Faculty of Biological Sciences

Prof Nigel Hooper

BSc 1984, PhD 1987, Leeds.
Professor of Biochemistry
School of Molecular and Cellular Biology

Background: Royal Society Mr and Mrs John Jaff Donation Research Fellow 1987-1989. Lecturer at Leeds 1989-1996; Senior Lecturer at Leeds 1996-99; Reader in Biochemistry 1999-2001; Professor of Biochemistry from August 2001.

Contact:  Miall 7.07 | +44(0) 113 34 35647 | email address for Prof Nigel Hooper 

You can read more about Prof Hooper's interests here:
www.astbury.leeds.ac.uk/People/staffpage.php?StaffID=NMH

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Admin roles

Dean
External Examiner (taught course): University College Dublin
External Examiner (taught course): University College Dublin
Faculty Research & Innovation Committee
FBS Equality and Diversity Committee (Chair)
FBS Exective Committee (Chair)
FBS Faculty Board (Chair)
FBS FTSEC
FBS GTSEC
FBS Health and Safety Committee (Chair)
FBS Strategy Group
FBS Student Recruitment Committee

Modules taught

BIOC2301/BIOL2210 - Integrated Biochemistry/Biological Membranes
BIOC2302 - Intermediate Biochem: Prac
BIOC3111/12/13/BIOL3112/5264M/BMSC3143/44/45/46 - ATU 27 - Neurodegeneration
BIOL2301/05 - Skills for Biol Sci & Biosciences
BIOL3399 - Extended Research Project Preparation
BIOL5292M - Bioscience MSc Research Proj
BIOL5294M - MSc Bioscience Res Project Pro
BIOW5904X - Folding and Assembly
BMSC1110/SPSC1220 - Foundation modules
BMSC3301 - Research Proj: Biomed Sciences
MEDI1216 - Introduction to Medical Sciences

Committees

Member of Faculty Taught Student Education Committee
Member of Graduate School Taught Student Education Committee

Centre membership:

Group Leader Prof Nigel Hooper  (Professor of Biochemistry)

Cell biology of Alzheimer's disease and ageing 


Dr Katherine Kellett  (Research Fellow)

Dr James Duce  (Alzheimer's Senior Research Fellow)

Dr Heledd Griffiths  (Research Fellow)

Dr Carolyn Jackson  (Laboratory Manager )

Dr Isobel Whitehouse  (Research Fellow)

Mr Andrew Tsatsanis  (Research Assistant)

Dr Nicole Watt  (Research Fellow)


Postgraduates

Robert Andrew  
Giorgia Magnatti  
Elizabeth Noble  

Cruchaga C; Karch CM; Jin SC; Benitez BA; Cai Y; Guerreiro R; Harari O; Norton J; Budde J; Bertelsen S; Jeng AT; Cooper B; Skorupa T; Carrell D; Levitch D; Hsu S; Choi J; Ryten M; UK Brain Expression Consortium; Hardy J; Ryten M; Trabzuni D; Weale ME; Ramasamy A; Smith C; Sassi C; Bras J; Gibbs JR; Hernandez DG; Lupton MK; Powell J; Forabosco P; Ridge PG; Corcoran CD; Tschanz JT; Norton MC; Munger RG; Schmutz C; Leary M; Demirci FY; Bamne MN; Wang X; Lopez OL; Ganguli M; Medway C; Turton J; Lord J; Braae A; Barber I; Brown K; Alzheimer’s Research UK Consortium; Passmore P; Craig D; Johnston J; McGuinness B; Todd S; Heun R; Kölsch H; Kehoe PG; Hooper NM; Vardy ER; Mann DM; Pickering-Brown S; Brown K; Kalsheker N; Lowe J; Morgan K; David Smith A; Wilcock G; Warden D; Holmes C; Pastor P; Lorenzo-Betancor O; Brkanac Z; Scott E; Topol E; Morgan K; Rogaeva E; Singleton AB; Hardy J; Kamboh MI; St George-Hyslop P; Cairns N; Morris JC; Kauwe JS; Goate AM Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature 505 550-554, 2014
DOI:10.1038/nature12825
View abstract

Rushworth JV; Ahmed A; Griffiths HH; Pollock NM; Hooper NM; Millner PA A label-free electrical impedimetric biosensor for the specific detection of Alzheimer's amyloid-beta oligomers. Biosens Bioelectron 56 83-90, 2014
DOI:10.1016/j.bios.2013.12.036
View abstract

Rushworth JV; Griffiths HH; Watt NT; Hooper NM Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J Biol Chem 288 8935-8951, 2013
DOI:10.1074/jbc.M112.400358
View abstract

Whitehouse IJ; Miners JS; Glennon EB; Kehoe PG; Love S; Kellett KA; Hooper NM Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage. PLoS One 8 e59554-, 2013
DOI:10.1371/journal.pone.0059554
View abstract

Watt NT; Griffiths HH; Hooper NM Neuronal zinc regulation and the prion protein. Prion 7 203-208, 2013
DOI:10.4161/pri.24503
View abstract

Clarke NE; Hooper NM; Turner AJ Angiotensin-Converting Enzyme-2, 2013
DOI:10.1016/B978-0-12-382219-2.00100-9

Hooper NM Xaa-Trp Aminopeptidase Handbook of Proteolytic Enzymes 2 1701-1702, 2013
DOI:10.1016/B978-0-12-382219-2.00387-2

Hooper NM Membrane dipeptidase Handbook of Proteolytic Enzymes 2 1670-1673, 2013
DOI:10.1016/B978-0-12-382219-2.00377-X

Glennon EB; Whitehouse IJ; Miners JS; Kehoe PG; Love S; Kellett KA; Hooper NM BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging. PLoS One 8 e78806-, 2013
DOI:10.1371/journal.pone.0078806
View abstract

Vardy ERLC; Kellett KAB; Cocklin SL; Hooper NM Alkaline Phosphatase Is Increased in both Brain and Plasma in Alzheimer's Disease NEURODEGENERATIVE DISEASES 9 31-37, 2012
DOI:10.1159/000329722

Lewis V; Whitehouse IJ; Baybutt H; Manson JC; Collins SJ; Hooper NM Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain. PLoS One 7 e31754-, 2012
DOI:10.1371/journal.pone.0031754
View abstract

Griffiths HH; Whitehouse IJ; Hooper NM Regulation of amyloid-β production by the prion protein. Prion 6 217-222, 2012
DOI:10.4161/pri.18988
View abstract

Watt NT; Taylor DR; Kerrigan TL; Griffiths HH; Rushworth JV; Whitehouse IJ; Hooper NM Prion protein facilitates uptake of zinc into neuronal cells. Nat Commun 3 1134-, 2012
DOI:10.1038/ncomms2135
View abstract

Standeven KF; Hess K; Carter AM; Rice GI; Cordell PA; Balmforth AJ; Lu B; Scott DJ; Turner AJ; Hooper NM; Grant PJ Neprilysin, obesity and the metabolic syndrome INT J OBESITY 35 1031-1040, 2011
DOI:10.1038/ijo.2010.227

Duff CJ; Hooper NM PCSK9: an emerging target for treatment of hypercholesterolemia EXPERT OPIN THER TAR 15 157-168, 2011
DOI:10.1517/14728222.2011.547480

