Faculty of Biological Sciences

Prof Adrian Goldman

Chair in Membrane Biology
School of Biomedical Sciences

Contact:  Astbury 6108b, +44(0) 113 34 38537, email address for  

Faculty Research and Innovation



Studentship information

See also:

Modules taught

BIOW5901X - Foundation module
BIOW5906X - Theory, computation and bioinformatics
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2120 - Scientific Skills
BMSC3301 - Research Project in Biomedical Sciences
BMSC3399 - Extended Research Project Preparation
BMSC5382M - Extended Research Project

Centre membership: The Astbury Centre for Structural Molecular Biology

Miss Amelia Lesiuk  (Senior Specialist Technician in Protein Purification)

Prof Jens Morth  (Visiting Cheney Fellow)

Dr Nita Shah  (Visiting Research Fellow)

Ms Claudia Stohrer  (Marie Curie Fellowship)

Mr Jannik Strauss  (Marie Curie Fellowship)

Novel Approaches to Proton Pumping Pyrophosphatases  


Postgraduates

James Henderson (Primary supervisor) 50% FTE
Claudia Stohrer (Primary supervisor) 100% FTE
Jannik Strauss (Primary supervisor) 100% FTE
Craig Wilkinson (Primary supervisor) 50% FTE
Jessica Boakes (Co-supervisor) 50% FTE
Brendan Farrell (Co-supervisor) 33% FTE
Eleanor Foy (Co-supervisor) 25% FTE
Aaron Wilkinson (Co-supervisor) 50% FTE
Jack Wright (Co-supervisor) 33% FTE

Saarma M, Goldman A Receptors identified for a weight regulator Nature 550 195-197, 2017
DOI:10.1038/nature24143

Parmar M, Rawson S, Scarff CA, Goldman A, Dafforn TR, Muench SP, Postis VLG Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure. Biochimica et biophysica acta -, 2017
DOI:10.1016/j.bbamem.2017.10.005
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Saarenpää T, Kogan K, Sidorova Y, Mahato AK, Tascón I, Kaljunen H, Yu L, Kallijärvi J, Jurvansuu J, Saarma M, Goldman A Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro PLoS One 12 -, 2017
DOI:10.1371/journal.pone.0176166
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Shah NR, Wilkinson C, Harborne SPD, Turku A, Li K-M, Sun Y-J, Harris S, Goldman A Insights into the mechanism of membrane pyrophosphatases by combining experiment and computer simulation Structural Dynamics 4 -, 2017
DOI:10.1063/1.4978038
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Wright J, Thomsen M, Kolodziejczyk R, Ridley J, Sinclair J, Carrington G, Singh B, Riesbeck K, Goldman A The crystal structure of PD1, a Haemophilus surface fibril domain Acta Crystallographica Section:F Structural Biology Communications 73 101-108, 2017
DOI:10.1107/S2053230X17001406
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Li KM, Wilkinson C, Kellosalo J, Tsai JY, Kajander T, Jeuken LJC, Sun YJ, Goldman A Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism Nature Communications 7 -, 2016
DOI:10.1038/ncomms13596
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Goldman A Music calculations out of tune NATURE 536 274-274, 2016

