Faculty of Biological Sciences

Dr Christopher Randall

BSc(Hons), Hull; MSc, Leeds; PhD, Leeds
Teaching Fellow
School of Molecular and Cellular Biology

Contact:  Garstang 6.58, +44(0) 113 343 5592, email address for  

Randall CP, Rasina D, Jirgensons A, O'Neill AJ Targeting multiple aminoacyl-tRNA synthetases overcomes the resistance liabilities associated with antibacterial inhibitors acting on a single such enzyme Antimicrobial Agents and Chemotherapy 60 6359-6361, 2016
DOI:10.1128/AAC.00674-16

Gupta A, Monteferrante C, Rasina D, Leitis G, Randall CP, Tomlinson JH, Jirgensons A, Goessens WHF, Hays JP, O'Neill AJ A polymorphism in leuS confers reduced susceptibility to GSK2251052 in a clinical isolate of Staphylococcus aureus Antimicrobial Agents and Chemotherapy 60 3219-3221, 2016
DOI:10.1128/AAC.02940-15
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Hrast M, Anderluh M, Knez D, Randall CP, Barreteau H, O'Neill AJ, Blanot D, Gobec S Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold. Eur J Med Chem 73 83-96, 2014
DOI:10.1016/j.ejmech.2013.11.031
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Randall CP, Gupta A, Jackson N, Busse D, O'Neill AJ Silver resistance in Gram-negative bacteria: A dissection of endogenous and exogenous mechanisms Journal of Antimicrobial Chemotherapy 70 1037-1046, 2014
DOI:10.1093/jac/dku523
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Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem 66 32-45, 2013
DOI:10.1016/j.ejmech.2013.05.013
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Randall CP, Oyama LB, Bostock JM, Chopra I, O'Neill AJ The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies. J Antimicrob Chemother 68 131-138, 2013
DOI:10.1093/jac/dks372
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Randall CP, Mariner KR, Chopra I, O'Neill AJ The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens. Antimicrob Agents Chemother 57 637-639, 2013
DOI:10.1128/AAC.02005-12
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Škedelj V, Arsovska E, Tomašić T, Kroflič A, Hodnik V, Hrast M, Bešter-Rogač M, Anderluh G, Gobec S, Bostock J, Chopra I, O'Neill AJ, Randall C, Zega A 6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase. PLoS One 7 e39922-, 2012
DOI:10.1371/journal.pone.0039922
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Blake KL, Randall CP, O'Neill AJ In vitro studies indicate a high resistance potential for the lantibiotic nisin in Staphylococcus aureus and define a genetic basis for nisin resistance. Antimicrob Agents Chemother 55 2362-2368, 2011
DOI:10.1128/AAC.01077-10
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Ooi N, Miller K, Randall C, Rhys-Williams W, Love W, Chopra I XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms. J Antimicrob Chemother 65 72-78, 2010
DOI:10.1093/jac/dkp409
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Elkrewi E, Randall CP, OOI N, Cottell JL, O'Neill AJ Cryptic silver resistance is prevalent and readily activated in certain Gram-negative pathogens Journal of Antimicrobial Chemotherapy -,
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