Faculty of Biological Sciences

Prof Joanne Tipper

BSc, PhD 1994, Leeds.
Professor of Medical and Biological Engineering
School of Biomedical Sciences

Background: Joanne studied for a degree in Biotechnology in 1990, which was followed by a PhD in skin microbiology in 1994, both at the University of Leeds. Following this Joanne's first postdoctoral research fellow investigated the relationship between Burkholderia Cepacia complex, an organism associated with poor prognosis in Cystic Fibrosis patients, and lung epithelial cells. After this in 1996 Joanne moved into the medical engineering field to investigate periprosthetic wear particles, a field she has been active in ever since.

Contact:  Garstang 6.65a, +44(0) 113 34 35611, email address for  

Research Interests

Host cell responses to periprosthetic wear products

 Several research areas of interest largely focussed on periprosthetic wear particles but more recently Joanne has also been investigating neural cell responses to wear products and impact forces.

  1.  Isolation and characterisation of polymer, metal, ceramic and coating wear particles from periprosthetic tissues and simulator lubricants from hip, knee, ankle and spinal replacement devices using novel methodologies and a variety of imaging techniques e.g. field emission gun SEM, TEM. In addition, using simple configuration wear simulators we can generate clinically relevant wear particles for cell culture experiments.
  2. Host cell responses to orthopaedic device wear particles and products including macrophage responses to polymer particles (including antioxidant UHMWPEs containing vitamin E and hindered phenols), metal particles (CoCr, stainless steel, Ti) and ceramic wear particles (alumina, ZTPA, SiN ceramic-like coatings) to investigate inflammation, osteolysis, cell membrane toxicity, oxidative stress and particle biocompatibility and toxicity.
  3. Spinal devices, instrumentation and injury with collaborators Prof Richard Hall and Dr James Phillips (UCL). Numerous challenges exist in developing instrumentation and devices for use in this area, the close proximity to the spinal cord and sensitive neural tissues is the main issue, however, also of importance is the increased range of periprosthetic tissues i.e. meninges, nerves, roots, spinal cord, blood vessels; the proximity to major vessels and organs and the catastrophic consequences of failure of these types of devices as well as the surgical difficulties (access, proximity of vessels). Significant challenges exist around understanding wear of total disc replacements in the lumbar and cervical spine, biological responses to wear products (both particulate and ions) in this physiological complex environment and around the post injury biological cascade that inhibits nerve repair. We are using 3D hydrogels (natural and synthetic) to create central nervous system models, which provide a more realistic spatial environment for neurons and glial cells than traditional 2D culture systems. They allow continuous observation and controlled manipulation, thereby facilitating analysis of cellular interactions. We are currently investigating neuronal and glial cell responses to spinal instrumentation wear products, spinal cord injury impact forces and the effects of changing matrix stiffness on cellular response.

 

Faculty Research and Innovation



Studentship information

Undergraduate project topics:

  • Biological responses to prosthetic wear particles from polymers, metals, and ceramics; wear particle characterisation using SEM, TEM, Nanosight.

Postgraduate studentship areas:

  • Biological responses to prosthetic wear particles from polymers, metals, and ceramics; wear development of novel methodologies for particle isolation and characterisation; 3D culture of neural cells and neural stem cells using hydrogels for neuronal repair after spinal cord injury; histological characterisation of cartilaginous tissues e.g. the labrum, ankle joint cartilage.
  • See EPSRC Centre for Doctoral Training Tissue Engineering and Regenerative Medicine (School of Mechanical Engineering)
  • http://www.imbe.leeds.ac.uk/doctoral-training-regenerative-medicine/

See also:

Modules taught

BMSC1103 - Basic Laboratory and Scientific Skills
BMSC1110 - Foundations of Biomedical Sciences
BMSC2233 - Topics in Medical Sciences
BMSC3301 - Research Project in Biomedical Sciences
BMSC5382M - Extended Research Project
FOBS1201/BIOL1214 - Molecular Physiology/Multicellular Systems
MECH5490M - Biomaterials (Short Course)
MICR2221 - Medical Immunology
MICR3212/BIOL3211 - ATU - Tissue replacement

