Faculty of Biological Sciences

Dr Chi Trinh

BSc, Bath; PhD, Leeds.
Research Fellow
School of Molecular and Cellular Biology

Contact:  Astbury 9.108g, +44(0) 113 34 33023, email address for  

You can read more about Dr Trinh's interests here:
http://www.fbs.leeds.ac.uk/facilities/xray/

Research Interests

Protein crystallography

Lane SW, Dennis CA, Lane CL, Trinh CH, Rizkallah PJ, Stockley PG, Phillips SEV Construction and crystal structure of recombinant STNV capsids. J Mol Biol 413 41-50, 2011
DOI:10.1016/j.jmb.2011.07.062
View abstract

Campeotto I, Bolt AH, Harman TA, Dennis C, Trinh CH, Phillips SEV, Nelson A, Pearson AR, Berry A Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution. J Mol Biol 404 56-69, 2010
DOI:10.1016/j.jmb.2010.08.008
View abstract

Smith MA, Pirrat P, Pearson AR, Kurtis CRP, Trinh CH, Gaule TG, Knowles PF, Phillips SEV, McPherson MJ Exploring the roles of the metal ions in Escherichia coli copper amine oxidase. Biochemistry 49 1268-1280, 2010
DOI:10.1021/bi901738k
View abstract

Anwar R, Valleley EMA, Trinh CH Novel human pathological mutations. Gene symbol: F13A1. Disease: Factor XIII Deficiency. Hum Genet 127 115-116, 2010

Trinh CH, Asipu A, Bonthron DT, Phillips SEV Structures of alternatively spliced isoforms of human ketohexokinase. Acta Crystallogr D Biol Crystallogr 65 201-211, 2009
DOI:10.1107/S0907444908041115
View abstract

Trinh CH, ElSayed W, Eshghi P, Miri-Moghaddam E, Zadeh-Vakili A, Markham A, Anwar R Molecular analysis of sixteen unrelated factor XIIIA deficient families from south-east of Iran BRIT J HAEMATOL 140 581-584, 2008
DOI:10.1111/j.1365-2141.2007.06963.x

Stevenson SR, Kamisugi Y, Trinh CH, Schmutz J, Jenkins JW, Grimwood J, Muchero W, Tuskan GA, Rensing SA, Lang D, Reski R, Melkonian M, Rothfels CJ, Li FW, Larsson A, Wong GKS, Edwards TA, Cuming AC Genetic analysis of Physcomitrella patens identifies ABSCISIC ACID NON-RESPONSIVE, a regulator of ABA responses unique to basal land plants and required for desiccation tolerance Plant Cell 28 1310-1327, 2016
DOI:10.1105/tpc.16.00091

Haywood NJ, Wolny M, Rogers B, Trinh CH, Shuping Y, Edwards TA, Peckham M Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation Biochemical Journal 473 2485-2493, 2016
DOI:10.1042/BCJ20160421

Surtees R, Ariza A, Punch EK, Trinh CH, Dowall SD, Hewson R, Hiscox JA, Barr JN, Edwards TA The crystal structure of the Hazara virus nucleocapsid protein BMC Structural Biology 15 -, 2015
DOI:10.1186/s12900-015-0051-3
View abstract

Hunter GJ, Trinh CH, Bonetta R, Stewart EE, Cabelli DE, Hunter T The structure of the Caenorhabditis elegans manganese superoxide dismutase MnSOD-3-azide complex Protein Science 1777-1788, 2015
DOI:10.1002/pro.2768
View abstract

Stockwell J, Daniels AD, Windle CL, Harman TA, Woodhall T, Lebl T, Trinh CH, Mulholland K, Pearson AR, Berry A, Nelson A Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: Scope, limitations and stereoselectivity Organic and Biomolecular Chemistry 14 105-112, 2015
DOI:10.1039/c5ob02037a
View abstract

Daniels AD, Campeotto I, van der Kamp MW, Bolt AH, Trinh CH, Phillips SEV, Pearson AR, Nelson A, Mulholland AJ, Berry A Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis. ACS Chem Biol 9 1025-1032, 2014
DOI:10.1021/cb500067z
View abstract

Tanner SJ, Ariza A, Richard C-A, Kyle HF, Dods RL, Blondot M-L, Wu W, Trincão J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eléouët J-F, Edwards TA, Barr JN Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. Proc Natl Acad Sci U S A 111 1580-1585, 2014
DOI:10.1073/pnas.1317262111
View abstract