Hollingworth P; Harold D; Sims R; Gerrish A; Lambert JC; Carrasquillo MM; Abraham R; Hamshere ML; Pahwa JS; Moskvina V; Dowzell K; Jones N; Stretton A; Thomas C; Richards A; Ivanov D; Widdowson C; Chapman J; Lovestone S; Powell J; Proitsi P; Lupton MK; Brayne C; Rubinsztein DC; Gill M; Lawlor B; Lynch A; Brown KS; Passmore PA; Craig D; McGuinness B; Todd S; Holmes C; Mann D; Smith AD; Beaumont H; Warden D; Wilcock G; Love S; Kehoe PG; Hooper NM; Vardy ER; Hardy J; Mead S; Fox NC; Rossor M; Collinge J; Maier W; Jessen F; Rüther E; Schürmann B; Heun R; Kölsch H; van den Bussche H; Heuser I; Kornhuber J; Wiltfang J; Dichgans M; Frölich L; Hampel H; Gallacher J; Hüll M; Rujescu D; Giegling I; Goate AM; Kauwe JS; Cruchaga C; Nowotny P; Morris JC; Mayo K; Sleegers K; Bettens K; Engelborghs S; De Deyn PP; Van Broeckhoven C; Livingston G; Bass NJ; Gurling H; McQuillin A; Gwilliam R; Deloukas P; Al-Chalabi A; Shaw CE; Tsolaki M; Singleton AB; Guerreiro R; Mühleisen TW; Nöthen MM; Moebus S; Jöckel KH; Klopp N; Wichmann HE; Pankratz VS; Sando SB; Aasly JO; Barcikowska M; Wszolek ZK; Dickson DW; Graff-Radford NR;Petersen RC; Alzheimer's Disease Neuroimaging Initiative; van Duijn CM; Breteler MM; Ikram MA; DeStefano AL; Fitzpatrick AL; Lopez O; Launer LJ; Seshadri S; CHARGE consortium; Berr C; Campion D; Epelbaum J; Dartigues JF; Tzourio C; Alpérovitch A; Lathrop M; EADI1 consortium; Feulner TM; Friedrich P; Riehle C; Krawczak M; Schreiber S; Mayhaus M; Nicolhaus S; Wagenpfeil S; Steinberg S; Stefansson H; Stefansson K; Snaedal J; Björnsson S; Jonsson PV; Chouraki V; Genier-Boley B; Hiltunen M; Soininen H; Combarros O; Zelenika D; Delepine M; Bullido MJ; Pasquier F; Mateo I; Frank-Garcia A; Porcellini E; Hanon O; Coto E; Alvarez V; Bosco P; Siciliano G; Mancuso M; Panza F; Solfrizzi V; Nacmias B; Sorbi S; Bossù P; Piccardi P; Arosio B; Annoni G; Seripa D; Pilotto A; Scarpini E; Galimberti D; Brice A; Hannequin D; Licastro F; Jones L; Holmans PA; Jonsson T; Riemenschneider M; Morgan K; YounkinSG; Owen MJ; O'Donovan M; Amouyel P; Williams J Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 43 429-435, 2011
DOI:10.1038/ng.803
View abstract

Lewis V; Hooper NM The role of lipid rafts in prion protein biology FRONT BIOSCI-LANDMRK 16 151-168, 2011
DOI:10.2741/3681

Griffiths HH; Whitehouse IJ; Baybutt H; Brown D; Kellett KAB; Jackson CD; Turner AJ; Piccardo P; Manson JC; Hooper NM Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein JOURNAL OF BIOLOGICAL CHEMISTRY 286 33489-33500, 2011
DOI:10.1074/jbc.M111.278556

Cilia La Corte AL; Carter AM; Rice GI; Duan QL; Rouleau GA; Adam A; Grant PJ; Hooper NM A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema. Hum Mutat 32 1326-1331, 2011
DOI:10.1002/humu.21579
View abstract

Kellett KAB; Vardy ERLC; Hooper NM; Williams J; Smith AD Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function International Journal of Molecular Epidemiology and Genetics 2 114-121, 2011
View abstract

Lewis V; Hooper NM The role of lipid rafts in prion protein biology Frontiers in Bioscience 16 169-186, 2011
DOI:10.2741/3682
View abstract

Cilia La Corte AL; Carter AM; Rice GI; Duan QL; Rouleau GA; Adam A; Grant PJ; Hooper NM A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema Human Mutation -, 2011

Turner AJ; Hooper NM Angiotensin-converting enzyme-2 (ACE2) xPharm: The Comprehensive Pharmacology Reference 1-4, 2011
DOI:10.1016/B978-008055232-3.62913-7
View abstract

Hooper NM Membrane dipeptidase xPharm: The Comprehensive Pharmacology Reference 1-5, 2011
DOI:10.1016/B978-008055232-3.62914-9
View abstract

Hooper NM Angiotensin i-converting enzyme (ACE) xPharm: The Comprehensive Pharmacology Reference 1-7, 2011
DOI:10.1016/B978-008055232-3.60552-5
View abstract

Bruns AF; Herbert SP; Odell AF; Jopling HM; Hooper NM; Zachary IC; Walker JH; Ponnambalam S Ligand-Stimulated VEGFR2 Signaling is Regulated by Co-Ordinated Trafficking and Proteolysis TRAFFIC 11 161-174, 2010
DOI:10.1111/j.1600-0854.2009.01001.x

Whitehouse IJ; Jackson C; Turner AJ; Hooper NM Prion Protein is Reduced in Aging and in Sporadic but not in Familial Alzheimer's Disease J ALZHEIMERS DIS 22 1023-1031, 2010
DOI:10.3233/JAD-2010-101071

Belyaev ND; Kellett KAB; Beckett C; Makova NZ; Revett TJ; Nalivaeva NN; Hooper NM; Turner AJ The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a beta-Secretase-dependent Pathway J BIOL CHEM 285 41443-41454, 2010
DOI:10.1074/jbc.M110.141390

Watt NT; Whitehouse IJ; Hooper NM The role of zinc in Alzheimer's disease. Int J Alzheimers Dis 2011 971021-, 2010
DOI:10.4061/2011/971021
View abstract

Rushworth JV; Hooper NM Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. Int J Alzheimers Dis 2011 603052-, 2010
DOI:10.4061/2011/603052
View abstract

Humphrey JV; Hooper NM Soluble, Fibrillar Amyloid-beta Oligomers Bind to the Cellular Prion Protein and Reduce its Cell Surface Expression PRION 4 187-187, 2010

Duff CJ; Scottt MJ; Kirby IT; Hutchinson SE; Martin SL; Hooper NM Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor BIOCHEM J 419 577-584, 2009
DOI:10.1042/BJ20082407

Kellett KAB; Hooper NM Prion protein and Alzheimer disease PRION 3 190-194, 2009

Vardy ERLC; Rice PJ; Bowie PCW; Holmes JD; Catto AJ; Hooper NM Plasma Angiotensin-Converting Enzyme in Alzheimer's Disease J ALZHEIMERS DIS 16 609-618, 2009
DOI:10.3233/JAD-2009-1002

Taylor DR; Whitehouse IJ; Hooper NM Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation PLOS PATHOG 5 -, 2009
DOI:10.1371/journal.ppat.1000666

Taylor DR; Parkin ET; Cocklin SL; Ault JR; Ashcroft AE; Turner AJ; Hooper NM Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein J BIOL CHEM 284 22590-22600, 2009
DOI:10.1074/jbc.M109.032599

Jopling HM; Odell AF; Hooper NM; Zachary IC; Walker JH; Ponnambalam S Rab GTPase Regulation of VEGFR2 Trafficking and Signaling in Endothelial Cells ARTERIOSCL THROM VAS 29 1119-U206, 2009
DOI:10.1161/ATVBAHA.109.186239

Walmsley AR; Watt NT; Taylor DR; Perera WSS; Hooper NM alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts MOL CELL NEUROSCI 40 242-248, 2009
DOI:10.1016/j.mcn.2008.10.012

Hein Z; Hooper NM; Naim HY Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway EXP CELL RES 315 348-356, 2009
DOI:10.1016/j.yexcr.2008.10.038

Mok NY; Chadwick J; Kellett KAB; Hooper NM; Johnson AP; Fishwick CWG Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening BIOORG MED CHEM LETT 19 6770-6774, 2009
DOI:10.1016/j.bmcl.2009.09.103

Taylor DR; Hooper NM The enigmatic membrane microdomain: Lipid rafts Biochemist 31 16-19, 2009

Griffiths HH; Morten IJ; Hooper NM Emerging and potential therapies for Alzheimer's disease EXPERT OPIN THER TAR 12 693-704, 2008
DOI:10.1517/14728220802097805

La Corte AIC; Carter AM; Turner AJ; Grant PJ; Hooper NM The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill J RENIN-ANGIO-ALDO S 9 221-225, 2008
DOI:10.1177/1470320308096405

Lambert DW; Clarke NE; Hooper NM; Turner AJ Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain FEBS LETT 582 385-390, 2008
DOI:10.1016/j.febslet.2007.11.085

