Faculty of Biological Sciences

Prof Frank Sobott


School of Molecular and Cellular Biology

Contact:  Astbury 8.110, +44(0) 113-34-32576, email address for  

Postgraduates

James Pitts (Co-supervisor) 33% FTE

Yefremova Y, Melder FTI, Danquah BD, Opuni KFM, Koy C, Ehrens A, Frommholz D, Illges H, Koelbel K, Sobott F, Glocker MO Apparent activation energies of protein-protein complex dissociation in the gas-phase determined by electrospray mass spectrometry. Anal Bioanal Chem -, 2017
DOI:10.1007/s00216-017-0603-4
View abstract

Cuypers B, Vermeylen S, Hammerschmid D, Trashin S, Rahemi V, Konijnenberg A, De Schutter A, Cheng C-HC, Giordano D, Verde C, De Wael K, Sobott F, Dewilde S, Van Doorslaer S Antarctic fish versus human cytoglobins– The same but yet so different Journal of Inorganic Biochemistry 173 66-78, 2017
DOI:10.1016/j.jinorgbio.2017.04.025
View abstract

van Dyck JF, Konijnenberg A, Sobott F Native Mass Spectrometry for the Characterization of Structure and Interactions of Membrane Proteins. Methods Mol Biol 1635 205-232, 2017
DOI:10.1007/978-1-4939-7151-0_11
View abstract

Mensch C, Konijnenberg A, Van Elzen R, Lambeir A-M, Sobott F, Johannessen C Raman optical activity of humanα -synuclein in intrinsically disordered, micelle-bound α -helical, molten globule and oligomeric β -sheet state Journal of Raman Spectroscopy 48 910-918, 2017
DOI:10.1002/jrs.5149

Heirbaut M, Lermyte F, Martin EM, Beelen S, Sobott F, Strelkov SV, Weeks SD Specific Sequences in the N-terminal Domain of Human Small Heat Shock Protein HSPB6 Dictate Preferential Heterooligomerization with the Orthologue HSPB1 Journal of Biological Chemistry 292 9944-9957, 2017
DOI:10.1074/jbc.M116.773515
View abstract

Jurėnas D, Chatterjee S, Konijnenberg A, Sobott F, Droogmans L, Garcia-Pino A, Van Melderen L AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet Nature Chemical Biology 13 640-646, 2017
DOI:10.1038/nchembio.2346
View abstract

Chatzi KE, Sardis MF, Tsirigotaki A, Koukaki M,Šoštarić N, Konijnenberg A, Sobott F, Kalodimos CG, Karamanou S, Economou A Preprotein mature domains contain translocase targeting signals that are essential for secretion Journal of Cell Biology 216 1357-1369, 2017
DOI:10.1083/jcb.201609022
View abstract

Boschmans J, Lemière F, Sobott F Analyzing complex mixtures of drug-like molecules: Ion mobility as an adjunct to existing liquid chromatography-(tandem) mass spectrometry methods Journal of Chromatography A 1490 80-88, 2017
DOI:10.1016/j.chroma.2017.02.015
View abstract

Li J, Lyu W, Rossetti G, Konijnenberg A, Natalello A, Ippoliti E, Orozco M, Sobott F, Grandori R, Carloni P Proton Dynamics in Protein Mass Spectrometry. J Phys Chem Lett 8 1105-1112, 2017
DOI:10.1021/acs.jpclett.7b00127
View abstract

Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics Molecular Cell 65 1044-1055.e5, 2017
DOI:10.1016/j.molcel.2017.02.013
View abstract

Verlackt CCW, Van Boxem W, Dewaele D, Lemière F, Sobott F, Benedikt J, Neyts EC, Bogaerts A Mechanisms of Peptide Oxidation by Hydroxyl Radicals: Insight at the Molecular Scale The Journal of Physical Chemistry C 121 5787-5799, 2017
DOI:10.1021/acs.jpcc.6b12278
View abstract

Burger VM, Vandervelde A, Hendrix J, Konijnenberg A, Sobott F, Loris R, Stultz CM Hidden States within Disordered Regions of the CcdA Antitoxin Protein Journal of the American Chemical Society 139 2693-2701, 2017
DOI:10.1021/jacs.6b11450
View abstract

