Faculty of Biological Sciences

Prof John Trinick

BSc Physics 1968, PhD Biochemistry 1973, Leicester.
Professor of Animal Cell Biology
School of Molecular and Cellular Biology

Contact:  Astbury 8.112, +44(0) 113 34 34350, email address for  

You can read more about Prof Trinick's interests here:
www.astbury.leeds.ac.uk/People/staffpage.php?StaffID=JT
www.contractility.org

Research Interests

Muscle structure, molecular motors, bioelasticity, giant proteins, cryo-electron microscopy

Movement is a defining feature of life and in humans skeletal and heart muscles form nearly half the weight of the body. It has been known for >50 years that muscle contracts as a result of relative sliding of thick and thin filaments composed mainly of myosin and actin. This results in shortening of the basic contractile unit, the sarcomere. Although much is known about myosin, actin and other sarcomere proteins in isolated, pure form, none of the major sarcomere structural elements (thick or thin filament, M- or Z-line) has been fully defined in molecular detail, which is a major impediment to understanding muscle action, also growth and wasting.

In addition to their fundamental importance in biology, many diseases originate in sarcomeres, particularly inherited diseases of the heart, whose mechanisms are poorly understood. Sarcomeres are assembled with extraordinary precision yet their proteins last only a few weeks and must constantly be replaced. Precise assembly and regeneration while maintaining activity is especially striking in the heart, which beats ~100,000x/day. We are therefore working to understand sarcomere structure and mechanisms in greater detail.

One of our interests is titin, which is the third most abundant  protein of muscle and gives sarcomeres their passive elasticity. Titin is formed from the largest polypetide yet found in nature, with isoforms up to ~3.8 MDa and >30,000 amino acids. Titin molecules are  >1 micron long and span between the M- and Z-lines. In the A-band we have proposed that titin regulates precise assembly of thick filaments, which contain exactly 294 myosin molecules. It has recently become clear that mutations in titin are the commonest cause of the heart disease dilated cardiomyopathy (DCM), which affects about 1 in 250 people and is a major cause of death. These mutations are mainly found in the A-band part of titin which binds myosin. I-band titin elastically connects thick filaments to the Z-line; these connections centre thick filaments between Z-discs and ensure that balanced forces are developed by myosin in opposing thick filament halves.

sarcomere diagram

Myosin and actin also form motile systems in many other cells than muscle, although the movements produced can only be seen under a microscope. These other systems are mainly active transport mechanisms that have evolved because passive transport by diffusion would be too slow. Nearly 50 highly divergent non-muscle myosin classes have now been identified from gene sequencing and most cells in the body make several at any one time; most however are otherwise still uncharacterised. We have studied myosins I, II, V, VI and XVIII. Myosin V, for instance, is 0.3% of brain protein and transports a variety of chemical cargoes in vesicles throughout the body. Myosin VI is involved in hearing, balance and cancer metastasis; remarkably, it walks backwards along actin filaments from all other classes so far studied.

We use a wide variety of biophysical techniques but specialise in electron microscopy, which allows us to observe directly protein shapes and how these change to make motile mechanisms. We use stained and dried specimens at room temperature and cryo-electron microscopy of frozen-hydrated specimens at ~-180°C.  Most proteins do not function independently but as parts of larger complexes. Electron microscopy is a powerful method for studying such complexes, which usually cannot be crystallised for X-ray diffraction. Recently, cryo-EM has improved substantially and many large complexes are now being solved to atomic or near-atomic resolution. Ultra-fast freezing (~10,000,000°C/sec) used in cryo-EM also facilitates time-resolved studies of mechanism, which is a method we have helped develop.

