHAIN-REACTION - ALREADY AN ESTABLISHED TECHNIQUE IN BIOCHEMISTRY BIOCHEM EDUC 20 87-91, 1992

Smith B, Selby P, Southgate J, Pittman K, Bradley C, Blair GE Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction. Lancet 338 1227-1229, 1991
View abstract

Mahon J, Blair GE, Wood GM, Scott BB, Losowsky MS, Howdle PD Is persistent adenovirus 12 infection involved in coeliac disease? A search for viral DNA using the polymerase chain reaction. Gut 32 1114-1116, 1991
View abstract

SCOTT N, SAGAR P, STEWART J, BLAIR GE, DIXON MF, QUIRKE P P53 AND THE ADENOMA-CARCINOMA SEQUENCE GUT 32 A1203-A1204, 1991

BRAITHWAITE AW, BLAIR GE, NELSON CC, MCGOVERN J, BELLETT AJD ADENOVIRUS E1B-58 KD ANTIGEN BINDS TO P53 DURING INFECTION OF RODENT CELLS - EVIDENCE FOR AN N-TERMINAL BINDING-SITE ON P53 ONCOGENE 6 781-787, 1991

BOULANGER PA, BLAIR GE EXPRESSION AND INTERACTIONS OF HUMAN ADENOVIRUS ONCOPROTEINS BIOCHEM J 275 281-299, 1991

Yusof R, Blair GE The effect of interferons on the expression of major histocompatibility class I genes in adenovirus-transformed cells. Biochem Soc Trans 19 83S-, 1991

Sharma E, Hollett T, Zajdel ME, Blair GE The role of adenovirus oncogenes in down-regulation of major histocompatibility class I gene expression. Biochem Soc Trans 19 84S-, 1991

SHARMA E, HOLLETT T, ZAJDEL MEB, BLAIR GE THE ROLE OF ADENOVIRUS ONCOGENES IN DOWN-REGULATION OF MAJOR HISTOCOMPATIBILITY CLASS-I GENE-EXPRESSION BIOCHEM SOC T 19 S84-S84, 1991

Scott N, Sagar P, Stewart J, Blair GE, Dixon MF, Quirke P p53 in colorectal cancer: clinicopathological correlation and prognostic significance. Br J Cancer 63 317-319, 1991
View abstract

HAMES BD, HIGGINS SJ, MCINTOSH E, BLAIR GE PRACTICAL MOLECULAR-BIOLOGY FOR STUDENTS - AN INTEGRATED APPROACH TO TEACHING BASIC TECHNIQUES BIOCHEM EDUC 18 141-144, 1990

Ackrill AM, Blair GE Interferon-gamma regulation of major histocompatibility class I gene expression in rat cells containing the adenovirus 12 E1A oncogene. Virology 174 325-328, 1990
View abstract

Blair GE, Dixon SC, Griffiths SA, Zajdel ME Restricted replication of human adenovirus type 5 in mouse cell lines. Virus Res 14 339-346, 1989
View abstract

Ackrill AM, Blair GE Nuclear proteins binding to an enhancer element of the major histocompatibility class I promoter: differences between highly oncogenic and nononcogenic adenovirus-transformed rat cells. Virology 172 643-646, 1989
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WALKER JH, BLAIR GE AGAROSE-GEL ELECTROPHORESIS OF DNA USING ALUMINUM ELECTRODES AND A 12 VOLT MAINS ADAPTER AS POWER-SUPPLY UNIT BIOCHEM EDUC 17 150-151, 1989

Howdle PD, Blair Zajdel ME, Smart CJ, Trejdosiewicz LK, Blair GE, Losowky MS Lack of a serologic response to an E1B protein of adenovirus 12 in coeliac disease. Scand J Gastroenterol 24 282-286, 1989
View abstract

Ackrill AM, Blair GE Expression of hamster MHC class I antigens in transformed cells and tumours induced by human adenoviruses. Eur J Cancer Clin Oncol 24 1745-1750, 1988
View abstract

Ackrill AM, Blair GE Regulation of major histocompatibility class I gene expression at the level of transcription in highly oncogenic adenovirus transformed rat cells. Oncogene 3 483-487, 1988
View abstract

BLAIR GE ANALYSIS OF RECOMBINANT PLASMIDS CONTAINING CLONED VIRAL GENES BY AGAROSE-GEL ELECTROPHORESIS AND RESTRICTION ENDONUCLEASE DIGESTION BIOCHEM SOC T 16 763-764, 1988