Wilkinson DK; Turner EJ; Parkin ET; Garner AE; Harrison PJ; Crawford M; Stewart GW; Hooper NM Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis. Biochim Biophys Acta 1778 125-132, 2008
DOI:10.1016/j.bbamem.2007.09.016
View abstract

Dupiereux I; Falisse-Poirrier N; Zorzi W; Watt NT; Thellin O; Zorzi D; Pierard O; Hooper NM; Heinen E; Elmoualij B Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells J NEUROSCI RES 86 653-659, 2008
DOI:10.1002/jnr.21506

Hooper NM; Turner AJ A new take on prians: preventing Alzheimer's disease TRENDS BIOCHEM SCI 33 151-155, 2008
DOI:10.1016/j.tibs.2008.01.004

Garner AE; Smith DA; Hooper NM Visualization of detergent solubilization of membranes: Implications for the isolation of rafts BIOPHYS J 94 1326-1340, 2008
DOI:10.1529/biophysj.107.114108

Hooper NM; Taylor DR; Watt NT Mechanism of the metal-mediated endocytosis of the prion protein BIOCHEM SOC T 36 1272-1276, 2008
DOI:10.1042/BST0361272

Lambert DW; Hooper NM; Turner AJ Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system BIOCHEM PHARMACOL 75 781-786, 2008
DOI:10.1016/j.bcp.2007.08.012

Taylor DR; Hooper NM Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins SEMIN CELL DEV BIOL 18 638-648, 2007
DOI:10.1016/j.semcdb.2007.07.008

Yoon HJ; Park SW; Lee HB; Im SY; Hooper NM; Park HS Release of renal dipeptidase from glycosylphosphatidylinositol anchor by insulin-triggered phospholipase C/intracellular Ca2+ ARCH PHARM RES 30 608-615, 2007

Say YH; Hooper NM Contamination of nuclear fractions with plasma membrane lipid rafts PROTEOMICS 7 1059-1064, 2007
DOI:10.1002/pmic.200600849

Taylor DR; Hooper NM The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein BIOCHEM J 402 17-23, 2007
DOI:10.1042/BJ20061736

Rice GI; Jones AL; Grant PJ; Carter AM; Turner AJ; Hooper NM Circulating Activities of Angiotensin Converting Enzyme (ACE), its Homolog ACE2 and Neprilysin in a Family Study Hypertension 48 1-7, 2007
DOI:10.1161/01.HYP.0000244543.91937.79

Watt NT; Routledge MN; Wild CP; Hooper NM Cellular prion protein protects against reactive-oxygen-species-induced DNA damage FREE RADICAL BIO MED 43 959-967, 2007
DOI:10.1016/j.freeradbiomed.2007.06.004

Garner AE; Smith DA; Hooper NM Sphingomyelin chain length influences the distribution of GPI-anchored proteins in rafts in supported lipid bilayers. Mol Membr Biol 24 233-242, 2007
DOI:10.1080/09687860601127770
View abstract

Parkin ET; Watt NT; Hussain I; Eckman EA; Eckman CB; Manson JC; Baybutt HN; Turner AJ; Hooper NM Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein P NATL ACAD SCI USA 104 11062-11067, 2007
DOI:10.1073/pnas.0609621104

Vardy ERLC; Rice PJ; Bowie PCW; Holmes JD; Grant PJ; Hooper NM Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease J ALZHEIMERS DIS 12 285-290, 2007

Cubbon RM; Rajwan A; Abbas A; Gale CP; Grant PJ; Wheatcroft SB; Barth JH; Kearney MT; Hall AS; EMMACE-2 Study Grp Hyperglycaemia, in relation to sex, and mortality after acute coronary syndrome EUR J CARDIOV PREV R 14 666-671, 2007

Hamming I; Cooper ME; Haagmans BL; Hooper NM; Korstanje R; Osterhaus ADME; Timens W; Turner AJ; Navis G; van Goor H The emerging role of ACE2 in physiology and disease J PATHOL 212 1-11, 2007
DOI:10.1002/path.2162

Rella M; Elliot JL; Revett TJ; Lanfear J; Phelan A; Jackson RM; Turner AJ; Hooper NM Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE BMC GENOMICS 8 -, 2007
DOI:10.1186/1471-2164-8-194

Watt NT; Hooper NM Prion protein in Alzheimer's diseases Future Neurology 2 587-590, 2007
DOI:10.2217/14796708.2.6.587

Vardy ERLC; Hooper NM Therapeutic developments in Alzheimer's disease Research and Practice in Alzheimer's Disease 12 196-202, 2007
View abstract

Taylor DR; Hooper NM The prion protein and lipid rafts. Mol Membr Biol 23 89-99, 2006
DOI:10.1080/09687860500449994
View abstract

Omaetxebarria MJ; Hagglund P; Elortza F; Hooper NM; Arizmendi JM; Jensen ON Isolation and characterization of glycosylphosphatidylinositol-anchored peptides by hydrophilic interaction chromatography and MALDI tandem mass spectrometry ANAL CHEM 78 3335-3341, 2006
DOI:10.1021/ac0517949

Vardy ER; Hussain I; Hooper NM Emerging therapeutics for Alzheimer's disease. Expert Rev Neurother 6 695-704, 2006
DOI:10.1586/14737175.6.5.695
View abstract

Hooper NM Foreword: lipid rafts/biophysics, cell signalling, trafficking and processing MOL MEMBR BIOL 23 1-3, 2006
DOI:10.1080/09687860500500879

Rice GI; Jones AL; Grant PJ; Carter AM; Turner AJ; Hooper NM Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension 48 914-920, 2006
DOI:10.1161/01.HYP.0000244543.91937.79
View abstract

Thomas DA; Francis P; Smith C; Ratcliffe S; Ede NJ; Kay C; Wayne G; Martin SL; Moore K; Amour A; Hooper NM A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates PROTEOMICS 6 2112-2120, 2006
DOI:10.1002/pmic.200500153

Cordy JM; Hooper NM; Turner AJ The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol 23 111-122, 2006
DOI:10.1080/09687860500496417
View abstract

Wallace EJ; Hooper NM; Olmsted PD Effect of hydrophobic mismatch on phase behavior of lipid membranes BIOPHYS J 90 4104-4118, 2006
DOI:10.1529/biophysj.105.062778

Hooper NM Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein. Biochem Soc Trans 33 335-338, 2005
DOI:10.1042/BST0330335
View abstract

Taylor DR; Watt NT; Perera WS; Hooper NM Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J Cell Sci 118 5141-5153, 2005
DOI:10.1242/jcs.02627
View abstract

Vardy ERLC; Catto AJ; Hooper NM Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease TRENDS MOL MED 11 464-472, 2005

Warner FJ; Lew RA; Smith IA; Lambert DW; Hooper NM; Turner AJ Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells J BIOL CHEM 280 39353-39362, 2005
DOI:10.1074/jbc.M508914200

Watt NT; Hooper NM Reactive oxygen species (ROS)-mediated beta-cleavage of the prion protein in the mechanism of the cellular response to oxidative stress BIOCHEM SOC T 33 1123-1125, 2005
View abstract

Lambert DW; Yarski M; Warner FJ; Thornhill P; Parkin ET; Smith AI; Hooper NM; Turner AJ Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem 280 30113-30119, 2005
DOI:10.1074/jbc.M505111200
View abstract

Guy JL; Lambert DW; Warner FJ; Hooper NM; Turner AJ Membrane-associated zinc peptidase families: comparing ACE and ACE2. Biochim Biophys Acta 1751 2-8, 2005
DOI:10.1016/j.bbapap.2004.10.010
View abstract

Urquhart P; Pang S; Hooper NM N-glycans as apical targeting signals in polarized epithelial cells BIOCHEM SOC SYMP 72 39-45, 2005
View abstract

Watt NT; Taylor DR; Gillott A; Thomas DA; Perera WSS; Hooper NM Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress J BIOL CHEM 280 35914-35921, 2005
DOI:10.1074/jbc.M507327200

Wallace EJ; Hooper NM; Olmsted PD The kinetics of phase separation in asymmetric membranes BIOPHYS J 88 4072-4083, 2005
DOI:10.1529/biophysj.104.054288

Leisle L; Parkin ET; Turner AJ; Hooper NM Angiotensin-converting enzyme as a GPIase: a critical reevaluation NAT MED 11 1139-1140, 2005
DOI:10.1038/nm1105-1139

