Dr Charlotte Scarff

Research Fellow
School of Molecular and Cellular Biology

Contact: Astbury 8.104, +44(0) 113 34 34370, email address for  

Drulyte I, Johnson RM, Hesketh EL, Hurdiss DL, Scarff CA, Porav SA, Ranson NA, Muench SP, Thompson RF Approaches to altering particle distributions in cryo-electron microscopy sample preparation Acta Crystallographica Section D: Structural Biology, 2018
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Scarff CA, Fuller MJG, Thompson RF, Iadaza MG Variations on Negative Stain Electron Microscopy Methods: Tools for Tackling Challenging Systems. Journal of Visualized Experiments, 2018
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Parmar M, Rawson S, Scarff CA, Goldman A, Dafforn TR, Muench SP, Postis VLG Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure Biochimica et Biophysica Acta - Biomembranes 1860 378-383, 2018
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Harvey DJ, Scarff CA, Edgeworth M, Pagel K, Thalassinos K, Struwe WB, Crispin M, Scrivens JH Travelling-wave ion mobility mass spectrometry and negative ion fragmentation of hybrid and complex N-glycans. Journal of Mass Spectrometry, 2016
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Harvey DJ, Scarff CA, Edgeworth M, Struwe WB, Pagel K, Thalassinos K, Crispin M, Scrivens J Travelling-wave ion mobility and negative ion fragmentation of high-mannose N-glycans Journal of Mass Spectrometry 51 219-235, 2016
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Scarff CA, Ashcroft AE, Radford SE Characterization of amyloid oligomers by electrospray ionization-ion mobility spectrometry-mass spectrometry (ESI-IMS-MS) In Methods in Molecular Biology, 2015
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Scarff CA, Almeida B, Fraga J, Macedo-Ribeiro S, Radford SE, Ashcroft AE Examination of ataxin-3 (atx-3) aggregation by structural mass spectrometry techniques: A rationale for expedited aggregation upon polyglutamine (polyQ) expansion Molecular and Cellular Proteomics 14 1241-1253, 2015
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Hofmann J, Struwe WB, Scarff CA, Scrivens JH, Harvey DJ, Pagel K Estimating collision cross sections of negatively charged N- glycans using traveling wave ion mobility-mass spectrometry Analytical Chemistry 86 10789-10795, 2014
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Leney AC, Pashley CL, Scarff CA, Radford SE, Ashcroft AE Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry. Mol Biosyst 10 412-420, 2014
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Harvey DJ, Scarff CA, Edgeworth M, Crispin M, Scanlan CN, Sobott F, Allman S, Baruah K, Pritchard L, Scrivens JH Travelling wave ion mobility and negative ion fragmentation for the structural determination of N-linked glycans. Electrophoresis 34 2368-2378, 2013
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Kondrat FDL, Kowald GR, Scarff CA, Scrivens JH, Blindauer CA Resolution of a paradox by native mass spectrometry: facile occupation of all four metal binding sites in the dimeric zinc sensor SmtB. Chem Commun (Camb) 49 813-815, 2013
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Harvey DJ, Scarff CA, Crispin M, Scanlan CN, Bonomelli C, Scrivens JH MALDI-MS/MS with traveling wave ion mobility for the structural analysis of N-linked glycans. J Am Soc Mass Spectrom 23 1955-1966, 2012
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Snelling JR, Scarff CA, Scrivens JH Characterization of complex polysorbate formulations by means of shape-selective mass spectrometry. Anal Chem 84 6521-6529, 2012
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Scarff CA, Snelling JR, Knust MM, Wilkins CL, Scrivens JH New structural insights into mechanically interlocked polymers revealed by ion mobility mass spectrometry. J Am Chem Soc 134 9193-9198, 2012
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Booyjzsen C, Scarff CA, Moreton B, Portman I, Scrivens JH, Costantini G, Sadler PJ Fibrillation of transferrin. Biochim Biophys Acta 1820 427-436, 2012
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Patel JV, Chackathayil J, Gammon B, Tracey I, Banerjee A, Lip GYH, Hughes EA, Gill PS, Lovick A, Scarff CA, Scrivens JH Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study Atherosclerosis, 2012
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Scarff CA, Sicorello A, Tomé RJL, Ashcroft AE, Radford SE, Macedo-Ribeiro S A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3 International Journal of Mass Spectrometry, 2012
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Booyjzsen C, Scarff CA, Moreton B, Portman IJ, Costantini G, Scrivens JH, Mukherjee A, Sadler PJ Human transferrin: Association and fibril formation, 2011

Harvey DJ, Sobott F, Crispin M, Wrobel A, Bonomelli C, Vasiljevic S, Scanlan CN, Scarff CA, Thalassinos K, Scrivens JH Ion mobility mass spectrometry for extracting spectra of N-glycans directly from incubation mixtures following glycan release: application to glycans from engineered glycoforms of intact, folded HIV gp120. J Am Soc Mass Spectrom 22 568-581, 2011
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Patel JV, Chackathayil J, Tracey I, Lovick A, Gill PS, Scarff CA, Konstantinos T, Scrivens JH, Lip GYH, Hughes EA Haemoglobin disorders and low HDL cholesterol in South Asians - Are they connected?, 2010

Scarff CA, Patel VJ, Thalassinos K, Scrivens JH Probing hemoglobin structure by means of traveling-wave ion mobility mass spectrometry. J Am Soc Mass Spectrom 20 625-631, 2009
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Scarff CA, Thalassinos K, Hilton GR, Scrivens JH Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements. Rapid Commun Mass Spectrom 22 3297-3304, 2008
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Robotham JV, Scarff CA, Jenkins DR, Medley GF Meticillin-resistant Staphylococcus aureus (MRSA) in hospitals and the community: model predictions based on the UK situation. J Hosp Infect 65 Suppl 2 93-99, 2007
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