Faculty of Biological Sciences

Prof Adrian Whitehouse

BSc, Sheffield; DPhil, Oxford
Professor of Molecular Virology
School of Molecular and Cellular Biology

Background: Postdoctoral Research Fellow 1994-1998, Molecular Medicine Unit, Leeds; MRC Non-Clinical Research Fellow, 1998-2001, Molecular Medicine Unit, Leeds. Appointed Lecturer 2002, Reader 2005 and to Professor in 2010.

Contact: Garstang 9.59, +44(0) 113 34 37096, email address for  

You can read more about Prof Whitehouse's interests here:

Viruses and Cancer

Infection is a major cause of cancer worldwide. Viruses are associated with approximately 10-15% of human cancers, resulting in about 2 million new cases every year in the world. Research in the the Whitehouse laboratory aims to understand how viruses cause cancer and develop novel antiviral strategies to prevent infection and tumourigenesis. We focus on studying the molecular biology of the two most recently discovered human tumour viruses, Kaposi's sarcoma-associated herpesvirus and Merkel cell polyomavirus.

(i) Kaposi's sarcoma associated herpesvirus (KSHV)
This is a human gamma-2 herpesviruses which has been associated with a variety of lymphoproliferative disorders including Kaposi's sarcoma (KS), primary effusion lymphoma and multicentric Castleman's disease. Widespread HIV infection has now turned KS into an epidemic disease in Africa. KS is now the most common adult tumour in parts of Africa. Like other herpesviruses, KSHV has two distinct forms of infection, latency and lytic replication. Although latency has been implicated in tumourigenesis, reactivation and lytic replication play an important part in the pathogenesis and spread of KSHV infection. Therefore, we have a major research focus to study the molecular mechanisms which regulate reactivation and lytic gene expression to provide a better understanding of KSHV pathogenesis.

(ii) Merkel cell polyomavirus (MCPyV)
Merkel cell carcinoma (MCC) is a highly aggressive human cancer of the skin that occurs in elderly and immunosuppressed patients. Merkel cell polyomavirus was discovered in 2008 and is present in 80% of human Merkel cell carcinomas. Therefore, MCPyV is likely to have a causative role in MCC. Due to its recent discovery, little is known about the link between MCPyV and MCC. Therefore, we are currently investigating the role of MCPyV encoded proteins in transformation and immortalisation of human cells.

Current Projects

 1. Identification of essential virus-host cell interactions which are required for virus replication or transformation.

We are utilising a range of cutting-edge transcriptomic and quantitative proteomic approaches to globally identify how viral proteins affect the cellular environment. These interactions can then be verified using biochemical and con-focal imaging techniques. This is helping to identify essential virus-host cell interactions which we can target by novel antiviral strategies to inhibit virus replication and transformation.
We are particularly interested in virus-host cell interactions which
1. Regulate reactivation in Kaposi's sarcoma associated herpesvirus
2. Regulate virus RNA processing
3. Immune evasion strategies employed by oncogenic viruses
4. Virus-host cell interactions required for the aggressive metastatic potential of some virus-induced cancers

2. Structural-based rational drug design approaches to inhibit oncogenic viruses.

To date, there are limited antiviral strategies for oncogenic viruses. Although vaccines have been developed for a few of these viruses, these are not available for all the 7 oncogenic viruses, incluing KSHV and MCPyV. Therefore novel antiviral straetgies are required to combat these important human pathogens.

Upon identification of essential virus-host cell interactions using transcriptomic and quantitative proteomic approaches, we utilise a structural-based rational drug design approach to molecular model and design small molecules to inhibit these interactions. Virtual high-throughput screening campaigns are conducted from a large libraries of commercially available compounds. Docking routines and ligand-similarity searches are utilised to design compounds which have the potential to inhibit these essential virus-host cel interactions. Once the virtual high-throughput screening campaign has been performed selected compounds are then assessed in virus-based assays for antiviral activity.