Guy JL; Jackson RM; Jensen HA; Hooper NM; Turner AJ Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis FEBS J 272 3512-3520, 2005
DOI:10.1111/j.1742-4658.2005.04756.x

Rice GI; Thomas DA; Grant PJ; Turner AJ; Hooper NM Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J 383 45-51, 2004
DOI:10.1042/BJ20040634
View abstract

Pang S; Urquhart P; Hooper NM N-glycans, not the GPI anchor, mediate the apical targeting of a naturally glycosylated, GPI-anchored protein in polarised epithelial cells. J Cell Sci 117 5079-5086, 2004
DOI:10.1242/jcs.01386
View abstract

Siemes C; Quast T; Klein E; Bieber T; Hooper NM; Herzog V Normalized proliferation of normal and psoriatic keratinocytes by suppression of sAPP alpha-release J INVEST DERMATOL 123 556-563, 2004
DOI:10.1111/j.0022-202X.2004.23320.x

Warner FJ; Smith AI; Hooper NM; Turner AJ Angiotensin-converting enzyme-2: a molecular and cellular perspective CELL MOL LIFE SCI 61 2704-2713, 2004
DOI:10.1007/s00018-004-4240-7

Allinson TM; Parkin ET; Condon TP; Schwager SL; Sturrock ED; Turner AJ; Hooper NM The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein. Eur J Biochem 271 2539-2547, 2004
DOI:10.1111/j.1432-1033.2004.04184.x
View abstract

Hooper NM; Lendeckel U Aminopeptidases In Proteases in Biology and Diseases , 2004

Parkin ET; Turner AJ; Hooper NM Secretase-mediated cell surface shedding of the angiotensin-converting enzyme PROTEIN PEPTIDE LETT 11 423-432, 2004

Parkin ET; Watt NT; Turner AJ; Hooper NM Dual mechanisms for shedding of the cellular prion protein. J Biol Chem 279 11170-11178, 2004
DOI:10.1074/jbc.M312105200
View abstract

Turner AJ; Hiscox JA; Hooper NM ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci 25 291-294, 2004
DOI:10.1016/j.tips.2004.04.001
View abstract

Ip SS; Kwan PC; Williams CH; Pang S; Hooper NM; Leung PS Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis INT J BIOCHEM CELL B 35 944-954, 2003

Allinson TM; Parkin ET; Turner AJ; Hooper NM ADAMs family members as amyloid precursor protein alpha-secretases Journal of Neuroscience Research 74 342-352, 2003
DOI:10.1002/jnr.10737

Hooper NM; Turner AJ An ACE structure NAT STRUCT BIOL 10 155-157, 2003
DOI:10.1038/nsb0303-155

Watt NT; Hooper NM The prion protein and neuronal zinc homeostasis TRENDS BIOCHEM SCI 28 406-410, 2003
DOI:10.1016/S0968-0004(03)00166-X

Parkin ET; Tan F; Skidgel RA; Turner AJ; Hooper NM The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts J CELL SCI 116 3079-3087, 2003

Walmsley AR; Zeng F; Hooper NM The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant. J Biol Chem 278 37241-37248, 2003
DOI:10.1074/jbc.M302036200
View abstract

Brooks DR; Hooper NM; Isaac RE The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction J BIOL CHEM 278 42795-42801, 2003
DOI:10.1074/jbc.M306216200

Guy JL; Jackson RM; Acharya KR; Sturrock ED; Hooper NM; Turner AJ Angiotensin-Converting Enzyme-2 (ACE2): Comparative Modeling of the Active Site, Specificity Requirements, and Chloride Dependence Biochemistry 42 13185-13192, 2003
DOI:10.1021/bi035268s
View abstract

Lendeckel U; Hooper NM Proteases in Biology and Disease. Volume 1: Proteases in tissue remodelling of lung and heart, 2003

Zeng F; Watt NT; Walmsley AR; Hooper NM Tethering the N-terminus of the prion protein compromises the cellular response to oxidative stress Journal of Neurochemistry 84 480-490, 2003
DOI:10.1046/j.1471-4159.2003.01529.x

Walmsley AR; Hooper NM Glycosylation efficiency of Asn-Xaa-Thr sequons is independent of distance from the C-terminus in membrane dipeptidase Glycobiology 13 641-646, 2003
DOI:10.1093/glycob/cwg080

Walmsley AR; Hooper NM Distance of sequons to the C-terminus influences the cellular N-glycosylation of the prion protein BIOCHEM J 370 351-355, 2003
DOI:10.1042/BJ20021303

Gruszynski AE; DeMaster A; Hooper NM; Bangs JD Surface coat remodeling during differentiation of Trypanosoma brucei Journal of Biological Chemistry 278 24665-24672, 2003
DOI:10.1074/jbc.M301497200

Cordy JM; Hussain I; Dingwall C; Hooper NM; Turner AJ Exclusively targetingβ-secretase to lipid rafts by GPI-anchor addition up-regulatesβ-site processing of the amyloid precursor protein Proceedings of the National Academy of Sciences of the United States of America 100 11735-11740, 2003
DOI:10.1073/pnas.1635130100
View abstract

Hooper NM Could inhibition of the proteasome cause mad cow disease? Trends in Biotechnology 21 144-145, 2003
DOI:10.1016/S0167-7799(03)00026-X

Canet-Aviles RM; Turner AJ; Hooper NM; Vaughan PFT Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C alpha, SRC-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C NEUROBIOL AGING 23 S527-S527, 2002

Turner AJ; Tipnis SR; Guy JL; Rice G; Hooper NM ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Can J Physiol Pharmacol 80 346-353, 2002
View abstract

Park SW; Kang BY; Yoon HJ; Park EM; Choi K; Lee HHB; Hooper NM; Park HS Spontaneous release of glycosylphosphatidylinositol (GPI)-anchored renal dipeptidase from porcine renal proximal tubules Archives of Pharmacal Research 25 80-85, 2002

Ofner LD; Hooper NM Ectodomain shedding of cystinyl aminopeptidase from human placental membranes PLACENTA 23 65-70, 2002
DOI:10.1053/plac.2001.0751

Plant L; Boyle JP; Thomas NM; Hipkins NJ; Benedikz E; Hooper NM; Henderson Z; Vaughan PFT; Peers C; Cowburn RF; Pearson HA Presenilin-1 mutations alter K+ currents in the human neuroblastoma cell line, SH-SY5Y. NeuroReport 13 1553-1556, 2002
DOI:10.1097/00001756-200208270-00013

Hooper NM; Turner AJ The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer's disease CURR MED CHEM 9 1107-1119, 2002

Park SW; Choi K; Lee HB; Park SK; Turner AJ; Hooper NM; Park HS Glycosyl-phosphatidytinositol (GPI)-anchored renal dipeptidase is released by a phospholipase C in vivo KIDNEY BLOOD PRESS R 25 7-12, 2002

Ofner LD; Hooper NM The C-terminal domain, but not the interchain disulphide, is required for the activity and intracellular trafficking of aminopeptidase A. Biochem J 362 191-197, 2002
View abstract

Hooper NM Proteases: a primer ESSAYS BIOCHEM 38 1-8, 2002

Hooper NM Prion disease: Close encounters of the cellular kind CURR BIOL 12 R248-R249, 2002

Turner AJ; Hooper NM The angiotensin-converting enzyme gene family: genomics and pharmacology Trends in Pharmacological Sciences 23 177-183, 2002
DOI:10.1016/S0165-6147(00)01994-5

Parkin ET; Trew AJ; Christie G; Faller A; Mayer R; Turner AJ; Hooper NM Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha ChemBioChem 41 4972-4981, 2002
DOI:10.1021/bi015936e

Park SW; Yoon HJ; Lee HB; Hooper NM; Park HS Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules BIOCHEM J 364 211-218, 2002

Hooper NM Prion Disease: Close Encounters of the The Cellular Kind Current Biology 12 248-249, 2002
DOI:10.1016/S0960-9822(02)00783-2

Canet-Aviles RM; Anderton M; Hooper NM; Turner AJ; Vaughan PFT Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C-alpha, src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C MOL BRAIN RES 102 62-72, 2002

