Faculty of Biological Sciences

Prof Ed White

BSc, Aberystwyth; PhD, Reading; PGCE, Exeter.
Professor in Cardiac Physiology
School of Biomedical Sciences

Background: BSc Zoology, University of Wales, Aberystwyth: PhD Zoology, Reading University: PGCE Biology and Outdoor Education, Exeter University: Post-Doc., Oxford University: Lecturer, Université de Tours, France: Lloyds of London and Wellcome Trust Fellow, Lecturer, Senior Lecturer, Reader: University of Leeds. Currently, visiting Professor, L'Instut de Rhythmologie et Modélisation Cardiaque, Université de Bordeaux, France

Contact:  Garstang 7.53a, +44(0) 113 34 34248, email address for  

You can read more about Prof White's interests here:
http://ajpheart.podbean.com/e/voluntary-exercise-in-heart-failure-rats/

Research Interests

Mechanical stimulation of the heart

Mechanical stimulation of the heart
Acute mechanical stimulation (e.g. stretch) affects the contractility of cardiac muscle in situations such as exercise, when diastolic ventricular volume is increased. Stretch and adrenergic stimulation are the 2 most important physiological mechanisms for increasing the strength of contraction of the heart. But stretch has also been implicated in the triggering of cardiac arrhythmias and chronic stretch provokes cardiac hypertrophy and eventually heart failure. Thus stretch may be involved in the beneficial effects of regular exercise and the cause of heart attacks, depending upon circumstances. My research group investigates the mechanisms that cause these varied effects on the contractile and electrical activity of the heart (see Fig 1).

Right heart failure
The right ventricle is structurally and functionally different from the left ventricle, it is thinner, operates at much lower pressures and has distinctive pathologies. The right ventricle is much less studied than the left. We are interested in the differences in physiology and pathology between the ventricles. We are currently using an animal model to study changes in contractile and electrical activity of the myocardium in right ventricular failure, linking these to changes in gene expression and in vivo cardiac function.

Comparative Cardiac Physiology
Vertebrate heart design varies from class to class, understanding the differences in physiology between vertebrate classes helps our thinking about mammalian physiology and pathology. In collaboration with colleagues from the University of Manchester we are investigating the cardiac physiology of fish.

Funding and international collaborations
We are funded by grants from The British Heart Foundation, The Medical Research Council and EU. We have overseas research collaborators in France (Bordeaux) and New Zealand (Auckland). The laboratory has welcomed researchers from Australia, Brazil, Canada, France, Italy, Japan, Poland and UAE.

Available Research Techniques
In vivo: ECG in unrestrained animals by telemetry; pressure:volume relationships of the ventricles.
Isolated whole hearts: Ventricular contractility (developed pressure) and electrical activity (optical mapping, monophasic action potentials)
Single cardiac myocytes:  Myocyte contractility (cell shortening and force development); ionic membrane currents (patch clamping) and intracellular ion concentrations (fluorescence microscopy); cytoskeletal structure (immunohistochemistry and confocal microscopy).
Molecular Biology: measurement of mRNA (real time RT-PCR); protein expression (Western blotting)

view movie

Figure 1: A single cardiac myocyte about 0.1 mm in length being stretched by carbon fibres. A specialist technique in our lab. is the recording of force and stretch in single cardiac myocytes (click on Figure 1 for a video demonstration of this technique). Force measurements can be combined with measurements of intracellular calcium or electrophysiology.

 

Current Projects

  • Changes in ion channel activity in right heart failure
  • Role of stretch in right heart failure
  • Cardiac physiology of non-mammalian vertebrates

 

 

Faculty Research and Innovation



Studentship information

Undergraduate project topics:

  • Cardiac muscle

Postgraduate studentship areas:

  • Contractile and electrical activity in right ventricular failure
  • The role of mechanical stimulation in cardiac physiology and pathology
  • University of Leeds has an endowed PhD studentship (The Emma and Leslie Reid Studentship) in the field of heart research. Applications from self-funding 1-year MSc by research students are welcome.

