Dr Natalia Riobo-Del Galdo

PhD
University Academic Fellow
School of Molecular and Cellular Biology

Contact: Other/Unknown ROB 2.09 - St. James\'s University Hospital, +44(0) 113 206 6511, email address for  

Faculty Research and Innovation

Modules taught

BIOC3160 - Laboratory/Literature/Computing Research Project
BIOL2211 - Human Diseases
BIOL3305 - Advanced Skills in the Biosciences
BIOL3306 - Biological Sciences Research Project
BIOL5294M - MSc Bioscience Research Project Proposal
BIOL5392M - Bioscience MSc Research Project

Group Leader Dr Natalia Riobo-Del Galdo  (University Academic Fellow)

Postgraduates

Cintli Carina Morales Alcalá (Primary supervisor) 80% FTE
Alex Timmis (Primary supervisor) 90% FTE

Guo X, Riobo-Del Galdo NA, Kim EJ, Grant GR, Manning DR Overlap in signaling between Smoothened and the alpha subunit of the heterotrimeric G protein G(13) PLOS ONE 13, 2018
DOI:10.1371/journal.pone.0197442

Cooper F, Overmiller AM, Loder A, Brennan-Crispi DM, McGuinn KP, Marous MR, Freeman TA, Riobo-Del Galdo NA, Siracusa LD, Wahl JK, Mahoney MG Enhancement of cutaneous wound healing by Dsg2 augmentation of uPAR secretion. The Journal of investigative dermatology, 2018
DOI:10.1016/j.jid.2018.04.024
View abstract

Chen LX, Morales-Alcala CC, Riobo-Del Galdo NA Autophagic Flux is Regulated by Interaction Between the C-terminal Domain of Patched1 and ATG101 Molecular Cancer Research, 2018
DOI:10.1158/1541-7786.MCR-17-0597
View abstract

Papadopoulos V, Tsapakidis K, Del Galdo NAR, Papandreou CN, Del Galdo F, Anthoney DA, Sakellaridis N, Dimas K, Kamposioras K The Prognostic Significance of the Hedgehog Signaling Pathway in Colorectal Cancer Clinical Colorectal Cancer 15 116-127, 2016
DOI:10.1016/j.clcc.2016.02.010
View abstract

Brennan-Crispi DM, Overmiller AM, Tamayo-Orrego L, Marous MR, McGuinn KP, Cooper F, Salas-Alanis J, Charron F, Millar SE, Riobo-Del Galdo NA, Mahoney MG, Sahu J Dsg2 enhances spontaneous BCC formation in Ptc1(+/-) mice, 2016
DOI:10.1016/j.jid.2016.02.104

Trerotola M, Ganguly KK, Fazli L, Carmine Fedele CF, Lu H, Dutta A, Liu Q, Angelis TD, Riddell LW, Riobo NA, Gleave ME, Zoubeidi A, Pestell RG, Altieri DC, Languino LR Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts Oncotarget 6 14318-14328, 2015
DOI:10.18632/oncotarget.3960
View abstract

Brennan-Crispi DM, Hossain C, Sahu J, Brady M, Riobo NA, Mahoney MG Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis Oncotarget 6 8593-8605, 2015
DOI:10.18632/oncotarget.3309
View abstract

Gupta A, Nitoiu D, Brennan-Crispi D, Addya S, Riobo NA, Kelsell DP, Mahoney MG Cell cycle- and cancer-associated gene networks activated by Dsg2: Evidence of cystatin a deregulation and a potential role in cell-cell adhesion PLoS ONE 10, 2015
DOI:10.1371/journal.pone.0120091
View abstract

Riobo NA Canonical and non-canonical hedgehog signaling pathways: Role of G proteins, 2015
DOI:10.1007/7355_2014_63
View abstract

Hedgehog Signaling Protocols, 2015

Brennan-Crispi DM, Mahoney MỸG, Riobo NA Methods for detection of ptc1-driven lacz expression in adult mouse skin In Methods in Molecular Biology, 2015
DOI:10.1007/978-1-4939-2772-2_15
View abstract

Manning DR, Shen F, Riobo NA Evaluating the activity of smoothened toward g proteins using [35 s]guanosine 5′-(3- o -thio)triphosphate ([35 s]gtpγs) In Methods in Molecular Biology, 2015
DOI:10.1007/978-1-4939-2772-2_4
View abstract

Ho L, Riobo NA Posttranslational Modifications and Secretion of the Hedgehog (Hh) Proteins. Preface Methods in molecular biology (Clifton, N.J.) 1322 v-xi, 2015