Walmsley AR; Zeng FN; Hooper NM Membrane topology influences N-glycosylation of the prion protein EMBO J 20 703-712, 2001

Stevens BA; White IJ; Hames BD; Hooper NM The carboxyl terminus of Dictyostelium discoideum protein 1I encodes a functional glycosyl-phosphatidylinositol signal sequence Biochimica et Biophysica Acta 1511 317-329, 2001
DOI:10.1016/S0005-2736(01)00289-9

Alfalah M; Parkin ET; Jacob R; Sturrock ED; Mentele R; Turner AJ; Hooper NM; Naim HY A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase J BIOL CHEM 276 21105-21109, 2001

Pang S; Chubb AJ; Schwager SL; Ehlers MR; Sturrock ED; Hooper NM Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding. Biochem J 358 185-192, 2001
View abstract

Tam BYY; Larouche D; Germain L; Hooper NM; Philip A Characterization of a 150 kDa accessory receptor for TFG-beta 1 on keratinocytes: Direct evidence for a GPI anchor and ligand binding of the released form Journal of Cellular Biochemistry 83 494-507, 2001
DOI:10.1002/jcb.1074

Sumudhu W; Perera S; Hooper NM Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region CURR BIOL 11 519-523, 2001

Parkin ET; Turner AJ; Hooper NM Differential effects of glycosphingolipids on the detergent-insolubility of the glycosylphosphatidylinositol-anchored membrane dipeptidase BIOCHEM J 358 209-216, 2001

Hooper NM Determination of glycosyl-phosphatidylinositol membrane protein anchorage PROTEOMICS 1 748-755, 2001
View abstract

Bangs JD; Ransom DA; Nimick M; Christie G; Hooper NM In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors Molecular and Biochemical Parasitology 114 111-117, 2001
DOI:10.1016/S0166-6851(01)00244-4

Park SW; Choi K; Kim IC; Lee HHB; Hooper NM; Park HS Endogenous glycosylphosphatidylinositol-specific phospholipase C releases renal dipeptidase from kidney proximal tubules in vitro Biochemical Journal 353 339-344, 2001
DOI:10.1042/0264-6021:3530339

Watt NT; Hooper NM The response of neurones and glial cells to elevated copper. Brain Res Bull 55 219-224, 2001
View abstract

Movahedi S; Pang S; Hooper NM Insulin stimulates the release of a subset of GPI-anchored proteins in a G-protein independent manner MOL MEMBR BIOL 17 41-45, 2000

Hooper NM; Trew AJ; Parkin ET; Turner AJ The role of proteolysis in Alzheimer's disease CELLULAR PEPTIDASES IN IMMUNE FUNCTIONS AND DISEASES 2 477 379-390, 2000

Hooper NM; Turner AJ Protein processing mechanisms: from angiotensin-converting enzyme to Alzheimer's disease BIOCHEMICAL SOCIETY TRANSACTIONS 28 441-446, 2000

Woodman ZL; Oppong SY; Cook S; Hooper NM; Schwager SLU; Brandt WF; Ehlers MRW; Sturrock ED Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage Biochemical Journal 347 711-718, 2000

Hames BD; Hooper NM Instant Notes in Biochemistry, 2000

Cottrell GS; Hooper NM; Turner AJ Cloning, expression, and characterization of human cytosolic aminopeptidase P: A single manganese(II)-dependent enzyme BIOCHEMISTRY-US 39 15121-15128, 2000

White I; Souabni A; Hooper NM Comparison of the glycosyl-phosphatidylinositol cleavage/attachment site between mammalian cells and parasitic protosoa Journal of Cell Science 113 721-727, 2000

Cottrell GS; Hyde RJ; Lim J; Parsons MR; Hooper NM; Turner AJ Identification of critical residues in the active site of porcine membrane-bound aminopeptidase P BIOCHEMISTRY-US 39 15129-15135, 2000

Tipnis SR; Hooper NM; Hyde R; Karran E; Christie G; Turner AJ A human homolog of angiotensin-converting enzyme - Cloning and functional expression as a captopril-insensitive carboxypeptidase J BIOL CHEM 275 33238-33243, 2000

Parvathy S; Turner AJ; Hooper NM Inhibition ofα-Secretase by Zinc Metalloproteinase Inhibitors. Methods Mol Med 32 203-215, 2000
DOI:10.1385/1-59259-195-7:203
View abstract

Parkin ET; Turner AJ; Hooper NM Distribution of Presenilins and Amyloid Precursor Protein (APP) in Detergent-Insoluble Membrane Domains. Methods Mol Med 32 345-360, 2000
DOI:10.1385/1-59259-195-7:345
View abstract

Woodman ZL; Oppong SY; Cook S; Hooper NM; Schwager SLU; Brandt WF; Ehlers MRW; Sturrock ED Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites BIOCHEM J 347 711-718, 2000

Grondin G; Hooper NM; LeBel D Progress in Histochemistry and Cytochemistry (Editorship) Journal of Histochemistry and Cytochemistry 47 489-497, 1999

Parkin ET; Turner AJ; Hooper NM Caveolae-like membranes and the amyloid precursor protein: a critical reassessment British Neurosci. Assoc. Abstr. 15 pp.59-, 1999

Turner AJ; Hooper NM Role for ADAM-family proteinases as membrane protein secretases BIOCHEMICAL SOCIETY TRANSACTIONS 27 255-259, 1999

Hooper NM Detergent-insoluble glycoshingolipid/cholesterol-rich membrane domain, lipid rafts and caveolae Molecular Membrane Biology 14 145-156, 1999

Parkin ET; Turner AJ; Hooper NM Amyloid precursor protein, although partially detergent- insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein Biochemical Journal 344 23-30, 1999

Parkin ET; Hussain M; Karran EH; Turner AJ; Hooper NM Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins Journal of Neurochemistry 72 1534-1543, 1999

Parvathy S; Hussain M; Karran EH; Turner AJ; Hooper NM Cleavage of Alzheimer's amyloid precursor protein by a-secretase occurs at the surface of neuronal cells ChemBioChem 38 9728-9734, 1999

Hooper NM; Parvathy S; Karran EH; Turner AJ Angiotensin-converting enzyme and the amyloid precursor protein secretases Biochemical Society Transactions 27 229-234, 1999

Perera WSS; Hooper NM Proteolytic fragmentation of the murine prion protein: role of Tyr-128 and His-177 FEBS LETT 463 273-276, 1999

Young T; Karran EH; Turner AJ; Hooper NM Expression and processing of the human beta-amyloid precursor protein in yeast British Neurosci. Assoc. Abstr. 15 pp.60-, 1999

White IJ; Lawson J; Hooper NM; Williams CH A continuous fluorometric assay for leukotriene D hydrolase Analytical Biochemistry 268 245-251, 1999
DOI:10.1006/abio.1998.3057
View abstract

Grondin G; Hooper NM; LeBel D Specific localization of membrane dipeptidase and dipeptidyl peptidase IV in secretion granules of two different pancreatic islet cells J HISTOCHEM CYTOCHEM 47 489-497, 1999

Parkin ET; Turner AJ; Hooper NM Caveolae-like membranes and the amyloid precursor protein: A critical reassessment J NEUROCHEM 72 S71-S71, 1999

Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by Meeting of the Biochemical Society, BIOCHEMICAL SOCIETY TRANSACTIONS 26 pp.247-, 1998

Houldsworth SL; Trew AJ; Hooper NM; Turner AJ Molecular characterisation of the Alzheimer's amyloid precursor protein secretases Biochemical Society Transactions 26 pp.245-, 1998

Hooper NM Membrane biology: Do glycolipid microdomains really exist? Current Biology 8 114-116, 1998

Houldsworth S; Trew AJ; Hooper NM; Turner AJ Angiotensin converting enzyme as a reporter protein for amyloid precursor protein secretase activities Neurobiology of Ageing 19 pp.39-, 1998

Hooper NM; Parvathy S; Hussain I; Turner AJ Inhibition of the amyloid precursor protein alpha-secretase at the cell-surface by hydroxamate-based zinc metalloprotease inhibitors Neurobiology of Ageing 19 pp.38-, 1998

Houldsworth S; Trew AJ; Hooper NM; Turner AJ Molecular characterisation of the Alzheimer's amyloid precursor protein secretases Meeting of the Biochemical Society, BIOCHEMICAL SOCIETY TRANSACTIONS 26 pp.245-, 1998