Centre membership: The Institute of Medical and Biological Engineering

Dr Saurabh Lal  (Research Fellow)


Postgraduates

Imran Asif (Primary supervisor) 40% FTE
Joss Atkinson (Primary supervisor) 100% FTE
Samuel James Beckett (Primary supervisor) 100% FTE
Katherine Bostock (Primary supervisor) 100% FTE
Ahranee Canden (Primary supervisor) 100% FTE
Kern Cowell (Primary supervisor) 100% FTE
Lisa Duff (Primary supervisor) 100% FTE
Roxanne Dyer (Primary supervisor) 100% FTE
Valeria Filippou (Primary supervisor) 100% FTE
Oluwasegun Kayode (Primary supervisor) 100% FTE
Jessica Kirk (Primary supervisor) 45% FTE
Patrick Lawson-Statham (Primary supervisor) 100% FTE
Trang Nguyen (Primary supervisor) 40% FTE
Hannah Pape (Primary supervisor) 100% FTE
Kinga Pasko (Primary supervisor) 50% FTE
Jayna Patel (Primary supervisor) 34% FTE
Laura Mary Shallcross (Primary supervisor) 100% FTE
Megan Sharrock (Primary supervisor) 100% FTE
Matthew Sullivan (Primary supervisor) 100% FTE
Daniel White (Primary supervisor) 100% FTE
Simon Williams (Primary supervisor) 100% FTE
Lauren Yarrow (Primary supervisor) 50% FTE
Elizabeth Young (Primary supervisor) 100% FTE
Philippa Clarkson (Co-supervisor) 35% FTE
Benjamin Golland (Co-supervisor) 20% FTE
Salah Hammouche (Co-supervisor) 33% FTE
William Jones (Co-supervisor) 10% FTE
Adam Kelly (Co-supervisor) 50% FTE
Lekha Koria (Co-supervisor) 10% FTE
Nivedah Kuganenderan (Co-supervisor) 25% FTE
Abigail Lucas (Co-supervisor) 10% FTE
Abimbola Oladokun (Co-supervisor) 25% FTE
Ashley Stratton-Powell (Co-supervisor) 20% FTE
Katherine Timms (Co-supervisor) 25% FTE

Baxter RM, Steinbeck MJ, Tipper JL, Parvizi J, Marcolongo M, Kurtz SM Comparison of Periprosthetic Tissue Digestion Methods for Ultra-High Molecular Weight Polyethylene Wear Debris Extraction J BIOMED MATER RES B 91B 409-418, 2009
DOI:10.1002/jbm.b.31416

Wirth MA, Klotz C, Deffenbaugh DL, McNulty D, Richards L, Tipper JL Cross-linked glenoid prosthesis: A wear comparison to conventional glenoid prosthesis with wear particulate analysis J SHOULDER ELB SURG 18 130-137, 2009
DOI:10.1016/j.jse.2008.06.015

Richards L, Brown C, Stone MH, Fisher J, Ingham E, Tipper JL Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo J BONE JOINT SURG BR 90B 1106-1113, 2008
DOI:10.1302/0301-620X.90B8.20737

Tipper JL, Galvin AL, Williams S, McEwen HMJ, Stone MH, Ingham E, Fisher J Isolation and characterization of UHMWPE wear particles down to ten nanometers in size from in vitro hip and knee joint simulators J BIOMED MATER RES A 78A 473-480, 2006
DOI:10.1002/jbm.a.30824

Partridge S, Tipper JL, Al-Hajjar M, Isaac GH, Fisher J, Williams S Evaluation of a new methodology to simulate damage and wear of polyethylene hip replacements subjected to edge loading in hip simulator testing. J Biomed Mater Res B Appl Biomater -, 2017
DOI:10.1002/jbm.b.33951
View abstract

Suñer S, Gowland N, Craven R, Joffe R, Emami N, Tipper JL Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: wear characterization and biological response to wear particles. J Biomed Mater Res B Appl Biomater -, 2016
DOI:10.1002/jbm.b.33821
View abstract