See also:

Modules managed

BMSC2228 - Experimental Skills in Physiology

Modules taught

BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC1215 - Life in the Extreme: Ultra Human Physiology
BMSC2228 - Experimental Skills in Physiology
BMSC3138 - Cellular Cardiology
BMSC3233/35/36 - Advanced Topics II
BMSC3301 - Research Project in Biomedical Sciences

Centre membership: The Multidisciplinary Cardiovascular Research Centre (MCRC)

Group Leader Prof Ed White  (Professor in Cardiac Physiology)

Mechanical stimulation of the heart 

Dr Matthew Hardy  (Teaching Fellow in Cardiovascular Sciences)

Dr Kathleen Wright  (Senior Scientific Officer in Cardiovascular Science)

Providing laboratory research support for multiple PIs, training new staff and laboratory/office management 


Postgraduates

Maxx Holmes (Co-supervisor) 50% FTE
Emma Steer (Co-supervisor) 20% FTE
Harley Stevenson-Cocks (Co-supervisor) 50% FTE

Chinnappa S, White E, Lewis N, Baldo O, Tu Y-K, Glorieux G, Vanholder R, El Nahas M, Mooney A Early and asymptomatic cardiac dysfunction in chronic kidney disease. Nephrol Dial Transplant -, 2017
DOI:10.1093/ndt/gfx064
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Diggle CP, Martinez-Garay I, Molnar Z, Brinkworth MH, White E, Fowler E, Hughes R, Hayward BE, Carr IM, Watson CM, Crinnion L, Asipu A, Woodman B, Coletta PL, Markham AF, Dear TN, Bonthron DT, Peckham M, Morrison EE, Sheridan E Atubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development PLoS ONE 12 -, 2017
DOI:10.1371/journal.pone.0174264
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Temple IP, Logantha SJRJ, Absi M, Zhang Y, Pervolaraki E, Yanni J, Atkinson A, Petkova M, Quigley GM, Castro S, Drinkhill M, Schneider H, Monfredi O, Cartwright E, Zi M, Yamanushi TT, Mahadevan VS, Gurney AM, White E, Zhang H, Hart G, Boyett MR, Dobrzynski H Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension Circulation: Arrhythmia and Electrophysiology 9 -, 2016
DOI:10.1161/CIRCEP.115.003432
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Fowler ED, Benoist D, Drinkhill MJ, Stones R, Helmes M, Wüst RCI, Stienen GJM, Steele DS, White E Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension Journal of Molecular and Cellular Cardiology 86 1-8, 2015
DOI:10.1016/j.yjmcc.2015.06.016
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Natali AJ, Fowler ED, Calaghan S, White E Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension. AJP - Heart and Circulatory Physiology 309 H421-H424, 2015
DOI:10.1152/ajpheart.00262.2015
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Fowler ED, Drinkhill MJ, Wust RC, Helmes M, Stienen GJM, Steele DS, White E Workloop Contractions in Isolated Cardiac Myocytes Reflect in vivo Pressure-Volume Dysfunction in Rat Right Heart Failure, 2015

Sequeira V, Najafi A, Mcconnell M, Fowler ED, Bollen IAE, Wüst RCI, Dos Remedios C, Helmes M, White E, Stienen GJM, Tardiff J, Kuster DWD, Van der Velden J Synergistic role of ADP and Ca<sup>2+</sup> in diastolic myocardial stiffness Journal of Physiology 593 3899-3916, 2015
DOI:10.1113/JP270354
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Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS The Golgi apparatus is a functionally distinct Ca<sup>2+</sup>store regulated by the PKA and Epac branches of the b1-adrenergic signaling pathway Science Signaling 8 -, 2015
DOI:10.1126/scisignal.aaa7677
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Benoist D, Stones R, Benson AP, Fowler ED, Drinkhill MJ, Hardy ME, Saint DA, Cazorla O, Bernus O, White E Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline. Progress in Biophysics and Molecular Biology 115 162-172, 2014
DOI:10.1016/j.pbiomolbio.2014.06.008
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Gilbert SH, Bernus O, White E, Roberts N, Treanor D, Magee D A framework for quantification of regional cardiac fibrosis from serial sections using 3D whole slide imaging, 2014
DOI:10.1109/EMBC.2014.6945181
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Rogers LJ, Lake AJ, White K, Hardy M, White E Effects of superoxide donor menadione in adult Rat myocardium are associated with increased diastolic intracellular calcium Bioscience Horizons 7 -, 2014
DOI:10.1093/biohorizons/hzt012
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Wolny M, Colegrave M, Colman L, White E, Knight PJ, Peckham M Erratum: Cardiomyopathy mutations in the tail ofβ-Cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes (Journal of Biological Chemistry (2013) 288 (36260)) Journal of Biological Chemistry 288 36260-, 2013
DOI:10.1074/jbc.A113.513291