Faculty Research and Innovation

Studentship information

Undergraduate project topics:

  • Investigation of viral-host cell interactions in oncogenic viruses
  • Development of herpesvirus-based gene delivery vectors
  • Keywords: Cancer, oncogenic viruses, herpesvirus, polyomavirus, gene therapy, viral vectors, molecular biology

Postgraduate studentship areas:

  • Virus-host cell interactions involved in viral mRNA export
  • Identification of oncoproteins encoded by McPyV
  • Development of Herpesvirus-based Gene Delivery Vectors

See also:

Modules taught

BIOC1301 - Introductory Integrated Biochemistry: the Molecules and Processes of Life
BIOC3160 - Laboratory/Literature/Computing Research Project
BIOC3221/22/BIOL3210/MICR3211 B - ATU - Life of an RNA
BIOC3231/32/BIOL3211/MICR3212 D - ATU - Human-microbe interactions
BIOL2301/03/05/MICR2320 - Intermediate Skills - BIOL/MICR
BIOL3215/11/BIOC3231/32/MICR3212 - ATU - molecular oncology
BIOL3215/11/BMSC3233/34/36 - ATU - cancer therapy
BIOL3399 - Extended Research Project Preparation
BIOL5296M - Treatment of Infectious Disease and Cancer
BIOL5382M - Extended Research Project
BIOL5394M - Specialised Research Topics and Skills
BIOW5901X - Foundation module
BIOW5907X - Biocatalysis
BMSC2210 - Chemotherapy
BMSC2233 - Topics in Medical Sciences
MICR2120/BIOC2301 - Integrated Biochemistry/Medical Bacteriology
MICR2121 - Molecular Virology
MICR3211/BIOL3210 A - ATU - emerging infections

Centre membership: The Astbury Centre for Structural Molecular Biology

Group Leader Prof Adrian Whitehouse  (Professor of Molecular Virology)

Dr Belinda Baquero  (Research Fellow)

Dr Sophie Schumann  (Research Fellow)


Holli Carden (Primary supervisor) 70% FTE
Alexander Coleman (Primary supervisor) 100% FTE
Samuel Dobson (Primary supervisor) 90% FTE
Becky Foster (Primary supervisor) 70% FTE
Zoe Jackson (Primary supervisor) 34% FTE
Oliver Manners (Primary supervisor) 70% FTE
James Murphy (Primary supervisor) 50% FTE
Nnenna Nwogu (Primary supervisor) 70% FTE
Benjamin Chadwick (Co-supervisor) 33% FTE
Aikaterini Douka (Co-supervisor) 20% FTE
Anna Leach (Co-supervisor) 50% FTE
Hayley Pearson (Co-supervisor) 33% FTE
Shola Richards (Co-supervisor) 50% FTE
Amy Stainthorp (Co-supervisor) 50% FTE
Ioannis Tsagakis (Co-supervisor) 10% FTE

Hughes DJ, Tiede C, Penswick N, Tang AAS, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology Science Signaling 10, 2017
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Antanaviciute A, Baquero-Perez B, Watson CM, Harrison SM, Lascelles C, Crinnion L, Markham AF, Bonthron DT, Whitehouse A, Carr IM m6aViewer: software for the detection, analysis and visualization of N6-methyl-adenosine peaks from m6A-seq/ME-RIP sequencing data. RNA 23 1493-1501, 2017
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Schumann S, Whitehouse A Targeting the human TREX complex to prevent herpesvirus replication: What is new? Future Virology 12 81-83, 2017

Abdul-Sada H, Müller M, Mehta R, Toth R, Arthur JSC, Whitehouse A, Macdonald A The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen Oncotarget 8 25418-25432, 2017
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Schumann S, Jackson BR, Yule I, Whitehead SK, Revill C, Foster R, Whitehouse A Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach Nature Microbiology 2 16201-16201, 2016

Schumann S, Baquero-Perez B, Whitehouse A Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29. J Gen Virol 97 1904-1910, 2016
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Wood JJ, Boyne JR, Paulus C, Jackson BR, Nevels MM, Whitehouse A, Hughes DJ ARID3B: A novel regulator of the Kaposi's sarcoma-associated herpesvirus lytic cycle Journal of Virology 90 9543-9555, 2016
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Baquero-Perez B, Whitehouse A Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments PLoS Pathogens 11, 2015
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Hughes DJ, Wood JJ, Jackson BR, Baquero B, Whitehouse A NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target. PLoS Pathogens 11, 2015
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Liu L, Lear Z, Hughes DJ, Wu W, Zhou E-M, Whitehouse A, Chen H, Hiscox JA Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology. Vet Microbiol 176 109-119, 2015
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Whitehouse A An emerging layer of gene regulation: Dynamic mRNA modifications Biochemist 37 14-18, 2015
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Whitehouse A, Macdonald A Stathmin drives virus-induced metastasis Oncotarget 6 32289-32290, 2015