Ciach MA,Łącki MK, Miasojedow B, Lermyte F, Valkenborg D, Sobott F, Gambin A Estimation of rates of reactions triggered by electron transfer in top-down mass spectrometry, 2017
DOI:10.1007/978-3-319-59575-7_9
View abstract

Lermyte F,Łącki MK, Valkenborg D, Gambin A, Sobott F Conformational Space and Stability of ETD Charge Reduction Products of Ubiquitin Journal of the American Society for Mass Spectrometry 28 69-76, 2017
DOI:10.1007/s13361-016-1444-7
View abstract

Heirbaut M, Lermyte F, Martin EM, Beelen S, Verschueren T, Sobott F, Strelkov SV, Weeks SD The preferential heterodimerization of human small heat shock proteins HSPB1 and HSPB6 is dictated by the N-terminal domain Archives of Biochemistry and Biophysics 610 41-50, 2016
DOI:10.1016/j.abb.2016.10.002
View abstract

Göth M, Lermyte F, Schmitt XJ, Warnke S, von Helden G, Sobott F, Pagel K Gas-phase microsolvation of ubiquitin: investigation of crown ether complexation sites using ion mobility-mass spectrometry. The Analyst 141 5502-5510, 2016
DOI:10.1039/C6AN01377E
View abstract

Burger VM, Vandervelde A, Konijnenberg A, Hendrix J, Sobott F, Loris R, Stultz CM A bacterial antitoxin's conformational ensemble provides insight into distinct functional roles of its distinct disordered states, 2016

Konijnenberg A, Ranica S, Narkiewicz J, Legname G, Grandori R, Sobott F, Natalello A Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding toα-Synuclein Analytical Chemistry 88 8468-8475, 2016
DOI:10.1021/acs.analchem.6b00731
View abstract

Martens C, Stein RA, Masureel M, Roth A, Mishra S, Dawaliby R, Konijnenberg A, Sobott F, Govaerts C, Mchaourab HS Lipids modulate the conformational dynamics of a secondary multidrug transporter Nature Structural&Molecular Biology 23 744-751, 2016
DOI:10.1038/nsmb.3262
View abstract

Wen Y, Sobott F, Devreese B ATP and autophosphorylation driven conformational changes of HipA kinase revealed by ion mobility and crosslinking mass spectrometry Analytical and Bioanalytical Chemistry 408 5925-5933, 2016
DOI:10.1007/s00216-016-9709-3
View abstract

Boschmans J, Jacobs S, Williams JP, Palmer M, Richardson K, Giles K, Lapthorn C, Herrebout WA, Lemière F, Sobott F Combining density functional theory (DFT) and collision cross-section (CCS) calculations to analyze the gas-phase behaviour of small molecules and their protonation site isomers Analyst 141 4044-4054, 2016
DOI:10.1039/c5an02456k
View abstract

Dewaele D, Sobott F, Lemière F Covalent adducts of melphalan with free amino acids and a model peptide studied by liquid chromatography/tandem mass spectrometry Rapid Communications in Mass Spectrometry 30 719-730, 2016
DOI:10.1002/rcm.7489
View abstract

Fisher GL, Pastrana CL, Taylor JA, Butterer A, Sobott F, Moreno-Herrero F, Dillingham MS Recognition and Condensation of the Bacterial Centromere by ParB, 2016

Burger VM, Konijnenberg A, Vanderwelde A, Sobott F, Loris R, Stultz CM Probing the Conformational Ensemble of a Bacterial Antitoxin through Molecular Dynamics Simulations and Mass Spectrometry, 2016

Maggi A, Ruivo E, Fissers J, Vangestel C, Chatterjee S, Joossens J, Sobott F, Staelens S, Stroobants S, Van Der Veken P, Wyffels L, Augustyns K Development of a novel antibody-tetrazine conjugate for bioorthogonal pretargeting Organic and Biomolecular Chemistry 14 7544-7551, 2016
DOI:10.1039/c6ob01411a
View abstract

Claesen J, Lermyte F, Sobott F, Burzykowski T, Valkenborg D Differences in the Elemental Isotope Definition May Lead to Errors in Modern Mass-Spectrometry-Based Proteomics Analytical Chemistry 87 10747-10754, 2015
DOI:10.1021/acs.analchem.5b01165
View abstract