Parvathy S; Hussain M; Karran EH; Turner AJ; Hooper NM The Alzheimer's amyloid precursor protein a-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase ChemBioChem 37 1680-1685, 1998

Moore W; Karran EH; Hooper NM; Turner AJ Development of betaAPP695 constructs for cell free assay for the secretases involved in the proteolytic processing of the amyloid precursor protein Neurobiology of Ageing 19 pp.39-, 1998

Parvathy S; Karran EH; Turner AJ; Hooper NM The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase FEBS LETT 431 63-65, 1998

Parvathy S; Hussain M; Karran EH; Turner AJ; Hooper NM Alzheimer's amyloid precursor protein a-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase ChemBioChem 37 1680-1685, 1998

Parkin ET; Hooper NM; Turner AJ Presenilin proteins are present in calveolae-like, detergent-insoluble membranes which are devoid of the amyloid precursor protein Neurobiology of Ageing 19 pp.188-, 1998

Cottrell GS; Hyde RJ; Hooper NM; Turner AJ The cloning and functional expression of human pancreatic aminopeptidase P Meeting of the Biochemical Society, BIOCHEMICAL SOCIETY TRANSACTIONS 26 pp.248-, 1998

LeBel D; Grondin G; Cook S; Hooper NM Membrane dipeptidase in the pig exocrine pancreas: Ultrastructural localization and secretion J HISTOCHEM CYTOCHEM 46 841-846, 1998

Hooper NM Membrane biology: do glycolipid microdomains really exist? Curr Biol 8 R114-R116, 1998
View abstract

Parkin ET; Turner AJ; Hooper NM Detergent solubility and processing of the familial Alzheimer's disease-related presenilin proteins Meeting of the Biochemical Society, BIOCHEMICAL SOCIETY TRANSACTIONS 26 pp.241-, 1998

Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by hydroxamic acid-based inhibitors. Biochem Soc Trans 26 S242-, 1998

Houldsworth SL; Trew AJ; Hooper NM; Turner AJ Molecular characterisation of the Alzheimer's amyloid precursor protein secretases. Biochem Soc Trans 26 S245-, 1998

Cottrell GS; Hyde RJ; Hooper NM; Turner AJ The cloning and functional expression of human pancreatic aminopeptidase P. Biochem Soc Trans 26 S248-, 1998

Parkin ET; Hussain M; Turner AJ; Hooper NM The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains Journal of Neurochemistry 69 2179-2188, 1997

Hooper NM; Karran EH; Turner AJ Membrane protein secretases BIOCHEM J 321 265-279, 1997

Hooper NM Glycosyl-phosphatidylinositol anchored membrane enzymes CLINICA CHIMICA ACTA 266 3-12, 1997

Lim J; Hyde RJ; Hooper NM; Turner AJ Site-directed mutagenesis of conserved histidine residues within the bradykinin degrading enzyme aminopeptidase P FASEB JOURNAL, ASBMB meeitng 11 pp.164-, 1997

Turner AJ; Hyde RJ; Lim J; Hooper NM Structural studies of aminopeptidase P - A novel cellular peptidase CELLULAR PEPTIDASES IN IMMUNE FUNCTIONS AND DISEASES 421 7-16, 1997

Keynan S; Asipu A; Hooper NM; Turner AJ; Blair GE Stable and temperature sensitive transformation of baby rat kidney cells by SV40 suppresses expression of membrane dipeptidase Oncogene 15 1241-1245, 1997

Hooper NM; Cook S; Laine J; LeBel D Identification of membrane dipeptidase as a major glycosyl-phosphatidylinositol-anchored protein of the pancreatic zymogen granule membrane, and evidence for its release by phospholipase A BIOCHEM J 324 151-157, 1997

Parvathy S; Oppong SY; Karran EH; Buckle DR; Turner AJ; Hooper NM Angiotensin converting enzyme secretase is inhibited by metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer Biochemical Journal 327 37-43, 1997

Turner AJ; Hooper NM Three glycolipid-anchored peptidases: membrane dipeptidase, aminopeptidase P and carboxypeptidase M Cell-surface peptidases 219-238, 1997

Hames BD; Hooper NM; Houghton JD Instant Notes in Biochemistry, 1997

White I; Hooper NM Investigation of the requirements for GPI anchoring of a mammalian protein FEDERATION AMER SOC EXP BIOL, FASEB Journal 11 pp.615-, 1997

Hesp JR; Hooper NM Proteolytic fragmentation reveals the oligomeric and domain structure of porcine aminopeptidase A BIOCHEMISTRY-US 36 3000-3007, 1997

Hooper NM; Turner AJ Inhibition of the formation of the Alzheimer’s beta-amyloid peptide In Emerging Therapeutic Targets , 1997

Turner AJ; Parkin ET; Hooper NM Glycosylation and glycophosphatidylinositol membrane anchors Regulatory Protein Modification: Techniques and Protocols 30 395-427, 1997

Keynan S; Hooper NM; Turner AJ Identification by site-directed mutagenesis of three essential histidine residues in membrane dipeptidase: a novel mammalian zinc peptidase Biochemical Journal 326 47-51, 1997

Hooper NM Membrane anchorage of cell-surface peptidases Cell-Surface Peptidases 33-46, 1997

Hooper NM Characterization of neuropeptidases using inhibitors. Methods Mol Biol 73 369-381, 1997

Movahedi S; Hooper NM Insulin stimulates the release of the glycosyl phosphatidylinositol-anchored membrane dipeptidase from 3T3-L1 Biochemical Journal 326 531-537, 1997

Lim J; Hyde RJ; Hooper NM; Turner AJ Site-directed mutagenesis of conserved histidine residues within the bradykinin degrading enzyme aminopeptidase P. FASEB J 11 A886-A886, 1997

White IJ; Hooper NM Investigation of the requirements for GPI anchoring of a mammalian protein FASEB J 11 A962-A962, 1997

Keynan S; Hooper NM; Turner AJ Molecular and functional aspects of membrane dipeptidase Zinc Metalloproteases in Health and Disease 285-309, 1996

Keynan S; Habgood NT; Hooper NM; Turner AJ Site-directed mutagenesis of conserved cysteine residues in porcine membrane dipeptidase: Cys 361 alone is involved in disulfide-linked dimerisation ChemBioChem 35 12511-12517, 1996

Lloyd GS; Hryszko J; Hooper NM; Turner AJ Inhibition and metal ion activation of pig kidney aminopeptidase P - Dependence on nature of substrate BIOCHEM PHARMACOL 52 229-236, 1996

Hyde RJ; Hooper NM; Turner AJ Molecular cloning and expression in COS-1 cells of porcine kidney aminopeptidase P Biochemical Journal 319 197-201, 1996

Parkin ET; Turner AJ; Hooper NM Isolation and characterization of two distinct low-density, Triton-insoluble, complexes from porcine lung membranes BIOCHEM J 319 887-896, 1996

Movahedi S; Hooper NM Insulin and glimepiride stimulate the release of the GPI-anchored membrane dipeptidase from 3T3 adipocytes Molecular Biology of the Cell 7 pp.1571-, 1996

Hyde RJ; Hooper NM; Turner AJ Cloning and functional expression of pig kidney aminopeptidase P Biochemical Society Transactions 24 pp.470-, 1996

Movahedi S; Hooper NM Insulin and glimepiride stimulate the release of the GPI-anchored membrane dipeptidase from 3T3 adipocytes. MOL BIOL CELL 7 1571-1571, 1996

Parkin ET; Turner AJ; Hooper NM Isolation and characterisation of detergent-insoluble membrane microdomains from porcine lung. MOL BIOL CELL 7 1594-1594, 1996

Lloyd GS; Hryszko J; Hooper NM; Turner AJ Inhibition and metal ion activation of pig kidney aminopeptidase P. Dependence on nature of substrate Biochemical Pharmacology 52 228-236, 1996
View abstract

Keynan S; Hooper NM; Felici A; Amicosante G; Turner AJ The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA. Antimicrob Agents Chemother 39 1629-1631, 1995
View abstract

Brewis IA; Ferguson MA; Mehlert A; Turner AJ; Hooper NM Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase. Comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures. J Biol Chem 270 22946-22956, 1995
View abstract