Knight LM, Stakaityte G, Wood JJ, Abdul-Sada H, Griffiths DA, Howell GJ, Wheat R, Blair GE, Steven NM, Macdonald A, Blackbourn DJ, Whitehouse A Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration Journal of Virology 89 35-47, 2015
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Akhbari P, Whitehouse A, Boyne JR Long non-coding RNAs drive metastatic progression in melanoma (Review). Int J Oncol 45 2181-2186, 2014
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Owen CB, Hughes DJ, Baquero-Perez B, Berndt A, Schumann S, Jackson BR, Whitehouse A Utilising proteomic approaches to understand oncogenic human herpesviruses (Review). Molecular and Clinical Oncology 2 891-903, 2014
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Stakaitytė G, Wood JJ, Knight LM, Abdul-Sada H, Adzahar NS, Nwogu N, Macdonald A, Whitehouse A Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus. Cancers (Basel) 6 1267-1297, 2014
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Jackson BR, Noerenberg M, Whitehouse A A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells. PLoS Pathog 10, 2014
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Griffiths DA, Abdul-Sada H, Knight LM, Jackson BR, Richards K, Prescott EL, Peach AHS, Blair GE, Macdonald A, Whitehouse A Merkel Cell Polyomavirus Small T Antigen Targets the NEMO Adaptor Protein To Disrupt Inflammatory Signaling JOURNAL OF VIROLOGY 87 13853-13867, 2013

Ingram N, Macnab SA, Marston G, Scott N, Carr IM, Markham AF, Whitehouse A, Coletta PL The use of high-frequency ultrasound imaging and biofluorescence for in vivo evaluation of gene therapy vectors BMC Medical Imaging 13 1-9, 2013
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Emmott E, Munday D, Bickerton E, Britton P, Rodgers MA, Whitehouse A, Zhou E-M, Hiscox JA The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology Journal of Virology 87 9486-9500, 2013
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Schumann S, Jackson BR, Baquero-Perez B, Whitehouse A Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing. Viruses 5 1901-1923, 2013
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Brown HF, Unger C, Whitehouse A Potential of herpesvirus saimiri-based vectors to reprogram a somatic Ewing's Sarcoma family tumor cell line Journal of Virology 87 7127-7139, 2013
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Turrell SJ, Macnab SA, Rose A, Melcher AA, Whitehouse A A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures. Int J Oncol 40 2081-2089, 2012
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Dyson OF, Walker LR, Whitehouse A, Cook PP, Akula SM Resveratrol Inhibits KSHV Reactivation by Lowering the Levels of Cellular EGR-1 PLOS ONE 7, 2012

Munday DC, Surtees R, Emmott E, Dove BK, Digard P, Barr JN, Whitehouse A, Matthews D, Hiscox JA Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes. Proteomics 12 666-672, 2012
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Turrell SJ, Filby MH, Whitehouse A, Wilson AJ Cellular uptake of highly-functionalized ruthenium(II) tris-bipyridine protein-surface mimetics. Bioorg Med Chem Lett 22 985-988, 2012
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Jackson BR, Noerenberg M, Whitehouse A The Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein and Its Multiple Roles in mRNA Biogenesis. Front Microbiol 3 59-, 2012
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Whitehouse A Production of recombinant Herpesvirus saimiri-based vectors. Cold Spring Harbor protocols 2011 1515-1519, 2011
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Whitehouse A Assessment of infectivity using a Herpesvirus saimiri (HVS) recombinant that expresses HVS-GFP. Cold Spring Harbor protocols 2011 1520-1523, 2011
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Whitehouse A Gardella gel analysis to detect Herpesvirus saimiri episomal DNA. Cold Spring Harbor protocols 2011 1524-1526, 2011
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Khandelwal N, Simpson J, Taylor G, Rafique S, Whitehouse A, Hiscox J, Stark LA Nucleolar NF-kappa B/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin CELL DEATH AND DIFFERENTIATION 18 1889-1903, 2011