Stratton-Powell AA, Pasko KM, Brockett CL, Tipper JL The Biologic Response to Polyetheretherketone (PEEK) Wear Particles in Total Joint Replacement: A Systematic Review Clinical Orthopaedics and Related Research 474 2394-2404, 2016
DOI:10.1007/s11999-016-4976-z
View abstract

Lal S, Hall RM, Tipper JL A novel method for isolation and recovery of ceramic nanoparticles and metal wear debris from serum lubricants at ultra-low wear rates Acta Biomaterialia 42 420-428, 2016
DOI:10.1016/j.actbio.2016.07.004
View abstract

Lal S, Allinson L, Hall R, Tipper J Biocompatibility of Silicon Nitride Nanoparticles and Cobalt Chromium Wear Debris from THR, 2016

Stratton-Powell AA, Tipper JL Characterization of UHMWPE Wear Particles In UHMWPE Biomaterials Handbook: Ultra High Molecular Weight Polyethylene in Total Joint Replacement and Medical Devices , 2016
DOI:10.1016/B978-0-323-35401-1.00033-8
View abstract

Suner S, Joffe R, Tipper JL, Emami N Ultra high molecular weight polyethylene/graphene oxide nanocomposites: Thermal, mechanical and wettability characterisation COMPOSITES PART B-ENGINEERING 78 185-191, 2015
DOI:10.1016/j.compositesb.2015.03.075

Liu A, Richards L, Bladen CL, Ingham E, Fisher J, Tipper JL The biological response to nanometre-sized polymer particles. Acta Biomater 23 38-51, 2015
DOI:10.1016/j.actbio.2015.05.016
View abstract

Hyde PJ, Tipper J, Fisher J, Hall RM Wear and biological effects of a semi-constrained total disc replacement subject to modified ISO standard test conditions Journal of the Mechanical Behavior of Biomedical Materials 44 43-52, 2015
DOI:10.1016/j.jmbbm.2014.12.001
View abstract

Elson KM, Fox N, Tipper JL, Kirkham J, Hall RM, Fisher J, Ingham E Non-destructive monitoring of viability in an ex vivo organ culture model of osteochondral tissue European Cells and Materials 29 356-369, 2015
View abstract

Papageorgiou I, Marsh R, Tipper JL, Hall RM, Fisher J, Ingham E Interaction of micron and nano-sized particles with cells of the dura mater. Journal of Biomedical Materials Research Part B: Applied Biomaterials 102 1496-1505, 2014
DOI:10.1002/jbm.b.33129
View abstract

Papageorgiou I, Abberton T, Fuller M, Tipper JL, Fisher J, Ingham E Biological Effects of Clinically Relevant CoCr Nanoparticles in the Dura Mater: An Organ Culture Study Nanomaterials 4 485-504, 2014
DOI:10.3390/nano4020485
View abstract

Suner S, Bladen CL, Gowland N, Tipper JL, Emami N Investigation of wear and wear particles from a UHMWPE/multi-walled carbon nanotube nanocomposite for total joint replacements Wear 317 163-169, 2014
DOI:10.1016/j.wear.2014.05.014
View abstract

Liu A, Ingham E, Fisher J, Tipper JL Generation of a large volume of clinically relevant nanometre-sized ultra-high-molecular-weight polyethylene wear particles for cell culture studies. Proceedings of the Institution of Mechanical Engineers Part H: Journal of Engineering in Medicine 228 418-426, 2014
DOI:10.1177/0954411914528308
View abstract

Behl B, Papageorgiou I, Brown C, Hall R, Tipper JL, Fisher J, Ingham E Biological effects of cobalt-chromium nanoparticles and ions on dural fibroblasts and dural epithelial cells. Biomaterials 34 3547-3558, 2013
DOI:10.1016/j.biomaterials.2013.01.023
View abstract

