Faculty of Biological Sciences

Dr Roland Remenyi

PhD in Molecular & Medical Pharmacology, UCLA, USA
Research Fellow
School of Molecular and Cellular Biology

Background: At the nexus of Virology and Microscopy.

Contact:  Garstang 7.58, +44(0) 113 34 33068, email address for  

You can read more about Dr Remenyi's interests here:



Research Interests

Developing research tools to visualise viral infection by advanced microscopy

  • Image created with IMARIS software.

Every innovation and advancement starts with great science.

My research focuses on generating tools and platforms to facilitate scientific discovery in virology. I am particularly interested in the role of the nonstructural protein 3 during Chikungunya virus (CHIKV) infection. My goal is to see, visualize, and comprehend the complex interactions between a viral pathogen and the host cell.

 

Current Projects

  • Developing research tools for the study of Chikungunya virus (CHIKV) by advanced microscopy
  • Live cell super-resolution microscopy of CHIKV infection
  • Uncovering interactions between CHIKV nonstructural protein 3 (nsP3) and cellular host proteins
  • Revealing the role of membraneless organelles during the CHIKV life cycle

 

Publications

Wu NC, Olson CA, Du Y, Le S, Tran K, Remenyi R, Gong D, Al-Mawsawi LQ, Qi H, Wu T-T. 2015. Functional constraint profiling of a viral protein reveals discordance of evolutionary conservation and functionality. PLoS Genet doi: 10.1371/journal.pgen.1005310

Remenyi R, Qi H, Su S-Y, Chen Z, Wu NC, Arumugaswami V, Truong S, Chu V, Stokelman T, Lo H-H. 2014. A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. MBio doi: 10.1128/mBio.01469-14

Qi H, Olson CA, Wu NC, Ke R, Loverdo C, Chu V, Truong S, Remenyi R, Chen Z, Du Y. 2014. A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity. PLoS Pathog doi.org/10.1371/journal.ppat.1004064

Kim S, Rusmevichientong A, Dong B, Remenyi R, Silverman RH, Chow SA. 2010. Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus. PLoS One doi.org/10.1371/journal.pone.0010255

Barat B, Sirk SJ, McCabe KE, Li J, Lepin EJ, Remenyi R, Koh AL, Olafsen T, Gambhir SS, Weiss S. 2009. Cys-diabody quantum dot conjugates (immunoQdots) for cancer marker detection. Bioconjugate chemistry 20:1474-1481. doi.org/10.1021/bc800421f

Arumugaswami V, Remenyi R, Kanagavel V, Sue EY, Ho TN, Liu C, Fontanes V, Dasgupta A, Sun R. 2008. High-resolution functional profiling of hepatitis C virus genome. PLoS Pathog 4:e1000182. doi.org/10.1371/journal.ppat.1000182