Faculty of Biological Sciences

Dr Andrew Tuplin

BSc, PhD 2004, Edinburgh
Lecturer in Molecular and Cellular Biology
School of Molecular and Cellular Biology

Contact:  Garstang 8.58, email address for  

You can read more about Dr Tuplin's interests here:
http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=AKT

Research Interests

Control of replication and translation in positive-strand RNA viruses.

Research in my group is focused on investigating how RNA viruses (particularly arboviruses) control  replication and translation of their genomes. Specifically, interactions between viral RNA structures, host cell proteins and non-coding RNA, and the potential of such interactions as novel therapeutic targets.

We predominantly work on flaviviruses (Dengue and Zika virus) and Chikungunya virus. 

  • Dengue, Zika and chikungunya viruses are mosquito transmited arboviruses and significant human pathogens.
  • Their genomes encode  RNA structures essential for replication in vertebrate and invertebrate host cells.
  • No vaccine or specific antiviral therapy is available for  dengue, zika or chikungunya virus.
  • The geographic range off all three viruses is increasing.

 

Our research is funded by the MRC, BBSRC and The Royal Society.

 

Current Projects

   

1:  Interactions and functional mechanisms of arbovirus RNA genome structures:

Comparing...   

  • Vertebrate and invertebrate hosts.
  • Alternative cellular compartments.
  • Different points of the virus life cycle.

In order to...

  • Dissect the structure, function and mechanisms by which dynamic RNA structures within viral genomes interact to control essential aspects of the virus life cycle. 
  • Investigate the potential of viral RNA structures or their interacting partners as novel antiviral therapeutic targets.

 

2:  The role of host ion channels during chikungunya virus genome replication:

 

3:  Recognition and targeting of specific viral RNA structures within the intracellular environment:

 

PhD opportunities: 

 

Self-funded or scholarship students:

APPLICATIONS ACCEPTED YEAR ROUND.

I actively encourage and support applications from International self-funded or scholarship/fellowship PhD or MSc students. International students must have a good command of both written and spoken English. Applications can be made throughout the year.

For further information, including international studentship fees and bench costs see the following links:

http://www.findaphd.com/search/ProjectDetails.aspx?PJID=49356&LID=735 

http://www.fbs.leeds.ac.uk/gradschool/research/index.php?tab=1

 

 

Faculty Research and Innovation



Studentship information

Undergraduate project topics:

  • Elucidate the structure and interactions of dynamic RNA structural elements within virus genomes.
  • Dissect the function and mechanisms by which RNA/protein interactions control essential aspects of the virus life cycle.
  • Investigate the potential of RNA elements as novel antiviral therapeutic targets using structure led inhibitor design.

Postgraduate studentship areas:

  • Elucidate the structure and interactions of dynamic RNA structural elements within virus genomes.
  • Dissect the function and mechanisms by which RNA/protein interactions control essential aspects of the virus life cycle.
  • Investigate the potential of RNA elements as novel antiviral therapeutic targets using structure led inhibitor design.
  • The role of host ion channels during chikungunya virus genome replication.

See also:

Modules managed

BIOL1305 - Integrated Skills in Biosciences 1

Modules taught

BIOC3160 - Laboratory/Literature/Computing Research Project
BIOC3900 - Cancer Biology
BIOL1302/1303/MICR1320 - Intro skills - Biological Science and Microbiology
BIOL1305 - Integrated Skills in Biosciences 1
BIOL3398 - Research Tools and Applications
BIOL5294M - MSc Bioscience Research Project Proposal
BIOL5392M - Bioscience MSc Research Project
BLGY1124/1128 - The Diversity of Life/Living Planet
BLGY1128 - Living Planet
MICR2121 - Molecular Virology
MICR2320/MICR3343 - Skills for Microbiology i
MICR3110 - Medical Microbiology Research Project
MICR3211/BIOL3210 A - ATU - emerging infections
MICR3343 - Skills for Microbiology in Relation to Medicine
MICR3370 - Microbiology with Virology Research Project

Centre membership: The Astbury Centre for Structural Molecular Biology

Group Leader Dr Andrew Tuplin  (Lecturer in Molecular and Cellular Biology)

Control of replication and translation in positive-strand RNA viruses. 

Miss Henna Khalid  (Technician )

Dr Marietta Müller  (Research Fellow)


Postgraduates

Lauren Branfield (Primary supervisor) 34% FTE
Catherine Kendall (Primary supervisor) 65% FTE
Oliver Prosser (Primary supervisor) 50% FTE
Yanni Gao (Co-supervisor) 50% FTE
Raymond Li (Co-supervisor) 50% FTE