Al-Hajjar M, Fisher J, Tipper JL, Williams S, Jennings LM Wear of 36-mm BIOLOX(R) delta ceramic-on-ceramic bearing in total hip replacements under edge loading conditions. Proc Inst Mech Eng H 227 535-542, 2013
DOI:10.1177/0954411912474613
View abstract

Bladen CL, Teramura S, Russell SL, Fujiwara K, Fisher J, Ingham E, Tomita N, Tipper JL Analysis of wear, wear particles, and reduced inflammatory potential of vitamin E ultrahigh-molecular-weight polyethylene for use in total joint replacement. Journal of Biomedical Materials Research Part B: Applied Biomaterials 101B 458-466, 2013
DOI:10.1002/jbm.b.32904
View abstract

Bladen CL, Tzu-Yin L, Fisher J, Tipper JL In vitro analysis of the cytotoxic and anti-inflammatory effects of antioxidant compounds used as additives in ultra high-molecular weight polyethylene in total joint replacement components Journal of Biomedical Materials Research - Part B Applied Biomaterials 101 B 407-413, 2013
DOI:10.1002/jbm.b.32798
View abstract

Al-Hajjar M, Fisher J, Williams S, Tipper JL, Jennings LM Effect of femoral head size on the wear of metal on metal bearings in total hip replacements under adverse edge-loading conditions Journal of Biomedical Materials Research - Part B Applied Biomaterials 101 B 213-222, 2013
DOI:10.1002/jbm.b.32824
View abstract

Gough CS, Mitchell EA, Wijayathunga VN, Tipper JL, Wilcox RK, Hall RM, Ingham E The biology of the ovine functional spinal unit, 2012

Jennings LM, Al-Hajjar M, Brockett CL, Williams S, Tipper JL, Ingham E, Fisher J (iv) Enhancing the safety and reliability of joint replacement implants Orthopaedics and Trauma 26 246-252, 2012
DOI:10.1016/j.mporth.2012.05.006
View abstract

Suñer S, Tipper JL, Emami N Biological effects of wear particles generated in total joint replacements: Trends and future prospects Tribology - Materials, Surfaces and Interfaces 6 39-52, 2012
DOI:10.1179/1751584X12Y.0000000005
View abstract

Ellison P, Tipper JL, Jennings LM, Fisher J Biological activity of polyethylene wear debris produced in the patellofemoral joint Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 226 377-383, 2012
DOI:10.1177/0954411912441316
View abstract

Vicars R, Prokopovich P, Brown TD, Tipper JL, Ingham E, Fisher J, Hall RM The effect of anterior-posterior shear on the wear of CHARITÉ total disc replacement. Spine (Phila Pa 1976) 37 E528-E534, 2012
DOI:10.1097/BRS.0b013e31823cbd6e
View abstract

Fisher J, Jin Z, Ingham E, Jennings L, Tipper J, Williams S Bearings: Tribological Aspects: To Wear or Not to Wear In The Corail Hip System: A practical approach based on 25 years of experience , 2011
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Gough CS, Wajayathunga VN, Tipper JL, Wilcox RK, Hall RM, Ingham E The biology of the ovine functional spinal unit, 2011

Elson KM, Tipper JL, Kirkham J, Hall RM, Ingham E In situ cell monitoring in organ culture, 2011

Vicars R, Hyde PJ, Brown TD, Tipper JL, Ingham E, Fisher J, Hall RM The effect of anterior-posterior shear load on the wear of ProDisc-L TDR EUR SPINE J 19 1356-1362, 2010
DOI:10.1007/s00586-010-1396-8

Galvin AL, Jennings LM, Tipper JL, Ingham E, Fisher J Wear and creep of highly crosslinked polyethylene against cobalt chrome and ceramic femoral heads P I MECH ENG H 224 1175-1183, 2010
DOI:10.1243/09544119JEIM741

Yuan CQ, Jin ZM, Tipper JL, Yan XP Numerical surface characterization of wear debris from artificial joints using atomic force microscopy CHINESE SCI BULL 54 4583-4588, 2009
DOI:10.1007/s11434-009-0588-2

