Dr Chi-Chuan Lin

Research Fellow
School of Molecular and Cellular Biology

Contact: LIGHT 7.15, email address for  

Suen KM, Lin CC, Seiler C, George R, Poncet-Montange G, Biter AB, Ahmed Z, Arold ST, Ladbury JE Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells International Journal of Biochemistry and Cell Biology 94 89-97, 2018
DOI:10.1016/j.biocel.2017.11.014
View abstract

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee Iv GR, Lin CC, Gagea M, Marti AA, Ladbury JE Erratum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function (Nature Communications (2015) 6:7354 DOI:10.1038/ncomms8354) Nature Communications 6, 2015
DOI:10.1038/ncomms9007

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee GR, Lin CC, Gagea M, Marti AA, Ladbury JE Grb2 monomer-dimer equilibrium determines normal versus oncogenic function Nature Communications 6, 2015
DOI:10.1038/ncomms8354
View abstract

Timsah Z, Ahmed Z, Lin CC, Melo FA, Stagg LJ, Leonard PG, Jeyabal P, Berrout J, O'Neil RG, Bogdanov M, Ladbury JE Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion Nature Structural and Molecular Biology 21 180-188, 2014
DOI:10.1038/nsmb.2752
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Ahmed Z, Lin CC, Suen KM, Melo FA, Levitt JA, Suhling K, Ladbury JE Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity Journal of Cell Biology 200 493-504, 2013
DOI:10.1083/jcb.201204106
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Suen KM, Lin CC, George R, Melo FA, Biggs ER, Ahmed Z, Drake MN, Arur S, Arold ST, Ladbury JE Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli Nature Structural and Molecular Biology 20 620-627, 2013
DOI:10.1038/nsmb2557
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Lin CC, Melo FA, Ghosh R, Suen KM, Stagg LJ, Kirkpatrick J, Arold ST, Ahmed Z, Ladbury JE Inhibition of basal FGF receptor signaling by dimeric Grb2 Cell 149 1514-1524, 2012
DOI:10.1016/j.cell.2012.04.033
View abstract

Ahmed Z, George R, Lin CC, Suen KM, Levitt JA, Suhling K, Ladbury JE Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function Cellular Signalling 22 23-33, 2010
DOI:10.1016/j.cellsig.2009.08.011
View abstract