Konijnenberg A, Van Dyck JF, Kailing LL, Sobott F Extending native mass spectrometry approaches to integral membrane proteins Biological Chemistry 396 991-1002, 2015
DOI:10.1515/hsz-2015-0136
View abstract

Lermyte F,Łacki MK, Valkenborg D, Baggerman G, Gambin A, Sobott F Understanding reaction pathways in top-down ETD by dissecting isotope distributions: A mammoth task International Journal of Mass Spectrometry 390 146-154, 2015
DOI:10.1016/j.ijms.2015.08.008
View abstract

Lermyte F, Williams JP, Brown JM, Martin EM, Sobott F Extensive charge reduction and dissociation of intact protein complexes following electron transfer on a quadrupole-ion mobility-time-of-flight MS Journal of the American Society for Mass Spectrometry 26 1068-1076, 2015
DOI:10.1007/s13361-015-1124-z
View abstract

Konijnenberg A, Sobott F Bouncing off the walls: Excited protein complexes tell their story Chemistry and Biology 22 563-564, 2015
DOI:10.1016/j.chembiol.2015.05.004

Warnke S, Seo J, Boschmans J, Sobott F, Scrivens JH, Bleiholder C, Bowers MT, Gewinner S, Schöllkopf W, Pagel K, Von Helden G Protomers of benzocaine: Solvent and permittivity dependence Journal of the American Chemical Society 137 4236-4242, 2015
DOI:10.1021/jacs.5b01338
View abstract

Bulatov E, Martin EM, Chatterjee S, Knebel A, Shimamura S, Konijnenberg A, Johnson C, Zinn N, Grandi P, Sobott F, Ciulli A Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: Suppressor of cytokine signaling 2 (SOCS2)-elongin Bc-cullin 5-ring box protein 2 (RBX2) Journal of Biological Chemistry 290 4178-4191, 2015
DOI:10.1074/jbc.M114.616664
View abstract

Taylor JA, Pastrana CL, Butterer A, Pernstich C, Gwynn EJ, Sobott F, Moreno-Herrero F, Dillingham MS Specific and non-specific interactions of ParB with DNA: Implications for chromosome segregation Nucleic Acids Research 43 719-731, 2015
DOI:10.1093/nar/gku1295
View abstract

Konijnenberg A, Bannwarth L, Yilmaz D, Koçer A, Venien-Bryan C, Sobott F Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment Protein Science 24 1292-1300, 2015
DOI:10.1002/pro.2703
View abstract

Lermyte F, Sobott F Electron transfer dissociation provides higher-order structural information of native and partially unfolded protein complexes Proteomics 15 2813-2822, 2015
DOI:10.1002/pmic.201400516
View abstract

Janssen L, Sobott F, De Deyn PP, Van Dam D Signal loss due to oligomerization in ELISA analysis of amyloid-beta can be recovered by a novel sample pre-treatment method MethodsX 2 112-123, 2015
DOI:10.1016/j.mex.2015.02.011
View abstract

Lermyte F, Verschueren T, Brown JM, Williams JP, Valkenborg D, Sobott F Characterization of top-down ETD in a travelling-wave ion guide Methods 89 22-29, 2015
DOI:10.1016/j.ymeth.2015.05.019
View abstract

D'Urzo A, Konijnenberg A, Rossetti G, Habchi J, Li J, Carloni P, Sobott F, Longhi S, Grandori R Molecular basis for structural heterogeneity of an intrinsically disordered protein bound to a partner by combined ESI-IM-MS and modeling Journal of the American Society for Mass Spectrometry 26 472-481, 2015
DOI:10.1007/s13361-014-1048-z
View abstract

De Gieter S, Konijnenberg A, Talavera A, Butterer A, Haesaerts S, De Greve H, Sobott F, Loris R, Garcia-Pino A The intrinsically disordered domain of the antitoxin phd chaperones the toxin doc against irreversible inactivation and misfolding Journal of Biological Chemistry 289 34013-34023, 2014
DOI:10.1074/jbc.M114.572396
View abstract

Konijnenberg A, Yilmaz D, Ingólfsson HI, Dimitrova A, Marrink SJ, Li Z, Vénien-Bryan C, Sobott F, Kocer A Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry Proceedings of the National Academy of Sciences of the United States of America 111 17170-17175, 2014
DOI:10.1073/pnas.1413118111
View abstract