Wu JP, Yan XP, Jin ZM, Tipper JL, Yuan CQ, Zhou XC Application of principal component analysis and a fuzzy C-means clustering algorithm to wear debris morphology classification PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY 223 1059-1066, 2009
DOI:10.1243/13506501JET585

Tipper JL, Richards L, Ingham E, Fisher J Characterization of UHMWPE Wear Particles In UHMWPE Biomaterials Handbook , 2009
View abstract

Wu JP, Yan XP, Yuan CQ, Zhou XC, Jin Z, Tipper JL Application of Principal Component Analysis and Fuzzy C-Means Clustering Algorithm to the Classification of UHMWPE Wear Debris from Artificial Joints, 2009

Baxter RM, Steinbeck MJ, Tipper JL, Rimnac CM, Parvizi J, Marcolongo M, Kurtz SM Evaluation of methods for optimized periprosthetic tissue digestion 8th World Biomaterials Congress 2008 2 961-, 2008

Pereni CI, Walker PG, Levesley MC, Keeling D, Jaber O, Watterson K, Tipper JL, Fisher J Wear characteristics of a knitted PET implantable scaffold 8th World Biomaterials Congress 2008 2 575-, 2008

Brown C, Williams S, Tipper JL, Fisher J, Ingham E Characterisation of wear particles produced by metal on metal and ceramic on metal hip prostheses under standard and microseparation simulation J MATER SCI-MATER M 18 819-827, 2007
DOI:10.1007/s10856-006-0015-z

Galvin AL, Tipper IL, Jennings LM, Stone MH, Jin ZM, Ingham E, Fisher J Wear and biological activity of highly crosslinked polyethylene in the hip under low serum protein concentrations P I MECH ENG H 221 1-10, 2007
DOI:10.1243/09544119JEIM99

Fisher J, Jin ZM, Tipper J, Stone M, Ingham E Presidential guest lecture - Tribology of alternative beatings CLIN ORTHOP RELAT R 25-34, 2006
DOI:10.1097/01.blo.0000238871.07604.49

Jin Z, Williams S, Tipper JL, Ingham E, Fisher J Tribology of hip joints from natural hip joints, cartilage substitution, artificial replacements to cartilage tissue engineering Journal of Biomechanical Science and Engineering 1 69-81, 2006
View abstract

Fisher J, McEwen H, Tipper J, Jennings L, Farrar R, Stone M, Ingham E Wear-simulation analysis of rotating-platform mobile-bearing knees ORTHOPEDICS 29 S36-S41, 2006

Tipper JL, Galvin AL, Ingham E, Fisher J Estimation of the osteolytic potential of noncrosslinked and crosslinked polyethylenes and ceramic-on-ceramic total hip prostheses Journal of ASTM International 3 -, 2006
View abstract

Galvin A, Kang L, Tipper J, Stone M, Ingham E, Jin ZM, Fisher J Wear of crosslinked polyethylene under different tribological conditions J MATER SCI-MATER M 17 235-243, 2006
DOI:10.1007/s10856-006-7309-z

Jin Z, Tipper JL, Stone MH, Ingham E, Fisher J Hip Joints, Artificial In Encyclopedia of Medical Devices and Instrumentation , 2006
View abstract

Tipper JL, Ingham E, Jin ZM, Fisher J The science of metal-on-metal articulation CURR ORTHOPAED 19 280-287, 2005
DOI:10.1016/j.cuor.2005.08.002

Galvin AL, Tipper JL, Ingham E, Fisher J Nanometre size wear debris generated from crosslinked and non-crosslinked ultra high molecular weight polyethylene in artificial joints WEAR 259 977-983, 2005
DOI:10.1016/j.wear.2005.02.035

Fisher J, Firkins P, Tipper JL, Farrar R, Ingham E Wear of a novel ceramic on metal bearings for hip prosthesis In New Developments in the Basic Science of Ceramics and Other Alternative Bearings , 2005

Fisher J, Galvin A, Tipper J, Stewart T, Stone M, Ingham E Comparison of the Functional Biological Activity and Osteolytic Potential of Ceramic on Ceramic and Cross Linked Polyethylene Bearings in the Hip, 2005