Wolny M, Colegrave M, Colman L, White E, Knight P, Peckham M Cardiomyopathy mutations in the tail of beta cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes. Journal of Biological Chemistry 288 31952-31962, 2013
DOI:10.1074/jbc.M113.513291
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Stones R, Benoist D, Peckham M, White E Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension. J Mol Cell Cardiol 56 91-96, 2013
DOI:10.1016/j.yjmcc.2012.12.010
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Walton RD, Benson AP, Hardy MEL, White E, Bernus O Electrophysiological and structural determinants of electrotonic modulation of repolarization by the activation sequence. Front Physiol 4 281-, 2013
DOI:10.3389/fphys.2013.00281
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Kim DY, White E, Saint DA Increased mechanically-induced ectopy in the hypertrophied heart. Prog Biophys Mol Biol 110 331-339, 2012
DOI:10.1016/j.pbiomolbio.2012.07.004
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Benoist D, Stones R, Drinkhill MJ, Benson AP, Yang Z, Cassan C, Gilbert SH, Saint DA, Cazorla O, Steele DS, Bernus O, White E Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension. Am J Physiol Heart Circ Physiol 302 H2381-H2395, 2012
DOI:10.1152/ajpheart.01084.2011
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Walton RD, Smith RM, Mitrea BG, White E, Bernus O, Pertsov AM Extracting surface activation time from the optically recorded action potential in three-dimensional myocardium. Biophys J 102 30-38, 2012
DOI:10.1016/j.bpj.2011.10.036
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Gilbert SH, Benoist D, Benson AP, White E, Tanner SF, Holden AV, Dobrzynski H, Bernus O, Radjenovic A Visualization and quantification of whole rat heart laminar structure using high-spatial resolution contrast-enhanced MRI. Am J Physiol Heart Circ Physiol 302 H287-H298, 2012
DOI:10.1152/ajpheart.00824.2011
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Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RAB, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol 107 4-10, 2011
DOI:10.1016/j.pbiomolbio.2011.07.001
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White E, Benoist D, Bernus O Regional variation in mechano-electric coupling: the right ventricle In Cardiac Mechano-electric Coupling and Arrhythmias , 2011
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White E Mechano-sensitive channel blockers: a new class of antiarrhythmic drugs? In Cardiac Mechano-electric Coupling and Arrhythmias , 2011
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White E Mechanical modulation of cardiac microtubules PFLUG ARCH EUR J PHY 462 177-184, 2011
DOI:10.1007/s00424-011-0963-0

Benoist D, Stones R, Drinkhill M, Bernus O, White E Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy AM J PHYSIOL-HEART C 300 H2230-H2237, 2011
DOI:10.1152/ajpheart.01226.2010

Patrick SM, White E, Shiels HA Rainbow trout myocardium does not exhibit a slow inotropic response to stretch J EXP BIOL 214 1118-1122, 2011
DOI:10.1242/jeb.048546

Patrick M, White E, Brill RW, Shiels HA The effect of stimulation frequency on the transmural ventricular monophasic action potential in yellowfin tuna Thunnus albacares J FISH BIOL 78 651-658, 2011
DOI:10.1111/j.1095-8649.2010.02869.x

Walton RD, Benoist D, Hyatt CJ, Gilbert SH, White E, Bernus O Dual excitation wavelength epifluorescence imaging of transmural electrophysiological properties in intact hearts HEART RHYTHM 7 1843-1849, 2010
DOI:10.1016/j.hrthm.2010.08.019

Weiss S, Benoist D, White E, Teng W, Saint DA Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current BRIT J PHARMACOL 160 1072-1082, 2010
DOI:10.1111/j.1476-5381.2010.00766.x