 

Faculty Research and Innovation



Studentship information

Undergraduate project topics:

  • Better methods for studying sarcomere structure

Postgraduate studentship areas:

  • Roles of the giant protein titin in muscle assembly and elasticity.
  • High resolution structural studies of molecules of the myosin superfamily by electron microscopy and image processing.
  • Studies of isolated Z-discs
  • Electron microscopy of intact sarcomeres
  • Electron microscopy of large protein complexes, including cryo- and time-resolved EM

See also:

Committees

Member of Graduate School Committee (Panel for Potential Chairs for Appeals Group)

Group Leader Prof John Trinick  (Professor of Animal Cell Biology)

Muscle structure, molecular motors, bioelasticity, giant proteins, cryo-electron microscopy

 

Dr Charlotte Scarff  (Research Fellow)

Dr Larissa Tskhovrebova  (Visiting Research Scientist)


Tskhovrebova L, Trinick J Titin and Nebulin in thick and thin filament length regulation In Fibrous Proteins: Structures and Mechanisms , 2017
DOI:10.1007/978-3-319-49674-0_10
View abstract

Tskhovrebova L, Bennett P, Gautel M, Trinick J Titin ruler hypothesis not refuted Proceedings of the National Academy of Sciences of the United States of America 112 E1172-, 2015
DOI:10.1073/pnas.1422326112

Rawson S, Phillips C, Huss M, Tiburcy F, Wieczorek H, Trinick J, Harrison MA, Muench SP Structure of the vacuolar H<sup>+</sup>-ATPase rotary motor reveals new mechanistic insights Structure 23 461-471, 2015
DOI:10.1016/j.str.2014.12.016
View abstract

Rusu M, Taylor D, Taylor K, Trinick J Cryo-Electron Tomography and Sub-Tomogram Averaging of Isolated Z-Discs from Honeybee Flight Muscle, 2015

Czajlik A, Thompson GS, Khan GN, Kalverda AP, Homans SW, Trinick J ¹H, ¹⁵N, and ¹³C backbone chemical shift assignment of titin domains A59-A60 and A60 alone Biomolecular NMR assignments 8 429-433, 2014
DOI:10.1007/s12104-013-9532-0

Muench SP, Rawson S, Eyraud V, Delmas AF, Da Silva P, Phillips C, Trinick J, Harrison MA, Gressent F, Huss M PA1b inhibitor binding to subunits c and e of the vacuolar ATPase reveals its insecticidal mechanism. J Biol Chem 289 16399-16408, 2014
DOI:10.1074/jbc.M113.541250
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Jiao Y, Walker M, Trinick J, Pernier J, Montaville P, Carlier M-F Mutagenetic and Electron Microscopy Analysis of Actin Filament Severing by Cordon-Bleu, a WH2 Domain Protein CYTOSKELETON 71 170-183, 2014
DOI:10.1002/cm.21161

Yang S, Barbu-Tudoran L, Orzechowski M, Craig R, Trinick J, White H, Lehman W Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state. Biophysical Journal 106 855-864, 2014
DOI:10.1016/j.bpj.2014.01.007
View abstract

Czajlik A, Thompson GS, Khan G, Kalverda AP, Homans SW, Trinick J (1)H, (15)N and (13)C backbone chemical shift assignment of titin domains A59-A60 and A60 alone Biomolecular NMR Assignments 8 429-433, 2014
DOI:10.1007/s12104-013-9532-0
View abstract

Muench SP, Scheres SHW, Huss M, Phillips C, Vitavska O, Wieczorek H, Trinick J, Harrison MA Subunit Positioning and Stator Filament Stiffness in Regulation and Power Transmission in the V-1 Motor of the Manduca sexta V-ATPase JOURNAL OF MOLECULAR BIOLOGY 426 286-300, 2014
DOI:10.1016/j.jmb.2013.09.018

Song CF, Papachristos K, Rawson S, Huss M, Wieczorek H, Paci E, Trinick J, Harrison MA, Muench SP Flexibility within the Rotor and Stators of the Vacuolar H+-ATPase PLOS ONE 8 -, 2013
DOI:10.1371/journal.pone.0082207

Tskhovrebova L, Trinick J Molecular rulers? Curr Biol 22 R317-R318, 2012
DOI:10.1016/j.cub.2012.02.049