Fisher J, McEwen HMJ, Tipper JL, Galvin AL, Ingram J, Kamali A, Stone MH, Ingham E Wear, debris, and biologic activity of cross-linked polyethylene in the knee - Benefits and potential concerns CLIN ORTHOP RELAT R 114-119, 2004
View abstract

Fisher J, Hu XQ, Stewart TD, Williams S, Tipper JL, Ingham E, Stone MH, Davies C, Hatto P, Bolton J, Riley M, Hardaker C, Isaac GH, Berry G Wear of surface engineered metal-on-metal hip prostheses J MATER SCI-MATER M 15 225-235, 2004

Fisher J, Nevelos J, Stewart TD, Tipper JL, Ingham E Long term wear of ceramic on ceramic hips, 2004

Stewart TD, Tipper JL, Insley G, Streicher RM, Ingham E, Fisher J Severe wear and fracture of zirconia heads against alumina inserts in hip simulator studies with microseparation J ARTHROPLASTY 18 726-734, 2003
DOI:10.1054/S0883-5403(03)00204-3

Williams S, Tipper JL, Hu XQ, Stone MH, Ingham E, Isaac GH, Hatto P, Fisher J The influence of swing phase loading on wear of metal-on-metal and Crn surface modified total hip replacements, 2003

Stewart TD, Tipper JL, Insley GM, Streicher RM, Ingham E, Fisher J Wear of alumina matrix composite ceramics for hip prostheses, 2003

Stewart TD, Tipper JL, Insley G, Streicher RM, Ingham E, Fisher J Long-term wear of ceramic matrix composite materials for hip prostheses under severe swing phase microseparation J BIOMED MATER RES B 66B 567-573, 2003
DOI:10.1002/jbm.b.10035

Fisher J, Hu XQ, Williams S, Tipper JL, Ingham E, Stone MH, Hatto P, Berry G, Hardaker C, Isaac G New bearing surfaces: What does the future hold? Seminars in Arthroplasty 14 131-139, 2003
View abstract

Williams S, Tipper JL, Ingham E, Stone MH, Fisher J In vitro analysis of the wear, wear debris and biological activity of surface-engineered coatings for use in metal-on-metal total hip replacements. Proc Inst Mech Eng H 217 155-163, 2003
DOI:10.1243/095441103765212659
View abstract

Stewert TD, Williams S, Tipper JL, Ingham E, Stone MH, Fisher J Advances in simulator testing of orthopaedic joint prostheses, 2003
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Tipper JL, Matthews JB, Ingham E, Stewart TD, Fisher J, Stone MH Wear and functional biological activity of wear debris generated from UHMWPE-on-Zirconia ceramic, metal-on-metal, and alumina ceramic-on-ceramic hip prostheses during hip simulator testing, 2003
View abstract

Tipper JL, Hatton A, Nevelos JE, Ingham E, Doyle C, Streicher R, Nevelos AB, Fisher J Alumina-alumina artificial hip joints. Part II: Characterisation of the wear debris from in vitro hip joint simulations BIOMATERIALS 23 3441-3448, 2002

Stewart TD, Tipper JL, Stone MH, Ingham E, Fisher J Wear of polyethylene against scratched metallic femoral heads in hip prostheses In Bioceramics in Joint Arthroplasty , 2002

Ingram J, Matthews JB, Tipper J, Stone M, Fisher J, Ingham E Comparison of the biological activity of grade GUR 1120 and GUR 415HP UHMWPE wear debris. Biomed Mater Eng 12 177-188, 2002
View abstract

Bell J, Tipper JL, Ingham E, Stone MH, Wroblewski BM, Fisher J Quantitative analysis of UHMWPE wear debris isolated from the periprosthetic femoral tissues from a series of Charnley total hip arthroplasties. Biomed Mater Eng 12 189-201, 2002
View abstract

