Faculty of Biological Sciences

Dr David Marples

BA, BM, BCh, MA, DPhil, Oxford. PhD 1990
Senior Lecturer in Physiology & Anatomy
School of Biomedical Sciences

Background: I trained as a medic at Oxford, and did a D.Phil. in physiology with Ann Taylor before finishing my medical training. After my house jobs, I got back to research as soon as possible... I spent another two years as a post-doc with Ann, studying the role of the cytoskeleton in the response to vasopressin. I then spent two years in Aarhus, Denmark, working with Soren Nielsen, mainly on the newly-discovered aquaporin-2 (AQP2) water channel. I am now continuing this work, often in collaboration with Soren, in Leeds.

Contact:  Garstang 5.55e | +44(0) 113 34 34245 | email address for Dr David Marples 

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Admin roles

External Examiner (taught course): Imperial College, London
FBS UGTSEC
UG Programme Leader: Medical Sciences

Modules managed

BMSC1110 - Foundations of Biomedical Sciences
BMSC2225 - Physiology of Absorption and Excretion
SPSC1107 - Functional Anatomy - Sport Sci

Modules taught

BMSC1103 - Basic Laboratory and Scientific Skills
BMSC1110 - Foundations of Biomedical Sciences
BMSC1110/SPSC1220 - Foundation modules
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC1214 - Human Endocrinology
BMSC2225 - Physiology of Absorption and Excretion
BMSC2229 - Exp Skills: Medical Sciences
BMSC3143/44/45/46 - ATUs - BMS specific
BMSC3233/34/35/36/37 - ATUs - BMS specific
BMSC3301 - Research Proj: Biomed Sciences
MEDI1203 - Nutrition and Energy
SPSC1107 - Functional Anatomy - Sport Sci
SPSC3061 - Research Project in Sport and Exercise Science II

Committees

Member of Undergraduate School Taught Student Education Committee

Group Leader Dr David Marples  (Senior Lecturer in Physiology & Anatomy)

Regulation of shuttling and expression of aquaporin 2 water channels 


Mobasheri A; Kendall BH; Maxwell JEJ; Sawran AV; German AJ; Marples D; Luck MR; Royal MD Cellular localization of aquaporins along the secretory pathway of the lactating bovine mammary gland: An immunohistochemical study ACTA HISTOCHEM 113 137-149, 2011
DOI:10.1016/j.acthis.2009.09.005

Mobasheri A; Moskaluk CA; Marples D; Shakibaei M Expression of aquaporin 1 (AQP1) in human synovitis ANN ANAT 192 116-121, 2010
DOI:10.1016/j.aanat.2010.01.001

Baggaley E; Nielsen S; Marples D Dehydration-induced increase in aquaporin-2 protein abundance is blocked by nonsteroidal anti-inflammatory drugs AM J PHYSIOL-RENAL 298 F1051-F1058, 2010
DOI:10.1152/ajprenal.90202.2008

Lutken SC; Kim SW; Jonassen T; Marples D; Knepper MA; Kwon TH; Frokiaer J; Nielsen S Changes of renal AQP2, ENaC, and NHE3 in experimentally induced heart failure: response to angiotensin II AT(1) receptor blockade AM J PHYSIOL-RENAL 297 F1678-F1688, 2009
DOI:10.1152/ajprenal.00010.2009

Richardson SM; Knowles R; Marples D; Hoyland JA; Mobasheri A Aquaporin expression in the human intervertebral disc J MOL HISTOL 39 303-309, 2008
DOI:10.1007/s10735-008-9166-1

Richardson SM; Knowles R; Hoyland JA; Marples D; Mobasheri A Aquaporin expression in the human intervertebral disc Journal of Molecular Histology 1-7, 2008
DOI:10.1007/s10735-008-9166-1
View abstract

Mobasheri A; Marples D; Young IS; Floyd RV; Moskaluk CA; Frigeri A Distribution of the AQP4 water channel in normal human tissues - Protein and tissue microarrays reveal expression in several new anatomical locations, including the prostate gland and seminal vesicles CHANNELS 1 -, 2007

Floyd RV; Mason SL; Proudman CJ; German AJ; Marples D; Mobasheri A Expression and nephron segment-specific distribution of major renal aquaporins (AQP1-4) in Equus caballus, the domestic horse American Journal of Physiology - Regulatory Integrative and Comparative Physiology 293 -, 2007
DOI:10.1152/ajpregu.00689.2005
View abstract