Lee SC, Knowles TJ, Postis VLG, Jamshad M, Parslow RA, Lin YP, Goldman A, Sridhar P, Overduin M, Muench SP, Dafforn TR A method for detergent-free isolation of membrane proteins in their local lipid environment Nature Protocols 11 1149-1162, 2016
DOI:10.1038/nprot.2016.070
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Parmar MJ, Lousa CDM, Muench SP, Goldman A, Postis VLG Artificial membranes for membrane protein purification, functionality and structure studies Biochemical Society Transactions 44 877-882, 2016
DOI:10.1042/BST20160054
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Ji Y, Postis VLG, Wang Y, Bartlam M, Goldman A Transport mechanism of a glutamate transporter homologue Glt<inf>Ph</inf> Biochemical Society Transactions 44 898-904, 2016
DOI:10.1042/BST20160055
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Shah NR, Vidilaseris K, Xhaard H, Goldman A Integral membrane pyrophosphatases: a novel drug target for human pathogens? AIMS Biophysics 3 171-194, 2016
DOI:10.3934/biophy.2016.1.171
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Goldman A, Boije af Gennis G, Xhaard H, Meri S, Yli-Kauhaluoma J [Pyrophosphate in medicine]. Duodecim; laaketieteellinen aikakauskirja 132 1111-1117, 2016
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Hao Z, Thomsen M, Postis VLG, Lesiuk A, Sharples D, Wang Y, Bartlam M, Goldman A A Novel and Fast Purification Method for Nucleoside Transporters. Frontiers in molecular biosciences 3 23-, 2016
DOI:10.3389/fmolb.2016.00023
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Bhattacharjee A, Reuter S, Trojnár E, Kolodziejczyk R, Hyvärinen HSS, Uzonyi B, Szilágyi Á, Prohászka Z, Goldman A, Józsi M, Jokiranta TS The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease Journal of Biological Chemistry 290 9500-9510, 2015
DOI:10.1074/jbc.M114.630871
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Rosti K, Goldman A, Kajander T Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1 BMC Biochemistry 16 -, 2015
DOI:10.1186/s12858-015-0037-6
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Saarenpää T, Jaakola VP, Goldman A Baculovirus-mediated expression of GPCRs in insect cells Methods in Enzymology 556 185-218, 2015
DOI:10.1016/bs.mie.2014.12.033
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Ma C, Hao Z, Huysmans G, Lesiuk A, Bullough P, Wang Y, Bartlam M, Phillips SE, Young JD, Goldman A, Baldwin SA, Postis VLG A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters. PLoS One 10 e0143010-, 2015
DOI:10.1371/journal.pone.0143010
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Tsai J-Y, Kellosalo J, Sun Y-J, Goldman A Proton/sodium pumping pyrophosphatases: the last of the primary ion pumps. Curr Opin Struct Biol 27 38-47, 2014
DOI:10.1016/j.sbi.2014.03.007
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Matic A, Böni P, Goldman A Neutron sources: road maps of no use to some physicists. Nature 507 169-, 2014
DOI:10.1038/507169c

Repo H, Kuokkanen E, Oksanen E, Goldman A, Heikinheimo P Is the Bovine lysosomal phospholipase B-like protein an amidase? Proteins 82 300-311, 2013
DOI:10.1002/prot.24388
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Happonen LJ, Oksanen E, Liljeroos L, Goldman A, Kajander T, Butcher SJ The structure of the NTPase that powers DNA packaging into Sulfolobus turreted icosahedral virus 2. J Virol 87 8388-8398, 2013
DOI:10.1128/JVI.00831-13
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Bhattacharjee A, Oeemig JS, Kolodziejczyk R, Meri T, Kajander T, Lehtinen MJ, Iwaï H, Jokiranta TS, Goldman A Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi. J Biol Chem 288 18685-18695, 2013
DOI:10.1074/jbc.M113.459040
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Kajander T, Kellosalo J, Goldman A Inorganic pyrophosphatases: one substrate, three mechanisms. FEBS Lett 587 1863-1869, 2013
DOI:10.1016/j.febslet.2013.05.003
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Meri T, Amdahl H, Lehtinen MJ, Hyvärinen S, McDowell JV, Bhattacharjee A, Meri S, Marconi R, Goldman A, Jokiranta TS Correction: Microbes Bind Complement Inhibitor Factor H via a Common Site. PLoS pathogens 9 -, 2013