Carbe CJ, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA G<inf>i</inf>proteins mediate activation of the canonical hedgehog pathway in the myocardium American Journal of Physiology - Heart and Circulatory Physiology 307, 2014
DOI:10.1152/ajpheart.00166.2014
View abstract

Chen XL, Chinchilla P, Fombonne J, Ho L, Guix C, Keen JH, Mehlen P, Riobo NA Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog Molecular and Cellular Biology 34 3855-3866, 2014
DOI:10.1128/MCB.00960-14
View abstract

Teperino R, Aberger F, Esterbauer H, Riobo N, Pospisilik JA Canonical and non-canonical hedgehog signalling and the control of metabolism Seminars in Cell and Developmental Biology 33 81-92, 2014
DOI:10.1016/j.semcdb.2014.05.007
View abstract

Shen F, Cheng L, Douglas AE, Riobo NA, Manning DR Smoothened is a fully competent activator of the heterotrimeric g protein gi Molecular Pharmacology 83 691-697, 2013
DOI:10.1124/mol.112.082511
View abstract

Riobo NA Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer Current Opinion in Pharmacology 12 736-741, 2012
DOI:10.1016/j.coph.2012.07.002
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Robbins DJ, Fei DL, Riobo NA The hedgehog signal transduction network Science Signaling 5, 2012
DOI:10.1126/scisignal.2002906
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Brennan D, Chen X, Cheng L, Mahoney M, Riobo NA Noncanonical Hedgehog Signaling Vitamins and Hormones 88 55-72, 2012
DOI:10.1016/B978-0-12-394622-5.00003-1
View abstract

Polizio AH, Chinchilla P, Chen X, Manning DR, Riobo NA Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to G<inf>i</inf>proteins, 2011
DOI:10.1126/scisignal.2002396
View abstract

Douglas AE, Heim JA, Shen F, Almada LL, Riobo NA, Fernández-Zapico ME, Manning DR Theα subunit of the G protein G<inf>13</inf>regulates activity of one or more gli transcription factors independently of smoothened Journal of Biological Chemistry 286 30714-30722, 2011
DOI:10.1074/jbc.M111.219279
View abstract

Polizio AH, Chinchilla P, Chen X, Kim S, Manning DR, Riobo NA Heterotrimeric G<inf>i</inf>proteins link hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration Journal of Biological Chemistry 286 19589-19596, 2011
DOI:10.1074/jbc.M110.197111
View abstract

Chinchilla P, Xiao L, Kazanietz MG, Riobo NA Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways Cell Cycle 9 570-579, 2010
DOI:10.4161/cc.9.3.10591
View abstract

Han F, Da T, Riobo NA, Becker LB Early mitochondrial dysfunction in electron transfer activity and reactive oxygen species generation after cardiac arrest. Critical care medicine 36, 2008
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Martinez-Chinchilla P, Riobo NA Chapter 11 Purification and Bioassay of Hedgehog Ligands for the Study of Cell Death and Survival, 2008
DOI:10.1016/S0076-6879(08)01611-X
View abstract

Riobo NA, Manning DR Pathways of signal transduction employed by vertebrate Hedgehogs Biochemical Journal 403 369-379, 2007
DOI:10.1042/BJ20061723
View abstract

Gavrielides MV, Gonzalez-Guerrico AM, Riobo NA, Kazanietz MG Androgens regulate protein kinase Cδ transcription and modulate its apoptotic function in prostate cancer cells Cancer Research 66 11792-11801, 2006
DOI:10.1158/0008-5472.CAN-06-1139
View abstract

Riobo NA, Saucy B, DiLizio C, Manning DR Activation of heterotrimeric G proteins by Smoothened Proceedings of the National Academy of Sciences of the United States of America 103 12607-12612, 2006
DOI:10.1073/pnas.0600880103
View abstract

Riobo NA, Lu K, Emerson CP Hedgehog signal transduction: Signal integration and cross talk in development and cancer Cell Cycle 5 1612-1615, 2006
DOI:10.4161/cc.5.15.3130
View abstract

Riobó NA, Lu K, Ai X, Haines GM, Emerson CP Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling Proceedings of the National Academy of Sciences of the United States of America 103 4505-4510, 2006
DOI:10.1073/pnas.0504337103
View abstract

Riobo NA, Haines GM, Emerson CP Protein kinase C-δ and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling Cancer Research 66 839-845, 2006
DOI:10.1158/0008-5472.CAN-05-2539
View abstract

