Faculty of Biological Sciences

Dr Lydia Young

Wellcome Trust ISSF Fellow
School of Molecular and Cellular Biology

Contact:  Other/Unknown, email address for  

Young LM, Ashcroft AE, Radford SE Small molecule probes of protein aggregation Current Opinion in Chemical Biology 39 90-99, 2017
DOI:10.1016/j.cbpa.2017.06.008
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Young LM, Tu LH, Raleigh DP, Ashcroft AE, Radford SE Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers Chemical Science 8 5030-5040, 2017
DOI:10.1039/c7sc00620a
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Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L, Khodaparast L, Couceiro JR, Langenberg T, Siemons M, Nyström S, Young LJ, Laine RF, Young L, Radaelli E, Benilova I, Kumar M, Staes A, Desager M, Beerens M, Vandervoort P, Luttun A, Gevaert K, Bormans G, Dewerchin M, Van Eldere J, Carmeliet P, Vande Velde G, Verfaillie C, Kaminski CF, De Strooper B, Hammarström P, Nilsson KPR, Serpell L, Schymkowitz J, Rousseau F De novo design of a biologically active amyloid Science 354 -, 2016
DOI:10.1126/science.aah4949
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Young LM, Saunders JC, Mahood RA, Revill CH, Foster RJ, Ashcroft AE, Radford SE ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules Methods 95 62-69, 2016
DOI:10.1016/j.ymeth.2015.05.017
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Saunders JC, Young LM, Mahood RA, Jackson MP, Revill CH, Foster RJ, Smith DA, Ashcroft AE, Brockwell DJ, Radford SE An in vivo platform for identifying inhibitors of protein aggregation Nature Chemical Biology 12 94-101, 2016
DOI:10.1038/nchembio.1988
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Young LM, Mahood RA, Saunders JC, Tu LH, Raleigh DP, Radford SE, Ashcroft AE Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry Analyst 140 6990-6999, 2015
DOI:10.1039/c5an00865d
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Tu LH, Young LM, Wong AG, Ashcroft AE, Radford SE, Raleigh DP Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: Critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions Biochemistry 54 666-676, 2015
DOI:10.1021/bi501016r
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Young LM, Saunders JC, Mahood RA, Revill CH, Foster RJ, Tu LH, Raleigh DP, Radford SE, Ashcroft AE Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry Nature Chemistry 7 73-81, 2015
DOI:10.1038/nchem.2129
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