Dr Chi Trinh

BSc, Bath; PhD, Leeds.
Research Fellow
School of Molecular and Cellular Biology

Contact: Astbury 9.108g, +44(0) 113 34 33023, email address for  

You can read more about Dr Trinh's interests here:

Research Interests

Protein crystallography

Lane SW, Dennis CA, Lane CL, Trinh CH, Rizkallah PJ, Stockley PG, Phillips SEV Construction and crystal structure of recombinant STNV capsids. J Mol Biol 413 41-50, 2011
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Campeotto I, Bolt AH, Harman TA, Dennis C, Trinh CH, Phillips SEV, Nelson A, Pearson AR, Berry A Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution. J Mol Biol 404 56-69, 2010
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Smith MA, Pirrat P, Pearson AR, Kurtis CRP, Trinh CH, Gaule TG, Knowles PF, Phillips SEV, McPherson MJ Exploring the roles of the metal ions in Escherichia coli copper amine oxidase. Biochemistry 49 1268-1280, 2010
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Anwar R, Valleley EMA, Trinh CH Novel human pathological mutations. Gene symbol: F13A1. Disease: Factor XIII Deficiency. Hum Genet 127 115-116, 2010

Trinh CH, Asipu A, Bonthron DT, Phillips SEV Structures of alternatively spliced isoforms of human ketohexokinase. Acta Crystallogr D Biol Crystallogr 65 201-211, 2009
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Trinh CH, ElSayed W, Eshghi P, Miri-Moghaddam E, Zadeh-Vakili A, Markham A, Anwar R Molecular analysis of sixteen unrelated factor XIIIA deficient families from south-east of Iran BRIT J HAEMATOL 140 581-584, 2008

Hunter T, Bonetta R, Sacco A, Vella M, Sultana PM, Trinh CH, Fadia HBR, Borowski T, Garcia-Fandiño R, Stockner T, Hunter GJ A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron Chemistry - A European Journal 24 5303-5308, 2018
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Hughes DJ, Tiede C, Penswick N, Tang AAS, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology Science Signaling 10, 2017
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Windle CL, Simmons KJ, Ault JR, Trinh CH, Nelson A, Pearson AR, Berry A Extending enzyme molecular recognition with an expanded amino acid alphabet Proceedings of the National Academy of Sciences of the United States of America 114 2610-2615, 2017
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Stevenson SR, Kamisugi Y, Trinh CH, Schmutz J, Jenkins JW, Grimwood J, Muchero W, Tuskan GA, Rensing SA, Lang D, Reski R, Melkonian M, Rothfels CJ, Li FW, Larsson A, Wong GKS, Edwards TA, Cuming AC Genetic analysis of Physcomitrella patens identifies ABSCISIC ACID NON-RESPONSIVE, a regulator of ABA responses unique to basal land plants and required for desiccation tolerance Plant Cell 28 1310-1327, 2016
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Haywood NJ, Wolny M, Rogers B, Trinh CH, Shuping Y, Edwards TA, Peckham M Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation Biochemical Journal 473 2485-2493, 2016
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Surtees R, Ariza A, Punch EK, Trinh CH, Dowall SD, Hewson R, Hiscox JA, Barr JN, Edwards TA The crystal structure of the Hazara virus nucleocapsid protein BMC Structural Biology 15, 2015
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Stockwell J, Daniels AD, Windle CL, Harman TA, Woodhall T, Lebl T, Trinh CH, Mulholland K, Pearson AR, Berry A, Nelson A Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: Scope, limitations and stereoselectivity Organic and Biomolecular Chemistry 14 105-112, 2015
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Hunter GJ, Trinh CH, Bonetta R, Stewart EE, Cabelli DE, Hunter T The structure of the Caenorhabditis elegans manganese superoxide dismutase MnSOD-3-azide complex Protein Science 1777-1788, 2015
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Daniels AD, Campeotto I, van der Kamp MW, Bolt AH, Trinh CH, Phillips SEV, Pearson AR, Nelson A, Mulholland AJ, Berry A Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis. ACS Chem Biol 9 1025-1032, 2014
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Tanner SJ, Ariza A, Richard C-A, Kyle HF, Dods RL, Blondot M-L, Wu W, Trincão J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eléouët J-F, Edwards TA, Barr JN Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. Proc Natl Acad Sci U S A 111 1580-1585, 2014
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Yuzugullu Y, Trinh CH, Fairhurst L, Ogel ZB, McPherson MJ, Pearson AR Investigating the active centre of the Scytalidium thermophilum catalase Acta Crystallographica Section F: Structural Biology and Crystallization Communications 69 369-375, 2013
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Timms N, Windle CL, Polyakova A, Ault JR, Trinh CH, Pearson AR, Nelson A, Berry A Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine withγ-thialysine by using a chemical mutagenesis strategy. Chembiochem 14 474-481, 2013
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Yuzugullu Y, Trinh CH, Smith MA, Pearson AR, Sutay Kocabas D, Phillips SEV, Bakir U, Ogel ZB, McPherson MJ Crystal structure, recombinant expression and mutagenesis studies of the bifunctional catalase-phenol oxidase from Scytalidium thermophilum Acta Crystallographica Section D: Biological Crystallography 69 398-408, 2013
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Phillips SEV, Lane SW, Dennis CA, Lane CL, Trinh CH, Rizkallah PJ, Bunka DH, Dykeman EC, Ford R, Barker A, Twarock R, Stockley PG Structure and RNA Recognition in Recombinant STNV Capsids, 2012