Patrick SM, White E, Shiels HA Mechano-Electric Feedback in the Fish Heart PLOS ONE 5 -, 2010
DOI:10.1371/journal.pone.0010548

Patrick SM, Hoskins AC, Kentish JC, White E, Shiels HA, Cazorla O Enhanced length-dependent Ca2+ activation in fish cardiomyocytes permits a large operating range of sarcomere lengths J MOL CELL CARDIOL 48 917-924, 2010
DOI:10.1016/j.yjmcc.2010.02.008

Kozera L, White E, Calaghan S Caveolae Act as Membrane Reserves Which Limit Mechanosensitive I-Cl,I-swell Channel Activation during Swelling in the Rat Ventricular Myocyte PLOS ONE 4 -, 2009
DOI:10.1371/journal.pone.0008312

Stones R, Billeter R, Zhang HG, Harrison S, White E The role of transient outward K+ current in electrical remodelling induced by voluntary exercise in female rat hearts BASIC RES CARDIOL 104 643-652, 2009
DOI:10.1007/s00395-009-0030-6

Pickering JD, White E, Duke AM, Steele DS DHPR activation underlies SR Ca2+ release induced by osmotic stress in isolated rat skeletal muscle fibers J GEN PHYSIOL 133 511-524, 2009
DOI:10.1085/jgp.200910191

Tran TA, Gillet L, Roger S, Besson P, White E, Le Guennec JY Non-anti-mitotic concentrations of taxol reduce breast cancer cell invasiveness BIOCHEM BIOPH RES CO 379 304-308, 2009
DOI:10.1016/j.bbrc.2008.12.073

Stones R, Natali A, Billeter R, Harrison S, White E Voluntary exercise-induced changes in beta(2)-adrenoceptor signalling in rat ventricular myocytes EXP PHYSIOL 93 1065-1075, 2008
DOI:10.1113/expphysiol.2008.042598

Shiels HA, White E The Frank-Starling mechanism in vertebrate cardiac myocytes J EXP BIOL 211 2005-2013, 2008
DOI:10.1242/jeb.003145

Calaghan S, Kozera L, White E Compartmentalisation of cAMP-dependent signalling by caveolae in the adult cardiac myocyte J MOL CELL CARDIOL 45 88-92, 2008
DOI:10.1016/j.yjmcc.2008.04.004

Stones R, Gilbert SH, Benoist D, White E Inhomogeneity in the response to mechanical stimulation: Cardiac muscle function and gene expression PROG BIOPHYS MOL BIO 97 268-281, 2008
DOI:10.1016/j.pbiomolbio.2008.02.01

Stones R, Calaghan SC, Billeter R, Harrison SM, White E Transmural variations in gene expression of stretch-modulated proteins in the rat left ventricle PFLUG ARCH EUR J PHY 454 545-549, 2007
DOI:10.1007/s00424-007-0237-z

Bingham AJ, Ooi L, Kozera L, White E, Wood IC The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes MOL CELL BIOL 27 4082-4092, 2007
DOI:10.1128/MCB.00269-07

Shiels H, O'Connell A, Qureshi MA, Howarth FC, White E, Calaghan S Stable microtubules contribute to cardiac dysfunction in the streptozotocin-induced model of type 1 diabetes in the rat MOL CELL BIOCHEM 294 173-180, 2007
DOI:10.1007/s11010-006-9257-9

Shiels HA, Calaghan SC, White E The cellular basis for enhanced volume-modulated cardiac output in fish hearts J GEN PHYSIOL 128 37-44, 2006
DOI:10.1085/jgp.200609543

Calaghan S, White E Caveolae modulate excitation-contraction coupling and beta(2)-adrenergic signalling in adult rat ventricular myocytes CARDIOVASC RES 69 816-824, 2006
DOI:10.1016/j.cardiores.2005.10.006

White E Mechanosensitive channels: Therapeutic targets in the myocardium? CURR PHARM DESIGN 12 3645-3663, 2006

Shiels HA, White E Temporal and spatial properties of cellular Ca2+ flux in trout ventricular myocytes American Journal of Physiology: Regulatory Integrative Comparative Physiology 288 R1756-R1766, 2005
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Stones R, Billeter R, Harrison S, White E Heterogenic contractile response of rat left ventricular myocytes to beta(1)-adrenoceptor stimulation EUR J PHARMACOL 512 117-120, 2005
DOI:10.1016/j.ejphar.2005.02.020

