Dr Thomas Zacharchenko

Research Fellow
School of Biology

Contact: Miall 8.16, email address for  

Baxter NJ, Zacharchenko T, Barsukov IL, Williamson MP Pressure-Dependent Chemical Shifts in the R3 Domain of Talin Show that It Is Thermodynamically Poised for Binding to Either Vinculin or RIAM Structure 25 1856-1866.e2, 2017
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Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras Nature Cell Biology 19 292-305, 2017
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Zacharchenko T, Barsukov I, Rigden DJ, Bennett D, Mayans O Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold Protein Journal 35 340-345, 2016
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Zacharchenko T, Qian X, Goult BT, Jethwa D, Almeida TB, Ballestrem C, Critchley DR, Lowy DR, Barsukov IL LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex Structure 24 1130-1141, 2016
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Lilja J, Zacharchenko T, Georgiadou M, Kreienkamp H, Barsukov I, Ivaska J SHANK3 Structure Reveals a RAS-associated Domain Regulating Integrin Activation., 2016

Zacharchenko T, Von Castelmur E, Rigden DJ, Mayans O Structural advances on titin: Towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding Biochemical Society Transactions 43 850-855, 2015
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Goult BT, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras AR, Elliott PR, Roberts GCK, Ballestrem C, Critchley DR, Barsukov IL RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover Journal of Biological Chemistry 288 8238-8249, 2013