Faculty of Biological Sciences

Dr Mark Richards

Research Fellow
School of Molecular and Cellular Biology

Contact:  Astbury 6.103, +44(0) 113 34 33171, email address for  

Woo CG, Seo S, Kim SW, Jang SJ, Park KS, Song JY, Lee B, Richards MW, Bayliss R, Lee DH, Choi J Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer ANNALS OF ONCOLOGY 28 791-797, 2017
DOI:10.1093/annonc/mdw693

Richards MW, Burgess SG, Poon E, Carstensen A, Eilers M, Chesler L, Bayliss R Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors Proceedings of the National Academy of Sciences of the United States of America 113 13726-13731, 2016
DOI:10.1073/pnas.1610626113
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Burgess SG, Oleksy A, Cavazza T, Richards MW, Vernos I, Matthews D, Bayliss R Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain Open Biology 6 -, 2016
DOI:10.1098/rsob.160089
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Bachmann G, Richards MW, Winter A, Beuron F, Morris E, Bayliss R A closed conformation of the Caenorhabditis elegans separase-securin complex Open Biology 6 -, 2016
DOI:10.1098/rsob.160032
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Bayliss R, Choi J, Fennell DA, Fry AM, Richards MW Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs Cellular and Molecular Life Sciences 73 1209-1224, 2016
DOI:10.1007/s00018-015-2117-6
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Haq T, Richards MW, Burgess SG, Gallego P, Yeoh S, O'Regan L, Reverter D, Roig J, Fry AM, Bayliss R Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization Nature Communications 6 -, 2015
DOI:10.1038/ncomms9771
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Richards MW, O'Regan L, Roth D, Montgomery JM, Straube A, Fry AM, Bayliss R Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain Biochemical Journal 467 529-536, 2015
DOI:10.1042/BJ20150039
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Joshi A, Newbatt Y, McAndrew PC, Stubbs M, Burke R, Richards MW, Bhatia C, Caldwell JJ, McHardy T, Collins I, Bayliss R Molecular mechanisms of human IRE1 activation through dimerization and ligand binding Oncotarget 6 13019-13035, 2015
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O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression Journal of Cell Biology 209 349-358, 2015
DOI:10.1083/jcb.201409151
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Richards MW, Edward EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypicalβ-propeller domain Proceedings of the National Academy of Sciences of the United States of America 111 5195-5200, 2014
DOI:10.1073/pnas.1322892111
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Hood FE, Williams SJ, Burgess SG, Richards MW, Roth D, Straube A, Pfuhl M, Bayliss R, Royle SJ Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding Journal of Cell Biology 202 463-478, 2013
DOI:10.1083/jcb.201211127
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Oberoi J, Richards MW, Crumpler S, Brown N, Blagg J, Bayliss R Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of Checkpoint with Forkhead-associated and RING domains (CHFR) Journal of Biological Chemistry 285 39348-39358, 2010
DOI:10.1074/jbc.M110.159855
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Dodson CA, Kosmopoulou M, Richards MW, Atrash B, Bavetsias V, Blagg J, Bayliss R Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: Insights into selectivity and drug design Biochemical Journal 427 19-28, 2010
DOI:10.1042/BJ20091530
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Richards MW, Leung JWC, Roe SM, Li K, Chen J, Bayliss R A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation Journal of Molecular Biology 395 908-915, 2010
DOI:10.1016/j.jmb.2009.11.029
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Richards MW, O'Regan L, Mas-Droux C, Blot JMY, Cheung J, Hoelder S, Fry AM, Bayliss R An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9 Molecular Cell 36 560-570, 2009
DOI:10.1016/j.molcel.2009.09.038
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Westwood I, Cheary DM, Baxter JE, Richards MW, van Montfort RLM, Fry AM, Bayliss R Insights into the Conformational Variability and Regulation of Human Nek2 Kinase Journal of Molecular Biology 386 476-485, 2009
DOI:10.1016/j.jmb.2008.12.033
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Richards MW, Leroy J, Pratt WS, Dolphin AC The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation. Channels (Austin, Tex.) 1 92-101, 2007
DOI:10.4161/chan.4145
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Butcher AJ, Leroy J, Richards MW, Pratt WS, Dolphin AC The importance of occupancy rather than affinity of Ca(V)beta subunits for the calcium channel I-II linker in relation to calcium channel function JOURNAL OF PHYSIOLOGY-LONDON 574 387-398, 2006
DOI:10.1113/jphysiol.2006.109744

Martin SW, Butcher AJ, Berrow NS, Richards MW, Paddon RE, Turner DJ, Dolphin AC, Sihra TS, Fitzgerald EM Phosphorylation sites on calcium channel alpha 1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channels CELL CALCIUM 39 275-292, 2006
DOI:10.1016/j.ceca.2005.11.002

Cantí C, Nieto-Rostro M, Foucault I, Heblich F, Wratten J, Richards MW, Hendrich J, Douglas L, Page KM, Davies A, Dolphin AC The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels. Proceedings of the National Academy of Sciences of the United States of America 102 11230-11235, 2005
DOI:10.1073/pnas.0504183102
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Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. The Journal of neuroscience : the official journal of the Society for Neuroscience 25 6984-6996, 2005
DOI:10.1523/jneurosci.1137-05.2005
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Richards MW, Butcher AJ, Dolphin AC Ca2+ channel beta-subunits: structural insights AID our understanding TRENDS IN PHARMACOLOGICAL SCIENCES 25 626-632, 2004
DOI:10.1016/j.tips.2004.10.008

Richards MW, Hanlon MR, Berrow NS, Butcher A, Dolphin AC, Wallace BA Synchrotron radiation circular dichroism (SRCD) and CD spectroscopic studies of the voltage-dependent calcium channel beta subunit and its domains BIOPHYSICAL JOURNAL 82 456A-456A, 2002

Bayliss RWA, Burgess SG, Leen E, Richards MW A moving target: structure and disorder in pursuit of Myc inhibitors Biochemical Society Transactions -,
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