Macnab SA, Turrell SJ, Carr IM, Markham AF, Coletta PL, Whitehouse A Herpesvirus saimiri-mediated delivery of the adenomatous polyposis coli tumour suppressor gene reduces proliferation of colorectal cancer cells. Int J Oncol 39 1173-1181, 2011
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Taylor A, Jackson BR, Noerenberg M, Hughes DJ, Boyne JR, Verow M, Harris M, Whitehouse A Mutation of a C-Terminal Motif Affects Kaposi's Sarcoma-Associated Herpesvirus ORF57 RNA Binding, Nuclear Trafficking, and Multimerization J VIROL 85 7881-7891, 2011

Hong Y, Macnab S, Lambert LA, Turner AJ, Whitehouse A, Usmani BA Herpesvirus saimiri-based endothelin-converting enzyme-1 shRNA expression decreases prostate cancer cell invasion and migration INT J CANCER 129 586-598, 2011

Jackson BR, Boyne JR, Noerenberg M, Taylor A, Hautbergue GM, Walsh MJ, Wheat R, Blackbourn DJ, Wilson SA, Whitehouse A An Interaction between KSHV ORF57 and UIF Provides mRNA-Adaptor Redundancy in Herpesvirus Intronless mRNA Export PLOS PATHOG 7, 2011

Tunnicliffe RB, Hautbergue GM, Kalra P, Jackson BR, Whitehouse A, Wilson SA, Golovanov AP Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57 PLOS PATHOG 7, 2011

Turrell SJ, Whitehouse A Mutation of Herpesvirus Saimiri ORF51 Glycoprotein Specifically Targets Infectivity to Hepatocellular Carcinoma Cell Lines J BIOMED BIOTECHNOL, 2011

Hiscox JA, Whitehouse A, Matthews DA Nucleolar proteomics and viral infection PROTEOMICS 10 4077-4086, 2010

Boyne JR, Jackson BR, Whitehouse A ORF57 Master regulator of KSHV mRNA biogenesis CELL CYCLE 9 2702-2703, 2010

Boyne JR, Jackson BR, Taylor A, Macnab SA, Whitehouse A Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs EMBO J 29 1851-1864, 2010

Boyne JR, Whitehouse A Nucleolar disruption impairs Kaposi's sarcoma-associated herpesvirus ORF57-mediated nuclear export of intronless viral mRNAs FEBS LETT 583 3549-3556, 2009

Macnab S, Whitehouse A Progress and prospects: human artificial chromosomes GENE THER 16 1180-1188, 2009

Gould F, Harrison SM, Hewitt EW, Whitehouse A Kaposi's Sarcoma-Associated Herpesvirus RTA Promotes Degradation of the Hey1 Repressor Protein through the Ubiquitin Proteasome Pathway J VIROL 83 6727-6738, 2009

Colgan KJ, Boyne JR, Whitehouse A Uncoupling of hTREX demonstrates that UAP56 and hTHO-complex recruitment onto herpesvirus saimiri intronless transcripts is required for replication J GEN VIROL 90 1455-1460, 2009

Colgan KJ, Boyne JR, Whitehouse A Identification of a response element In a herpesvirus saimiri mRNA recognized by the ORF57 protein J GEN VIROL 90 596-601, 2009

Gao JY, Coulson JM, Whitehouse A, Blake N Reduction in RNA Levels Rather than Retardation of Translation Is Responsible for the Inhibition of Major Histocompatibility Complex Class I Antigen Presentation by the Glutamic Acid-Rich Repeat of Herpesvirus Saimiri Open Reading Frame 73 J VIROL 83 273-282, 2009

Griffiths R, Harrison SM, Macnab S, Whitehouse A Mapping the minimal regions within the ORF73 protein required for herpesvirus saimiri episomal persistence J GEN VIROL 89 2843-2850, 2008

Emmott E, Dove BK, Howell G, Chappell LA, Reed ML, Boyne JR, You JH, Brooks G, Whitehouse A, Hiscox JA Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus VIROLOGY 380 191-202, 2008

Emmott EP, Dove BK, Howell G, Chappell LA, Reed ML, Boyne JR, You JH, Brooks G, Whitehouse A, Hiscox JA Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus Virology 380 191-202, 2008
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Boyne JR, Colgan KJ, Whitehouse A Recruitment of the Complete hTREX Complex Is Required for Kaposi's Sarcoma-Associated Herpesvirus Intronless mRNA Nuclear Export and Virus Replication PLOS PATHOG 4, 2008