Kellosalo J, Kajander T, Honkanen R, Goldman A Crystallization and preliminary X-ray analysis of membrane-bound pyrophosphatases. Mol Membr Biol 30 64-74, 2013
DOI:10.3109/09687688.2012.712162
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Meri T, Amdahl H, Lehtinen MJ, Hyvärinen S, McDowell JV, Bhattacharjee A, Meri S, Marconi R, Goldman A, Jokiranta TS Microbes bind complement inhibitor factor H via a common site. PLoS Pathog 9 e1003308-, 2013
DOI:10.1371/journal.ppat.1003308
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Mikula KM, Kolodziejczyk R, Goldman A Yersinia infection tools-characterization of structure and function of adhesins. Frontiers in cellular and infection microbiology 2 169-, 2012
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Zhang H, Patana A-S, Mackenzie PI, Ikushiro S, Goldman A, Finel M Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics. Drug Metab Dispos 40 1935-1944, 2012
DOI:10.1124/dmd.112.046086
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Kellosalo J, Kajander T, Kogan K, Pokharel K, Goldman A The structure and catalytic cycle of a sodium-pumping pyrophosphatase Science 337 473-476, 2012
DOI:10.1126/science.1222505
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Mikula KM, Leo JC,Łyskowski A, Kedracka-Krok S, Pirog A, Goldman A The translocation domain in trimeric autotransporter adhesins is necessary and sufficient for trimerization and autotransportation. J Bacteriol 194 827-838, 2012
DOI:10.1128/JB.05322-11
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Kajander T, Kuja-Panula J, Rauvala H, Goldman A Crystal structure and role of glycans and dimerization in folding of neuronal leucine-rich repeat protein AMIGO-1. J Mol Biol 413 1001-1015, 2011
DOI:10.1016/j.jmb.2011.09.032
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Kellosalo J, Kajander T, Palmgren MG, Lopez-Marques RL, Goldman A Heterologous expression and purification of membrane-bound pyrophosphatases PROTEIN EXPRESSION AND PURIFICATION 79 25-34, 2011
DOI:10.1016/j.pep.2011.05.020

Linke D, Goldman A Erratum: Bacterial Adhesion (Advances in Experimental Medicine and Biology (715) DOI: 10.1007/978-94-007-0940-9), 2011
DOI:10.1007/978-94-007-0940-9_23

