Faculty of Biological Sciences

Dr Nikesh Patel

Research Fellow
School of Molecular and Cellular Biology

Contact:  Miall 10.23, +44(0) 113 34 33065, email address for  

Patel N, Wroblewski E, Leonov G, Phillips SEV, Tuma R, Twarock R, Stockley PG Rewriting nature's assembly manual for a ssRNA virus. Proceedings of the National Academy of Sciences of the United States of America 114 12255-12260, 2017
DOI:10.1073/pnas.1706951114
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Patel N, White SJ, Thompson RF, Bingham R, Weiß EU, Maskell DP, Zlotnick A, Dykeman EC, Tuma R, Twarock R, Ranson NA, Stockley PG HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly Nature Microbiology 2 -, 2017
DOI:10.1038/nmicrobiol.2017.98
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Bingham R, Leonov G, Patel N, Weiss E, White S, Dykeman E, Stockley P, Twarock R A30 Recombination&evolution in two viral families: effective steps or a random walk?, 2017
DOI:10.1093/ve/vew036.029

Stockley PG, White SJ, Dykeman E, Manfield I, Rolfsson O, Patel N, Bingham R, Barker A, Wroblewski E, Chandler-Bostock R, Weiß EU, Ranson NA, Tuma R, Twarock R Bacteriophage MS2 genomic RNA encodes an assembly instruction manual for its capsid. Bacteriophage 6 e1157666-, 2016
DOI:10.1080/21597081.2016.1157666
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Patel N, Dykeman EC, Coutts RHA, Lomonossoff GP, Rowlands DJ, Phillips SEV, Ranson N, Twarock R, Tuma R, Stockley PG, Johnson JE Revealing the density of encoded functions in a viral RNA Proceedings of the National Academy of Sciences of the United States of America 112 2227-2232, 2015
DOI:10.1073/pnas.1420812112
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Patel N, Exell JC, Jardine E, Ombler B, Finger LD, Ciani B, Grasby JA Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing. J Biol Chem 288 34239-34248, 2013
DOI:10.1074/jbc.M113.509489
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Finger LD, Patel N, Beddows A, Ma L, Exell JC, Jardine E, Jones AC, Grasby JA Observation of unpaired substrate DNA in the flap endonuclease-1 active site. Nucleic Acids Res 41 9839-9847, 2013
DOI:10.1093/nar/gkt737
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Beddows A, Patel N, Finger LD, Atack JM, Williams DM, Grasby JA Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases. Chem Commun (Camb) 48 8895-8897, 2012
DOI:10.1039/c2cc33400c
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Patel N, Atack JM, Finger LD, Exell JC, Thompson P, Tsutakawa S, Tainer JA, Williams DM, Grasby JA Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends Nucleic Acids Research 40 4507-4519, 2012
DOI:10.1093/nar/gks051
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