Heirbaut M, Beelen S, Martin E, Lermyte F, Verschueren T, Sobott F, Strelkov S, Weeks S Elucidating the Structure And Dynamics Of Small Heat Shock Protein Complexes Using A Hybrid Approach, 2014

Lermyte F, Konijnenberg A, Williams JP, Brown JM, Valkenborg D, Sobott F ETD allows for native surface mapping of a 150 kDa noncovalent complex on a commercial Q-TWIMS-TOF instrument Journal of the American Society for Mass Spectrometry 25 343-350, 2014
DOI:10.1007/s13361-013-0798-3
View abstract

Sobott F Native Ion Mobility-Mass Spectrometry: from Flexible Proteins to Ion Channels, 2014

Yilmaz D, Konijnenberg A, Ingolfsson H, Dimitrova A, Marrink SJ, Sobott F, Kocer A Following the Global Structural Changes of an Ion Channel During its Gating by using a Novel Mass Spectrometry Approach, 2014

Butterer A, Pernstich C, Smith RM, Sobott F, Szczelkun MD, Tóth J Type III restriction endonucleases are heterotrimeric: Comprising one helicase-nuclease subunit and a dimeric methyltransferase that binds only one specific DNA Nucleic Acids Research 42 5139-5150, 2014
DOI:10.1093/nar/gku122
View abstract

Santambrogio C, Sperandeo P, Villa R, Sobott F, Polissi A, Grandori R LptA assembles into rod-like oligomers involving disorder-to-order transitions Journal of the American Society for Mass Spectrometry 24 1593-1602, 2013
DOI:10.1007/s13361-013-0687-9
View abstract

Henderson CA, Vincent HA, Casamento A, Stone CM, Phillips JO, Cary PD, Sobott F, Gowers DM, Taylor JE, Callaghan AJ Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS RNA 19 1089-1104, 2013
DOI:10.1261/rna.034595.112
View abstract

Harvey DJ, Scarff CA, Edgeworth M, Crispin M, Scanlan CN, Sobott F, Allman S, Baruah K, Pritchard L, Scrivens JH Travelling wave ion mobility and negative ion fragmentation for the structural determination of N-linked glycans Electrophoresis 34 2368-2378, 2013
DOI:10.1002/elps.201200669
View abstract

Konijnenberg A, Butterer A, Sobott F Native ion mobility-mass spectrometry and related methods in structural biology Biochimica et Biophysica Acta - Proteins and Proteomics 1834 1239-1256, 2013
DOI:10.1016/j.bbapap.2012.11.013
View abstract

Smith RM, Marshall JJT, Jacklin AJ, Retter SE, Halford SE, Sobott F Organization of the BcgI restriction-modification protein for the cleavage of eight phosphodiester bonds in DNA Nucleic Acids Research 41 391-404, 2013
DOI:10.1093/nar/gks1023
View abstract

Smith RM, Jacklin AJ, Marshall JJT, Sobott F, Halford SE Organization of the BcgI restriction-modification protein for the transfer of one methyl group to DNA Nucleic Acids Research 41 405-417, 2013
DOI:10.1093/nar/gks1000
View abstract

Harvey DJ, Crispin M, Scanlan CN, Allman S, Baruah K, Pritchard L, Scarff CA, Edgeworth M, Scrivens JH, Sobott F Travelling wave ion mobility and negative ion fragmentation for the structural determination of N-linked glycans Electrophoresis -, 2013
DOI:10.1002/elps.201200669
View abstract

Zhang W, Tyl M, Ward R, Sobott F, Maman J, Murthy AS, Watson AA, Fedorov O, Bowman A, Owen-Hughes T, El Mkami H, Murzina NV, Norman DG, Laue ED Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1 Nature Structural and Molecular Biology 20 29-35, 2013
DOI:10.1038/nsmb.2446
View abstract

Vincent HA, Henderson CA, Stone CM, Cary PD, Gowers DM, Sobott F, Taylor JE, Callaghan AJ The low-resolution solution structure of Vibrio cholerae Hfq in complex with Qrr1 sRNA Nucleic Acids Research 40 8698-8710, 2012
DOI:10.1093/nar/gks582
View abstract