Harrison SM, Whitehouse A Kaposi's sarcoma-associated herpesvirus (KSHV) Rta and cellular HMGB1 proteins synergistically transactivate the KSHVORF50 promoter FEBS LETT 582 3080-3084, 2008

Macnab S, White R, Hiscox J, Whitehouse A Production of an infectious Herpesvirus saimiri-based episomally maintained amplicon system J BIOTECHNOL 134 287-296, 2008

Boyne JR, Colgan KJ, Whitehouse A Herpesvirus saimiri ORF57: a post-transcriptional regulatory protein FRONT BIOSCI 13 2928-2938, 2008

Wilson SJ, Tsao EH, Webb BLJ, Ye HT, Dalton-Griffin L, Tsantoulas C, Gale CV, Du MQ, Whitehouse A, Kellam P X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency J VIROL 81 13578-13586, 2007

Griffiths R, Whitehouse A Herpesvirus saimiri episomal persistence is maintained via interaction between open reading frame 73 and the cellular chromosome-associated protein MeCP2 J VIROL 81 4021-4032, 2007

Boyne JR, Whitehouse A Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA P NATL ACAD SCI USA 103 15190-15195, 2006

Griffiths RA, Boyne JA, Whitehouse A Herpesvirus saimiri-based gene delivery vectors CURR GENE THER 6 1-15, 2006

Boyne JR, Whitehouse A gamma-2 Herpes virus post-transcriptional gene regulation CLIN MICROBIOL INFEC 12 110-117, 2006

Boyne JR, Whitehouse A γ-2 herpes virus post-transcriptional gene regulation Clinical Microbiology and Infection 12 110-117, 2006
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Wakenshaw L, Walters MS, Whitehouse A The herpesvirus saimiri replication and transcription activator acts synergistically with CCAAT enhancer binding protein alpha to activate the DNA polymerase promoter J VIROL 79 13548-13560, 2005

Calderwood M, White RE, Griffiths RA, Whitehouse A Open reading frame 73 is required for herpesvirus saimiri A11-S4 episomal persistence J GEN VIROL 86 2703-2708, 2005

Smith PG, Oakley F, Fernandez M, Mann DA, Lemoine NR, Whitehouse A Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging GENE THER 12 1465-1476, 2005

Williams BJL, Boyne JR, Goodwin DJ, Roaden L, Hautbergue GM, Wilson SA, Whitehouse A The prototype gamma-2 herpesvirus nucleocytoplasmic shuttling protein, ORF 57, transports viral RNA through the cellular mRNA export pathway BIOCHEM J 387 295-308, 2005

Smith PG, Burchill SA, Brooke D, Coletta PL, Whitehouse A Efficient infection and persistence of a herpesvirus saimiri-based gene delivery vector into human tumor xenografts and multicellular spheroid cultures CANCER GENE THER 12 248-256, 2005

Walters MS, Hall KT, Whitehouse A The herpesvirus saimiri Rta gene autostimulates via binding to a non-consensus response element J GEN VIROL 86 581-587, 2005

Walters MS, Hall KT, Whitehouse A The herpesvirus saimiri open reading frame (ORF) 50 (Rta) protein contains an AT hook required for binding to the ORF 50 response element in delayed-early promoters J VIROL 78 4936-4942, 2004

Calderwood NA, White RE, Whitehouse A Development of herpesvirus-based episomally maintained gene delivery vectors EXPERT OPIN BIOL TH 4 493-505, 2004

Calderwood MA, Hall KT, Matthews DA, Whitehouse A The herpesvirus saimiri ORF73 gene product interacts with host-cell mitotic chromosomes and self-associates via its C terminus J GEN VIROL 85 147-153, 2004

White RE, Calderwood MA, Whitehouse A Generation and precise modification of a herpesvirus salmiri bacterial artificial chromosome demonstrates that the terminal repeats are required for both virus production and episomal persistence J GEN VIROL 84 3393-3403, 2003

Whitehouse A Herpesvirus saimiri: A potential gene delivery vector (Review) INT J MOL MED 11 139-148, 2003

Giles MS, Smith PG, Coletta PL, Hall KT, Whitehouse A The herpesvirus saimiri ORF 73 regulatory region provides long-term transgene expression in human carcinoma cell lines CANCER GENE THER 10 49-56, 2003