Czajlik A, Thompson GS, Khan GN, Kalverda AP, Homans SW, Trinick J ¹H, ¹⁵N and ¹³C backbone chemical shift assignment of the titin A67-A68 domain tandem. Biomol NMR Assign 6 39-41, 2012
DOI:10.1007/s12104-011-9321-6
View abstract

Tskhovrebova L, Trinick J Making muscle elastic: the structural basis of myomesin stretching. PLoS Biol 10 e1001264-, 2012
DOI:10.1371/journal.pbio.1001264
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Kennaway CK, Taylor JE, Song CF, Potrzebowski W, Nicholson W, White JH, Swiderska A, Obarska-Kosinska A, Callow P, Cooper LP, Roberts GA, Artero J-B, Bujnicki JM, Trinick J, Kneale GG, Dryden DTF Structure and operation of the DNA-translocating type I DNA restriction enzymes. Genes Dev 26 92-104, 2012
DOI:10.1101/gad.179085.111
View abstract

Muench SP, Trinick J, Harrison MA Structural divergence of the rotary ATPases Q REV BIOPHYS 44 311-356, 2011
DOI:10.1017/S0033583510000338

Nicholson WV, White H, Trinick J An approach to automated acquisition of cryoEM images from lacey carbon grids J STRUCT BIOL 172 395-399, 2010
DOI:10.1016/j.jsb.2010.08.014

Song CF, Sader K, White H, Kendrick-Jones J, Trinick J Nucleotide-Dependent Shape Changes in the Reverse Direction Motor, Myosin VI BIOPHYS J 99 3336-3344, 2010
DOI:10.1016/j.bpj.2010.09.014

Tskhovrebova L, Walker ML, Grossmann JG, Khan GN, Baron A, Trinick J Shape and Flexibility in the Titin 11-Domain Super-Repeat J MOL BIOL 397 1092-1105, 2010
DOI:10.1016/j.jmb.2010.01.073

Oke OA, Burgess SA, Forgacs E, Knight PJ, Sakamoto T, Sellers JR, White H, Trinick J Influence of lever structure on myosin 5a walking P NATL ACAD SCI USA 107 2509-2514, 2010
DOI:10.1073/pnas.0906907107

Tskhovrebova L, Trinick J Roles of Titin in the Structure and Elasticity of the Sarcomere JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY -, 2010
DOI:10.1155/2010/612482

Tassieri M, Waigh TA, Trinick J, Aggeli A, Evans RML Analysis of the linear viscoelasticity of polyelectrolytes by magnetic microrheometry-Pulsed creep experiments and the one particle response J RHEOL 54 117-131, 2010
DOI:10.1122/1.3266946

Sader K, Studer D, Zuber B, Gnaegi H, Trinick J Preservation of high resolution protein structure by cryo-electron microscopy of vitreous sections ULTRAMICROSCOPY 110 43-47, 2009
DOI:10.1016/j.ultramic.2009.09.004

Pan YH, Sader K, Powell JJ, Bleloch A, Gass M, Trinick J, Warley A, Li A, Brydson R, Brown A 3D morphology of the human hepatic ferritin mineral core: New evidence for a subunit structure revealed by single particle analysis of HAADF-STEM images J STRUCT BIOL 166 22-31, 2009
DOI:10.1016/j.jsb.2008.12.001

Muench SP, Huss M, Song CF, Phillips C, Wieczorek H, Trinick J, Harrison MA Cryo-electron Microscopy of the Vacuolar ATPase Motor Reveals its Mechanical and Regulatory Complexity J MOL BIOL 386 989-999, 2009
DOI:10.1016/j.jmb.2009.01.014

Tskhovrebova L, Trinick J Giant Proteins: Sensing Tension with Titin Kinase CURR BIOL 18 R1141-R1142, 2008
DOI:10.1016/j.cub.2008.10.035

