Dr Amy Barker

MChem Newcastle upon Tyne
Research Technician
School of Molecular and Cellular Biology

Contact: Miall 10.23, +44(0) 113 34 33065, email address for  

Barnard A, Miles JA, Burslem GM, Barker AM, Wilson AJ Multivalent helix mimetics for PPI-inhibition Organic and Biomolecular Chemistry 13 258-264, 2015
DOI:10.1039/c4ob02066a
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Sarell CJ, Karamanos TK, White SJ, Bunka DHJ, Kalverda AP, Thompson GS, Barker AM, Stockley PG, Radford SE Distinguishing closely related amyloid precursors using an RNA aptamer Journal of Biological Chemistry 289 26859-26871, 2014
DOI:10.1074/jbc.M114.595066
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Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M, Pearson AR, Rowlands, D. J., Homans SW, Harris M, Foster R, Griffin S Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release Hepatology 59 408-422, 2014
DOI:10.1002/hep.26685
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Roberts GA, Chen K, Bower EKM, Madrzak J, Woods A, Barker AM, Cooper LP, White JH, Blakely G, Manfield IW, Dryden DTF Mutations of the domain forming the dimeric interface of the ArdA protein affect dimerization and antimodification activity but not antirestriction activity The Federation of European Biochemical Societies (FEBS) Journal 4903-4914, 2013
DOI:10.1111/febs.12467
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Dent K, Thompson R, Barker A, Hiscox J, Barr J, Stockley P, Ranson N The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release Structure 21 1225-1234, 2013
DOI:10.1016/j.str.2013.05.012
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Ford RJ, Barker AM, Bakker SE, Coutts RH, Ranson NA, Phillips SEV, Pearson AR, Stockley PG Sequence-specific, RNA-protein interactions overcome electrostatic barriers preventing assembly of satellite tobacco necrosis virus coat protein. J Mol Biol 425 1050-1064, 2013
DOI:10.1016/j.jmb.2013.01.004
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Stockley PG, Barker AM, Borodavka A, Ford RJ, Pearson AR, Ranson NA, Tuma R, Twarock R, Dykeman E, Phillips SEV, Bakker SE Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism Journal of Biological Physics 1-11, 2013
DOI:10.1007/s10867-013-9313-0
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Bakker SE, Ford RJ, Barker AM, Robottom J, Saunders K, Pearson AR, Ranson NA, Stockley PG Isolation of an asymmetric RNA uncoating intermediate for a single-stranded RNA plant virus. J Mol Biol 417 65-78, 2012
DOI:10.1016/j.jmb.2012.01.017
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Phillips SEV, Lane SW, Dennis CA, Lane CL, Trinh CH, Rizkallah PJ, Bunka DH, Dykeman EC, Ford R, Barker A, Twarock R, Stockley PG Structure and RNA Recognition in Recombinant STNV Capsids Biophysical Journal 102 641a-, 2012
DOI:10.1016/j.bpj.2011.11.3487

Bunka DHJ, Lane SW, Lane CL, Dykeman EC, Ford RJ, Barker AM, Twarock R, Phillips SEV, Stockley PG Degenerate RNA packaging signals in the genome of Satellite Tobacco Necrosis Virus: implications for the assembly of a T=1 capsid. J Mol Biol 413 51-65, 2011
DOI:10.1016/j.jmb.2011.07.063
View abstract