White E Temporal modulation of mechano-electric feedback in cardiac muscle In Cardiac mechano-electric feedback and arrhythmias: from pipette to patient , 2005

Calaghan SC, White E Mechanical modulation of intracellular ion concentrations: Mechanisms and electrical consequences In Mechanosensitivity in Cells and Tissues , 2005

Calaghan SC, White E Activation of Na<sup>+</sup>-H<sup>+</sup>exchange and stretch-activated channels underlies the slow inotropic response to stretch in myocytes and muscle from the rat heart Journal of Physiology 559 205-214, 2004
DOI:10.1113/jphysiol.2004.069021
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McCrossan ZA, Billeter R, White E Transmural changes in size, contractile and electrical properties of SHR left ventricular myocytes during compensated hypertrophy CARDIOVASC RES 63 283-292, 2004
DOI:10.1016/j.cardiores.2004.04.013

Calaghan SC, Le Guennec JY, White E Cytoskeletal modulation of electrical and mechanical activity in cardiac myocytes PROG BIOPHYS MOL BIO 84 29-59, 2004
DOI:10.1016/S0073-6107(03)00057-9

Jude S, Bedut S, Roger S, Pinault M, Champeroux P, White E, Le Guennec JY Peroxidation of docosahexaenoic acid is responsible for its effects on I-TO and I-SS in rat ventricular myocytes BRIT J PHARMACOL 139 816-822, 2003
DOI:10.1038/sj.bjp.0705308

Calaghan SC, Belus A, White E Do stretch-induced changes in intracellular calcium modify the electrical activity of cardiac muscle? PROG BIOPHYS MOL BIO 82 81-95, 2003
DOI:10.1016/S0079-6107(03)00007-5

Miller G, Maycock J, White E, Peckham M, Calaghan S Heterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes. J Physiol 548 167-174, 2003
DOI:10.1113/jphysiol.2002.031922
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Belus A, White E Streptomycin and intracellular calcium modulate the response of single guinea-pig ventricular myocytes to axial stretch. J Physiol 546 501-509, 2003
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Howarth FC, Qureshi MA, White E Effects of hyperosmotic shrinking on ventricular myocyte shortening and intracellular Ca2+ in streptozotocin-induced diabetic rats PFLUG ARCH EUR J PHY 444 446-451, 2002
DOI:10.1007/s00424-002-0830-0

Natali AJ, Wilson LA, Peckham M, Turner DL, Harrison SM, White E Different regional effects of voluntary exercise on the mechanical and electrical properties of rat ventricular myocytes Journal of Physiology 541 863-875, 2002
DOI:10.1113/jphysiol.2001.013415

Belus A, White E Effects of streptomycin sulphate on ICaL, IKr and IKs in guinea-pig ventricular myocytes. European Journal of Pharmacology 445 171-178, 2002
DOI:10.1016/S0014-2999(02)01791-0

Howarth FC, Qureshi MA, White E, Calaghan SC Cardiac microtubules are more resistant to chemical depolymerisation in streptozotocin-induced diabetes in the rat. Pflugers Archiv: European Journal of Physiology 444 423-437, 2002

Calaghan SC, Le Guennec JY, White E Modulation of Ca<sup>2+</sup>signalling by microtubule disruption in rat ventricular myocytes and its dependence on the ruptured patch-clamp configuration Circulation Research 88 32-37, 2001

Natali AJ, Turner DL, Harrison SM, White E Regional effects of voluntary exercise on cell size and contraction-frequency responses in rat cardiac myocytes J EXP BIOL 204 1191-1199, 2001

Belus A, White E Effects of antibiotics on the contractility and Ca2+ transients of rat cardiac myocytes European Journal of Pharmacology 412 121-126, 2001
DOI:10.1016/S0014-2999(01)00717-8
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Calaghan SC, White E Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle. Pflugers Arch 441 514-520, 2001
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Calaghan SC, White E, Le Guennec JY A unifying mechanism for the role of microtubules in the regulation of [Ca2+]i and contraction in cardiac myocytes Circulation Research 89 e31-, 2001