Endo M, Tipper JL, Barton DC, Stone MH, Ingham E, Fisher J Comparison of wear, wear debris and functional biological activity of moderately crosslinked and non-crosslinked polyethylenes in hip prostheses. Proc Inst Mech Eng H 216 111-122, 2002
DOI:10.1243/0954411021536333
View abstract

Fisher J, Hu XQ, Tipper JL, Stewart TD, Williams S, Stone MH, Davies C, Hatto P, Bolton J, Riley M, Hardaker C, Isaac GH, Berry G, Ingham E An in vitro study of the reduction in wear of metal-on-metal hip prostheses using surface-engineered femoral heads. Proc Inst Mech Eng H 216 219-230, 2002
DOI:10.1243/09544110260138709
View abstract

Tipper JL, Firkins PJ, Besong AA, Barbour PSM, Nevelos J, Stone MH, Ingham E, Fisher J Characterisation of wear debris from UHMWPE on zirconia ceramic, metal-on-metal and alumina ceramic-on-ceramic hip prostheses generated in a physiological anatomical hip joint simulator WEAR 250 120-128, 2001

Firkins PJ, Tipper JL, Ingham E, Stone MH, Farrar R, Fisher J A novel low wearing differential hardness, ceramic-on-metal hip joint prosthesis J BIOMECH 34 1291-1298, 2001

Endo MM, Barbour PS, Barton DC, Fisher J, Tipper JL, Ingham E, Stone MH Comparative wear and wear debris under three different counterface conditions of crosslinked and non-crosslinked ultra high molecular weight polyethylene. Biomed Mater Eng 11 23-35, 2001
View abstract

Howling GI, Barnett PI, Tipper JL, Stone MH, Fisher J, Ingham E Quantitative characterization of polyethylene debris isolated from periprosthetic tissue in early failure knee implants and early and late failure Charnley hip implants. J Biomed Mater Res 58 415-420, 2001
View abstract

Firkins PJ, Tipper JL, Saadatzadeh MR, Ingham E, Stone MH, Farrar R, Fisher J Quantitative analysis of wear and wear debris from metal-on-metal hip prostheses tested In a physiological hip joint simulator BIO-MED MATER ENG 11 143-157, 2001

Bell J, Tipper JL, Ingham E, Stone MH, Fisher J The influence of phospholipid concentration in protein-containing lubricants on the wear of ultra-high molecular weight polyethylene in artificial hip joints. Proc Inst Mech Eng H 215 259-263, 2001
DOI:10.1243/0954411011533661
View abstract

Fisher J, Stone MH, Tipper JL, Ingham E Wear debris generation with metal-on-polyethylene, metal-on-metal and ceramic-on-ceramic hip prostheses. How good are our in vitro hip joint simulation methods?, 2001

Stewart T, Tipper J, Streicher R, Ingham E, Fisher J Long-term wear of HIPed alumina on alumina bearings for THR under microseparation conditions J MATER SCI-MATER M 12 1053-1056, 2001
View abstract

Fisher J, Bell J, Barbour PSM, Tipper JL, Matthews JB, Besong AA, Stone MH, Ingham E A novel method for the prediction of functional biological activity of polyethylene wear debris P I MECH ENG H 215 127-132, 2001

Firkins PJ, Tipper JL, Ingham E, Stone MH, Farrar R, Fisher J Influence of simulator kinematics on the wear of metal-on-metal hip prostheses. Proc Inst Mech Eng H 215 119-121, 2001
DOI:10.1243/0954411011533481
View abstract

Fisher J, Firkins P, Tipper JL, Ingham E, Stone MH, Farrar R Ceramic-on-metal hip joint prostheses, 2001