HOWDLE PD, ZAJDEL MEB, SMART CJ, TREJDOSIEWICZ LK, BLAIR GE, LOSOWSKY MS EVIDENCE AGAINST THE INVOLVEMENT OF ADENOVIRUS-12 IN THE PATHOGENESIS OF CELIAC-DISEASE GUT 29 A1469-A1469, 1988

ACKRILL AM, BLAIR GE MODULATION OF EXPRESSION OF MAJOR HISTOCOMPATIBILITY CLASS-I GENES IN HIGHLY ONCOGENIC ADENOVIRUS-TRANSFORMED RAT-CELLS BIOCHEM SOC T 16 605-606, 1988

GRIFFITHS SA, BLAIR GE IMMUNOCHEMICAL ANALYSIS OF MYELIN PROTEINS OF THE RAT CENTRAL NERVOUS-SYSTEM BIOCHEM SOC T 16 614-615, 1988

Blair Zajdel ME, Blair GE The intracellular distribution of the transformation-associated protein p53 in adenovirus-transformed rodent cells. Oncogene 2 579-584, 1988
View abstract

BLAIR GE, SAWECKA J, GRIFFITHS SA, BLAIRZAJDEL ME BIOSYNTHESIS OF 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE (WOLFGRAM PROTEINS) IN RAT-BRAIN AND GLIOMA-CELLS BIOCHEM SOC T 16 212-213, 1988

ACKRILL AM, BLAIR GE MODULATION OF EXPRESSION OF CLASS-I MHC GENES IN RODENT CELLS TRANSFORMED BY HUMAN ADENOVIRUSES WHICH DIFFER IN THEIR ONCOGENIC POTENTIAL EUR J CANCER CLIN ON 23 1725-1725, 1987

BLAIRZAJDEL ME, DIXON SC, ACKRILL AM, BLAIR GE EXPRESSION OF THE TRANSFORMATION-ASSOCIATED PROTEIN P53 IN RODENT CELLS TRANSFORMED BY HUMAN ADENOVIRUSES WHICH DIFFER IN THEIR ONCOGENIC POTENTIAL EUR J CANCER CLIN ON 23 1736-1736, 1987

ZAJDEL MEB, BARKER MD, DIXON SC, BLAIR GE THE USE OF MONOCLONAL-ANTIBODIES TO STUDY THE PROTEINS SPECIFIED BY THE TRANSFORMING REGION OF HUMAN ADENOVIRUSES BIOCHEM J 225 649-655, 1985

ZAJDELBLAIR ME, BLAIR GE, CELIS JE THE SYNTHESIS AND INTRACELLULAR-LOCALIZATION OF ADENOVIRUS HEXON PROTEIN STUDIED BY MICRO-INJECTION OF MESSENGER-RNA INTO HUMAN-CELLS EXP CELL RES 140 461-464, 1982

ZAIDELBLAIR ME, BLAIR GE, BENNICH H PURIFICATION AND CHARACTERIZATION OF THE MESSENGER-RNA FOR THE HEAVY-CHAIN OF RAT IMMUNOGLOBULIN-E NUCLEIC ACIDS RES 9 4547-4555, 1981

Blair GE, Russell WC Identification of a protein kinase activity associated with human adenoviruses Virology 86 157-166, 1978
DOI:10.1016/0042-6822(78)90016-8
View abstract

DAHL HHM, TRUELSEN E, BLAIR GE PURIFICATION AND PROPERTIES OF 2 LOW-MOLECULAR-WEIGHT PROTEINS REQUIRED FOR INITIATION OF TRANSLATION IN ASCITES TUMOR-CELLS EUR J BIOCHEM 77 209-216, 1977

BLAIR GE, DAHL HHM, TRUELSEN E, LELONG JC FUNCTIONAL IDENTITY OF A MOUSE ASCITES AND A RABBIT RETICULOCYTE INITIATION-FACTOR REQUIRED FOR NATURAL MESSENGER-RNA TRANSLATION NATURE 265 651-653, 1977

Ellis RJ, Blair GE, Hartley MR The nature and function of chloroplast protein synthesis. Biochemical Society symposium 137-162, 1973

BLAIR GE, ELLIS RJ PROTEIN-SYNTHESIS IN CHLOROPLASTS .1. LIGHT-DRIVEN SYNTHESIS OF LARGE SUBUNIT OF FRACTION I PROTEIN BY ISOLATED PEA CHLOROPLASTS BIOCHIM BIOPHYS ACTA 319 223-234, 1973