Faculty of Biological Sciences

Prof Paul Millner

BSc, PhD Feb 1979, Leeds
Professor in Bionanotechnology
School of Biomedical Sciences

Background: Postdoctoral work at Purdue University, Indiana USA and Imperial College, London. Appointed Lecturer 1986, Senior Lecturer 1993, Reader 2006.

Contact:  LIGHT 7.04 | +44(0) 113 34 33149/34272 | email address for Prof Paul Millner 

You can read more about Prof Millner's interests here:
www.fbs.leeds.ac.uk/lab/Millner_P/
www.colorectal.htc.nihr.ac.uk

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Admin roles

External Examiner (taught course): Dublin City University
External Examiner (taught course): Imperial College, London
Faculty Research & Innovation Committee
FBS Equality and Diversity Committee
FBS Exective Committee
FBS Faculty Board
FBS Health and Safety Committee
FBS Strategy Group
FBS Student Recruitment Committee
Head of School

Modules managed

BIOL3111 - Biomedical Nanotechnology

Modules taught

BIOL3111 - Biomedical Nanotechnology
BIOL5262M - Molecular Diagnostics, Drug Delivery and Therapies
BIOL5262M/CMNS5710M - Molecular Diagnostics/Biosensors and drug delivery
BIOL5272M - Advanced Biomolecular Technologies
BIOL5292M - Bioscience MSc Research Proj
BIOL5294M - MSc Bioscience Res Project Pro
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2233 - Topics in Medical Sciences
BMSC3301 - Research Proj: Biomed Sciences
SPSC1211 - Tutorial and Practical Skills in Sport and Exercise Science

Centre membership: The Centre for Molecular Nanoscience

Group Leader Prof Paul Millner  (Professor in Bionanotechnology)

Nano-scale enginering of surfaces for biosensor applications, nanoparticulate supports, bio-affinity systems 


Dr Timothy Gibson  (Visiting Research Administrator)

Research Interests and Practical Exploitation of Research:
Biosensors and Chemical Sensor Technology, Electronic Nose Technology, Molecular Interactions at Sensor Surfaces and Stabilisation of Proteins, Enzymes and Antibodies.
 

Dr Carolyn Jackson  (Laboratory Manager )

Dr Jo Rushworth  (Visiting Research Fellow)


Postgraduates

Asif Ahmed  
Kaniz Chowdhury  
Jack Goode  
Natalie Hirst  
Thanisorn Mahatnirunkul  
Douglas Pike  
Pattanapong Thangsunan  
James Tiernan  
Forough Torabi Baghkomeh  

Hirst NA; Tiernan JP; Millner PA; Jayne DG Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery. Colorectal Dis 16 95-109, 2014
DOI:10.1111/codi.12411
View abstract

Rushworth JV; Ahmed A; Griffiths HH; Pollock NM; Hooper NM; Millner PA A label-free electrical impedimetric biosensor for the specific detection of Alzheimer's amyloid-beta oligomers. Biosens Bioelectron 56 83-90, 2014
DOI:10.1016/j.bios.2013.12.036
View abstract

Hirst NA; Hazelwood LD; Jayne DG; Millner PA An amperometric lactate biosensor using H2O2 reduction via a Prussian Blue impregnated poly(ethyleneimine) surface on screen printed carbon electrodes to detect anastomotic leak and sepsis SENSORS AND ACTUATORS B-CHEMICAL 186 674-680, 2013
DOI:10.1016/j.snb.2013.06.090

Ahmed A; Rushworth JV; Wright JD; Millner PA Novel Impedimetric Irnmunosensor for Detection of Pathogenic Bacteria Streptococcus pyogenes in Human Saliva ANALYTICAL CHEMISTRY 85 12118-12125, 2013
DOI:10.1021/ac403253j

Caygill RL; Hodges CS; Holmes JL; Higson SP; Blair GE; Millner PA Novel impedimetric immunosensor for the detection and quantitation of Adenovirus using reduced antibody fragments immobilized onto a conducting copolymer surface. Biosens Bioelectron 32 104-110, 2012
DOI:10.1016/j.bios.2011.11.041
View abstract

Billah MM; Hays HCW; Millner PA; Hodges CS; Ponnambalam S; Vohra R Mixed self-assembled monolayer (mSAM) based impedimetric immunosensors for cardiac troponin I (cTnI) and soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) Sensors and Actuators, B: Chemical -, 2012
DOI:10.1016/j.snb.2012.07.017
View abstract