Łyskowski A, Leo JC, Goldman A Structure and biology of trimeric autotransporter adhesins Advances in Experimental Medicine and Biology 715 143-158, 2011
DOI:10.1007/978-94-007-0940-9_9
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Leo JC, Lyskowski A, Hattula K, Hartmann MD, Schwarz H, Butcher SJ, Linke D, Lupas AN, Goldman A The structure of E. coli IgG-binding protein D suggests a general model for bending and binding in trimeric autotransporter adhesins. Structure 19 1021-1030, 2011
DOI:10.1016/j.str.2011.03.021
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Kaila VRI, Oksanen E, Goldman A, Bloch DA, Verkhovsky MI, Sundholm D, Wikström M A combined quantum chemical and crystallographic study on the oxidized binuclear center of cytochrome c oxidase. Biochim Biophys Acta 1807 769-778, 2011
DOI:10.1016/j.bbabio.2010.12.016
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Lyskowski A, Oeemig JS, Jaakkonen A, Rommi K, DiMaio F, Zhou D, Kajander T, Baker D, Wlodawer A, Goldman A, Iwaï H Cloning, expression, purification, crystallization and preliminary X-ray diffraction data of the Pyrococcus horikoshii RadA intein. Acta Crystallogr Sect F Struct Biol Cryst Commun 67 623-626, 2011
DOI:10.1107/S1744309111008372
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Kajander T, Lehtinen MJ, Hyvärinen S, Bhattacharjee A, Leung E, Isenman DE, Meri S, Goldman A, Jokiranta TS Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proc Natl Acad Sci U S A 108 2897-2902, 2011
DOI:10.1073/pnas.1017087108
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Jurvansuu JM, Goldman A Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein. PLoS One 6 e25317-, 2011
DOI:10.1371/journal.pone.0025317
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Oksanen E, Dauvergne F, Goldman A, Budayova-Spano M Design of a novel Peltier-based cooling device and its use in neutron diffraction data collection of perdeuterated yeast pyrophosphatase Journal of Applied Crystallography 43 1113-1120, 2010
DOI:10.1107/S0021889810027111
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Leo JC, Elovaara H, Bihan D, Pugh N, Kilpinen SK, Raynal N, Skurnik M, Farndale RW, Goldman A First analysis of a bacterial collagen-binding protein with collagen toolkits: Promiscuous binding of YadA to collagens may explain how YadA interferes with host processes Infection and Immunity 78 3226-3236, 2010
DOI:10.1128/IAI.01057-09
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Tuominen H, Salminen A, Oksanen E, Jämsen J, Heikkilä O, Lehtiö L, Magretova NN, Goldman A, Baykov AA, Lahti R Crystal structures of the CBS and DRTGG domains of the regulatory region of Clostridiumperfringens pyrophosphatase complexed with the inhibitor, AMP, and activator, diadenosine tetraphosphate. J Mol Biol 398 400-413, 2010
DOI:10.1016/j.jmb.2010.03.019
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Leo JC, Goldman A Jacks of all trades?--Probably not. The E. coli Eib proteins bind IgG Fc. Mol Immunol 47 1870-1872, 2010
DOI:10.1016/j.molimm.2009.11.007
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Bhattacharjee A, Lehtinen MJ, Kajander T, Goldman A, Jokiranta TS Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d. Mol Immunol 47 1686-1691, 2010
DOI:10.1016/j.molimm.2010.03.007
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Brookhart M, Huang Z, MacArthur AHR, Carson EC, Goldman A, Scott SL, Vicente BC Alkane metathesis and dehydrogenation employing alumina-supported pincer iridium catalysts ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 239 -, 2010

Biswas S, Brookhart M, Choliy Y, Goldman A, Huang Z, Krogh-Jespersen K Catalytic dehydrogenation and metathesis of alkanes: Selectivity and mechanistic aspects ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 239 -, 2010

Ora A, Oksanen E, Kajander T, Goldman A, Butcher SJ Crystallization and preliminary crystallographic analysis of mouse peroxiredoxin II with significant pseudosymmetry. Acta Crystallogr Sect F Struct Biol Cryst Commun 66 357-360, 2010
DOI:10.1107/S1744309110003684
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Oksanen E, Goldman A Introduction to macromolecular X-ray crystallography, 2010

Leppänen V-M, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K Structural determinants of growth factor binding and specificity by VEGF receptor 2. Proc Natl Acad Sci U S A 107 2425-2430, 2010
DOI:10.1073/pnas.0914318107
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Kajander T, Sachs JN, Goldman A, Regan L Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering. J Biol Chem 284 25364-25374, 2009
DOI:10.1074/jbc.M109.033894
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Bhattacharjee A, Lehtinen MJ, Kajander T, Goldman A, Jokiranta TS Both domains 19 and 20 are involved in binding of FH to C3d/C3b MOLECULAR IMMUNOLOGY 46 2819-2819, 2009
DOI:10.1016/j.molimm.2009.05.191

Parkash V, Goldman A Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling. Acta Crystallogr Sect F Struct Biol Cryst Commun 65 551-558, 2009
DOI:10.1107/S1744309109017722
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Leo JC, Goldman A The immunoglobulin-binding Eib proteins from Escherichia coli are receptors for IgG Fc MOLECULAR IMMUNOLOGY 46 1860-1866, 2009
DOI:10.1016/j.molimm.2009.02.024

Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, Leppänen V-M, Goldman A The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. Protein Eng Des Sel 22 233-241, 2009
DOI:10.1093/protein/gzn080
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Parkash V, Leppänen V-M, Virtanen H, Jurvansuu JM, Bespalov MM, Sidorova YA, Runeberg-Roos P, Saarma M, Goldman A The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding. J Biol Chem 283 35164-35172, 2008
DOI:10.1074/jbc.M802543200
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Patana A-S, Kurkela M, Finel M, Goldman A Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases. Protein Eng Des Sel 21 537-543, 2008
DOI:10.1093/protein/gzn030
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Leo JC, Elovaara H, Brodsky B, Skurnik M, Goldman A The Yersinia adhesin YadA binds to a collagenous triple-helical conformation but without sequence specificity Protein Engineering, Design and Selection 21 475-484, 2008
DOI:10.1093/protein/gzn025
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Paavilainen VO, Oksanen E, Goldman A, Lappalainen P Structure of the actin-depolymerizing factor homology domain in complex with actin. J Cell Biol 182 51-59, 2008
DOI:10.1083/jcb.200803100
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Xiong Y, Patana AS, Miley MJ, Zielinska AK, Bratton SM, Miller GP, Goldman A, Finel M, Redinbo MR, Radominska-Pandya A The first aspartic acid of the DQxD motif for human UDP- glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis Drug Metabolism and Disposition 36 517-522, 2008
DOI:10.1124/dmd.107.016469
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Jurvansuu JM, Goldman A Recent inventions on receptor tyrosine kinase RET modulation. Recent Pat Biotechnol 2 47-54, 2008
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Patana A-S, Kurkela M, Goldman A, Finel M The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site. Mol Pharmacol 72 604-611, 2007
DOI:10.1124/mol.107.036871
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Leppänen V-M, Tossavainen H, Permi P, Lehtiö L, Rönnholm G, Goldman A, Kilpelaïnen I, Pihlajamaa T Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family. J Biol Chem 282 23219-23230, 2007
DOI:10.1074/jbc.M702514200
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Rantanen MK, Lehtiö L, Rajagopal L, Rubens CE, Goldman A Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ion. FEBS J 274 3128-3137, 2007
DOI:10.1111/j.1742-4658.2007.05845.x
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Rantanen MK, Lehtiö L, Rajagopal L, Rubens CE, Goldman A Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution. Acta Crystallogr D Biol Crystallogr 63 738-743, 2007
DOI:10.1107/S0907444907019695
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Oksanen E, Ahonen A-K, Tuominen H, Tuominen V, Lahti R, Goldman A, Heikinheimo P A complete structural description of the catalytic cycle of yeast pyrophosphatase BIOCHEMISTRY 46 1228-1239, 2007
DOI:10.1021/bi0619977

Kurkela M, Patana A-S, Mackenzie PI, Court MH, Tate CG, Hirvonen J, Goldman A, Finel M Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6. Pharmacogenet Genomics 17 115-126, 2007
DOI:10.1097/FPC.0b013e328011b598
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Fabrichniy IP, Lehtio L, Tammenkoski M, Zyryanov AB, Oksanen E, Baykov AA, Lahti R, Goldman A A trimetal site and substrate distortion in a family II inorganic pyrophosphatase JOURNAL OF BIOLOGICAL CHEMISTRY 282 1422-1431, 2007
DOI:10.1074/jbc.M513161200

von Ossowski I, Oksanen E, von Ossowski L, Cai C, Sundberg M, Goldman A, Keinänen K Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide. FEBS J 273 5219-5229, 2006
DOI:10.1111/j.1742-4658.2006.05521.x
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Oksanen E, Jaakola VP, Tolonen T, Valkonen K, Akerström B, Kalkkinen N, Virtanen V, Goldman A Reindeer beta-lactoglobulin crystal structure with pseudo-body-centred noncrystallographic symmetry. Acta Crystallogr D Biol Crystallogr 62 1369-1374, 2006
DOI:10.1107/S0907444906031519
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Halak S, Lehtio L, Basta T, Buerger S, Contzen M, Stolz A, Goldman A Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2 FEBS JOURNAL 273 5169-5182, 2006
DOI:10.1111/j.1742-4658.2006.05512.x

