Dr Zhaokang Yang

BSc, MSc, PhD, PR China
Research Fellow
School of Biomedical Sciences

Contact: Garstang G7.53, +44(0) 113 34 31869, email address for  

Venturi E, Lindsay C, Lotteau S, Yang Z, Steer E, Witschas K, Wilson AD, Wickens JR, Russell AJ, Steele D, Calaghan S, Sitsapesan R Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform British Journal of Pharmacology 175 938-952, 2018
DOI:10.1111/bph.14136
View abstract

Yang Z, Kirton HM, Al-Owais M, Thireau J, Richard S, Peers C, Steele D Epac2-Rap1 signaling regulates reactive oxygen species production and susceptibility to cardiac arrhythmias Antioxidants and Redox Signaling 27 117-132, 2017
DOI:10.1089/ars.2015.6485
View abstract

Yang Z, Kirton HM, Al-Owais M, Peers C, Steele DS Epac2-Rap1 Signaling Influences Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias, 2017
DOI:10.1016/j.bpj.2016.11.576

Lotteau S, Yang Z, Venturi E, Steer E, Witschas K, Sitsapesan R, Steele D, Calaghan S Simvastatin has Profound Effects on Sarcoplasmic Reticulum Ca2+ Leak in Skeletal but not Cardiac Muscle: A Mechanism for Myopathy, 2016
DOI:10.1016/j.bpj.2015.11.1453

Kirton HM, Yang Z, Steele DS Conditions that Promote Golgi Ca2+ Release Facilitate Trafficking of VEGFR-1 to the Surface Membrane in Rat Ventricular Myocytes, 2016
DOI:10.1016/j.bpj.2015.11.2350

Kirton HM, Yang Z, Steele DS Phosphodiesterase Inhibition Leads to Activation of Epac and Stimulation of Ca2+ Release from both the Golgi Apparatus and the SR, 2015
DOI:10.1016/j.bpj.2014.11.1452

Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS The Golgi apparatus is a functionally distinct Ca<sup>2+</sup>store regulated by the PKA and Epac branches of the b1-adrenergic signaling pathway Science Signaling 8, 2015
DOI:10.1126/scisignal.aaa7677
View abstract

Yang Z, Steele DS The EPAC Activator 8-CPT Protects against Isoproterenol-Induced Cell Death in Adult Ventricular Myocytes, 2013
DOI:10.1016/j.bpj.2012.11.1747

Dallas ML, Yang Z, Boyle JP, Boycott HE, Scragg JL, Milligan CJ, Elies J, Duke A, Thireau J, Reboul C, Richard S, Bernus O, Steele DS, Peers C Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. Am J Respir Crit Care Med 186 648-656, 2012
DOI:10.1164/rccm.201204-0688OC
View abstract

Benoist D, Stones R, Drinkhill MJ, Benson AP, Yang Z, Cassan C, Gilbert SH, Saint DA, Cazorla O, Steele DS, Bernus O, White E Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension. Am J Physiol Heart Circ Physiol 302 H2381-H2395, 2012
DOI:10.1152/ajpheart.01084.2011
View abstract

Yang Z, Steele DS The Golgi Apparatus is a Juxtanuclear Ca2+ Store Regulated by beta 1-Adrenergic Signalling via Both PKA and EPAC Pathways, 2011

Duncan DJ, Yang Z, Hopkins PM, Steele DS, Harrison SM TNF-alpha and IL-1beta increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes. Cell Calcium 47 378-386, 2010
DOI:10.1016/j.ceca.2010.02.002
View abstract

Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass J.Mol.Cell Cardiol. 48 293-301, 2010
View abstract

Duncan DJ, Yang Z, Hopkins PM, Steele DS, Harrison SM TNF-α and IL-1β increase Ca<sup>2+</sup>leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes Cell Calcium 47 378-386, 2010
DOI:10.1016/j.ceca.2010.02.002
View abstract

Yang Z, Steele DS Evidence that prolonged nuclear C2+ release events originate from the Golgi Apparatus in rat ventricular myocytes, 2007

Yang ZK, Steele DS Evidence that prolonged nuclear C2+ release events originate from the Golgi Apparatus in rat ventricular myocytes, 2007