Tiernan JP; Ansari I; Hirst NA; Millner PA; Hughes TA; Jayne DG Intra-operative tumour detection and staging in colorectal cancer surgery. Colorectal Dis 14 e510-e520, 2012
DOI:10.1111/j.1463-1318.2012.03078.x
View abstract

Pike DJ; Kapur N; Millner PA; Stewart DI Flow cell design for effective biosensing. Sensors (Basel) 13 58-70, 2012
DOI:10.3390/s130100058
View abstract

Neville F; Broderick MJF; Gibson T; Millner PA Fabrication and Activity of Silicate Nanoparticles and Nanosilicate-Entrapped Enzymes Using Polyethyleneimine As a Biomimetic Polymer LANGMUIR 27 279-285, 2011
DOI:10.1021/la1033492

Pchelintsev NA; Vakurov A; Hays HH; Millner PA Thiols deposition onto the surface of glassy carbon electrodes mediated by electrical potential ELECTROCHIM ACTA 56 2696-2702, 2011
DOI:10.1016/j.electacta.2010.12.043

Conroy DJR; Millner PA; Stewart DI; Pollmann K Biosensing for the Environment and Defence: Aqueous Uranyl Detection Using Bacterial Surface Layer Proteins SENSORS-BASEL 10 4739-4755, 2010
DOI:10.3390/s100504739

Billah MM; Hodges CS; Hays HCW; Millner PA Directed immobilization of reduced antibody fragments onto a novel SAM on gold for myoglobin impedance immunosensing BIOELECTROCHEMISTRY 80 49-54, 2010
DOI:10.1016/j.bioelechem.2010.08.005

Rodgers MA; Findlay JBC; Millner PA Lipocalin based biosensors for low mass hydrophobic analytes; development of a novel SAM for polyhistidine tagged proteins SENSOR ACTUAT B-CHEM 150 12-18, 2010
DOI:10.1016/j.snb.2010.07.053

Caygill RL; Blair GE; Millner PA A review on viral biosensors to detect human pathogens ANAL CHIM ACTA 681 8-15, 2010
DOI:10.1016/j.aca.2010.09.038

Millner PA; Hays HCW; Vakurov A; Pchelintsev NA; Billah MM; Rodgers MA Nanostructured transducer surfaces for electrochemical biosensor construction-Interfacing the sensing component with the electrode SEMIN CELL DEV BIOL 20 34-40, 2009
DOI:10.1016/j.semcdb.2009.01.011

Pchelintsev NA; Vakurov A; Millner PA Simultaneous deposition of Prussian Blue and creation of an electrostatic surface for rapid biosensor construction SENSOR ACTUAT B-CHEM 138 461-466, 2009
DOI:10.1016/j.snb.2009.02.039

Neville F; Pchelintsev NA; Broderick MJF; Gibson T; Millner PA Novel one-pot synthesis and characterization of bioactive thiol-silicate nanoparticles for biocatalytic and biosensor applications NANOTECHNOLOGY 20 -, 2009
DOI:10.1088/0957-4484/20/5/055612

Pchelintsev NA; Neville F; Millner PA Biomimetic silication of surfaces and its application to preventing leaching of electrostatically immobilized enzymes SENSOR ACTUAT B-CHEM 135 21-26, 2008
DOI:10.1016/j.snb.2008.07.015

Billah M; Hays HCW; Millner PA Development of a myoglobin impedimetric immunosensor based on mixed self-assembled monolayer onto gold MICROCHIMICA ACTA 160 447-454, 2008
DOI:10.1007/s00604-007-0793-0

Pchelintsev NA; Millner PA A novel procedure for rapid surface functionalisation and mediator loading of screen-printed carbon electrodes ANAL CHIM ACTA 612 190-197, 2008
DOI:10.1016/j.aca.2008.02.022

Tsekenis G; Garifallou GZ; Davis F; Millner PA; Gibson TD; Higson SPJ Label-less immunosensor assay for myelin basic protein based upon an ac impedance protocol ANAL CHEM 80 2058-2062, 2008
DOI:10.1021/ac702070e

Tsekenis G; Garifallou GZ; Davis F; Millner PA; Pinacho DG; Sanchez-Baeza F; Marco MP; Gibson TD; Higson SPJ Detection of Fluoroquinolone Antibiotics in Milk via a Labeless Immunoassay Based upon an Alternating Current Impedance Protocol ANAL CHEM 80 9233-9239, 2008
DOI:10.1021/ac8014752