Vincent HA, Henderson CA, Ragan TJ, Garza-Garcia A, Cary PD, Gowers DM, Malfois M, Driscoll PC, Sobott F, Callaghan AJ Characterization of Vibrio cholerae Hfq provides novel insights into the role of the Hfq C-terminal region Journal of Molecular Biology 420 56-69, 2012
DOI:10.1016/j.jmb.2012.03.028
View abstract

Becker EBE, Zuliani L, Pettingill R, Lang B, Waters P, Dulneva A, Sobott F, Wardle M, Graus F, Bataller L, Robertson NP, Vincent A Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia Journal of Neurology, Neurosurgery and Psychiatry 83 437-440, 2012
DOI:10.1136/jnnp-2011-301506
View abstract

Santambrogio C, Ricagno S, Sobott F, Colombo M, Bolognesi M, Grandori R Characterization ofβ2-microglobulin conformational intermediates associated to different fibrillation conditions Journal of Mass Spectrometry 46 734-741, 2011
DOI:10.1002/jms.1946
View abstract

Brocca S, Testa L, Sobott F,Šamalikova M, Natalello A, Papaleo E, Lotti M, De Gioia L, Doglia SM, Alberghina L, Grandori R Compaction properties of an intrinsically disordered protein: Sic1 and its kinase-inhibitor domain Biophysical Journal 100 2243-2252, 2011
DOI:10.1016/j.bpj.2011.02.055
View abstract

Harvat EM, Daltrop O, Sobott F, Moreau M, Barker PD, Stevens JM, Ferguson SJ Metal and redox selectivity of protoporphyrin binding to the heme chaperone CcmE Metallomics 3 363-368, 2011
DOI:10.1039/c0mt00085j
View abstract

Harvey DJ, Sobott F, Crispin M, Wrobel A, Bonomelli C, Vasiljevic S, Scanlan CN, Scarff CA, Thalassinos K, Scrivens JH Ion mobility mass spectrometry for extracting spectra of n-glycans directly from incubation mixtures following glycan release: Application to glycans from engineered glycoforms of intact, folded HIV gp120 Journal of the American Society for Mass Spectrometry 22 568-581, 2011
DOI:10.1007/s13361-010-0053-0
View abstract

Sobott F Characterisation of proteins and protein complexes by ion mobility-mass spectrometry CHIMICA OGGI-CHEMISTRY TODAY 29 20-24, 2011

Testa L, Samalikova M, Papaleo E, Natalello A, Sobott F, Brocca S (Dis)Ordered Conformations of the Kinase Inhibitory Domain of Sic1, 2010
DOI:10.1016/j.jbiotec.2010.09.824

Sobott F, Halford SE, Jacklin AJ, Marshall JJT, Smith RM DNA Nanomachines Investigated By Non-Denaturing Mass Spectrometry, 2010

Sobott F, Watt SJ, Smith J, Edelmann MJ, Kramer HB, Kessler BM Comparison of CID Versus ETD Based MS/MS Fragmentation for the Analysis of Protein Ubiquitination Journal of the American Society for Mass Spectrometry 20 1652-1659, 2009
DOI:10.1016/j.jasms.2009.04.023
View abstract

Stubbs CJ, Loenarz C, Mecinović J, Kar KY, Hindley N, Liénard BM, Sobott F, Schofield CJ, Flashman E Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure Journal of Medicinal Chemistry 52 2799-2805, 2009
DOI:10.1021/jm900285r
View abstract

Benesch JLP, Ruotolo BT, Sobott F, Wildgoose J, Gilbert A, Bateman R, Robinson CV Quadrupole-time-of-flight mass spectrometer modified for higher-energy dissociation reduces protein assemblies to peptide fragments Analytical Chemistry 81 1270-1274, 2009
DOI:10.1021/ac801950u
View abstract

Burgess-Brown NA, Sharma S, Sobott F, Loenarz C, Oppermann U, Gileadi O Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study Protein Expression and Purification 59 94-102, 2008
DOI:10.1016/j.pep.2008.01.008
View abstract

