Faculty of Biological Sciences

Dr Matthew Hardy

PhD, Leicester; MSc, Manchester; BSc (Hons), London
Teaching Fellow in Cardiovascular Sciences
School of Biomedical Sciences

Contact:  Garstang 7.53, +44(0) 113 34 39676, email address for  

Modules managed

BMSC1213 - Basic Laboratory and Scientific Skills 2

Modules taught

BIOL5294M - MSc Bioscience Research Project Proposal
BIOL5392M - Bioscience MSc Research Project
BMSC1103 - Basic Laboratory and Scientific Skills
BMSC1110 - Foundations of Biomedical Sciences
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2117/3302 - Cardio-respiratory Phys & Med Phar
BMSC2120 - Scientific Skills
BMSC2227 - Experimental Skills in Neuroscience
BMSC2232 - Topics in Physiology
BMSC3138 - Cellular Cardiology
BMSC3233/34/35/36 - Advanced topics for BMS students II
BMSC3301 - Research Project in Biomedical Sciences
FOBS1201/BIOL1214 - Molecular Physiology/Multicellular Systems

Dr Kathleen Wright  (Senior Scientific Officer in Cardiovascular Science)

Supporting laboratory research development, training and management in the department of Cardiovascular Sciences 

Hassinen M, Haverinen J, Hardy ME, Shiels HA, Vornanen M Inward rectifier potassium current (I K1) and Kir2 composition of the zebrafish (Danio rerio) heart. Pflugers Archiv - European Journal of Physiology 467 2437-2446, 2015
DOI:10.1007/s00424-015-1710-8
View abstract

Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS The Golgi apparatus is a functionally distinct Ca<sup>2+</sup>store regulated by the PKA and Epac branches of the b1-adrenergic signaling pathway Science Signaling 8 -, 2015
DOI:10.1126/scisignal.aaa7677
View abstract

Benoist D, Stones R, Benson AP, Fowler ED, Drinkhill MJ, Hardy MEL, Saint DA, Cazorla O, Bernus O, White E Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline Progress in Biophysics and Molecular Biology 115 162-172, 2014
DOI:10.1016/j.pbiomolbio.2014.06.008
View abstract

Rogers LJ, Lake AJ, White K, Hardy M, White E Effects of superoxide donor menadione in adult Rat myocardium are associated with increased diastolic intracellular calcium Bioscience Horizons 7 -, 2014
DOI:10.1093/biohorizons/hzt012
View abstract

Karnik R, Ludlow MJ, Abuarab N, Smith AJ, Hardy MEL, Elliott DJS, Sivaprasadarao A Endocytosis of hERG is clathrin-independent and involves arf6 PLoS ONE 8 -, 2013
DOI:10.1371/journal.pone.0085630
View abstract

Walton RD, Benson AP, Hardy MEL, White E, Bernus O Electrophysiological and structural determinants of electrotonic modulation of repolarization by the activation sequence Frontiers in Physiology 4 OCT -, 2013
DOI:10.3389/fphys.2013.00281
View abstract

Hardy ME, Bernus O, White E Mechanisms of Steeper APD Restitution in Rat Failing Right Ventricular Myocytes, 2013

Hardy MEL, Bernus O, White E Altered Action Potential Heterogeneity in Hypertrophic Right Ventricles of Rats, 2012

Hardy MEL, Pollard CE, Small BG, Bridgland-Taylor M, Woods AJ, Valentin J-P, Abi-Gerges N Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes. J Pharmacol Toxicol Methods 60 94-106, 2009
DOI:10.1016/j.vascn.2009.03.005
View abstract

Rainbow RD, Hardy MEL, Standen NB, Davies NW Glucose reduces endothelin inhibition of voltage-gated potassium channels in rat arterial smooth muscle cells. J Physiol 575 833-844, 2006
DOI:10.1113/jphysiol.2006.114009
View abstract

Hardy MEL, Lawrence CL, Standen NB, Rodrigo GC Can optical recordings of membrane potential be used to screen for drug-induced action potential prolongation in single cardiac myocytes? J Pharmacol Toxicol Methods 54 173-182, 2006
DOI:10.1016/j.vascn.2006.02.013
View abstract

Hardy MEL, Lawrence CL, Standen NB, Rodrigo GC Drug-induced action potential prolongation in isolated cardiac myocytes recorded using a voltage-sensitive dye, 2005

Al-Owais MM, Hettiarachchi NT, Kirton HM, Hardy ME, Boyle JP, Scragg JL, Steele DS, Peers CS A Key Role for Peroxynitrite-mediated Inhibition of Cardiac ERG (Kv11.1) K+ Channels in Carbon Monoxide Induced Pro-arrhythmic Early Afterdepolarizations FASEB Journal -,
View abstract