Faculty of Biological Sciences

Dr Zhaokang Yang

BSc, MSc, PhD, PR China
Research Fellow
School of Biomedical Sciences

Contact:  Garstang G7.53, +44(0) 113 34 31869, email address for  

Yang Z, Kirton HM, Al-Owais M, Thireau J, Richard S, Peers C, Steele D Epac2-Rap1 signaling regulates reactive oxygen species production and susceptibility to cardiac arrhythmias Antioxidants and Redox Signaling 27 117-132, 2017
DOI:10.1089/ars.2015.6485
View abstract

Yang Z, Kirton HM, Al-Owais M, Peers C, Steele DS Epac2-Rap1 Signaling Influences Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias, 2017

Kirton HM, Yang Z, Steele DS Conditions that Promote Golgi Ca2+ Release Facilitate Trafficking of VEGFR-1 to the Surface Membrane in Rat Ventricular Myocytes, 2016

Lotteau S, Yang Z, Venturi E, Steer E, Witschas K, Sitsapesan R, Steele D, Calaghan S Simvastatin has Profound Effects on Sarcoplasmic Reticulum Ca2+ Leak in Skeletal but not Cardiac Muscle: A Mechanism for Myopathy, 2016

Kirton HM, Yang Z, Steele DS Phosphodiesterase Inhibition Leads to Activation of Epac and Stimulation of Ca2+ Release from both the Golgi Apparatus and the SR, 2015

Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS The Golgi apparatus is a functionally distinct Ca<sup>2+</sup>store regulated by the PKA and Epac branches of the b1-adrenergic signaling pathway Science Signaling 8 -, 2015
DOI:10.1126/scisignal.aaa7677
View abstract

Yang Z, Steele DS The EPAC Activator 8-CPT Protects against Isoproterenol-Induced Cell Death in Adult Ventricular Myocytes, 2013

Dallas ML, Yang Z, Boyle JP, Boycott HE, Scragg JL, Milligan CJ, Elies J, Duke A, Thireau J, Reboul C, Richard S, Bernus O, Steele DS, Peers C Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. Am J Respir Crit Care Med 186 648-656, 2012
DOI:10.1164/rccm.201204-0688OC
View abstract

Benoist D, Stones R, Drinkhill MJ, Benson AP, Yang Z, Cassan C, Gilbert SH, Saint DA, Cazorla O, Steele DS, Bernus O, White E Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension. Am J Physiol Heart Circ Physiol 302 H2381-H2395, 2012
DOI:10.1152/ajpheart.01084.2011
View abstract

Yang Z, Steele DS The Golgi Apparatus is a Juxtanuclear Ca2+ Store Regulated by beta 1-Adrenergic Signalling via Both PKA and EPAC Pathways, 2011

Duncan DJ, Yang Z, Hopkins PM, Steele DS, Harrison SM TNF-alpha and IL-1beta increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes. Cell Calcium 47 378-386, 2010
DOI:10.1016/j.ceca.2010.02.002
View abstract

Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass J.Mol.Cell Cardiol. 48 293-301, 2010
View abstract

Duncan DJ, Yang Z, Hopkins PM, Steele DS, Harrison SM TNF-α and IL-1β increase Ca<sup>2+</sup>leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes Cell Calcium 47 378-386, 2010
DOI:10.1016/j.ceca.2010.02.002
View abstract

Duncan D, Yang ZK, Hopkins PM, Steele DS, Harrison SM Altered ryanodine receptor gating by TNF-alpha and IL-1 beta, 2007

Duncan D, Yang Z, Hopkins PM, Steele DS, Harrison SM Altered ryanodine receptor gating by TNF-alpha and IL-1 beta, 2007

Yang ZK, Steele DS Evidence that prolonged nuclear C2+ release events originate from the Golgi Apparatus in rat ventricular myocytes, 2007