Kleinschroth T, Castellani M, Trinh CH, Morgner N, Brutschy B, Ludwig B, Hunte C X-ray structure of the dimeric cytochrome bc(1) complex from the soil bacterium Paracoccus denitrificans at 2.7-angstrom resolution BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1807 1606-1615, 2011

Campeotto I, Carr SB, Trinh CH, Nelson AS, Berry A, Phillips SEV, Pearson AR Structure of an Escherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 angstrom resolution ACTA CRYSTALLOGR F 65 1088-1090, 2009

Kocabas DS, Pearson AR, Phillips SEV, Bakir U, Ogel ZB, McPherson MJ, Trinh CH Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum ACTA CRYSTALLOGR F 65 486-488, 2009

Stead MA, Rosbrook GO, Hadden JM, Trinh CH, Carr SB, Wright SC Structure of the wild-type human BCL6 POZ domain ACTA CRYSTALLOGR F 64 1101-1104, 2008

Trinh CH, Hunter T, Stewart EE, Phillips SEV, Hunter GJ Purification, crystallization and X-ray structures of the two manganese superoxide dismutases from Caenorhabditis elegans ACTA CRYSTALLOGR F 64 1110-1114, 2008

Stead MA, Trinh CH, Garnett JA, Carr SB, Baron AJ, Edwards TA, Wright SC A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain J MOL BIOL 373 820-826, 2007

Trinh C-H, Liu Y, Phillips SEV, Phillips-Jones MK Structure of the response regulator VicR DNA-binding domain. Acta Crystallogr D Biol Crystallogr 63 266-269, 2007
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Bingham RJ, Findlay JBC, Hsieh SY, Kalverda AP, Kjeliberg A, Perazzolo C, Phillips SEV, Seshadri K, Trinh CH, Turnbull WB, Bodenhausen G, Homans SW Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the major urinary protein J AM CHEM SOC 126 1675-1681, 2004

Trinh CH, Smith DP, Kalverda AP, Phillips SEV, Radford SE Crystal structure of monomeric humanß-2-microglobulin reveals clues to its amyloidogenic properties Proceedings of the National Academy of Sciences of the United States of America 99 9771-9776, 2002

Anwar R, Minford A, Gallivan L, Trinh CH, Markham AF Delayed umbilical bleeding - A presenting feature for factor XIII deficiency: Clinical features, genetics, and management PEDIATRICS 109, 2002

Anwar R, Gallivan L, Trinh CH, Hill FG, Miloszewski KJA, Markham AF Identification of a new Leu354Pro mutation responsible for factor XIII deficiency European Journal of Haematology 66 133-136, 2001

Gallivan L, Minford A, Trinh CH, Markham AF, Anwar R Clinical features, molecular genetics and management of six factor XIII deficient patients., 2001

Trinh CH, Hemmington SD, Verhoeyen ME, Phillips SEV Antibody fragment Fv4155 bound to two closely related steroid hormones: The structural basis of fine specificity Structure 5 937-948, 1997
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