Contact: Astbury 7.103 / 7.106 / 7.110, +44(0) 113 34 33025,
I am a senior research technician for the BioScreening Technology Group (BSTG), a facility for the development and screening of non-antibody binding proteins. The BSTG has developed libraries based on a small stable scaffold protein called Adhiron, which can be screened against a wide range of target molecules by phage display to identify specific binders. The BSTG has formed collaborative partnerships with academics, clinicians and industry to develop Adhiron technology as reagents for R&D, diagnostics, and therapeutics. We work closely with Avacta Life Sciences where Adhiron technology has been commercialised as Affimer technology.
As well as working full-time, I am also a part-time PhD student (from October 2015). My project is the study of protein-protein interaction (PPI) domains (e.g. SH3 domains) in cell signalling pathways implicated in human cancers.
Previous to my career at the University of Leeds, I have been employed as a research and development scientist in both industry, and academia, and now have more than 10 years’ experience in the fields of bioscience.
Connect with me on LinkedIn: www.linkedin.com/in/anna-tang-69682376
Tiede C, Tang AA, Deacon SE, Mandal U, Nettleship JE, Owen RL, George SE, Harrison DJ, Owens RJ, Tomlinson DC and McPherson MJ. Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications. Protein Eng Des Sel, 2014, 27(5):145-55. https://doi.org/10.1093/protein/gzu007
Rawlings AE, Bramble JP, Tang AAS, Somner LA, Monnington AE, Cooke DJ, McPherson MJ, Tomlinson DC and Staniland SS. Phage display selected magnetite interacting Adhirons for shape controlled nanoparticle synthesis. Chemical Science, 2015, 6, 5586-5594. https://doi.org/10.1039/C5SC01472G
Koutsoumpeli E, Tiede C, Murray J, Tang A, Bon RS, Tomlinson DC and Johnson S. Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance. Analytical Chemistry, 2017, 89, 3051−3058. https://doi.org/10.1021/acs.analchem.6b04790
Sharma R, Deacon SE, Nowak D, George SE, Szymonik MP, Tang AA, Tomlinson DC, Davies AG, McPherson MJ and Wälti C. Label-free electrochemical impedance biosensor to detect human interleukin-8 in serum with sub-pg/ml sensitivity. Biosensors and Bioelectronics, 2016, 80, 607-613. https://doi.org/10.1016/j.bios.2016.02.028
Tiede C, Bedford R, Heseltine SJ, Smith G, Wijetunga I, Ross R, AlQallaf D, Roberts AP, Balls A, Curd A, Hughes RE, Martin H, Needham SR, Zanetti-Domingues LC, Sadigh Y, Peacock TP, Tang AA, Gibson N, Kyle H, Platt GW, Ingram N, Taylor T, Coletta LP, Manfield I, Knowles M, Bell S, Esteves F, Maqbool A, Prasad RK, Drinkhill M, Bon RS, Patel V, Goodchild SA, Martin-Fernandez M, Owens RJ, Nettleship JE, Webb ME, Harrison M, Lippiat JD, Ponnambalam S, Peckham M, Smith A, Ferrigno PK, Johnson M, McPherson MJ, Tomlinson DC. Affimer proteins are versatile and renewable affinity reagents. eLife, 2017, 6:e24903. https://doi.org/10.7554/eLife.24903.001