Calaghan SC, Trinick J, Knight PJ, White E A role for C-protein in the regulation of contraction and intracellular Ca2+ in intact rat ventricular myocytes JOURNAL OF PHYSIOLOGY-LONDON 528 151-156, 2000
DOI:10.1111/j.1469-7793.2000.00151.x

Hongo K, Brette FP, Haroon MM, White E Mechanisms associated with the negative inotropic effect of D20 in single rat ventricular myocytes Experimental Physiology 85 133-142, 2000

Cazorla O, Le Guennec JY, White E Regional differences in the length-tension relationship of single centricular myocytes from rate and ferret hearts Journal of Molecular and Cellular Cardiology 32 735-744, 2000

Calaghan SC, White E, Bedut S, Le Guennec JY Cytochalasin D reduces Ca2+ sensitivity and maximum tension via interactions with myofilaments in rat skinned cardiac myocytes Journal of Physiology 529 405-411, 2000

Harwood C, Howarth FC, Altringham JD, White E Rate dependent changes in cell shortening, intracellular calcium and membrane potential in single, isolated rainbow trout (Oncorhynchus mykiss) ventricular myocytes Journal of Experimental Biology 203 493-504, 2000

Kohl P, Le Guennec JY, White E The relationship of diastolic function and electrophysiology Cardiology Clinics 18 1010-1015, 2000

Brette FP, Calaghan SC, Lappin S, White E, Colyer J, Le Guennec JY Biphasic effects of hypo-osmotic challenge on excitation-contraction coupling in rat ventricular myocytes American Journal of Physiology 279 1963-1971, 2000

Calaghan SC, Colyer J, White E Cyclic AMP but not phosphorylation of phospholamban increase during the slow response to stretch in ferret papillary muscle. Pflugers Archiv: European Journal of Physiology 437 780-782, 1999

Calaghan SC, White E The role of calcium in the response of cardiac muscle to stretch Progress in Biophysics&Molecular Biology 71 59-90, 1999

Howarth FC, Calaghan SC, Boyett MR, White E Effect of the microtubule polymerizing agent taxol on contraction, Ca2+ transients and L-type Ca2+ current in single rat ventricular myocytes. Journal of Physiology 516 409-419, 1999

Howarth FC, Boyett MR, White E Rapid effects of cytochalasin-D on contraction and intracellular calcium in single rat ventricular myocytes. Pflugers Archiv: European Journal of Physiology 436 804-806, 1998

Pascarel C, Hongo K, Cazorla O, Gannier F, White E, Le Guennec JY Different effects of gadolinium on 1KR, 1KS and 1KI in guinea-pig isolated ventricular myocytes British Journal of Pharmacology 124 356-360, 1998

Calaghan SC, White E, Colyer J Co-ordinated changes in cAMP, phosphorylation of phospholamban, Ca2+, and contraction following beta-adrenergic stimulation of rat heart. Pflugers Archiv: European Journal of Physiology 436 948-956, 1998

Calaghan SC, White E, Colyer J Preservation of the in vivo phosphorylation status of phospholamban in the heart: Evidence for an in situ difference in the dephosphorylation of phospholamban Biochemical and Biophysical Research Communications 248 701-705, 1998

Pascarel C, Cazorla O, Le Guennec JY, Orchard CH, White E The effect of the venom of a Chilean tarantua "Phrixotrichus spatulatus" on isolated guinea-pig ventricular myocytes. Toxicology and Applied Pharmacology 147 363-371, 1997

Hongo K, Pascarel C, Cazorla O, Gannier F, Le Guennec JY, White E Gadolinium blocks the delayed rectifier potassium current in isolated guinea-pig ventricular myocytes Experimental Physiology 82 647-656, 1997

Gannier F, White E, Garnier D, Le Guennec JY A possible mechanism for large stretch-induced increases in [Ca2+]i in isolated guinea-pig ventricular myocytes Cardiovascular Research 32 158-167, 1996

Hongo K, White E, Le Guennec JY, Orchard CH Changes in [Ca2+]i, [Na+]i and Ca2+ current in isolated rat ventricular myocytes following an increase in cell length. Journal of Physiology 491.3 609-619, 1996