Rantanen MK, Lehtiö L, Rajagopal L, Rubens CE, Goldman A Crystallization and preliminary crystallographic analysis of two Streptococcus agalactiae proteins: the family II inorganic pyrophosphatase and the serine/threonine phosphatase. Acta Crystallogr Sect F Struct Biol Cryst Commun 62 891-894, 2006
DOI:10.1107/S174430910602954X
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Jokiranta TS, Jaakola V-P, Lehtinen MJ, Pärepalo M, Meri S, Goldman A Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. EMBO J 25 1784-1794, 2006
DOI:10.1038/sj.emboj.7601052
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Lehtio L, Grossmann JG, Kokona B, Fairman R, Goldman A Crystal structure of a glycyl radical enzyme from Archaeoglobus fulgidus JOURNAL OF MOLECULAR BIOLOGY 357 221-235, 2006
DOI:10.1016/j.jmb.2005.12.049

Jaakola V-P, Rehn M, Moeller M, Alexiev U, Goldman A, Turner GJ G-protein-coupled receptor domain overexpression in Halobacterium salinarum: long-range transmembrane interactions in heptahelical membrane proteins. Proteins 60 412-423, 2005
DOI:10.1002/prot.20498
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Sen S, Jaakola V-P, Pirilä P, Finel M, Goldman A Functional studies with membrane-bound and detergent-solubilized alpha2-adrenergic receptors expressed in Sf9 cells. Biochim Biophys Acta 1712 62-70, 2005
DOI:10.1016/j.bbamem.2005.03.014
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Virtanen H, Yang J, Bespalov MM, Hiltunen JO, Leppänen V-M, Kalkkinen N, Goldman A, Saarma M, Runeberg-Roos P The first cysteine-rich domain of the receptor GFRalpha1 stabilizes the binding of GDNF. Biochem J 387 817-824, 2005
DOI:10.1042/BJ20041257
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Merckel MC, Huiskonen JT, Goldman A, Bamford DM, Tuma R The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture Molecular Cell 18 161-170, 2005
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Halonen P, Tammenkoski M, Niiranen L, Huopalahti S, Parfenyev AN, Goldman A, Baykov A, Lahti R Effects of active site mutations on the metal binding affinity, catalytic competence, and stability of the family II pyrophosphatase from Bacillus subtilis. Biochemistry 44 4004-4010, 2005
DOI:10.1021/bi047926u
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Lehtiö L, Fabrichniy I, Hansen T, Schönheit P, Goldman A Unusual twinning in an acetyl coenzyme A synthetase (ADP-forming) from Pyrococcus furiosus. Acta Crystallogr D Biol Crystallogr 61 350-354, 2005
DOI:10.1107/S0907444904034389
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Jaakola V-P, Prilusky J, Sussman JL, Goldman A G protein-coupled receptors show unusual patterns of intrinsic unfolding. Protein Eng Des Sel 18 103-110, 2005
DOI:10.1093/protein/gzi004
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Jaakola VP, Vainio M, Sen S, Rehn M, Heimo H, Scheinin M, Goldman A Intracellularly truncated human alpha(2B)-adrenoceptors: Stable and functional GPCRs for structural studies JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 25 99-124, 2005
DOI:10.1081/RRS-200068745