Houmeida A, Baron A, Keen J, Khan GN, Knight PJ, Stafford WF, Thirumurugan K, Thompson B, Tskhovrebova L, Trinick J Evidence for the Oligomeric State of 'Elastic' Titin in Muscle Sarcomeres J MOL BIOL 384 299-312, 2008
DOI:10.1016/j.jmb.2008.09.030

Tassieri M, Evans RML, Barbu-Tudoran L, Khaname GN, Trinick J, Waigh TA Dynamics of Semiflexible Polymer Solutions in the Highly Entangled Regime PHYSICAL REVIEW LETTERS 101 -, 2008
DOI:10.1103/PhysRevLett.101.198301

Tassieri M, Evans RML, Barbu-Tudoran L, Trinick J, Waigh TA The self-assembly, elasticity, and dynamics of cardiac thin filaments BIOPHYS J 94 2170-2178, 2008
DOI:10.1529/biophysj.107.116087

Lukoyanova N, Baldwin SA, Trinick J 3D reconstruction of mammalian septin filaments J MOL BIOL 376 1-7, 2008
DOI:10.1016/j.jmb.2007.11.029

Sader K, Reedy M, Popp D, Lucaveche C, Trinick J Measuring the resolution of uncompressed plastic sections cut using an oscillating knife ultramicrotome J STRUCT BIOL 159 29-35, 2007
DOI:10.1016/j.jsb.2007.01.019

Pan Y, Brown AP, Sader K, Trinick J, Brydson R, Bleloch A, Gass M Aberration corrected scanning TEM applied to biological specimens MICROSC MICROANAL 13 132-133, 2007
DOI:10.1017/S1431927607072595

Di Cola E, Waigh TA, Trinick J, Tskhovrebova L, Houmeida A, Pyckhout-Hintzen W, Dewhurst C Persistence length of titin from rabbit skeletal muscles measured with scattering and microrheology techniques BIOPHYS J 88 4095-4106, 2005
DOI:10.1529/biophysj.104.054908

Tskhovrebova L, Trinick J Muscle disease: a giant feels the strain NAT MED 11 478-479, 2005
DOI:10.1038/nm0505-478

Stafford WF, Walker ML, Trinick JA, Coluccio LM Mammalian class I myosin, Myo1b, is monomeric and cross-links actin filaments as determined by hydrodynamic studies and electron microscopy BIOPHYS J 88 384-391, 2005
DOI:10.1529/biophysj.104.045245

Tskhovrebova L, Houmeida A, Trinick J Can the passive elasticity of muscle be explained directly from the mechanics of individual titin molecules? J Muscle Res Cell Motil 26 285-289, 2005
DOI:10.1007/s10974-005-9034-5
View abstract

Roberts R, Lister I, Schmitz S, Walker M, Veigel C, Trinick J, Buss F, Kendrick-Jones J Myosin VI: cellular functions and motor properties Philosophical transactions of the Royal Society of London. B: Biological Sciences 359 1931-1944, 2004
DOI:10.1098/rstb.2004.1563
View abstract

Tskhovrebova L, Trinick J Properties of titin immunoglobulin and fibronectin-3 domains. J Biol Chem 279 46351-46354, 2004
DOI:10.1074/jbc.R400023200

Lister I, Roberts R, Schmitz S, Walker M, Trinick J, Veigel C, Buss F, Kendrick-Jones J Myosin VI: a multifunctional motor. Biochem Soc Trans 32 685-688, 2004
DOI:10.1042/BST0320685
View abstract

Burgess SA, Walker ML, Thirumurugan K, Trinick J, Knight PJ Use of negative stain and single-particle image processing to explore dynamic properties of flexible macromolecules J STRUCT BIOL 147 247-258, 2004
DOI:10.1016/j.jsb.2004.04.004