Duncan D, Yang Z, Hopkins PM, Steele DS, Harrison SM Altered ryanodine receptor gating by TNF-alpha and IL-1 beta, 2007

Duncan D, Yang ZK, Hopkins PM, Steele DS, Harrison SM Altered ryanodine receptor gating by TNF-alpha and IL-1 beta, 2007

Yang Z, Ikemoto N, Lamb GD, Steele DS Corrigendum to: The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes [Cardiovascular Research 70 (2006) 475-485] (DOI:10.1016/j.cardiores.2006.03.001) Cardiovascular Research 71 606-, 2006
DOI:10.1016/j.cardiores.2006.06.009

Yang Z, Ikemoto N, Lamb GD, Steele DS The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes (vol 70, pg 475, 2006) CARDIOVASCULAR RESEARCH 71 606-606, 2006
DOI:10.1016/j.cardiores.2006.06.009

Yang ZK, Ikemoto N, Lamb GD, Steele DS The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes (vol 70, pg 475, 2006) CARDIOVASC RES 71 606-606, 2006
DOI:10.1016/j.cardiores.2006.06.009

Yang Z, Ikemoto N, Lamb GD, Steele DS The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes. Cardiovasc Res 70 475-485, 2006
DOI:10.1016/j.cardiores.2006.03.001
View abstract

Yang Z, Steele DS Caffeine decreases the cytosolic [Ca2+] threshold required for spontaneous Ca2+ release in isolated ventricular myocytes from RAT, 2005

Yang Z, Steele DS Characteristics of prolonged Ca2+ release events associated with the nuclei in adult cardiac myocytes. Circ Res 96 82-90, 2005
DOI:10.1161/01.RES.0000151841.63705.01
View abstract

Yang Z, Harrison SM, Steele DS ATP-dependent effects of halothane on SR Ca2+ regulation in permeabilized atrial myocytes. Cardiovasc Res 65 167-176, 2005
DOI:10.1016/j.cardiores.2004.09.008
View abstract

Orchard CH, Brette F, Hussain M, Kawai M, Komukai K, Pascarel C, Steele D, Yang Z Subcellular heterogeneity in cardiac ventricular myocytes, 2002

Yang Z, Pascarel C, Steele DS, Kornukai K, Brette F, Orchard CH Na+-Ca2+ exchange activity is localized in the T-tubules of rat ventricular myocytes CIRC RES 91 315-322, 2002
DOI:10.1161/01.RES.0000030180.06028.23

Yang Z, Pascarel C, Steele DS, Komukai K, Brette FP, Orchard CH Na<sup>+</sup>-Ca<sup>2+</sup>Exchange Activity Is Localized in the T-Tubules of Rat Ventricular Myocytes Circulation Research 91 315-322, 2002
DOI:10.1161/01.RES.0000030180.06028.23

Yang Z, Steele DS Effects of phosphocreatine on SR Ca(2+) regulation in isolated saponin-permeabilized rat cardiac myocytes. J Physiol 539 767-777, 2002
View abstract

Yang Z, Steele DS Effects of phosphocreatine on SR Ca2+ regulation in isolated saponin-permeabilized rat cardiac myocytes. Journal of Physiology 539 767-778, 2002
DOI:10.1113/jphysiol.2001.012987

Yang Z, Steele DS, Orchard CH, Komukai K, Brette F Changes in the pattern of Ca2+ influx and efflux induced by detubulation in isolated rat ventricular myocytes, 2001

Yang Z, Steele DS Effects of cytosolic ATP on Ca(2+) sparks and SR Ca(2+) content in permeabilized cardiac myocytes. Circ Res 89 526-533, 2001
View abstract

Yang Z, Steele DS Effects of Cytosolic ATP on Ca<sup>2+</sup>Sparks and SR Ca<sup>2+</sup>Content in Permeabilized Cardiac Myocytes Circulation Research 89 526-533, 2001
DOI:10.1161/hh1801.096264

Yang Z, Steele DS Effects of cytosolic ATP on spontaneous and triggered calcium-induced calcium release in permeabilized rat ventricular myocytes Journal of Physiology 523 29-44, 2000