Harel HYM; Fontaine V; Chen H; Jones IM; Millner PA Display of a Maize cDNA library on baculovirus infected insect cells BMC BIOTECHNOL 8 -, 2008
DOI:10.1186/1472-6750-8-64

Bidoki SM; Lewis DM; Clark M; Vakorov A; Millner PA; McGorman D Ink-jet fabrication of electronic components J MICROMECH MICROENG 17 967-974, 2007
DOI:10.1088/0960-1317/17/5/017

Neville FC; Broderick MJF; Vakourov AV; Millner PA Small solutions for greener chemistry None 108-114, 2007
View abstract

Hannah MA; Kramer KM; Geffroy V; Kopka J; Blair MW; Erban A; Vallejos CE; Heyer AG; Sanders FET; Millner PA; Pilbeam DJ Hybrid weakness controlled by the dosage-dependent lethal (DL) gene system in common bean (Phaseolus vulgaris) is caused by a shoot-derived inhibitory signal leading to salicylic acid-associated root death NEW PHYTOL 176 537-549, 2007
DOI:10.1111/j.1469-8137.2007.02215.x

Garifallou GZ; Tsekenis G; Davis F; Higson SPJ; Millner PA; Pinacho DG; Sanchez-Baeza F; Marco MP; Gibson TD Labeless immunosensor assay for fluoroquinolone antibiotics based upon an AC impedance protocol ANAL LETT 40 1412-1422, 2007
DOI:10.1080/00032710701327070

Pchelintsev NA; Millner PA Development of surface activated screen-printed carbon transducers for biosensors application ANAL LETT 40 1317-1332, 2007
DOI:10.1080/00032710701326684

Hays HCW; Millner PA; Prodromidis MI Development of capacitance based immunosensors on mixed self-assembled monolayers SENSOR ACTUAT B-CHEM 114 1064-1070, 2006
DOI:10.1016/j.snb.2005.08.039

Hleli S; Martelet C; Abdelghani A; Bessueille F; Errachid A; Samitier J; Hays HCW; Millner PA; Bums N; Jaffrezic-Renault N An immunosensor for haemoglobin based on impedimetric properties of a new mixed self-assembled monolayer MATERIALS SCIENCE&ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 26 322-327, 2006
DOI:10.1016/j.msec.2005.10.054

Vakurov A; Simpson CE; Daly CL; Gibson TD; Millner PA Acetylecholinesterase-based biosensor electrodes for organophosphate pesticide detection - II. Immobilization and stabilization of acetylecholinesterase BIOSENS BIOELECTRON 20 2324-2329, 2005
DOI:10.1016/j.bios.2004.07.022

Hays HCW; Millner PA; Jones JK; Rayner-Brandes MH A novel and convenient self-drying system for bacterial preservation J MICROBIOL METH 63 29-35, 2005
DOI:10.1016/j.mimet.2005.02.014

Weiss S; Millner PA; Nelson AS Monitoring protein binding to phospholipid monolayers using electrochemical impedance spectroscopy Electrochimica Acta 50 4248-4256, 2005
DOI:10.1016/j.electacta.2005.05.045
View abstract

Elnashar MM; Millner PA; Johnson AF; Gibson T Parallel plate equipment for preparation of uniform gel sheets Biotechnology Letters 27 737-739, 2005
DOI:10.1007/s10529-005-5363-0
View abstract

Pritchard JA; Law KA; Vakurov A; Millner PA; Higson SPJ Sonochemically fabricated enzyme microelectrode arrays for the environmental moniroting of pesticides Biosensors and Bioelectronics 20 765-772, 2004
DOI:10.1016/j.bios.2004.06.008

Swarup R; Kargul J; Marchant A; Zadik D; Rahman A; Mills R; Yemm A; May S; Williams L; Millner PA; Tsurumi S; Moore I; Napier R; Kerr ID; Bennett MJ Structure-Function Analysis of the Presumptive Arabidopsis Auxin Permease AUX1 Plant Cell 16 3069-3083, 2004
DOI:10.1105/tpc.104.024737
View abstract

Robinson SA; Smith JE; Millner PA Toxoplasma gondii major surface antigen (SAG1): in vitro analysis of host cell binding. Parasitology 128 391-396, 2004
View abstract

