Dr Christopher Randall

BSc(Hons), Hull; MSc, Leeds; PhD, Leeds
Teaching Fellow
School of Molecular and Cellular Biology

Contact: Garstang 6.58, +44(0) 113 343 5592, email address for  

Charlton MH, Aleksis R, Saint-Leger A, Gupta A, Loza E, Ribas De Pouplana L, Kaula I, Gustina D, Madre M, Lola D, Jaudzems K, Edmund G, Randall CP, Kime L, O'Neill AJ, Goessens W, Jirgensons A, Finn PW N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors ACS Medicinal Chemistry Letters 9 84-88, 2018
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Nass NM, Farooque S, Hind C, Wand ME, Randall CP, Sutton JM, Seipke RF, Rayner CM, O'Neill AJ Revisiting unexploited antibiotics in search of new antibacterial drug candidates: The case ofγ-actinorhodin Scientific Reports 7, 2017
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Renzoni A, Von Dach E, Landelle C, Diene SM, Manzano C, Gonzales R, Abdelhady W, Randall CP, Bonetti EJ, Baud D, O Neill AJ, Bayer A, Cherkaoui A, Schrenzel J, Harbarth S, François P Impact of exposure of methicillin-resistant Staphylococcus aureus to polyhexanide in vitro and in vivo Antimicrobial Agents and Chemotherapy 61, 2017
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Elkrewi E, Randall CP, Ooi N, Cottell JL, O'Neill AJ Cryptic silver resistance is prevalent and readily activated in certain Gram-negative pathogens Journal of Antimicrobial Chemotherapy 72 3043-3046, 2017
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Randall CP, Rasina D, Jirgensons A, O'Neill AJ Targeting multiple aminoacyl-tRNA synthetases overcomes the resistance liabilities associated with antibacterial inhibitors acting on a single such enzyme Antimicrobial Agents and Chemotherapy 60 6359-6361, 2016
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Gupta A, Monteferrante C, Rasina D, Leitis G, Randall CP, Tomlinson JH, Jirgensons A, Goessens WHF, Hays JP, O'Neill AJ A polymorphism in leuS confers reduced susceptibility to GSK2251052 in a clinical isolate of Staphylococcus aureus Antimicrobial Agents and Chemotherapy 60 3219-3221, 2016
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Hrast M, Anderluh M, Knez D, Randall CP, Barreteau H, O'Neill AJ, Blanot D, Gobec S Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold. Eur J Med Chem 73 83-96, 2014
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Randall CP, Gupta A, Jackson N, Busse D, O'Neill AJ Silver resistance in Gram-negative bacteria: A dissection of endogenous and exogenous mechanisms Journal of Antimicrobial Chemotherapy 70 1037-1046, 2014
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Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem 66 32-45, 2013
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Randall CP, Mariner KR, Chopra I, O'Neill AJ The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens. Antimicrob Agents Chemother 57 637-639, 2013
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Randall CP, Oyama LB, Bostock JM, Chopra I, O'Neill AJ The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies. J Antimicrob Chemother 68 131-138, 2013
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Škedelj V, Arsovska E, Tomašić T, Kroflič A, Hodnik V, Hrast M, Bešter-Rogač M, Anderluh G, Gobec S, Bostock J, Chopra I, O'Neill AJ, Randall C, Zega A 6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase. PLoS One 7 e39922-, 2012
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Blake KL, Randall CP, O'Neill AJ In vitro studies indicate a high resistance potential for the lantibiotic nisin in Staphylococcus aureus and define a genetic basis for nisin resistance. Antimicrob Agents Chemother 55 2362-2368, 2011
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Ooi N, Miller K, Randall C, Rhys-Williams W, Love W, Chopra I XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms. J Antimicrob Chemother 65 72-78, 2010
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