Fabrichniy IP, Lehtiö L, Salminen A, Zyryanov AB, Baykov AA, Lahti R, Goldman A Structural studies of metal ions in family II pyrophosphatases: The requirement for a janus ion Biochemistry 43 14403-14411, 2004
DOI:10.1021/bi0484973
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Zyryanov AB, Tammenkoski M, Salminen A, Kolomiytseva GY, Fabrichniy IP, Goldman A, Lahti R, Baykov AA Site-specific effects of zinc on the activity of family II pyrophosphatase Biochemistry 43 14395-14402, 2004
DOI:10.1021/bi048470j
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Lehtiö L, Goldman A The pyruvate formate lyase family: sequences, structures and activation. Protein Eng Des Sel 17 545-552, 2004
DOI:10.1093/protein/gzh059
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Leppänen V-M, Bespalov MM, Runeberg-Roos P, Puurand U, Merits A, Saarma M, Goldman A The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation. EMBO J 23 1452-1462, 2004
DOI:10.1038/sj.emboj.7600174
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Tuominen VU, Myles DAA, Dauvergne M-T, Lahti R, Heikinheimo P, Goldman A Production and preliminary analysis of perdeuterated yeast inorganic pyrophosphatase crystals suitable for neutron diffraction. Acta Crystallogr D Biol Crystallogr 60 606-609, 2004
DOI:10.1107/S0907444903029585
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Nummelin H, Merckel MC, Leo JC, Lankinen H, Skurnik M, Goldman A The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll EMBO JOURNAL 23 701-711, 2004
DOI:10.1038/sj.emboj.7600100

Zyryanov AB, Vener AV, Salminen A, Goldman A, Lahti R, Baykov AA Rates of Elementary Catalytic Steps for Different Metal Forms of the Family II Pyrophosphatase from Streptococcus gordonii Biochemistry 43 1065-1074, 2004
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Sen S, Jaakola VP, Heimo H, Engstrom M, Larjomaa P, Scheinin M, Lundstrom K, Goldman A Functional expression and direct visualization of the human alpha(2B)-adrenergic receptor and alpha(2B)-AR-green fluorescent fusion protein in mammalian cell using Semliki Forest virus vectors PROTEIN EXPRESSION AND PURIFICATION 32 265-275, 2003
DOI:10.1016/j.pep.2003.08.006

Kajander T, Lehtiö L, Schlömann M, Goldman A The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function. Protein Sci 12 1855-1864, 2003
DOI:10.1110/ps.0388503
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Merckel MC, Tanskanen J, Edelman S, Westerlund-Wikström B, Korhonen TK, Goldman A The structural basis of receptor-binding by Escherichia coli associated with diarrhea and septicemia. J Mol Biol 331 897-905, 2003
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Nummelin H, Merckel MC, El Tahir Y, Ollikka P, Skurnik M, Goldman A Structural studies of Yersinia adhesin YadA Advances in Experimental Medicine and Biology 529 85-88, 2003

Bartus CL, Jaakola VP, Reusch R, Valentine HH, Heikinheimo P, Levay A, Potter LT, Heimo H, Goldman A, Turner GJ Downstream coding region determinants of bacterio-opsin, muscarinic acetylcholine receptor and adrenergic receptor expression in Halobacterium salinarum BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1610 109-123, 2003
DOI:10.1016/S0005-2736(02)00710-1

Lehtiö L, Leppänen V-M, Kozarich JW, Goldman A Structure of Escherichia coli pyruvate formate-lyase with pyruvate. Acta Crystallogr D Biol Crystallogr 58 2209-2212, 2002
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Halonen P, Baykov AA, Goldman A, Lahti R, Cooperman BS Single-turnover kinetics of Saccharomyces cerevisiae inorganic pyrophosphatase BIOCHEMISTRY 41 12025-12031, 2002
DOI:10.1021/bi026018z

Sen S, Jaakola VP, Heimo H, Kivelä P, Scheinin M, Lundstrom K, Goldman A Development of a scintiplate assay for recombinant humanα<inf>2B</inf>-adrenergic receptor Analytical Biochemistry 307 280-286, 2002
DOI:10.1016/S0003-2697(02)00041-6
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Nummelin H, El Tahir Y, Ollikka P, Skurnik M, Goldman A Expression, purification and crystallization of a collagen-binding fragment of Yersinia adhesin YadA ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 58 1042-1044, 2002
DOI:10.1107/S0907444902005231

