Faculty of Biological Sciences

Dr Elton Zeqiraj

UAF
School of Molecular and Cellular Biology

Contact:  Astbury 8.109, +44 113 3433079, email address for  

You can read more about Dr Zeqiraj's interests here:
http://www.personal.leeds.ac.uk/~fbsez

Research Interests

Our lab studies how Ubiquitin governs cell signalling networks

Modules taught

BIOC3160 - Laboratory/Literature/Computing Research Project
BIOC3303 - Advanced Biochemistry: Skills
BIOL3306 - Biological Sciences Research Project

Mrs Upasana Sykora  (Research Technician)

Postgraduates

Safi Kani Masandi (Primary supervisor) 90% FTE

Zeqiraj E, Sicheri F Getting a handle on glycogen synthase - Its interaction with glycogenin Molecular Aspects of Medicine 46 63-69, 2015
DOI:10.1016/j.mam.2015.08.004
View abstract

Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AFA, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJR, Guarné A, Greenberg RA, Sicheri F Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol Cell 59 970-983, 2015
DOI:10.1016/j.molcel.2015.07.028
View abstract

Hunter RW, Zeqiraj E, Morrice N, Sicheri F, Sakamoto K Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells Protein Expression and Purification 108 23-29, 2015
DOI:10.1016/j.pep.2014.12.007
View abstract

Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, Von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri F Structural basis for the recruitment of glycogen synthase by glycogenin Proceedings of the National Academy of Sciences of the United States of America 111 -, 2014
DOI:10.1073/pnas.1402926111
View abstract

Keszei AFA, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase Molecular and Cellular Biology 34 362-373, 2014
DOI:10.1128/MCB.01360-13
View abstract

Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LCK, Juang YC, Mao DYL, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Guarné A, Silverman RH, Sicheri F Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity Molecular Cell 53 221-234, 2014
DOI:10.1016/j.molcel.2013.12.025
View abstract

Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS A strategy for modulation of enzymes in the ubiquitin system Science 339 590-595, 2013
DOI:10.1126/science.1230161
View abstract

Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase Cellular Signalling 24 2085-2094, 2012
DOI:10.1016/j.cellsig.2012.06.018
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Ogunjimi AA, Zeqiraj E, Ceccarelli DF, Sicheri F, Wrana JL, David L Structural basis for specificity of TGFβ family receptor small molecule inhibitors Cellular Signalling 24 476-483, 2012
DOI:10.1016/j.cellsig.2011.09.027
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Filippi BM, De Los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases EMBO Journal 30 1730-1741, 2011
DOI:10.1038/emboj.2011.78
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Zeqiraj E, van Aalten DMF Pseudokinases-remnants of evolution or key allosteric regulators? Current Opinion in Structural Biology 20 772-781, 2010
DOI:10.1016/j.sbi.2010.10.001
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Zeqiraj E, Filippi BM, Deak M, Alessi DR, Van Aalten DMF Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation Science 326 1707-1711, 2009
DOI:10.1126/science.1178377
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Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, Van Aalten DMF ATP and MO25α regulate the conformational state of the STRADα pseudokinase and activation of the LKB1 tumour suppressor PLoS Biology 7 -, 2009
DOI:10.1371/journal.pbio.1000126
View abstract

Saint-Guirons J, Zeqiraj E, Schumacher U, Greenwell P, Dwek M Proteome analysis of metastatic colorectal cancer cells recognized by the lectin Helix pomatia agglutinin (HPA) Proteomics 7 4082-4089, 2007
DOI:10.1002/pmic.200700434
View abstract

Alessi DR, Zeqiraj E Protein phosphorylation: The governor Biochemist 29 20-23, 2007
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