Dr Stefan Kepinski

BSc, PhD July 1998, Liverpool
Senior Lecturer
School of Biology

Contact: Manton 9.09, +44(0) 113 34 32865, email address for  

You can read more about Dr Kepinski's interests here:

Faculty Research and Innovation

Studentship information

See also:

Modules managed

BIOL5251M - Plant Biotechnology
BLGY2163 - How Plants Work

Modules taught

BIOL5251M - Plant Biotechnology
BIOL5294M - MSc Bioscience Research Project Proposal
BIOL5392M - Bioscience MSc Research Project
BLGY1300 - Coastal and Upland Habitats Field Course
BLGY1303 - Tutorials for Biology and Genetics
BLGY2100 - Enhanced Study Skills for Biologists
BLGY2163 - How Plants Work
BLGY3345 - Biology Integrated Research Projects

Academic roles

UG Programme Leader - UG Biology and Joint Honours programmes


Member of Undergraduate School Taught Student Education Committee (Programme Manager: Biology and Joint Honours)

Centre membership: The Centre for Plant Sciences

Miss Marta Del Bianco  (Research Fellow)

Miss Suruchi Roychoudhry  (Research Fellow )


Adam Binns (Primary supervisor) 34% FTE
Ryan Kaye (Primary supervisor) 90% FTE
Maxime Josse (Co-supervisor) 10% FTE
Alastair Plant (Co-supervisor) 10% FTE

Huang G, Liang W, Sturrock CJ, Pandey BK, Giri J, Mairhofer S, Wang D, Muller L, Tan H, York LM, Yang J, Song Y, Kim YJ, Qiao Y, Xu J, Kepinski S, Bennett MJ, Zhang D Rice actin binding protein RMD controls crown root angle in response to external phosphate Nature Communications 9, 2018
View abstract

Rast-Somssich MI,Žádníková P, Schmid S, Kieffer M, Kepinski S, Simon R The Arabidopsis JAGGED LATERAL ORGANS (JLO) gene sensitizes plants to auxin Journal of Experimental Botany 68 2741-2755, 2017
View abstract

Roychoudhry S, Kieffer M, Del Bianco M, Liao CY, Weijers D, Kepinski S The developmental and environmental regulation of gravitropic setpoint angle in Arabidopsis and bean Scientific Reports 7, 2017
View abstract

Wang R, Zhang Y, Kieffer M, Yu H, Kepinski S, Estelle M Corrigendum: HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1 Nature Communications 7, 2016

Wang R, Zhang Y, Kieffer M, Yu H, Kepinski S, Estelle M HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1 Nature Communications 7, 2016
View abstract

Roychoudhry S, Kepinski S Analysis of gravitropic setpoint angle control in arabidopsis, 2015
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Roychoudhry S, Kepinski S Shoot and root branch growth angle control - the wonderfulness of lateralness. Current Opinion in Plant Biology 23 124-131, 2015
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Lee S, Sundaram S, Armitage L, Evans JP, Hawkes T, Kepinski S, Ferro N, Napier RM Defining binding efficiency and specificity of auxins for SCF(TIR1/AFB)-Aux/IAA co-receptor complex formation. ACS Chemical Biology 9 673-682, 2014
View abstract

Boer DR, Freire-Rios A, van den Berg WAM, Saaki T, Manfield IW, Kepinski S, López-Vidrieo I, Franco-Zorrilla JM, de Vries SC, Solano R, Weijers D, Coll M Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors. Cell 156 577-589, 2014
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Roychoudhry S, Del Bianco M, Kieffer M, Kepinski S Auxin controls gravitropic setpoint angle in higher plant lateral branches. Current Biology 23 1497-1504, 2013
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De Rybel B, Audenaert D, Xuan W, Overvoorde P, Strader LC, Kepinski S, Hoye R, Brisbois R, Parizot B, Vanneste S, Liu X, Gilday A, Graham IA, Nguyen L, Jansen L, Njo MF, Inzé D, Bartel B, Beeckman T A role for the root cap in root branching revealed by the non-auxin probe naxillin. Nat Chem Biol 8 798-805, 2012
View abstract