Burgess S, Walker M, Knight PJ, Sparrow J, Schmitz S, Offer G, Bullard B, Leonard K, Holt J, Trinick J Structural studies of arthrin: monoubiquitinated actin. J Mol Biol 341 1161-1173, 2004
DOI:10.1016/j.jmb.2004.06.077
View abstract

Lister I, Schmitz S, Walker M, Trinick J, Buss F, Veigel C, Kendrick-Jones J A monomeric myosin VI with a large working stroke. EMBO J 23 1729-1738, 2004
DOI:10.1038/sj.emboj.7600180
View abstract

Trinick J Professor Koscak Maruyama (1930-2003) - Obituary J MUSCLE RES CELL M 25 283-283, 2004

Mutungi G, Trinick J, Ranatunga KW Resting tension characteristics in differentiating intact rat fast- and slow-twitch muscle fibers. J Appl Physiol (1985) 95 2241-2247, 2003
DOI:10.1152/japplphysiol.00990.2002
View abstract

Tskhovrebova L, Trinick J Titin: Properties and family relationships NAT REV MOL CELL BIO 4 679-689, 2003
DOI:10.1038/nrm1198

Harrison M, Durose L, Song CF, Barratt E, Trinick J, Jones R, Findlay JBC Structure and function of the vacuolar H+-ATPase: moving from low-resolution models to high-resolution structures. J Bioenerg Biomembr 35 337-345, 2003
View abstract

White HD, Thirumurugan K, Walker ML, Trinick J A Second Generation Apparatus for Time-Resolved Electron Cryo-microscopy using Stepper Motors and Electrospray. Journal of Structural Biology 144 246-252, 2003
DOI:10.1016/j.jsb.2003.09.027

Trinick J, Tskhovrebova LA Giant protein titin: structural and functional aspects In Elastomeric Proteins , 2003

Burgess S, Walker M, Wang F, Sellers JR, White HD, Knight PJ, Trinick J The prepower stroke conformation of myosin V. J Cell Biol 159 983-991, 2002
DOI:10.1083/jcb.200208172
View abstract

Brockwell DJ, Beddard GS, Clarkson J, Zinober RC, Blake AW, Trinick J, Olmsted PD, Smith DAM, Radford SE The Effect of Core Destabilization on the Mechanical Resistance of I27 Biophysical Journal 83 458-472, 2002

Tskhovrebova L, Trinick J Role of titin in vertebrate striated muscle PHILOS T R SOC B 357 199-206, 2002
DOI:10.1098/rstb.2001.1028

Burgess S, Walker ML, Wang F, Sellers JR, Knight PJ, Trinick J The pre-power stroke conformation of myosin V., 2002

Tskhovrebova L, Trinick J Flexibility and extensibility in the titin molecule: Analysis of electron microscope data J MOL BIOL 310 755-771, 2001

Liversage AD, Holmes D, Knight PJ, Tskhovrebova L, Trinick J Titin and the sarcomere symmetry paradox J MOL BIOL 305 401-409, 2001
DOI:10.1006/jmbi.2000.4279

Tskhovrebova L, Trinick J Extensibility in the titin molecule and its relation to muscle elasticity, 2000
View abstract

Walker ML, Burgess S, Sellers JR, Wang F, Hammer JA, Trinick J, Knight PJ Two-headed binding of a processive myosin to F-actin Nature 405 804-807, 2000

Tskhovrebova LA, Trinick J Extensibility in the titin molecule and its relation to muscle elasticity Advances in Experimental Medicine and Biology 481 163-178, 2000
View abstract

Calaghan SC, Trinick J, Knight PJ, White E A role for C-protein in the regulation of contraction and intracellular Ca2+ in intact rat ventricular myocytes. Journal of Physiology 528 151-156, 2000

Trinick J, Tskhovrebova L Titin: a molecular control freak. Trends in Cell Biology 9 377-380, 1999

Walker M, Zhang XZ, Jiang W, Trinick J, White HD Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: Evidence that the start of the crossbridge power stroke in muscle has variable geometry. Proceedings of the National Academy of Sciences of the United States of America 96 465-470, 1999