Yang Z, Steele DS Evidence that prolonged nuclear C2+ release events originate from the Golgi Apparatus in rat ventricular myocytes, 2007

Yang ZK, Ikemoto N, Lamb GD, Steele DS The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes (vol 70, pg 475, 2006) CARDIOVASC RES 71 606-606, 2006
DOI:10.1016/j.cardiores.2006.06.009

Yang Z, Ikemoto N, Lamb GD, Steele DS The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes (vol 70, pg 475, 2006) CARDIOVASCULAR RESEARCH 71 606-606, 2006
DOI:10.1016/j.cardiores.2006.06.009

Yang Z, Ikemoto N, Lamb GD, Steele DS Corrigendum to: The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes [Cardiovascular Research 70 (2006) 475-485] (DOI:10.1016/j.cardiores.2006.03.001) Cardiovascular Research 71 606-, 2006
DOI:10.1016/j.cardiores.2006.06.009

Yang Z, Ikemoto N, Lamb GD, Steele DS The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes. Cardiovasc Res 70 475-485, 2006
DOI:10.1016/j.cardiores.2006.03.001
View abstract

Yang Z, Steele DS Caffeine decreases the cytosolic [Ca2+] threshold required for spontaneous Ca2+ release in isolated ventricular myocytes from RAT, 2005

Yang Z, Steele DS Characteristics of prolonged Ca2+ release events associated with the nuclei in adult cardiac myocytes. Circ Res 96 82-90, 2005
DOI:10.1161/01.RES.0000151841.63705.01
View abstract

Yang Z, Harrison SM, Steele DS ATP-dependent effects of halothane on SR Ca2+ regulation in permeabilized atrial myocytes. Cardiovasc Res 65 167-176, 2005
DOI:10.1016/j.cardiores.2004.09.008
View abstract

Orchard CH, Brette F, Hussain M, Kawai M, Komukai K, Pascarel C, Steele D, Yang Z Subcellular heterogeneity in cardiac ventricular myocytes, 2002

Yang Z, Pascarel C, Steele DS, Kornukai K, Brette F, Orchard CH Na+-Ca2+ exchange activity is localized in the T-tubules of rat ventricular myocytes CIRC RES 91 315-322, 2002
DOI:10.1161/01.RES.0000030180.06028.23

Yang Z, Pascarel C, Steele DS, Komukai K, Brette FP, Orchard CH Na<sup>+</sup>-Ca<sup>2+</sup>Exchange Activity Is Localized in the T-Tubules of Rat Ventricular Myocytes Circulation Research 91 315-322, 2002
DOI:10.1161/01.RES.0000030180.06028.23

Yang Z, Steele DS Effects of phosphocreatine on SR Ca(2+) regulation in isolated saponin-permeabilized rat cardiac myocytes. J Physiol 539 767-777, 2002
View abstract

Yang Z, Steele DS Effects of phosphocreatine on SR Ca2+ regulation in isolated saponin-permeabilized rat cardiac myocytes. Journal of Physiology 539 767-778, 2002
DOI:10.1113/jphysiol.2001.012987

Yang Z, Steele DS, Orchard CH, Komukai K, Brette F Changes in the pattern of Ca2+ influx and efflux induced by detubulation in isolated rat ventricular myocytes, 2001

Yang Z, Steele DS Effects of cytosolic ATP on Ca(2+) sparks and SR Ca(2+) content in permeabilized cardiac myocytes. Circ Res 89 526-533, 2001
View abstract

Yang Z, Steele DS Effects of Cytosolic ATP on Ca<sup>2+</sup>Sparks and SR Ca<sup>2+</sup>Content in Permeabilized Cardiac Myocytes Circulation Research 89 526-533, 2001
DOI:10.1161/hh1801.096264

Yang Z, Steele DS Effects of cytosolic ATP on spontaneous and triggered calcium-induced calcium release in permeabilized rat ventricular myocytes Journal of Physiology 523 29-44, 2000