Eswaran J, Bernad A, Ligos JM, Guinea B, Debreczeni JE, Sobott F, Parker S, Najmanovich R, Turk BE, Knapp S Structure of the Human Protein Kinase MPSK1 Reveals an Atypical Activation Loop Architecture Structure 16 115-124, 2008
DOI:10.1016/j.str.2007.10.026
View abstract

Bunkoczi G, Salah E, Filippakopoulos P, Fedorov O, Müller S, Sobott F, Parker SA, Zhang H, Min W, Turk BE, Knapp S Structural and Functional Characterization of the Human Protein Kinase ASK1 Structure 15 1215-1226, 2007
DOI:10.1016/j.str.2007.08.011
View abstract

Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA The centaurinγ-1 GTPase-like domain functions as an NTPase Biochemical Journal 401 679-688, 2007
DOI:10.1042/BJ20060555
View abstract

Yang X, Lee WH, Sobott F, Papagrigoriou E, Robinson CV, Grossmann JG, Sundström M, Doyle DA, Elkins JM Structural basis for protein-protein interactions in the 14-3-3 protein family Proceedings of the National Academy of Sciences of the United States of America 103 17237-17242, 2006
DOI:10.1073/pnas.0605779103
View abstract

Vaughan CK, Gohlke U, Sobott F, Good VM, Ali MMU, Prodromou C, Robinson CV, Saibil HR, Pearl LH Structure of an Hsp90-Cdc37-Cdk4 Complex Molecular Cell 23 697-707, 2006
DOI:10.1016/j.molcel.2006.07.016
View abstract

Benesch JLP, Aquilina JA, Ruotolo BT, Sobott F, Robinson CV Tandem Mass Spectrometry Reveals the Quaternary Organization of Macromolecular Assemblies Chemistry and Biology 13 597-605, 2006
DOI:10.1016/j.chembiol.2006.04.006
View abstract

Sobott F, Robinson CV Understanding Protein Interactions and Their Representation in the Gas Phase of the Mass Spectrometer In Principles of Mass Spectrometry Applied to Biomolecules , 2006
DOI:10.1002/047005042X.ch4

McLaughlin SH, Sobott F, Yao ZP, Zhang W, Nielsen PR, Grossmann JG, Laue ED, Robinson CV, Jackson SE The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins Journal of Molecular Biology 356 746-758, 2006
DOI:10.1016/j.jmb.2005.11.085
View abstract

Ilag LL, Videler H, McKay AR, Sobott F, Fucini P, Nierhaus KH, Robinson CV Heptameric (L12)<inf>6</inf>/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria Proceedings of the National Academy of Sciences of the United States of America 102 8192-8197, 2005
DOI:10.1073/pnas.0502193102
View abstract

Sobott F, Mccammon MG, Hernández H, Robinson CV, Karplus M, Dobson CM, Scoles G, Zewail AH, McMillan PF, Finney JL The flight of macromolecular complexes in a mass spectrometer Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 363 379-391, 2005
DOI:10.1098/rsta.2004.1498
View abstract

Sobott F, Robinson CV Characterising electrosprayed biomolecules using tandem-MS - The noncovalent GroEL chaperonin assembly International Journal of Mass Spectrometry 236 25-32, 2004
DOI:10.1016/j.ijms.2004.05.010
View abstract

Zhang W, Hirshberg M, McLaughlin SH, Lazar GA, Grossmann JG, Nielsen PR, Sobott F, Robinson CV, Jackson SE, Laue ED Biochemical and structural studies of the interaction of Cdc37 with Hsp90 Journal of Molecular Biology 340 891-907, 2004
DOI:10.1016/j.jmb.2004.05.007
View abstract

McCammon MG, Hernández H, Sobott F, Robinson CV Tandem Mass Spectrometry Defines the Stoichiometry and Quaternary Structural Arrangement of Tryptophan Molecules in the Multiprotein Complex TRAP Journal of the American Chemical Society 126 5950-5951, 2004
DOI:10.1021/ja0317170
View abstract

Sobott F, McCammon MG, Robinson CV Gas-phase dissociation pathways of a tetrameric protein complex International Journal of Mass Spectrometry 230 193-200, 2003
DOI:10.1016/j.ijms.2003.09.008
View abstract

Benesch JLP, Sobott F, Robinson CV Thermal dissociation of multimeric protein complexes by using nanoelectrospray mass spectrometry Analytical Chemistry 75 2208-2214, 2003
DOI:10.1021/ac034132x
View abstract