Hall KT, Giles MS, Calderwood MA, Goodwin DJ, Matthews DA, Whitehouse A The herpesvirus saimiri open reading frame 73 gene product interacts with the cellular protein p32 J VIROL 76 11612-11622, 2002

Smith PG, Coletta PL, Markham AF, Whitehouse A In vivo episomal maintenance of a herpesvirus saimiri-based gene delivery vector. Gene Ther 8 1762-1769, 2001
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Goodwin DJ, Whitehouse A A gamma-2 herpesvirus nucleocytoplasmic shuttle protein interacts with importin alpha 1 and alpha 5 J BIOL CHEM 276 19905-19912, 2001

Goodwin DJ, Whitehouse A Aγ-2 Herpesvirus Nucleocytoplasmic Shuttle Protein Interacts with Importin α1 and α5 Journal of Biological Chemistry 276 19905-19912, 2001
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Goodwin DJ, Walters MS, Smith PG, Thurau M, Fickenscher H, Whitehouse A Herpesvirus saimiri open reading frame 50 (Rta) protein reactivates the lytic replication cycle in a persistently infected A549 cell line. J Virol 75 4008-4013, 2001
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Goodwin DJ, Walters MS, Smith PG, Thurau M, Fickenscher H, Whitehouse A Herpesvirus saimiri open reading frame 50 (Rta) protein reactivates the lytic replication cycle in a persistently infected A549 cell line Journal of Virology 75 4008-4013, 2001

Hall KT, Giles MS, Goodwin DJ, Calderwood MA, Markham AF, Whitehouse A Characterization of the herpesvirus saimiri ORF73 gene product J GEN VIROL 81 2653-2658, 2000

Goodwin DJ, Hall KT, Giles MS, Calderwood MA, Markham AF, Whitehouse A The carboxy terminus of the herpesvirus saimiri ORF 57 gene contains domains that are required for transactivation and transrepression J GEN VIROL 81 2253-2265, 2000

Stevenson AJ, Giles MS, Hall KT, Goodwin DJ, Calderwood MA, Markham AF, Whitehouse A Specific oncolytic activity of herpesvirus saimiri in pancreatic cancer cells. Br J Cancer 83 329-332, 2000
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Hall KT, Giles MS, Goodwin DJ, Calderwood MA, Carr IM, Stevenson AJ, Markham AF, Whitehouse A Analysis of gene expression in a human cell line stably transduced with herpesvirus saimiri J VIROL 74 7331-7337, 2000

Stevenson AJ, Frolova-Jones E, Hall KT, Kinsey SE, Markham AF, Whitehouse A, Meredith DM A herpesvirus saimiri-based gene therapy vector with potential for use in cancer immunotherapy CANCER GENE THER 7 1077-1085, 2000

Thurau M, Whitehouse A, Wittmann S, Meredith D, Fickenscher H Distinct transcriptional and functional properties of the R transactivator gene orf50 of the transforming herpesvirus Saimiri strain C488 VIROLOGY 268 167-177, 2000

Stevenson AJ, Clarke D, Meredith DM, Kinsey SE, Whitehouse A, Bonifer C Herpesvirus saimiri-based gene delivery vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro GENE THER 7 464-471, 2000

Hall KT, Stevenson AJ, Goodwin DJ, Gibson PC, Markham AF, Whitehouse A The activation domain of herpesvirus saimiri R protein interacts with the TATA-binding protein J VIROL 73 9756-9763, 1999

Goodwin DJ, Hall KT, Stevenson AJ, Markham AF, Whitehouse A The open reading frame 57 gene product of herpesvirus saimiri shuttles between the nucleus and cytoplasm and is involved in viral RNA nuclear export J VIROL 73 10519-10524, 1999

Bello LJ, Davison AJ, Glenn MA, Whitehouse A, Rethmeier N, Schulz TF, Clements JB The human herpesvirus-8 ORF 57 gene and its properties J GEN VIROL 80 3207-3215, 1999

Cooper M, Goodwin DJ, Hall KT, Stevenson AJ, Meredith DM, Markham AF, Whitehouse A The gene product encoded by ORF 57 of herpesvirus saimiri regulates the redistribution of the splicing factor SC-35 J GEN VIROL 80 1311-1316, 1999

Stevenson AJ, Cooper M, Griffiths JC, Gibson PC, Whitehouse A, Jones EF, Markham AF, Kinsey SE, Meredith DM Assessment of Herpesvirus saimiri as a potential human gene therapy vector J MED VIROL 57 269-277, 1999