Trinick J A computer controlled spray-freezing apparatus for a millisecond time-resolution electron cryo-microscopy Journal of Structural Biology 121 306-313, 1998

Tskhovrebova LA, Trinick J Direct visualisation of extensibility in isolated titin molecules Journal of Molecular Biology 265 100-106, 1997

Tskhovrebova LA, Trinick J, Sleep JA, Simmons RM Elasticity and unfolding of single molecules of the giant muscle protein titin. Nature 387 308-312, 1997

Burgess S, Walker ML, White HD, Trinick J Flexibility within Myosin Heads Revealed by Negative Stain and Single-particle Analysis. Journal of Cell Biology 139 675-681, 1997

Hallett P, Tskhovrebova LA, Trinick J, Offer G, Miles MJ Improvements in atomic force microscopy protocols for imaging fibrous proteins Journal of Vacuum Science and Technology 14 1444-1448, 1996
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Trinick J Titin as a scaffold and spring. Cytoskeleton. Curr Biol 6 258-260, 1996
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Trinick J Interaction of titin/connectin with the thick filament. Adv Biophys 33 81-90, 1996

Houmeida A, Holt J, Tskhovrebova L, Trinick J Studies of the interaction between titin and myosin. J Cell Biol 131 1471-1481, 1995
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Walker M, Trinick J, White H Millisecond time resolution electron cryo-microscopy of the M-ATP transient kinetic state of the acto-myosin ATPase. Biophys J 68 87S-91S, 1995
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Trinick J Titin and nebulin: protein rulers in muscle? Trends Biochem Sci 19 405-409, 1994
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Walker M, White H, Belknap B, Trinick J Electron cryomicroscopy of acto-myosin-S1 during steady-state ATP hydrolysis. Biophys J 66 1563-1572, 1994
DOI:10.1016/S0006-3495(94)80948-8
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Soteriou A, Clarke A, Martin S, Trinick J Titin folding energy and elasticity. Proc Biol Sci 254 83-86, 1993
DOI:10.1098/rspb.1993.0130
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Soteriou A, Gamage M, Trinick J A survey of interactions made by the giant protein titin. J Cell Sci 104 ( Pt 1) 119-123, 1993
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Trinick J Understanding the functions of titin and nebulin. FEBS Lett 307 44-48, 1992
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LABEIT S, GAUTEL M, LAKEY A, TRINICK J TOWARDS A MOLECULAR UNDERSTANDING OF TITIN EMBO J 11 1711-1716, 1992

Trinick J Molecular rulers in muscle? Curr Biol 2 75-77, 1992

LABEIT S, GIBSON T, LAKEY A, LEONARD K, ZEVIANI M, KNIGHT P, WARDALE J, TRINICK J EVIDENCE THAT NEBULIN IS A PROTEIN-RULER IN MUSCLE THIN-FILAMENTS FEBS LETT 282 313-316, 1991

Trinick J Elastic filaments and giant proteins in muscle. Curr Opin Cell Biol 3 112-119, 1991
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WALKER M, KNIGHT P, TRINICK J PROPERTIES OF THE MYOSIN MOLECULE REVEALED BY NEGATIVE STAINING MICRON MICROSC ACTA 22 413-422, 1991

Trinick J, Cooper J Concentration of solutes during preparation of aqueous suspensions for cryo-electron microscopy. J Microsc 159 215-222, 1990
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LABEIT S, BARLOW DP, GAUTEL M, GIBSON T, HOLT J, HSIEH CL, FRANCKE U, LEONARD K, WARDALE J, WHITING A, TRINICK J A REGULAR PATTERN OF 2 TYPES OF 100-RESIDUE MOTIF IN THE SEQUENCE OF TITIN NATURE 345 273-276, 1990