Hayashi K-I, Neve J, Hirose M, Kuboki A, Shimada Y, Kepinski S, Nozaki H Rational design of an auxin antagonist of the SCF(TIR1) auxin receptor complex. ACS Chem Biol 7 590-598, 2012
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Brunoud G, Wells DM, Oliva M, Larrieu A, Mirabet V, Burrow AH, Beeckman T, Kepinski S, Traas J, Bennett MJ, Vernoux T A novel sensor to map auxin response and distribution at high spatio-temporal resolution. Nature 482 103-106, 2012
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Calderón Villalobos LIA, Lee S, De Oliveira C, Ivetac A, Brandt W, Armitage L, Sheard LB, Tan X, Parry G, Mao H, Zheng N, Napier R, Kepinski S, Estelle M A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin Nature Chemical Biology 8 477-485, 2012
View abstract

Bridge LJ, Mirams GR, Kieffer ML, King JR, Kepinski S Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: models with two Aux/IAA and ARF proteins, and two target gene-sets. Math Biosci 235 32-44, 2012
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Vernoux T, Brunoud G, Farcot E, Morin V, Van den Daele H, Legrand J, Oliva M, Das P, Larrieu A, Wells D, Guedon Y, Armitage L, Picard F, Guyomarc'h S, Cellier C, Parry G, Koumproglou R, Doonan JH, Estelle M, Godin C, Kepinski S, Bennett M, De Veylder L, Traas J The auxin signalling network translates dynamic input into robust patterning at the shoot apex MOL SYST BIOL 7, 2011

Brown LA, O'Leary-Steele C, Brookes P, Armitage L, Kepinski S, Warriner SL, Baker A A small molecule with differential effects on the PTS1 and PTS2 peroxisome matrix import pathways PLANT J 65 980-990, 2011

Del Bianco M, Kepinski S Context, specificity, and self-organization in auxin response. Cold Spring Harb Perspect Biol 3 a001578-, 2011
View abstract

Kieffer M, Neve J, Kepinski S Defining auxin response contexts in plant development CURR OPIN PLANT BIOL 13 12-20, 2010

De Rybel B, Audenaert D, Beeckman T, Kepinski S The Past, Present, and Future of Chemical Biology in Auxin Research ACS CHEM BIOL 4 987-998, 2009

Kepinski S Pull-down assays for plant hormone research. Methods Mol Biol 495 61-80, 2009
View abstract

Hayashi K, Tan X, Zheng N, Hatate T, Kimura Y, Kepinski S, Nozaki H Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling P NATL ACAD SCI USA 105 5632-5637, 2008

Kepinski S The anatomy of auxin perception BIOESSAYS 29 953-956, 2007

Kepinski S Integrating hormone signaling and patterning mechanisms in plant development CURR OPIN PLANT BIOL 9 28-34, 2006

Yamazoe A, Hayashi K, Kepinski S, Leyser O, Nozaki H Characterization of terfestatin A, a new specific inhibitor for auxin signaling PLANT PHYSIOL 139 779-789, 2005

Kepinski S, Leyser O The Arabidopsis F-box protein TIR1 is an auxin receptor NATURE 435 446-451, 2005

Kepinski S, Leyser O Plant development: auxin in loops. Curr Biol 15 R208-R210, 2005
View abstract

Kepinski S, Leyser O Auxin-induced SCFTIR1-Aux/IAA interaction involves stable modification of the SCFTIR1 complex P NATL ACAD SCI USA 101 12381-12386, 2004

Kepinski S, Leyser O SCF-mediated proteolysis and negative regulation in ethylene signaling. Cell 115 647-648, 2003
View abstract

Kepinski S, Leyser O An axis of auxin Nature 426 132-135, 2003
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Kepinski S, Leyser O Plant development: an axis of auxin. Nature 426 132-135, 2003

Kepinski S, Leyser O Ubiquitination and auxin signaling: A degrading story PLANT CELL 14 S81-S95, 2002

Gray WM, Kepinski S, Rouse D, Leyser O, Estelle M Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins NATURE 414 271-276, 2001