Heywood SP; Hooper NM Purification of GPI anchors by immunoaffinity chromatography. Biochem Soc Trans 23 101S-, 1995

Heywood SP; Hooper NM Development and application of a fluorometric assay for mammalian membrane dipeptidase. Anal Biochem 226 10-14, 1995
DOI:10.1006/abio.1995.1184
View abstract

Connolly C; Oppong SY; Turner AJ; Hooper NM Purification and characterization of the angiotensin converting enzyme secretase. Biochem Soc Trans 23 551S-, 1995

GALASKO GTF; BAO YD; BROOMFIELD SJ; HOOPER NM; TURNER AJ; LARNER J CIRCULATING FACTORS AND INSULIN-RESISTANCE .1. A NOVEL MYOINOSITOL 1,2-CYCLIC PHOSPHATE PHOSPHOGLYCAN INSULIN ANTAGONIST FROM HUMAN PLASMA IS ELEVATED IN NONINSULIN-DEPENDENT DIABETES-MELLITUS J CLIN ENDOCR METAB 80 2419-2429, 1995

HEYWOOD SP; HOOPER NM INHIBITION OF FRUCTOSE-1,6-BISPHOSPHATASE BY GLYCOSYL-PHOSPHATIDNOSITOL FASEB J 9 A1367-A1367, 1995

KEYNAN S; HABGOOD NT; HOOPER NM; TURNER AJ CONSTRUCTION AND EXPRESSION OF A MONOMERIC AND SECRETED FORM OF MEMBRANE DIPEPTIDASE FASEB J 9 A1437-A1437, 1995

HOOPER NM; TURNER AJ SPECIFICITY OF THE ALZHEIMER AMYLOID PRECURSOR PROTEIN ALPHA-SECRETASE TRENDS BIOCHEM SCI 20 15-16, 1995

HOOPER NM FAMILIES OF ZINC METALLOPROTEASES FEBS LETT 354 1-6, 1994

Brewis IA; Turner AJ; Hooper NM Activation of the glycosyl-phosphatidylinositol-anchored membrane dipeptidase upon release from pig kidney membranes by phospholipase C. Biochem J 303 ( Pt 2) 633-638, 1994
View abstract

Keynan S; Hooper NM; Turner AJ Directed mutagenesis of pig renal membrane dipeptidase. His219 is critical but the DHXXH motif is not essential for zinc binding or catalytic activity. FEBS Lett 349 50-54, 1994
View abstract

Hooper NM; Hesp RJ; Tieku S Metabolism of aspartame by human and pig intestinal microvillar peptidases. Biochem J 298 Pt 3 635-639, 1994
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HOOPER NM; HESP RJ; TIEKU S; BOESTEN WHJ; TONIOLO C; KAMPHUIS J STABILITY OF N-DERIVATIZED AND ALPHA-METHYL ANALOGS OF ASPARTAME TO HYDROLYSIS BY MAMMALIAN CELL-SURFACE PEPTIDASES J AGR FOOD CHEM 42 1397-1401, 1994

CHANG WJ; YING YS; ROTHBERG KG; HOOPER NM; TURNER AJ; GAMBLIEL HA; DEGUNZBURG J; MUMBY SM; GILMAN AG; ANDERSON RGW PURIFICATION AND CHARACTERIZATION OF SMOOTH-MUSCLE CELL CAVEOLAE J CELL BIOL 126 127-138, 1994

Broomfield SJ; Hooper NM Characterization of an antibody to the cross-reacting determinant of the glycosyl-phosphatidylinositol anchor of human membrane dipeptidase. Biochim Biophys Acta 1145 212-218, 1993
View abstract

Brewis IA; Howell S; Hooper NM; Kenny AJ; Turner AJ Membrane peptidase expression by confluent cultures of Caco-2 cells. Biochem Soc Trans 21 ( Pt 3) 252S-, 1993

Howell S; Brewis IA; Hooper NM; Kenny AJ; Turner AJ Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells. FEBS Lett 317 109-112, 1993
View abstract

Lloyd GS; Habgood NT; Hooper NM; Turner AJ Aminopeptidase P: immunoaffinity purification and molecular characterisation. Biochem Soc Trans 21 ( Pt 3) 236S-, 1993

Patel D; Hooper NM; Scott CS Subcellular fractionation studies indicate an intracellular localization for human monocyte specific esterase (MSE). Br J Haematol 84 608-614, 1993
View abstract

Tieku S; Hooper NM Inhibitor profile of porcine aminopeptidase W. Biochem Soc Trans 21 ( Pt 3) 250S-, 1993

Oppong SY; Turner AJ; Hooper NM Characterization of the soluble and membrane-bound forms of porcine angiotensin converting enzyme. Biochem Soc Trans 21 ( Pt 3) 251S-, 1993

Oppong SY; Hooper NM Characterization of a secretase activity which releases angiotensin-converting enzyme from the membrane. Biochem J 292 ( Pt 2) 597-603, 1993
View abstract

Brewis IA; Hooper NM; Turner AJ Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase. Biochem Soc Trans 21 44S-, 1993

Broomfield SJ; Hooper NM Investigation of glycolipid anchor addition using a synthetic peptide as substrate. Biochem Soc Trans 21 45S-, 1993

Brewis IA; Ferguson MA; Turner AJ; Hooper NM Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases. Biochem Soc Trans 21 46S-, 1993

BROOMFIELD SJ; HOOPER NM DEVELOPMENT OF AN ASSAY FOR GPI ANCHOR ADDITION FASEB J 7 A1044-A1044, 1993

BREWIS IA; FERGUSON MAJ; TURNER AJ; HOOPER NM COMPARISON OF THE GPI ANCHOR STRUCTURES ON HUMAN AND PORCINE MEMBRANE DIPEPTIDASE FASEB J 7 A1044-A1044, 1993

Hooper NM Determination of mammalian membrane protein anchorage: Glycosyl-phosphatidylinositol (G-PI) or transmembrane polypeptide anchor Biochemical Education 21 212-216, 1993

Lloyd GS; Habgood NT; Hooper NM; Turner AJ Aminopeptidase P: Immunoaffinity purification and molecular characterisation Biochemical Society Transactions 21 -, 1993

Tieku S; Hooper NM Inhibitor profile of porcine aminopeptidase W Biochemical Society Transactions 21 -, 1993

Oppong SY; Turner AJ; Hooper NM Characterization of the soluble and membrane-bound forms of porcine angiotensin converting enzyme Biochemical Society Transactions 21 -, 1993

Brewis IA; Howell S; Hooper NM; Kenny AJ; Turner AJ Membrane peptidase expression by confluent cultures of Caco-2 cells Biochemical Society Transactions 21 -, 1993

Hooper NM; Hryszko J; Oppong SY; Turner AJ Inhibition by converting enzyme inhibitors of pig kidney aminopeptidase P. Hypertension 19 281-285, 1992
View abstract

Broomfield SJ; Hooper NM Purification and characterisation of antibodies to the glycosyl-phosphatidylinositol anchor of human membrane dipeptidase. Biochem Soc Trans 20 118S-, 1992

Oppong SY; Hooper NM Characterization of the post-translational release from membranes of angiotensin converting enzyme. Biochem Soc Trans 20 253S-, 1992

Williams TA; Hooper NM; Barnes K; Kenny AJ; Turner AJ Immunological studies on the endothelial and testicular forms of angiotensin converting enzyme. Biochem Soc Trans 20 281S-, 1992

Williams TA; Barnes K; Kenny AJ; Turner AJ; Hooper NM A comparison of the zinc contents and substrate specificities of the endothelial and testicular forms of porcine angiotensin converting enzyme and the preparation of isoenzyme-specific antisera. Biochem J 288 ( Pt 3) 875-881, 1992
View abstract

Tieku S; Hooper NM Inhibition of aminopeptidases N, A and W. A re-evaluation of the actions of bestatin and inhibitors of angiotensin converting enzyme. Biochem Pharmacol 44 1725-1730, 1992
View abstract