Walker M, Trinick J Electron microscopy of negatively stained scallop myosin molecules. Effect of regulatory light chain removal on head structure. J Mol Biol 208 469-475, 1989
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Whiting A, Wardale J, Trinick J Does titin regulate the length of muscle thick filaments? J Mol Biol 205 263-268, 1989
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Walker M, Trinick J Visualization of domains in native and nucleotide-trapped myosin heads by negative staining. J Muscle Res Cell Motil 9 359-366, 1988
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Offer G, Starr R, Trinick J Phosphofructokinase: a component of the thick filament? Adv Exp Med Biol 226 61-73, 1988
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TRINICK J, BERRIMAN J ZERO-LOSS ELECTRON-MICROSCOPY WITH THE ZEISS EM902 ULTRAMICROSCOPY 21 393-397, 1987

WALKER M, TRINICK J ELECTRON-MICROSCOPE STUDY OF THE EFFECT OF TEMPERATURE ON THE LENGTH OF THE TAIL OF THE MYOSIN MOLECULE J MOL BIOL 192 661-667, 1986

CRAIG R, TRINICK J, KNIGHT P DISCREPANCIES IN LENGTH OF MYOSIN HEAD NATURE 320 688-688, 1986

TRINICK J, COOPER J, SEYMOUR J, EGELMAN EH CRYOELECTRON MICROSCOPY AND 3-DIMENSIONAL RECONSTRUCTION OF ACTIN-FILAMENTS J MICROSC-OXFORD 141 349-360, 1986

WALKER M, KNIGHT P, TRINICK J NEGATIVE STAINING OF MYOSIN MOLECULES J MOL BIOL 184 535-542, 1985

TRINICK J, KNIGHT P, WHITING A PURIFICATION AND PROPERTIES OF NATIVE TITIN J MOL BIOL 180 331-356, 1984

KNIGHT P, TRINICK J STRUCTURE OF THE MYOSIN PROJECTIONS ON NATIVE THICK FILAMENTS FROM VERTEBRATE SKELETAL-MUSCLE J MOL BIOL 177 461-482, 1984

COOPER J, TRINICK J BINDING AND LOCATION OF AMP DEAMINASE IN RABBIT PSOAS MUSCLE MYOFIBRILS J MOL BIOL 177 137-152, 1984

OFFER G, TRINICK J A UNIFYING HYPOTHESIS FOR THE MECHANISM OF CHANGES IN THE WATER-HOLDING CAPACITY OF MEAT J SCI FOOD AGR 34 1018-1019, 1983

OFFER G, TRINICK J ON THE MECHANISM OF WATER HOLDING IN MEAT - THE SWELLING AND SHRINKING OF MYOFIBRILS MEAT SCI 8 245-281, 1983

KNIGHT PJ, TRINICK JA PREPARATION OF MYOFIBRILS METHOD ENZYMOL 85 9-12, 1982

TRINICK JA PREPARATION OF NATIVE THICK FILAMENTS METHOD ENZYMOL 85 17-20, 1982

TRINICK JA END-FILAMENTS - A NEW STRUCTURAL ELEMENT OF VERTEBRATE SKELETAL-MUSCLE THICK FILAMENTS J MOL BIOL 151 309-314, 1981

TRINICK J, COOPER J SEQUENTIAL DISASSEMBLY OF VERTEBRATE MUSCLE THICK FILAMENTS J MOL BIOL 141 315-321, 1980

TRINICK J, OFFER G CROSS-LINKING OF ACTIN-FILAMENTS BY HEAVY-MEROMYOSIN J MOL BIOL 133 549-556, 1979

Trinick J, Lowey S M-protein from chicken pectoralis muscle: Isolation and characterization Journal of Molecular Biology 113 343-368, 1977
DOI:10.1016/0022-2836(77)90146-2

Trinick JA, Lowey S M-protein from chicken pectoralis muscle J Mol Biol 113 343-368, 1977

Scarff C, Balaguer AF, Winkelmann D, Trinick J Electron Microscopy of the Complex Formed by Heavy Meromyosin and C-Protein,