Faculty of Biological Sciences

Dr Zahra Timsah

PhD,MSc,BSc (Principal Investigator: Projects conducted at St. James's and FBS labs)
University Academic Fellow in Molecular Mechanisms of Cancer Biology
School of Molecular and Cellular Biology

Contact:  LIGHT 7.15b, +44(0) 113 34 30991, email address for  

You can read more about Dr Timsah's interests here:



Projects: Oncology Biomarker Research

Past and present group members: Eleni Kyriakopoulou, Thomas Hall, Laura Wesley, Sujanitha Umamaheswaran, Isabelle Trayton...

 

Current Projects

 

  1. Dissecting the role of SH3 domains in ovarian /lung cancer progression and clinical outcome: bench to bedside project
  2. Role of receptor tyrosine kinase membrane signalling in miRNA biogenesis and cancer
  3. Role of unstimulated receptor tyrosine kinases in cancer metastasis
 

Faculty Research and Innovation

Modules taught

BIOC3221/22/BIOL3210 A - ATU - Signal trasduction in cancer and cardiovascular disease

Centre memberships:

Group Leader Dr Zahra Timsah  (University Academic Fellow in Molecular Mechanisms of Cancer Biology)

Postgraduates

Eleni Kyriakopoulou (Primary supervisor) 90% FTE

Berrout J, Kyriakopoulou E, Moparthi L, Hogea AS, Berrout L, Ivan C, Lorger M, Boyle J, Peers C, Muench S, Gomez JE, Hu X, Hurst C, Hall T, Umamaheswaran S, Wesley L, Gagea M, Shires M, Manfield I, Knowles MA, Davies S, Suhling K, Gonzalez YT, Carragher N, Macleod K, Abbott NJ, Calin GA, Gamper N, Zygmunt PM, Timsah Z TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p Nature Communications 8 -, 2017
DOI:10.1038/s41467-017-00983-w
View abstract

Bekdash A, Darwish M, Timsah Z, Kassab E, Ghanem H, Najjar V, Ghosn M, Nasser S, El-Hajj H, Bazerbachi A, Liu S, Leppla SH, Frankel AE, Abi-Habib RJ Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF). Transl Oncol 8 347-357, 2015
DOI:10.1016/j.tranon.2015.07.001
View abstract

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee Iv GR, Lin CC, Gagea M, Marti AA, Ladbury JE Erratum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function (Nature Communications (2015) 6:7354 DOI:10.1038/ncomms8354) Nature Communications 6 -, 2015
DOI:10.1038/ncomms9007

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee GR, Lin C-C, Gagea M, Marti AA, Ladbury JE Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nature Communications 6 7354-, 2015
DOI:10.1038/ncomms8354
View abstract

Timsah Z, Berrout J, Suraokar M, Behrens C, Song J, Lee JJ, Ivan C, Gagea M, Shires M, Hu X, Vallien C, Kingsley CV, Wistuba I, Ladbury JE Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma. Am J Cancer Res 5 3135-3148, 2015
View abstract

Timsah Z, Ahmed Z, Lin C-C, Melo FA, Stagg LJ, Leonard PG, Jeyabal P, Berrout J, O'Neil RG, Bogdanov M, Ladbury JE Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion. Nature structural&molecular biology 21 180-188, 2014
DOI:10.1038/nsmb.2752
View abstract

Kassab E, Darwish M, Timsah Z, Liu SH, Leppla SH, Frankel AE, Abi-Habib RJ Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity Translational Oncology 6 25-32, 2013
DOI:10.1593/tlo.12313
View abstract

Abi-Habib R, Kassab E, Darwish M, Timsah Z, Liu S, Leppla S, Frankel A Acute Myeloid Leukemia (AML) Cell Lines Are Sensitive to the Anthrax Lethal Toxin (LeTx)-Mediated Inhibition of the MAPK Pathway, 2012
DOI:10.1016/S0959-8049(12)72124-X

Abi-Habib RJ, Timsah Z, Darwish M, Alfano R, Liu S, Leppla S, Frankel A Sensitivity of Acute Myeloid Leukemia (AML) cells to a urokinase-activated recombinant anthrax toxin., 2011
View abstract

Abi-Habib R, Kassab E, Darwish M, Timsah Z, Liu S, Leppla S, Frankel A 326 Acute Myeloid Leukemia (AML) Cell Lines Are Sensitive to the Anthrax Lethal Toxin (LeTx)-Mediated Inhibition of the MAPK Pathway,

Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GNA, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung M-C, Sood AK, Bogdanov M, Ladbury JE Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene 35 2186-2196,
DOI:10.1038/onc.2015.279
View abstract