Yuzugullu Y, Trinh CH, Fairhurst L, Ogel ZB, McPherson MJ, Pearson AR Investigating the active centre of the Scytalidium thermophilum catalase Acta Crystallographica Section F: Structural Biology and Crystallization Communications 69 369-375, 2013
DOI:10.1107/S1744309113004211
View abstract

Timms N, Windle CL, Polyakova A, Ault JR, Trinh CH, Pearson AR, Nelson A, Berry A Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine withγ-thialysine by using a chemical mutagenesis strategy. Chembiochem 14 474-481, 2013
DOI:10.1002/cbic.201200714
View abstract

Yuzugullu Y, Trinh CH, Smith MA, Pearson AR, Sutay Kocabas D, Phillips SEV, Bakir U, Ogel ZB, McPherson MJ Crystal structure, recombinant expression and mutagenesis studies of the bifunctional catalase-phenol oxidase from Scytalidium thermophilum Acta Crystallographica Section D: Biological Crystallography 69 398-408, 2013
DOI:10.1107/S0907444912049001
View abstract

Phillips SEV, Lane SW, Dennis CA, Lane CL, Trinh CH, Rizkallah PJ, Bunka DH, Dykeman EC, Ford R, Barker A, Twarock R, Stockley PG Structure and RNA Recognition in Recombinant STNV Capsids, 2012

Kleinschroth T, Castellani M, Trinh CH, Morgner N, Brutschy B, Ludwig B, Hunte C X-ray structure of the dimeric cytochrome bc(1) complex from the soil bacterium Paracoccus denitrificans at 2.7-angstrom resolution BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1807 1606-1615, 2011
DOI:10.1016/j.bbabio.2011.09.017

Campeotto I, Carr SB, Trinh CH, Nelson AS, Berry A, Phillips SEV, Pearson AR Structure of an Escherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 angstrom resolution ACTA CRYSTALLOGR F 65 1088-1090, 2009
DOI:10.1107/S1744309109037403

Kocabas DS, Pearson AR, Phillips SEV, Bakir U, Ogel ZB, McPherson MJ, Trinh CH Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum ACTA CRYSTALLOGR F 65 486-488, 2009
DOI:10.1107/S1744309109012007

Trinh CH, Hunter T, Stewart EE, Phillips SEV, Hunter GJ Purification, crystallization and X-ray structures of the two manganese superoxide dismutases from Caenorhabditis elegans ACTA CRYSTALLOGR F 64 1110-1114, 2008
DOI:10.1107/S1744309108037056

Stead MA, Rosbrook GO, Hadden JM, Trinh CH, Carr SB, Wright SC Structure of the wild-type human BCL6 POZ domain ACTA CRYSTALLOGR F 64 1101-1104, 2008
DOI:10.1107/S1744309108036063

Stead MA, Trinh CH, Garnett JA, Carr SB, Baron AJ, Edwards TA, Wright SC A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain J MOL BIOL 373 820-826, 2007
DOI:10.1016/j.jmb.2007.08.026

Trinh C-H, Liu Y, Phillips SEV, Phillips-Jones MK Structure of the response regulator VicR DNA-binding domain. Acta Crystallogr D Biol Crystallogr 63 266-269, 2007
DOI:10.1107/S0907444906043435
View abstract

Bingham RJ, Findlay JBC, Hsieh SY, Kalverda AP, Kjeliberg A, Perazzolo C, Phillips SEV, Seshadri K, Trinh CH, Turnbull WB, Bodenhausen G, Homans SW Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the major urinary protein J AM CHEM SOC 126 1675-1681, 2004
DOI:10.1021/ja038461i

Trinh CH, Smith DP, Kalverda AP, Phillips SEV, Radford SE Crystal structure of monomeric humanß-2-microglobulin reveals clues to its amyloidogenic properties Proceedings of the National Academy of Sciences of the United States of America 99 9771-9776, 2002
DOI:10.1073/pnas.152337399

Anwar R, Minford A, Gallivan L, Trinh CH, Markham AF Delayed umbilical bleeding - A presenting feature for factor XIII deficiency: Clinical features, genetics, and management PEDIATRICS 109 -, 2002

Anwar R, Gallivan L, Trinh CH, Hill FG, Miloszewski KJA, Markham AF Identification of a new Leu354Pro mutation responsible for factor XIII deficiency European Journal of Haematology 66 133-136, 2001
DOI:10.1034/j.1600-0609.2001.00370.x

Gallivan L, Minford A, Trinh CH, Markham AF, Anwar R Clinical features, molecular genetics and management of six factor XIII deficient patients., 2001