Faculty of Biological Sciences

Dr Glyn Hemsworth

UAF
School of Molecular and Cellular Biology

Background: Postdoctoral work at the York Structural Biology Laboratory, Department of Chemistry, University of York. Appointed University Academic Fellow in Structural Molecular Biology and BBSRC David Phillips Fellow in 2016.

Contact:  Astbury 10.107, +44(0) 113 3434349, email address for  

You can read more about Dr Hemsworth's interests here:
http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=GRH

Faculty Research and Innovation

Roth C, Chan S, Offen WA, Hemsworth GR, Willems LI, King DT, Varghese V, Britton R, Vocadlo DJ, Davies GJ Structural and functional insight into human O-GlcNAcase. Nature Chemical Biology 13 610-612, 2017
DOI:10.1038/nchembio.2358
View abstract

Hemsworth GR, Thompson AJ, Stepper J, SobalaŁF, Coyle T, Larsbrink J, Spadiut O, Goddard-Borger ED, Stubbs KA, Brumer H, Davies GJ Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut. Open Biol 6 -, 2016
DOI:10.1098/rsob.160142
View abstract

Chaplin AK, Wilson MT, Hough MA, Svistunenko DA, Hemsworth GR, Walton PH, Vijgenboom E, Worrall JAR Heterogeneity in the histidine-brace copper coordination sphere in auxiliary activity family 10 (AA10) lytic polysaccharide monooxygenases Journal of Biological Chemistry 291 12838-12850, 2016
DOI:10.1074/jbc.M116.722447
View abstract

Frandsen KEH, Simmons TJ, Dupree P, Poulsen JCN, Hemsworth GR, Ciano L, Johnston EM, Tovborg M, Johansen KS, Von Freiesleben P, Marmuse L, Fort S, Cottaz S, Driguez H, Henrissat B, Lenfant N, Tuna F, Baldansuren A, Davies GJ, Lo Leggio L, Walton PH The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases Nature Chemical Biology 12 298-303, 2016
DOI:10.1038/nchembio.2029
View abstract

Hemsworth GR, Déjean G, Davies GJ, Brumer H Learning from microbial strategies for polysaccharide degradation Biochemical Society Transactions 44 94-108, 2016
DOI:10.1042/BST20150180

Gregory RC, Hemsworth GR, Turkenburg JP, Hart SJ, Walton PH, Davies GJ Activity, stability and 3-D structure of the Cu(II) form of a chitin-active lytic polysaccharide monooxygenase from: Bacillus amyloliquefaciens Dalton Transactions 45 16904-16912, 2016
DOI:10.1039/c6dt02793h

Lo Leggio L, Simmons TJ, Poulsen J-CN, Frandsen KEH, Hemsworth GR, Stringer MA, Von Freiesleben P, Tovborg M, Johansen KS, De Maria L, Harris PV, Soong C-L, Dupree P, Tryfona T, Lenfant N, Henrissat B, Davies GJ, Walton PH Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase Nature Communications 6 -, 2015
DOI:10.1038/ncomms6961
View abstract

Hemsworth GR, Johnston EM, Davies GJ, Walton PH Lytic Polysaccharide Monooxygenases in Biomass Conversion Trends in Biotechnology 33 747-761, 2015
DOI:10.1016/j.tibtech.2015.09.006

Kjaergaard CH, Qayyum MF, Wong SD, Xu F, Hemsworth GR, Walton DJ, Young NA, Davies GJ, Walton PH, Johansen KS, Hodgson KO, Hedman B, Solomon EI Spectroscopic and computational insight into the activation of O₂ by the mononuclear Cu center in polysaccharide monooxygenases Proceedings of the National Academy of Sciences 111 8797-8802, 2014
DOI:10.1073/pnas.1408115111
View abstract

Larsbrink J, Rogers TE, Hemsworth GR, McKee LS, Tauzin AS, Spadiut O, Klinter S, Pudlo NA, Urs K, Koropatkin NM, Creagh AL, Haynes CA, Kelly AG, Cederholm SN, Davies GJ, Martens EC, Brumer H A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes Nature 506 498-502, 2014
DOI:10.1038/nature12907
View abstract

Hemsworth GR, Henrissat B, Davies GJ, Walton PH Discovery and characterization of a new family of lytic polysaccharide monooxygenases Nature Chemical Biology 10 122-126, 2014
DOI:10.1038/nchembio.1417
View abstract

Hemsworth GR, González-Pacanowska D, Wilson KS On the catalytic mechanism of dimeric dUTPases Biochemical Journal 456 81-88, 2013
DOI:10.1042/BJ20130796

Hemsworth GR, Davies GJ, Walton PH Recent insights into copper-containing lytic polysaccharide mono-oxygenases Current Opinion in Structural Biology 23 660-668, 2013
DOI:10.1016/j.sbi.2013.05.006

Anstey-Gilbert CS, Hemsworth GR, Flemming CS, Hodskinson MRG, Zhang J, Sedelnikova SE, Stillman TJ, Sayers JR, Artymiuk PJ The structure of Escherichia coli ExoIX—implications for DNA binding and catalysis in flap endonucleases Nucleic Acids Research 41 8357-8367, 2013
DOI:10.1093/nar/gkt591
View abstract

Hemsworth GR, Taylor EJ, Kim RQ, Gregory RC, Lewis SJ, Turkenburg JP, Parkin A, Davies GJ, Walton PH The copper active site of CBM33 polysaccharide oxygenases Journal of the American Chemical Society 135 6069-6077, 2013
DOI:10.1021/ja402106e
View abstract

Hemsworth GR, Price HP, Smith DF, Wilson KS Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei Protein Science 22 196-203, 2013
DOI:10.1002/pro.2198
View abstract

Larsbrink J, Izumi A, Hemsworth GR, Davies GJ, Brumer H Structural Enzymology of Cellvibrio japonicus Agd31B Protein Revealsα-Transglucosylase Activity in Glycoside Hydrolase Family 31 Journal of Biological Chemistry 287 43288-43299, 2012
DOI:10.1074/jbc.M112.416511
View abstract

Carpenter B, Hemsworth GR, Wu Z, Maamra M, Strasburger CJ, Ross RJ, Artymiuk PJ Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody Structure 20 487-497, 2012
DOI:10.1016/j.str.2012.01.019

Hemsworth GR, Moroz OV, Fogg MJ, Scott B, Bosch-Navarrete C, González-Pacanowska D, Wilson KS The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine Journal of Biological Chemistry 286 16470-16481, 2011
DOI:10.1074/jbc.M111.224873