McNie CM, Barton DC, Ingham E, Tipper JL, Fisher J, Stone MH The prediction of polyethylene wear rate and debris morphology produced by microscopic asperities on femoral heads. J Mater Sci Mater Med 11 163-174, 2000
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Tipper JL, Ingham E, Hailey JL, Besong AA, Fisher J, Wroblewski BM, Stone MH Quantitative analysis of polyethylene wear debris, wear rate and head damage in retrieved Charnley hip prostheses. J Mater Sci Mater Med 11 117-124, 2000
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Landers P, Kerr KG, Rowbotham TJ, Tipper JL, Keig PM, Ingham E, Denton M Survival and growth of Burkholderia cepacia within the free-living amoeba Acanthamoeba polyphaga. Eur J Clin Microbiol Infect Dis 19 121-123, 2000
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Bell J, Besong AA, Tipper JL, Ingham E, Wroblewski BM, Stone MH, Fisher J Influence of gelatin and bovine serum lubricants on ultra-high molecular weight polyethylene wear debris generated in in vitro simulations P I MECH ENG H 214 513-518, 2000

Tipper JL, Firkins PJ, Ingham E, Fisher J, Stone MH, Farrar R Quantitative analysis of the wear and wear debris from low and high carbon content cobalt chrome alloys used in metal on metal total hip replacements. J Mater Sci Mater Med 10 353-362, 1999
View abstract

Besong AA, Tipper JL, Mathews BJ, Ingham E, Stone MH, Fisher J The influence of lubricant on the morphology of ultra-high molecular weight polyethylene wear debris generated in laboratory tests. Proc Inst Mech Eng H 213 155-158, 1999
DOI:10.1243/0954411991534870
View abstract

Endo MM, Barbour PS, Barton DC, Wroblewski BM, Fisher J, Tipper JL, Ingham E, Stone MH A comparison of the wear and debris generation of GUR 1120 (compression moulded) and GUR 4150HP (ram extruded) ultra high molecular weight polyethylene. Biomed Mater Eng 9 113-124, 1999
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Germain MA, Tipper JL, Ingham E, Makarem R, Wroblewski BM, Fisher J Analysis of debris from brushing the femoral canal with a plastic brush--a potential cause of loosening in total hip replacement. Proc Inst Mech Eng H 213 503-506, 1999
DOI:10.1243/0954411991535112
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Tipper JL, Ingham E, Cove JH, Todd NJ, Kerr KG Survival and multiplication of Burkholderia cepacia within respiratory epithelial cells Clinical Microbiology and Infection 4 450-459, 1998
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Besong AA, Tipper JL, Ingham E, Stone MH, Wroblewski BM, Fisher J Quantitative comparison of wear debris from UHMWPE that has and has not been sterilised by gamma irradiation. J Bone Joint Surg Br 80 340-344, 1998
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Fisher J, Barbour PSM, King MJ, Besong AA, Hailey J, Tipper JL, Ingham E, Stone M, Wroblewski BM Wear of ultrahigh molecular weight polyethylene in artificial joints: A new approach to the quantification of wear debris, 1997

Eady EA, Jones CE, Tipper JL, Cove JH, Cunliffe WJ, Layton AM Antibiotic resistant propionibacteria in acne: need for policies to modify antibiotic usage. BMJ 306 555-556, 1993

Eady EA, Ross JI, Tipper JL, Walters CE, Cove JH, Noble WC Distribution of genes encoding erythromycin ribosomal methylases and an erythromycin efflux pump in epidemiologically distinct groups of staphylococci. J Antimicrob Chemother 31 211-217, 1993
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TIPPER JL, JONES CE, COVE JH, EADY EA, CUNLIFFE WJ THE CONTINUING EVOLUTION OF ANTIBIOTIC-RESISTANT PROPIONIBACTERIA - AN EMERGING CLINICAL PROBLEM J INVEST DERMATOL 98 521-521, 1992

EADY EA, JONES CE, TIPPER JL, COVE JH, CUNLIFFE WJ TETRACYCLINE RESISTANT PROPIONIBACTERIA FROM ACNE PATIENTS ARE CROSS RESISTANT TO DOXYCYCLINE BUT SENSITIVE TO MINOCYCLINE J INVEST DERMATOL 98 521-521, 1992

Lal S, Hall RM, Tipper JL Concentration and size distribution data of silicon nitride nanoparticles measured using nanoparticle tracking analysis Data in Brief -,
DOI:10.1016/j.dib.2017.09.011
View abstract