Mobasheri A; Wray S; Marples D Distribution of AQP2 and AQP3 water channels in human tissue microarrays J MOL HISTOL 36 1-14, 2005
DOI:10.1007/s10735-004-2633-4

Mobasheri A; Marples D; Young I; Moskaluk C; Frigeri A Distribution of the AQP-4 water channel in normal human tissue microarrays, 2005

Shaw S; Marples D N-ethylmaleimide causes aquaporin-2 trafficking in the renal inner medullary collecting duct by direct activation of protein kinase A AM J PHYSIOL-RENAL 288 F832-F839, 2005
DOI:10.1152/ajprenal.00041.2004

Mobasheri A; Marples D; Frigeri A Distribution of the aquaporin water channels AQP1, AQP3, AQP4, and AQP9 in the human choroid plexus, 2005

Mobasheri A; Airley R; Hewitt SM; Marples D Heterogeneous expression of the aquaporin 1 (AQP1) water channel in tumors of the prostate, breast, ovary, colon and lung: A study using high density multiple human tumor tissue microarrays INT J ONCOL 26 1149-1158, 2005

Mobasheri A; Marples D; Young I; Moskaluk C; Frigeri A Tissue distribution of the AQP-4 water channel: A study using normal human Tissue MicroArrays, 2005

Christensen BM; Marples DDR; Kim YH; Wang WD; Frokiaer J; Nielsen S Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI American Journal of Physiology: Cell Physiology 286 C952-C964, 2004
View abstract

Trujillo E; Gonzalez T; Marin R; Martin-Vasallo P; Marples DDR; Mobasheri A Human articular chondrocytes, synoviocytes and synovial microvessels express aquaporin water channels; upregulation of AQP1 in rheumatoid arthritis Histology and Histopathology 19 435-444, 2004
View abstract

Mobasheri A; Marples DDR Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology American Journal of Physiology: Cell Physiology 286 C529-C537, 2004
View abstract

Mobasheri A; Trujillo E; Bell S; Carter SD; Clegg PD; Martin-Vasallo P; Marples DDR Aquaporin water channels AQP1 and AQP3, are expressed in equine articular chondrocytes The Veterinary Journal 168 143-150, 2004
DOI:10.1016/j.tvjl.2003.08.001
View abstract

Mobasheri A; Shakibaei M; Marples DDR Immunohistochemical localization of aquaporin 10 in the apical membranes of the human ileum: a potential pathway for luminal water and small solute absorption Histochemistry and Cell Biology 121 463-471, 2004
DOI:10.1007/s00418-004-0657-1
View abstract

Shaw S; Marples DDR N-ethylmaleimide (NEM) causes an aquaporin-2 trafficking in the renal inner medullary collecting duct by direct activation of protein kinase A American Journal of Physiology: Renal Physiology 1 1-10, 2004
View abstract

Baggaley EM; Marples D Prostagla E-2 and I-2 cause AQP2 shuttling in isolated rat inner medullary collecting ducts, 2003

Marples D; Chipperfield S Angiotensin II causes shuttling of AQP2 water channels in rat inner medullary collecting ducts, 2003

Christensen BM; Marples DDR; Kim YH; Wang W; Frokiaer J; Nielsen S Changes in cellular composition of kidney collecting duct in rats with lithium-induced NDI American Journal of Physiology: Cell Physiology -, 2003

Mobasheri A; Marples DDR Expression of the aquaporin 1 (AQP1) water channel in normal human tissues: a semi-quantitative study using tissue microarray technology American Journal of Physiology: Cell Physiology -, 2003

Shaw S; Marples D Dynein is important in vasopressin-induced shuttling of AQP2 water channels. J AM SOC NEPHROL 13 480A-480A, 2002

Nielsen S; Frokiaer J; Marples DDR; Kwon TH; Agre P; Knepper MA Aquaporins in the kidney: From molecules to medicine. Physiological Reviews 82 205-244, 2002

Mobasheri A; Trujillo E; Martin-Vasallo P; Marples D Aquaporins 1 and 3 are expressed in porcine articular chondrocytes J PHYSIOL-LONDON 539 14P-14P, 2002

Shaw S; Marples D Protein kinase C modulates the response to vasopressin in rat inner medullary collecting ducts. J AM SOC NEPHROL 13 481A-481A, 2002

Trujillo-Martin E; Marin R; Masrani B; Marples D; Martin-Vasallo P; Gonzalez T; Mobasheri A Aquaporin water channels in porcine and human articular cartilage: Differential expression in pathologies of human cartilage., 2002