Stevenson AJ, Cooper M, Griffiths JC, Gibson PC, Whitehouse A, Jones EF, Markham AF, Kinsey SE, Meredith DM Assessment of Herpesvirus saimiri as a potential human gene therapy vector Journal of Medical Virology 57 269-269, 1999

Carr IM, Whitehouse A, Coletta PL, Markham AF Structural and evolutionary characterization of the human sorbitol dehydrogenase gene duplication MAMM GENOME 9 1042-1048, 1998

Whitehouse A, Cooper M, Hall KT, Meredith DM The open reading frame (ORF) 50a gene product regulates ORF 57 gene expression in herpesvirus saimiri J VIROL 72 1967-1973, 1998

Whitehouse A, Meredith DM, Markham AF DNA mismatch repair genes and their association with colorectal cancer (Review) INT J MOL MED 1 469-474, 1998

Whitehouse A, Cooper M, Meredith DM The immediate-early gene product encoded by open reading frame 57 of herpesvirus saimiri modulates gene expression at a posttranscriptional level J VIROL 72 857-861, 1998

Deeble JV, Whitehouse A, Roberts E, Woods CG, Meredith D, Markham AF, Taylor GR Evaluation of enzymatic methods of mutation detection. AM J HUM GENET 61 A219-A219, 1997

Deeble J, Whitehouse A, Meredith DM, Markham AF, Woods CG, Taylor GR Use of Thermus thermophilus HB8 MutS in a filter binding format for mismatch detection. J MED GENET 34 1306-1306, 1997

Whitehouse A, Stevenson AJ, Cooper M, Meredith DM Identification of a cis-acting element within the herpesvirus saimiri ORF 6 promoter that is responsive to the HVS.R transactivator J GEN VIROL 78 1411-1415, 1997

Whitehouse A, Deeble J, Parmar R, Taylor GR, Markham AF, Meredith DM Analysis of the mismatch and insertion/deletion binding properties of Thermus thermophilus, HB8, MutS BIOCHEM BIOPH RES CO 233 834-837, 1997

Whitehouse A, Deeble J, Taylor GR, Guillou PJ, Phillips SEV, Meredith DM, Markham AF Mapping the minimal domain of hMSH-2 sufficient for binding mismatched oligonucleotides BIOCHEM BIOPH RES CO 232 10-13, 1997

Whitehouse A, Carr IM, Griffiths JC, Meredith DM The herpesvirus Saimiri ORF50 gene, encoding a transcriptional activator homologous to the Epstein-Barr virus R protein, is transcribed from two distinct promoters of different temporal phases J VIROL 71 2550-2554, 1997

Whitehouse A, Parmar R, Deeble J, Taylor GR, Phillips SEV, Meredith DM, Markham AF Mutational analysis of the nucleotide binding domain of the mismatch repair enzyme hMSH-2 BIOCHEM BIOPH RES CO 229 147-153, 1996

Whitehouse A, Taylor GR, Deeble J, Phillips SEV, Meredith DM, Markham AF A carboxy terminal domain of the hMSH-2 gene product is sufficient for binding specific mismatched oligonucleotides BIOCHEM BIOPH RES CO 225 289-295, 1996

Norris AL, Bailey A, Askham J, Whitehouse A, Clissold PM, Markham AF, Meredith DM Characterization of the human beta-catenin gene MAMM GENOME 7 160-162, 1996

Stakaitytė G, Nwogu N, Dobson SJ, Knight LM, Wasson CW, Salguero FJ, Blackbourn DJ, Blair GE, Mankouri J, Macdonald A, Whitehouse A Merkel cell polyomavirus small T antigen drives cell motility via Rho-GTPase-induced filopodia formation Journal of Virology, 2017
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Stakaityte G, Nwogu N, Lippiat JD, Blair GE, Poterlowicz K, Boyne JR, Macdonald A, Mankouri J, Whitehouse A The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility Journal of Biological Chemistry, 2018
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Bussey KA, Lau U, Schumann S, Gallo A, Osbelt L, Stempel M, Arnold C, Wissing J, Gad HH, Hartmann R, Brune W, Jänsch L, Whitehouse A, Brinkmann MM The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein PLoS Pathogens