Riobo NA, Manning DR Receptors coupled to heterotrimeric G proteins of the G<inf>12</inf>family Trends in Pharmacological Sciences 26 146-154, 2005
DOI:10.1016/j.tips.2005.01.007
View abstract

Riobó NA, Melani M, Sanjuán N, Fiszman ML, Gravielle MC, Cecilia Carreras M, Cadenas E, Poderoso JJ The modulation of mitochondrial nitric-oxide synthase activity in rat brain development Journal of Biological Chemistry 277 42447-42455, 2002
DOI:10.1074/jbc.M204580200
View abstract

Gatto EM, Riobó N, Carreras MC, Poderoso JJ, Micheli FE Neuroprotection in Parkinson's disease; a commentary Neurotoxicity Research 4 141-145, 2002
DOI:10.1080/10298420290015881
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Riobó NA, Schöpfer FJ, Boveris AD, Cadenas E, Poderoso JJ The reaction of nitric oxide with 6-hydroxydopamine: Implications for Parkinson's disease Free Radical Biology and Medicine 32 115-121, 2002
DOI:10.1016/S0891-5849(01)00758-4
View abstract

Carreras MC, Melani M, Riobó N, Converso DP, Gatto EM, Poderoso JJ Neuronal nitric oxide synthases in brain and extraneural tissues Methods in Enzymology 359 413-423, 2002
DOI:10.1016/S0076-6879(02)59203-X

Riobó NA, Clementi E, Melani M, Boveris A, Cadenas E, Moncada S, Poderoso JJ Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation Biochemical Journal 359 139-145, 2001
DOI:10.1042/0264-6021:3590139
View abstract

Carreras MC, Schöpfer F, Lisdero C, Riobo N, Poderoso JJ Mitochondrial Function and Nitric Oxide Utilization Biological Research 33 177-183, 2000

Schöpfer F, Riobó N, Carreras MC, Alvarez B, Radi R, Boveris A, Cadenas E, Poderoso JJ Oxidation of ubiquinol by peroxynitrite: Implications for protection of mitochondria against nitrosative damage Biochemical Journal 349 35-42, 2000
DOI:10.1042/0264-6021:3490035
View abstract

Gatto EM, Riobó NA, Carreras MC, Cherñavsky A, Rubio A, Satz ML, Poderoso JJ Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease Nitric Oxide - Biology and Chemistry 4 534-539, 2000
DOI:10.1006/niox.2000.0288
View abstract

Poderoso JJ, Lisdero C, Schöpfer F, Riobó N, Carreras MC, Cadenas E, Boveris A The regulation of mitochondrial oxygen uptake by redox reactions involving nitric oxide and ubiquinol Journal of Biological Chemistry 274 37709-37716, 1999
DOI:10.1074/jbc.274.53.37709
View abstract

Gatto EM, Riobó NA, Carreras MC, Schöpfer FJ, Pargament GA, Poderoso JJ Circulating plasma factors in Parkinson's disease enhance nitric oxide release of normal human neutrophils Journal of the Neurological Sciences 165 66-70, 1999
DOI:10.1016/S0022-510X(99)00079-9
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Poderoso JJ, Carreras MC, Schöpfer F, Lisdero CL, Riobó NA, Giulivi C, Boveris AD, Boveris A, Cadenas E The reaction of nitric oxide with ubiquinol: Kinetic properties and biological significance Free Radical Biology and Medicine 26 925-935, 1999
DOI:10.1016/S0891-5849(98)00277-9
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Poderoso JJ, Carreras MC, Lisdero C, Schöpfer F, Riobó N, Peralta J Shock: Concepts towards a definition Medicina 58 341-349, 1998
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Carreras MC, Riobó NA, Pargament GA, Boveris A, Poderoso JJ Effects of respiratory burst inhibitors on nitric oxide production by human neutrophils Free Radical Research 26 325-334, 1997

Gatto EM, Carreras MC, Pargament GA, Riobo NA, Reides C, Repetto M, Fernandez Pardal MM, Llesuy S, Poderoso JJ Neutrophil function, nitric oxide, and blood oxidative stress in Parkinson's disease Movement Disorders 11 261-267, 1996
DOI:10.1002/mds.870110308
View abstract

Poderoso JJ, Carreras MC, Lisdero C, Riobó N, Schöpfer F, Boveris A Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles Archives of Biochemistry and Biophysics 328 85-92, 1996
DOI:10.1006/abbi.1996.0146
View abstract