Dr Lydia Young

Wellcome Trust ISSF Fellow
School of Molecular and Cellular Biology

Contact: Other/Unknown, email address for  

Khodaparast L, Khodaparast L, Gallardo R, Louros NN, Michiels E, Ramakrishnan R, Ramakers M, Claes F, Young L, Shahrooei M, Wilkinson H, Desager M, Mengistu Tadesse W, Nilsson KPR, Hammarström P, Aertsen A, Carpentier S, Van Eldere J, Rousseau F, Schymkowitz J Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis Nature Communications 9, 2018
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Doherty CPA, Young LM, Karamanos TK, Smith HI, Jackson MP, Radford SE, Brockwell DJ A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides. Protein science : a publication of the Protein Society, 2018
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Young LM, Ashcroft AE, Radford SE Small molecule probes of protein aggregation Current Opinion in Chemical Biology 39 90-99, 2017
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Young LM, Tu LH, Raleigh DP, Ashcroft AE, Radford SE Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers Chemical Science 8 5030-5040, 2017
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Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L, Khodaparast L, Couceiro JR, Langenberg T, Siemons M, Nyström S, Young LJ, Laine RF, Young L, Radaelli E, Benilova I, Kumar M, Staes A, Desager M, Beerens M, Vandervoort P, Luttun A, Gevaert K, Bormans G, Dewerchin M, Van Eldere J, Carmeliet P, Vande Velde G, Verfaillie C, Kaminski CF, De Strooper B, Hammarström P, Nilsson KPR, Serpell L, Schymkowitz J, Rousseau F De novo design of a biologically active amyloid Science 354, 2016
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Young LM, Saunders JC, Mahood RA, Revill CH, Foster RJ, Ashcroft AE, Radford SE ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules Methods 95 62-69, 2016
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Saunders JC, Young LM, Mahood RA, Jackson MP, Revill CH, Foster RJ, Smith DA, Ashcroft AE, Brockwell DJ, Radford SE An in vivo platform for identifying inhibitors of protein aggregation Nature Chemical Biology 12 94-101, 2016
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Young LM, Mahood RA, Saunders JC, Tu LH, Raleigh DP, Radford SE, Ashcroft AE Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry Analyst 140 6990-6999, 2015
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Tu LH, Young LM, Wong AG, Ashcroft AE, Radford SE, Raleigh DP Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: Critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions Biochemistry 54 666-676, 2015
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Young LM, Saunders JC, Mahood RA, Revill CH, Foster RJ, Tu LH, Raleigh DP, Radford SE, Ashcroft AE Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry Nature Chemistry 7 73-81, 2015
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Young LM, Cao P, Raleigh DP, Ashcroft AE, Radford SE Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors Journal of the American Chemical Society 136 660-670, 2014
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Young L, Ndlovu H, Knapman TW, Harris SA, Radford SE, Ashcroft AE Monitoring oligomer formation from self-aggregating amylin peptides using ESI-IMS-MS International Journal for Ion Mobility Spectrometry 16 29-39, 2013
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