Dr Gary Thompson

BSc, York: PhD, Reading
Research Fellow
School of Molecular and Cellular Biology

Contact: Miall 4.21a, +44(0) 113 34 33024, email address for  

Sanfelice D, Koss H, Bunney TD, Thompson GS, Farrell B, Katan M, Breeze AL NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074 Biomolecular NMR Assignments 1-5, 2018
DOI:10.1007/s12104-018-9814-7
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Bunney TD, Inglis AJ, Sanfelice D, Farrell B, Kerr CJ, Thompson GS, Masson GR, Thiyagarajan N, Svergun DI, Williams RL, Breeze AL, Katan M Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System Structure 26 446-458.e8, 2018
DOI:10.1016/j.str.2018.01.016
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Karamanos TK, Pashley CL, Kalverda AP, Thompson GS, Mayzel M, Orekhov VY, Radford SE A Population Shift between Sparsely Populated Folding Intermediates Determines Amyloidogenicity Journal of the American Chemical Society 138 6271-6280, 2016
DOI:10.1021/jacs.6b02464
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Tomlinson JH, Thompson GS, Kalverda AP, Zhuravleva A, O'Neill AJ A target-protection mechanism of antibiotic resistance at atomic resolution: Insights into FusB-type fusidic acid resistance Scientific Reports 6, 2016
DOI:10.1038/srep19524
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Hiruma-Shimizu K, Shimizu H, Thompson GS, Kalverda AP, Patching SG Deuterated detergents for structural and functional studies of membrane proteins: Properties, chemical synthesis and applications Molecular Membrane Biology 32 139-155, 2015
DOI:10.3109/09687688.2015.1125536
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Klein T, Vajpai N, Phillips JJ, Davies G, Holdgate GA, Phillips C, Tucker JA, Norman RA, Scott AD, Higazi DR, Lowe D, Thompson GS, Breeze AL Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase Nature Communications 6, 2015
DOI:10.1038/ncomms8877
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Karamanos TK, Kalverda AP, Thompson GS, Radford SE Mechanisms of amyloid formation revealed by solution NMR Progress in Nuclear Magnetic Resonance Spectroscopy 88-89 86-104, 2015
DOI:10.1016/j.pnmrs.2015.05.002
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Monteiro DCF, Patel V, Bartlett CP, Nozaki S, Grant TD, Gowdy JA, Thompson GS, Kalverda AP, Snell EH, Niki H, Pearson AR, Webb ME The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme a Chemistry and Biology 22 492-503, 2015
DOI:10.1016/j.chembiol.2015.03.017
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Czajlik A, Thompson GS, Khan GN, Kalverda AP, Homans SW, Trinick J ¹H, ¹⁵N, and ¹³C backbone chemical shift assignment of titin domains A59-A60 and A60 alone Biomolecular NMR assignments 8 429-433, 2014
DOI:10.1007/s12104-013-9532-0
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Czajlik A, Thompson GS, Khan GN, Kalverda AP, Homans SW, Trinick J ¹H, ¹⁵N, and ¹³C backbone chemical shift assignment of titin domains A59-A60 and A60 alone. Biomol NMR Assign 8 429-433, 2014
DOI:10.1007/s12104-013-9532-0
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Sarell CJ, Karamanos TK, White SJ, Bunka DHJ, Kalverda AP, Thompson GS, Barker AM, Stockley PG, Radford SE Distinguishing closely related amyloid precursors using an RNA aptamer. J Biol Chem 289 26859-26871, 2014
DOI:10.1074/jbc.M114.595066
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Morin S, Linnet TE, Lescanne M, Schanda P, Thompson GS, Tollinger M, Teilum K, Gagné S, Marion D, Griesinger C, Blackledge M, d'Auvergne EJ relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data. Bioinformatics 30 2219-2220, 2014
DOI:10.1093/bioinformatics/btu166
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Karamanos TK, Kalverda AP, Thompson GS, Radford SE Visualization of transient protein-protein interactions that promote or inhibit amyloid assembly. Mol Cell 55 214-226, 2014
DOI:10.1016/j.molcel.2014.05.026
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Kalverda AP, Gowdy J, Thompson GS, Homans SW, Henderson PJF, Patching SG TROSY NMR with a 52 kDa sugar transport protein and the binding of a small-molecule inhibitor. Mol Membr Biol 31 131-140, 2014
DOI:10.3109/09687688.2014.911980
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Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M, Pearson AR, Rowlands, D. J., Homans SW, Harris M, Foster R, Griffin S Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release Hepatology 59 408-422, 2014
DOI:10.1002/hep.26685
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Czajlik A, Thompson GS, Khan GN, Kalverda AP, Homans SW, Trinick J ¹H, ¹⁵N and ¹³C backbone chemical shift assignment of the titin A67-A68 domain tandem. Biomol NMR Assign 6 39-41, 2012
DOI:10.1007/s12104-011-9321-6
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Pashley CL, Morgan GJ, Kalverda AP, Thompson GS, Kleanthous C, Radford SE Conformational properties of the unfolded state of Im7 in nondenaturing conditions. J Mol Biol 416 300-318, 2012
DOI:10.1016/j.jmb.2011.12.041
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Cox G, Thompson GS, Jenkins HT, Peske F, Savelsbergh A, Rodnina MV, Wintermeyer W, Homans SW, Edwards TA, O'Neill AJ Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proc Natl Acad Sci U S A 109 2102-2107, 2012
DOI:10.1073/pnas.1117275109
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Heyda J, Kožíšek M, Bednárova L, Thompson G, Konvalinka J, Vondrášek J, Jungwirth P Urea and guanidinium induced denaturation of a Trp-cage miniprotein Journal of Physical Chemistry B 115 8910-8924, 2011
DOI:10.1021/jp200790h
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Eichner T, Kalverda AP, Thompson GS, Homans SW, Radford SE Conformational conversion during amyloid formation at atomic resolution. Mol Cell 41 161-172, 2011
DOI:10.1016/j.molcel.2010.11.028
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Czajlik A, Thompson GS, Khan GN, Kalverda AP, Homans SW, Trinick J 1H, 15N and 13C backbone chemical shift assignment of the titin A67-A68 domain tandem Biomolecular NMR Assignments 1-3, 2011