Sugawara KI, Sobott F, Vakhtin AB Reactions of gold cluster cations Au<inf>n</inf><sup>+</sup>(n=1-12) with H<inf>2</inf>S and H<inf>2</inf> Journal of Chemical Physics 118 7808-7816, 2003
DOI:10.1063/1.1564057
View abstract

Sobott F, McCammon MG, Hernández H, Robinson CV A high-mass Q-TOF for the analysis of protein complexes, 2002
View abstract

Benesch J, Sobott F, Vierling E, Robinson CV A nano-electrospray investigation into the subunit exchange of small heat shock proteins, 2002
View abstract

Sobott F, Robinson CV Protein complexes gain momentum Current Opinion in Structural Biology 12 729-734, 2002
DOI:10.1016/S0959-440X(02)00400-1
View abstract

Sobott F, Benesch JLP, Vierling E, Robinson CV Subunit exchange of multimeric protein complexes: Real-time monitoring of subunit exchange between small heat shock proteins by using electrospray mass spectrometry Journal of Biological Chemistry 277 38921-38929, 2002
DOI:10.1074/jbc.M206060200
View abstract

Sobott F, Hernández H, McCammon MG, Tito MA, Robinson CV A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies Analytical Chemistry 74 1402-1407, 2002
DOI:10.1021/ac0110552
View abstract

Wattenberg A, Sobott F, Barth HD, Brutschy B Studying noncovalent protein complexes in aqueous solution with laser desorption mass spectrometry International Journal of Mass Spectrometry 203 49-57, 2000
DOI:10.1016/S1387-3806(00)00261-X
View abstract

Wattenberg A, Sobott F, Brutschy B Detection of intact hemoglobin from aqueous solution with laser desorption mass spectrometry Rapid Communications in Mass Spectrometry 14 859-861, 2000
DOI:10.1002/(SICI)1097-0231(20000530)14:10<859::AID-RCM956>3.0.CO;2-M
View abstract

Wattenberg A, Sobott F, Brutschy B Detection of intact hemoglobin from aqueous solution with laser desorption mass spectrometry RAPID COMMUNICATIONS IN MASS SPECTROMETRY 14 859-861, 2000
DOI:10.1002/(SICI)1097-0231(20000530)14:10<859::AID-RCM956>3.3.CO;2-D

Bussian P, Sobott F, Brutschy B, Schrader W, Schuth F Speciation in solution: Silicate oligomers in aqueous solutions detected by mass spectrometry ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 39 3901-+, 2000
DOI:10.1002/1521-3773(20001103)39:21<3901::AID-ANIE3901>3.0.CO;2-D

Wattenberg A, Sobott F, Barth HD, Brutschy B Laser desorption mass spectrometry on liquid beams European Journal of Mass Spectrometry 5 71-76, 1999
View abstract

Sobott F, Wattenberg A, Barth HD, Brutschy B Ionic clathrates from aqueous solutions detected with laser induced liquid beam ionization/desorption mass spectrometry International Journal of Mass Spectrometry 185 271-279, 1999
DOI:10.1016/S1387-3806(98)14158-1
View abstract

Sobott F, Wattenberg A, Kleinekofort W, Pfenninger A, Brutschy B Laser desorption mass spectrometry on thin liquid jets, 1998
View abstract

Sobott F, Schunk SA, Schüth F, Brutschy B Examination of condensation products of Group 4 alkoxides with laser- induced liquid beam ionization/desorption mass spectrometry Chemistry - A European Journal 4 2353-2359, 1998
DOI:10.1002/(SICI)1521-3765(19981102)4:11<2353::AID-CHEM2353>3.0.CO;2-I
View abstract

Sobott F, Kleinekofort W, Brutschy B Cation Selectivity of Natural and Synthetic lonophores Probed with Laser-Induced Liquid Beam Mass Spectrometry Analytical Chemistry 69 3587-3594, 1997
View abstract

Lermyte F, Sobott F A broader view on ion heating in traveling-wave devices using fragmentation of CsI clusters and extent of H˙ migration as molecular thermometers. Analyst -,
DOI:10.1039/c7an00161d
View abstract