Vakurov A; Simpson CE; Daly CL; Gibson TD; Millner PA Acetylcholinesterase-based biosensor electrodes for organophosphate pesticide detection. I. Modification of carbon surface for immobilization of acetylcholinesterase. Biosens Bioelectron 20 1118-1125, 2004
DOI:10.1016/j.bios.2004.03.039
View abstract

Manios T; Stentiford EI; Millner PA The Removal of Chemical Oxygen Demand from Primary-Treated Domestic Wastewater in Subsurface-Flow Reed Beds Using Different Substrates Water Environment Research 75 336-341, 2003
DOI:10.2175/106143003X141141

Manios T; Stentiford EI; Millner PA Removal of heavy metals from a metaliferous water solution by Typha latifolia plants and sewage sludge compost Chemosphere 53 487-494, 2003
DOI:10.1016/S0045-6535(03)00537-X

Manios T; Stentiford EI; Millner PA The effect of heavy metals accumulation on the chlorophyll concentration of Typha latifolia plants, growing in a substrate containing sewage sludge compost and watered with metaliferus water Ecological Engineering 20 65-74, 2003
DOI:10.1016/S0925-8574(03)00004-1

Manios T; Stentiford EI; Millner PA Removal of total suspended solids from wastewater in constructed horizontal flow subsurface wetlands Journal of Environmental Science and Health. Part A. Toxic Hazardous Sustances and Environmental Engineering. 38 1073-1085, 2003

Manios T; Stentiford EI; Millner PA The removal of indicator microorganisms from primary treated wastewater in subsurface reed beds using different substrates ENVIRON TECHNOL 23 767-774, 2002

Mello LV; Millner PA; Findlay JBC Biochemical characteristics of guanine nucleotide binding protein alpha-subunit recombinant protein and three mutants: Investigation of a domain motion involved in GDP-GTP exchange J PROTEIN CHEM 21 29-34, 2002

Manios T; Stentiford EI; Millner PA The effect of heavy metals on the total protein concentration of Typha latifolia plants, growing in a substrate containing sewage sludge compost and watered with metaliferus wastewater Journal of Environmental Science and Health. Part A. Toxic Hazardous Sustances and Environmental Engineering. 37 1441-1451, 2002

Manios T; Stentiford EI; Millner PA The removal of NH3-N from primary treated wastewater in subsurface reed beds using different substrates J ENVIRON SCI HEAL A 37 297-308, 2002

Mello LV; Millner PA; Findlay JBC Biochemical characteristics of guanine nucleotide binding proteinα-subunit recombinant protein and three mutants: Investigation of a domain motion involved in GDP-GTP exchange Protein Journal 21 29-34, 2002
View abstract

Millner PA Heterotrimeric G-proteins in plant cell signaling NEW PHYTOL 151 165-174, 2001

Ricart CAO; Wise A; Findlay JBC; Millner PA Presence of rhodopsin-like proteins in Sorghum bicolor and Pisum sativum Journal of Plant Physiology 156 300-305, 2000

Hutton JL; Knight CD; Millner PA The Physcomitrella patens GPalpha1 homologue is located at protonemal cell junctions Journal of Experimental Botany 49 1113-1118, 1998

Wise A; Thomas PG; Carr TH; Murphy GA; Millner PA Expression of the Arabidopsis G-protein GPalpha1: purification and expression of the recombinant protein Plant Molecular Biology 33 723-728, 1997

Millner PA; Causier BE G-protein coupled receptors in plant cells Journal of Experimental Botany 47 983-992, 1996

Barbier-Brygoo H; Zimmerman S; Thomine S; White I; Millner PA; Guern J Elementary auxin response chains at the plasma membrane involve external abp 1 and multiple electrogenic ion transport proteins Plant Growth Regulation 18 23-28, 1996

Causier BE; Millner PA G-protein regulated phopsholipase D - another piece in the plant cell signalling jigsaw Trends in Plant Science 1 168-170, 1996

Bennett MJ; Marchant A; Green HG; May ST; Ward SP; Millner PA; Walker AR; Schulz B; Feldmann KA Arabidopsis AUX1 gene: A permease-like regulator of root gravitropism Science 273 948-950, 1996

Millner PA; Groarke DA; White IR Synthetic peptides as probes of plant cell signalling: the auxin signalling pathway Plant Growth Regulation 18 143-147, 1996
View abstract