Hooper NM More than just a membrane anchor. Curr Biol 2 617-619, 1992

VOGEL M; KOWALEWSKI H; ZIMMERMANN H; HOOPER NM; TURNER AJ SOLUBLE LOW-KM 5'-NUCLEOTIDASE FROM ELECTRIC-RAY (TORPEDO-MARMORATA) ELECTRIC ORGAN AND BOVINE CEREBRAL-CORTEX IS DERIVED FROM THE GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED ECTOENZYME BY PHOSPHOLIPASE-C CLEAVAGE BIOCHEM J 284 621-624, 1992

Broomfield SJ; Hooper NM Parification and characterisation of antibodies to the glycosyl-phosphatidylinositol anchor of human membrane dipeptidase Biochemical Society Transactions 20 -, 1992

Williams TA; Hooper NM; Turner AJ Characterization of neuronal and endothelial forms of angiotensin converting enzyme in pig brain. J Neurochem 57 193-199, 1991
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Hooper NM Angiotensin converting enzyme: implications from molecular biology for its physiological functions. Int J Biochem 23 641-647, 1991
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Hooper NM; Broomfield SJ; Turner AJ Characterization of antibodies to the glycosyl-phosphatidylinositol membrane anchors of mammalian proteins. Biochem J 273(Pt 2) 301-306, 1991
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Hooper NM; Bashir A Glycosyl-phosphatidylinositol-anchored membrane proteins can be distinguished from transmembrane polypeptide-anchored proteins by differential solubilization and temperature-induced phase separation in Triton X-114. Biochem J 280 ( Pt 3) 745-751, 1991
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Turner AJ; dos Santos Medeiros M; Hooper NM The molecular biology of GPI-anchored border hydrolases. Cell Biol Int Rep 15 1083-1099, 1991

HOOPER NM PHASE-SEPARATION IN TRITON-X-114 CAN DISTINGUISH BETWEEN GLYCOLIPID AND POLYPEPTIDE ANCHORED MEMBRANE-PROTEINS FASEB J 5 A1546-A1546, 1991

TURNER AJ; HOOPER NM INHIBITION OF AMINOPEPTIDASE-P BY ANGIOTENSIN CONVERTING ENZYME-INHIBITORS FASEB J 5 A828-A828, 1991

Williams TA; Hooper NM; Kenny AJ; Turner AJ Molecular forms of angiotensin-converting enzyme in brain microvessels. Biochem Soc Trans 18 887-, 1990

Hooper NM; Keen JN; Turner AJ Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme. Biochem J 265 429-433, 1990
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Hooper NM; Hryszko J; Turner AJ Purification and characterization of pig kidney aminopeptidase P. A glycosyl-phosphatidylinositol-anchored ectoenzyme. Biochem J 267 509-515, 1990
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RACHED E; HOOPER NM; JAMES P; SEMENZA G; TURNER AJ; MANTEI N CDNA CLONING AND EXPRESSION IN XENOPUS-LAEVIS OOCYTES OF PIG RENAL DIPEPTIDASE, A GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED ECTOENZYME BIOCHEM J 271 755-760, 1990

HOOPER NM ANGIOTENSIN CONVERTING ENZYME - HOW RELIABLE IS THE FLUOROMETRIC ASSAY WITH BENZOYL-GLY-HIS-LEU AS SUBSTRATE BIOCHEM J 270 840-841, 1990

Hooper NM; Turner AJ Ectoenzymes of the kidney microvillar membrane. Isolation and characterization of the amphipathic form of renal dipeptidase and hydrolysis of its glycosyl-phosphatidylinositol anchor by an activity in plasma. Biochem J 261 811-818, 1989
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Turner AJ; Hooper NM Phosphatidylinositol-glycan-tailed membrane proteins: the biochemistry of glycolipid anchors. Biochem Soc Trans 17 864-866, 1989

Littlewood GM; Hooper NM; Turner AJ Ectoenzymes of the kidney microvillar membrane. Affinity purification, characterization and localization of the phospholipase C-solubilized form of renal dipeptidase. Biochem J 257 361-367, 1989
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HOOPER NM; TURNER AJ HYDROLYSIS OF THE GLYCOSYL-PHOSPHATIDYLINOSITOL ANCHORS OF RENAL MICROVILLAR PEPTIDASES BY A PLASMA PHOSPHOLIPASE-D BIOCHEM SOC T 17 885-886, 1989

HOOPER NM; TURNER AJ CHARACTERIZATION AND ISOLATION OF THE MEMBRANE ANCHOR OF ANGIOTENSIN-CONVERTING ENZYME BIOCHEM SOC T 17 660-661, 1989

Hooper NM; Turner AJ Ectoenzymes of the kidney microvillar membrane. Differential solubilization by detergents can predict a glycosyl-phosphatidylinositol membrane anchor. Biochem J 250 865-869, 1988
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Barnes K; Matsas R; Hooper NM; Turner AJ; Kenny AJ Endopeptidase-24.11 is striosomally ordered in pig brain and, in contrast to aminopeptidase N and peptidyl dipeptidase A ('angiotensin converting enzyme'), is a marker for a set of striatal efferent fibres. Neuroscience 27 799-817, 1988
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Hooper NM; Turner AJ Ectoenzymes of the kidney microvillar membrane. Aminopeptidase P is anchored by a glycosyl-phosphatidylinositol moiety. FEBS Lett 229 340-344, 1988
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HOOPER NM; TURNER AJ DETERGENT SOLUBILIZATION OF PHOSPHATIDYLINOSITOL-ANCHORED ECTO-ENZYMES BIOCHEM SOC T 16 583-584, 1988

Hooper NM; Low MG; Turner AJ Renal dipeptidase is one of the membrane proteins released by phosphatidylinositol-specific phospholipase C. Biochem J 244 465-469, 1987
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Hooper NM; Keen J; Pappin DJ; Turner AJ Pig kidney angiotensin converting enzyme. Purification and characterization of amphipathic and hydrophilic forms of the enzyme establishes C-terminal anchorage to the plasma membrane. Biochem J 247 85-93, 1987
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TURNER AJ; HRYSZKO J; HOOPER NM; DOWDALL MJ PURIFICATION AND CHARACTERIZATION OF A PEPTIDYL DIPEPTIDASE RESEMBLING ANGIOTENSIN CONVERTING ENZYME FROM THE ELECTRIC ORGAN OF TORPEDO-MARMORATA J NEUROCHEM 48 910-916, 1987

HOOPER NM; TURNER AJ ISOLATION OF 2 DIFFERENTIALLY GLYCOSYLATED FORMS OF PEPTIDYL-DIPEPTIDASE-A (ANGIOTENSIN CONVERTING ENZYME) FROM PIG BRAIN - A REEVALUATION OF THEIR ROLE IN NEUROPEPTIDE METABOLISM BIOCHEM J 241 625-633, 1987

HOOPER NM; TURNER AJ CHARACTERIZATION OF ANGIOTENSIN-CONVERTING ENZYME FROM PIG BRAIN BIOCHEM SOC T 14 1249-1250, 1986

HOOPER NM; TURNER AJ CHARACTERIZATION OF ANGIOTENSIN CONVERTING ENZYME FROM PIG BRAIN BIOL CHEM H-S 367 1114-1115, 1986

HOOPER NM; TURNER AJ THE HYDROLYSIS OF NEUROKININ-A AND NEUROKININ-B BY CELL-SURFACE PEPTIDASES BIOCHEM SOC T 14 348-349, 1986

HOOPER NM; TURNER AJ NEUROKININ-B IS HYDROLYZED BY SYNAPTIC-MEMBRANES AND BY ENDOPEPTIDASE-24.11 (ENKEPHALINASE) BUT NOT BY ANGIOTENSIN CONVERTING ENZYME FEBS LETT 190 133-136, 1985

HOOPER NM; KENNY AJ; TURNER AJ THE METABOLISM OF NEUROPEPTIDES - NEUROKININ-A (SUBSTANCE-K) IS A SUBSTRATE FOR ENDOPEPTIDASE-24.11 BUT NOT FOR PEPTIDYL DIPEPTIDASE-A (ANGIOTENSIN-CONVERTING ENZYME) BIOCHEM J 231 357-361, 1985

Fishwick CWG; Chadwick J; Kellet K; Casas_Arce E; Hooper N; Johnson AP; Mok Y Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design Journal of Medicinal Chemistry 0 null-null,
DOI:10.1021/jm301127x