Houssen WE, Wright SH, Kalverda AP, Thompson GS, Kelly SM, Jaspars M Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34. Chembiochem 11 1867-1873, 2010
DOI:10.1002/cbic.201000305
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Kalverda AP, Thompson GS, Vogel A, Schroder M, Bowie AG, Khan AR, Homans SW Poxvirus K7 Protein Adopts a Bcl-2 Fold: Biochemical Mapping of Its Interactions with Human DEAD Box RNA Helicase DDX3 J MOL BIOL 385 843-853, 2009
DOI:10.1016/j.jmb.2008.09.048

Stöckmann H, Bronowska A, Syme NR, Thompson GS, Kalverda AP, Warriner SL, Homans SW Residual ligand entropy in the binding of p-substituted benzenesulfonamide ligands to bovine carbonic anhydrase II. J Am Chem Soc 130 12420-12426, 2008
DOI:10.1021/ja803755m
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Rolfsson O, Toropova K, Morton V, Francese S, Basnak G, Thompson GS, Homans SW, Ashcroft AE, Stonehouse NJ, Ranson NA, Stockley PG RNA packing specificity and folding during assembly of the bacteriophage MS2 COMPUT MATH METHOD M 9 339-349, 2008
DOI:10.1080/17486700802168445

Stockley PG, Rolfsson O, Thompson GS, Basnak G, Francese S, Stonehouse NJ, Homans SW, Ashcroft AE A simple, RNA-mediated allosteric switch controls the pathway to formation of a T=3 viral capsid J MOL BIOL 369 541-552, 2007
DOI:10.1016/j.jmb.2007.03.020

Kalverda AP, Thompson GS, Turnbull WB The importance of protein structural dynamics and the contribution of NMR spectroscopy In Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, 2005

Stockley PG, Ashcroft AE, Francese S, Thompson GS, Ranson NA, Smith AM, Homans SW, Stonehouse NJ Dissecting the fine details of assembly of a T=3 capsid Journal of Theoretical Medicine 6 119-125, 2005
DOI:10.1080/10273660500149869

Yung A, Turnbull WB, Kalverda AP, Thompson GS, Homans SW, Kitov P, Bundle DR Large-scale millisecond intersubunit dynamics in the B subunit homopentamer of the toxin derived from Escherichia coli O157. J Am Chem Soc 125 13058-13062, 2003
DOI:10.1021/ja0367288
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Milne BF, Morris LA, Jaspars M, Thompson GS Conformational change in the thiazole and oxazoline containing cyclic octapeptides, the patellamides. Part 2. Solvent dependent conformational change J CHEM SOC PERK T 2 1076-1080, 2002
DOI:10.1039/b201824c

Barratt EA, Thompson GS, Harrison MA, Homans SW, Findlay JBC Structural analysis of Vma7p, subunit F of the vacuolar H+ATPase BIOPHYS J 82 455A-455A, 2002

Morris LA, Milne BF, Thompson GS, Jaspars M Conformational change in the thiazole and oxazoline containing cyclic octapeptides, the patellamides. Part 1. Cu2+ and Zn2+ induced conformational change J CHEM SOC PERK T 2 1072-1075, 2002
DOI:10.1039/b202823n

Barratt EA, Thompson GS, Harrison MA, Homans SW, Findlay JBC Structural analysis of Vma7p, subunit F of the vacuolar H+ATPase Biophysical Journal 82 pp.2218-, 2002

Reader JS, Van Nuland NAJ, Thompson GS, Ferguson SJ, Dobson CM, Radford SE A partially folded intermediate species of the beta-sheet protein apo-pseudoazurin is trapped during proline-limited folding PROTEIN SCI 10 1216-1224, 2001

Thompson GS, Shimizu H, Homans SW, Donohue-Rolfe A Localization of the binding site for the oligosaccharide moiety of Gb<inf>3</inf>on verotoxin 1 using NMR residual dipolar coupling measurements Biochemistry 39 13153-13156, 2000
DOI:10.1021/bi001394+
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Morris LA, Jantina Kettenes Van Den Bosch J, Versluis K, Thompson GS, Jaspars M Structure determination and MS(n) analysis of two new lissoclinamides isolated from the Indo-Pacific ascidian Lissoclinum patella: NOE restrained molecular dynamics confirms the absolute stereochemistry derived by degradative methods Tetrahedron 56 8345-8353, 2000
DOI:10.1016/S0040-4020(00)00746-8
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Thompson GS, Radford SE The solution structure and backbone dynamics of Cu(I) pseudoazurin from Paracoccus pantotropus. Protein Science 846-858, 2000

Thompson GS, Leung YC, Ferguson SJ, Radford SE, Redfield C The structure and dynamics in solution of Cu(I) pseudoazurin from Paracoccus pantotrophus Protein Science 9 846-858, 2000
DOI:10.1110/ps.9.5.846
View abstract