Faculty of Biological Sciences

Dr Ildar Sadreev

PhD

Contact: Garstang 10.127b, +44 113 343 3072, email address for  

  • Bioinformatics: NGS and Microarray data analysis, developing pipelines for CHIP-seq data analysis, modeling, simulation, data mining, signal processing
  • Systems Biology: Mathematical modeling of pharmaceutically important signal transduction pathways that regulate intracellular processes involved in human diseases
 

Current Projects

  • Investigation of Ibrutinib-mediated changes in chromatin organization (Dr Pascal Lefevre, LICAP). This project involves the analysis of CHIP-seq data in patients with Chronic Lymphocytic Leukemia (CLL).
  • Study of the mechanisms underlying the resistance of Chronic Myeloid Leukemia (CML) patients treated with Imatinib (Dr Peter Laslo, LICAP). For this project, the analysis of Microarray gene expression data is performed.
 

Sadreev II, Chen MZQ, Umezawa Y, Biktashev VN, Kemper C, Salakhieva DV, Welsh GI, Kotov NV The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells Immunology, 2017
DOI:10.1111/imm.12851
View abstract

Salakhieva DV, Sadreev II, Chen MZQ, Umezawa Y, Evstifeev AI, Welsh GI, Kotov NV Kinetic regulation of multi-ligand binding proteins BMC Systems Biology 10, 2016
DOI:10.1186/s12918-016-0277-0
View abstract

Bazanovas AN, Evstifeev AI, Khaiboullina SF, Sadreev II, Skorinkin AI, Kotov NV Erythrocyte: A systems model of the control of aggregation and deformability BioSystems 131 1-8, 2015
DOI:10.1016/j.biosystems.2015.03.003
View abstract

Sadreev II, Chen MZQ, Welsh GI, Umezawa Y, Kotov NV, Valeyev NV A Systems Model of Phosphorylation for Inflammatory Signaling Events PLOS ONE 9, 2014
DOI:10.1371/journal.pone.0110913