White E Length-dependent mechanisms in single cardiac myocytes Experimental Physiology 81 885-897, 1996

Hongo K, White E, Orchard CH Effect of stretch on contraction and the Ca2+ transient in ferret ventricular muscles during hypoxia and acidosis. Am J Physiol 269 C690-C697, 1995
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Hongo K, White E, Orchard CH The effect of mechanical loading on the response of rat ventricular myocytes to acidosis. Exp Physiol 80 701-712, 1995
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Mustafa MR, White E, Hongo K, Othman I, Orchard CH The mechanism underlying the cardiotoxic effect of the toxin from the jellyfish Chironex fleckeri. Toxicol Appl Pharmacol 133 196-206, 1995
DOI:10.1006/taap.1995.1142
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ORCHARD CH, MUSTAFA MR, WHITE E OSCILLATIONS AND WAVES OF INTRACELLULAR [CA2+] IN CARDIAC-MUSCLE-CELLS CHAOS SOLITON FRACT 5 447-458, 1995

White E, Boyett MR, Orchard CH The effects of mechanical loading and changes of length on single guinea-pig ventricular myocytes. J Physiol 482 ( Pt 1) 93-107, 1995
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Shah N, Than N, White E, Bennett KL, Orchard CH The role of the sarcoplasmic reticulum in the response of isolated ferret cardiac muscle to beta-adrenergic stimulation. Exp Physiol 79 929-941, 1994
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Gannier F, White E, Lacampagne A, Garnier D, Le Guennec JY Streptomycin reverses a large stretch induced increases in [Ca2+]i in isolated guinea pig ventricular myocytes. Cardiovasc Res 28 1193-1198, 1994
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Ward H, White E Reduction in the contraction and intracellular calcium transient of single rat ventricular myocytes by gadolinium and the attenuation of these effects by extracellular NaH2PO4. Exp Physiol 79 107-110, 1994
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White E, Connors SP, Gill EW, Terrar DA The positive inotropic effect of compound II, a novel analogue of sotalol, on guinea-pig papillary muscles and single ventricular myocytes. Br J Pharmacol 110 95-98, 1993
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Cannings I, Harrison S, White E, Boyett M The effect of a range of alcohols on the contraction of guinea-pig ventricular myocytes. Eur J Pharmacol 248 213-216, 1993
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White E, Le Guennec JY, Nigretto JM, Gannier F, Argibay JA, Garnier D The effects of increasing cell length on auxotonic contractions; membrane potential and intracellular calcium transients in single guinea-pig ventricular myocytes. Exp Physiol 78 65-78, 1993
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White E, Terrar DA Inactivation of Ca current during the action potential in guinea-pig ventricular myocytes. Exp Physiol 77 153-164, 1992
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Le Guennec JY, White E, Gannier F, Argibay JA, Garnier D Stretch-induced increase of resting intracellular calcium concentration in single guinea-pig ventricular myocytes. Exp Physiol 76 975-978, 1991
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White E, Terrar DA Action potential duration and the inotropic response to reduced extracellular potassium in guinea-pig ventricular myocytes. Exp Physiol 76 705-716, 1991
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Bonnet P, Argibay JA, White E, Garnier D Differences in the hypoxic contraction of small isolated pulmonary arteries of cat and rabbit. J Comp Physiol B 161 543-547, 1991
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White E, Terrar DA The effects of ryanodine and caffeine on Ca-activated current in guinea-pig ventricular myocytes. Br J Pharmacol 101 399-405, 1990
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White E, Terrar DA The action of strophanthidin on calcium-activated current and contraction in single guinea-pig ventricular myocytes. Exp Physiol 75 559-572, 1990
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Terrar DA, White E Changes in cytosolic calcium monitored by inward currents during action potentials in guinea-pig ventricular cells. Proc R Soc Lond B Biol Sci 238 171-188, 1989
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Terrar DA, White E Mechanism of potentiation of contraction by depolarization during action potentials in guinea-pig ventricular muscle. Q J Exp Physiol 74 355-358, 1989
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Terrar DA, White E Mechanisms and significance of calcium entry at positive membrane potentials in guinea-pig ventricular muscle cells. Q J Exp Physiol 74 121-139, 1989
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