Shaw S; Marples D A rat kidney tubule suspension for the study of vasopressin-induced shuttling of AQP2 water channels. Am J Physiol Renal Physiol 283 F1160-F1166, 2002
DOI:10.1152/ajprenal.00207.2002
View abstract

Christensen BM; Marples D; Wang W; Frokiaer J; Nielsen S Decreased fraction of principal cells in parallel with increased fraction of intercalated cells in rats with lithium-induced NDI. J AM SOC NEPHROL 13 270A-270A, 2002

Marples D; Shaw S N-ethyl maleimide causes AQP2 trafficking by direct activation of protein kinase A. J AM SOC NEPHROL 13 481A-481A, 2002

Nejsum LN; Kwon TH; Marples D; Flyvbjerg A; Knepper MA; Frokiaer J; Nielsen S Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus AM J PHYSIOL-RENAL 280 F715-F726, 2001

Marples DDR Aquaporins: Roles in renal function and peritoneal dialysis Peritoneal Dialysis International 21 212-218, 2001
View abstract

Nielsen S; Kwon TH; Nager H; Knepper MA; Marples D; Frokiaer J Pathophysiology of renal aquaporins CURR TOP MEMBR 51 155-183, 2001

Li CL; Wang WD; Kwon TH; Isikay L; Wen JG; Marples D; Djurhuus JC; Stockwell A; Knepper MA; Nielsen S; Froklaer J Downregulation of AQP1,-2, and-3 after ureteral obstruction is associated with a long-term urine-concentrating defect AM J PHYSIOL-RENAL 281 F163-F171, 2001

Dobrzynski H; Marples DDR; Musa H; Yamanushi TT; Henderson Z; Takagishi Y; Honjo H; Kodama I; Boyett MR Distribution of the muscarinic K+ channel proteins Kir3.1 and Kir3.4 in the ventricle, atrium, and sinoatrial node of heart J HISTOCHEM CYTOCHEM 49 1221-1234, 2001

Shaw S; Marples D N-ethylmaleimide induces shuttling of aquaporin-2 water channels in a rat kidney tubule suspension, 2001

Nielsen S; Hager H; Frøkiaer J; Kwon T-H; Knepper MA; Marples D Chapter 4 Pathophysiology of renal aquaporins Current Topics in Membranes 51 155-183, 2001

Dobrzynski H; Rothery SM; Marples DDR; Coppen SR; Takagishi Y; Honjo H; Tamkun MM; Henderson Z; Kodama I; Boyett MR; Severs NJ Presence of the Kv1.5 K(+) channel in the sinoatrial node. Journal of Histochemistry and Cytochemistry 48 769-780, 2000

Kwan TH; Laursen UH; Maunsbach AB; Marples DDR Altered expression of renal AQPs and Na+ transporters in rats with Lithium-induced NDI American Journal of Physiology 279 552-564, 2000

Frokiaer J; Marples DDR; Valtin H; Morris JF; Knepper MA; Neilsen S Low aquaporin-2 levels in polyuric DI +/+ severe mice with constitutively high cAMP-phosphodiesterase activity. Journal of Physiology 276 179-190, 1999

Marples DDR; Christensen BM; Frokiaer J; Knepper MA; Neilsen S Dehydration reverses vasopressin antagonist-induced diuresis and aquaporin-2 downregulation in rats. Journal of Physiology 275 400-409, 1998

Christensen BM; Marples DDR; Jenson UB; Frokiaer J; Sheikh-Hamad D; Knepper MA; Neilsen S Acute effects of vasopressin V2-receptor antagonist on kidney AQP2 expression and subcellular distribution. American Journal of Physiology 275 285-297, 1998

Marples DDR; Schroer TA; Ahrens N; Taylor A; Knepper MA; Neilsen S Dynein and dynactin colocalize with AQP2 water channels in intracellular vesicles from kidney collecting duct. Journal of Physiology 274 384-394, 1998

Nielsen S; Terris J; Andersen D; Ecelbarger C; Frokiaer J; Jonassen T; Marples DDR; Knepper MA; Petersen JS Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct Proceedings of the National Academy of Sciences of the United States of America 94 5450-5455, 1997

Frokiaer J; Dorup J; Knepper MA; Marples DDR Hypokalemia-induced downregulation of Aquaprin-2 water channel expression in rat kidney medulla and cortex Journal of Clinical Investigation 97 1960-1968, 1996