Dr Hannah Marie Kirton

BSc (Hons) and Ph.D, Leeds
Research Fellow
School of Biomedical Sciences

Contact: Garstang 7.53, +44(0) 113 34 31869, email address for  

Kirton HM, Al-Owais M, Peers C, Steele DS The EPAC2 Inhibitor ESI-05 Prolongs the Action Potential and Increases Susceptibility to EAD Arrhythmias, 2018

Al-Owais MM, Hettiarachchi NT, Kirton HM, Hardy ME, Boyle JP, Scragg JL, Steele DS, Peers C A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K+ channels in carbon monoxide-induced proarrhythmic early afterdepolarizations FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 4845-4854, 2017
DOI:10.1096/fj.201700259R
View abstract

Yang Z, Kirton HM, Al-Owais M, Thireau J, Richard S, Peers C, Steele DS Epac2-Rap1 signaling regulates reactive oxygen species production and susceptibility to cardiac arrhythmias Antioxidants and Redox Signaling 27 117-132, 2017
DOI:10.1089/ars.2015.6485
View abstract

Yang Z, Kirton HM, Al-Owais M, Peers C, Steele DS Epac2-Rap1 Signaling Influences Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias, 2017
DOI:10.1016/j.bpj.2016.11.576

Kirton HM, Yang Z, Steele DS Conditions that Promote Golgi Ca2+ Release Facilitate Trafficking of VEGFR-1 to the Surface Membrane in Rat Ventricular Myocytes, 2016
DOI:10.1016/j.bpj.2015.11.2350

Kirton HM, Yang Z, Steele DS Phosphodiesterase Inhibition Leads to Activation of Epac and Stimulation of Ca2+ Release from both the Golgi Apparatus and the SR, 2015
DOI:10.1016/j.bpj.2014.11.1452

Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS The Golgi apparatus is a functionally distinct Ca<sup>2+</sup>store regulated by the PKA and Epac branches of the b1-adrenergic signaling pathway Science Signaling 8, 2015
DOI:10.1126/scisignal.aaa7677
View abstract

Kirton HM, Pettinger L, Gamper N Transient overexpression of genes in neurons using nucleofection. Methods Mol Biol 998 55-64, 2013
DOI:10.1007/978-1-62703-351-0_4
View abstract

Kirton HM Competitive Interactions of Kv7 Channel Carboxy-Termini with PIP2 and Calmodulin BIOPHYSICAL JOURNAL 102 133A-133A, 2012
DOI:10.1016/j.bpj.2011.11.738