Dr Louise Kime

BSc (Hons) Medical Sciences, PhD Leeds
Research Fellow
School of Molecular and Cellular Biology

Contact: Garstang 8.52, email address for  

Charlton MH, Aleksis R, Saint-Leger A, Gupta A, Loza E, Ribas de Pouplana L, Kaula I, Gustina D, Madre M, Lola D, Jaudzems K, Edmund G, Randall CP, Kime L, O'Neill AJ, Goessens W, Jirgensons A, Finn PW N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors ACS Medicinal Chemistry Letters 9 84-88, 2018
DOI:10.1021/acsmedchemlett.7b00374
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Kime L, Vincent HA, Gendoo DMA, Jourdan SS, Fishwick CWG, Callaghan AJ, McDowall KJ Erratum: The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family Scientific Reports 5, 2015
DOI:10.1038/srep09781

Kime L, Vincent HA, Gendoo DMA, Jourdan SS, Fishwick CWG, Callaghan AJ, McDowall KJ The first small-molecule inhibitors of members of the ribonuclease E family Scientific Reports 5 8028-, 2015
DOI:10.1038/srep08028
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Clarke JE, Kime L, Romero A D, McDowall KJ Direct entry by RNase e is a major pathway for the degradation and processing of RNA in Escherichia coli Nucleic Acids Research 42 11733-11751, 2014
DOI:10.1093/nar/gku808
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Kime L, Clarke JE, Romero A D, Grasby JA, McDowall KJ Adjacent single-stranded regions mediate processing of tRNA precursors by RNase E direct entry. Nucleic Acids Res 42 4577-4589, 2014
DOI:10.1093/nar/gkt1403
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Romero DA, Hasan AH, Lin YF, Kime L, Ruiz-Larrabeiti O, Urem M, Bucca G, Mamanova L, Laing EE, van Wezel GP, Smith CP, Kaberdin VR, Mcdowall KJ A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide-resolution transcription maps produced in parallel by global and differential RNA sequencing Molecular Microbiology 94 963-987, 2014
DOI:10.1111/mmi.12810
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Kime L, Jourdan SS, Stead JA, Hidalgo-Sastre A, McDowall KJ Rapid cleavage of RNA by RNase E in the absence of 5' monophosphate stimulation. Mol Microbiol 76 590-604, 2010
DOI:10.1111/j.1365-2958.2009.06935.x
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Jourdan SS, Kime L, McDowall KJ The sequence of sites recognised by a member of the RNase E/G family can control the maximal rate of cleavage, while a 5'-monophosphorylated end appears to function cooperatively in mediating RNA binding. Biochem Biophys Res Commun 391 879-883, 2010
DOI:10.1016/j.bbrc.2009.11.156
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Kime L, Jourdan SS, McDowall KJ Chapter 12 Identifying and Characterizing Substrates of the RNase E/G Family of Enzymes Methods in Enzymology 447 215-241, 2008
DOI:10.1016/S0076-6879(08)02212-X
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Kime L, Jourdan SS, McDowall KJ IDENTIFYING AND CHARACTERIZING SUBSTRATES OF THE RNASE E/G FAMILY OF ENZYMES, 2008
DOI:10.1016/S0076-6879(08)02212-X

Kime L, Wright SC Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc. Biochem J 370 291-298, 2003
DOI:10.1042/BJ20021679
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Barnes K, Walkden BJ, Kime L, Turner AJ Localization and regulation of the isoforms of brain endothelin converting enzyme-1 ESN/ISN Meeting, JOURNAL OF NEUROCHEMISTRY 71 pp.43-, 1998