Salminen A, Parfenyev AN, Salli K, Efimova IS, Magretova NN, Goldman A, Baykov AA, Lahti R Modulation of dimer stability in yeast pyrophosphatase by mutations at the subunit interface and ligand binding to the active site. J Biol Chem 277 15465-15471, 2002
DOI:10.1074/jbc.M200101200
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Merckel MC, Kajander T, Deacon AM, Thompson A, Grossmann JG, Kalkkinen N, Goldman A 3-Carboxy-cis,cis-muconate lactonizing enzyme from Neurospora crassa: MAD phasing with 80 selenomethionines. Acta Crystallogr D Biol Crystallogr 58 727-734, 2002
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Kajander T, Merckel MC, Thompson A, Deacon AM, Mazur P, Kozarich JW, Goldman A The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme, a beta propeller cycloisomerase. Structure 10 483-492, 2002
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Merckel MC, Fabrichniy IP, Salminen A, Kalkkinen N, Baykov AA, Lahti R, Goldman A Crystal structure of Streptococcus mutans pyrophosphatase: A new fold for an old mechanism Structure 9 289-297, 2001
DOI:10.1016/S0969-2126(01)00587-1
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Liitti S, Matikainen MT, Scheinin M, Glumoff T, Goldman A Immunoaffinity purification and reconstitution of human alpha(2)-adrenergic receptor subtype C2 into phospholipid vesicles. Protein Expr Purif 22 1-10, 2001
DOI:10.1006/prep.2001.1410
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Hyytiä T, Halonen P, Salminen A, Goldman A, Lahti R, Cooperman BS Ligand binding sites in Escherichia coli inorganic pyrophosphatase: Effects of active site mutations Biochemistry 40 4645-4653, 2001
DOI:10.1021/bi010049x
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Heikinheimo P, Tuominen V, Ahonen AK, Teplyakov A, Cooperman BS, Baykov AA, Lahti R, Goldman A Toward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphatase. Proc Natl Acad Sci U S A 98 3121-3126, 2001
DOI:10.1073/pnas.061612498
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Tuominen H, Heikinheimo P, Loo BM, Kataja K, Oker-Blom C, Uutela M, Jalkanen M, Goldman A Expression and glycosylation studies of human FGF receptor 4. Protein Expr Purif 21 275-285, 2001
DOI:10.1006/prep.2000.1375
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Zyryanov AB, Pohjanjoki P, Kasho VN, Shestakov AS, Goldman A, Lahti R, Baykov AA The Electrophilic and Leaving Group Phosphates in the Catalytic Mechanism of Yeast Pyrophosphatase Journal of Biological Chemistry 276 17629-17634, 2001
DOI:10.1074/jbc.M100343200
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Pohjanjoki P, Fabrichniy IP, Kasho VN, Cooperman BS, Goldman A, Baykov AA, Lahti R Probing essential water in yeast pyrophosphatase by directed mutagenesis and fluoride inhibition measurements. J Biol Chem 276 434-441, 2001
DOI:10.1074/jbc.M007360200
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Frang H, Hellman J, Goldman A, Scheinin M, Glumoff T A two-site immunometric assay for the detection of the expression level ofα<inf>2</inf>(C2)-adrenergic receptor produced in Escherichia coli Biotechnology Letters 22 1963-1966, 2000
DOI:10.1023/A:1026766330471
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Kajander T, Kahn PC, Passila SH, Cohen DC, Lehtiö L, Adolfsen W, Warwicker J, Schell U, Goldman A Buried charged surface in proteins. Structure 8 1203-1214, 2000
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Belogurov GA, Fabrichniy IP, Pohjanjoki P, Kasho VN, Lehihuhta E, Turkina MV, Cooperman BS, Goldman A, Baykov AA, Lahti R Catalytically important ionizations along the reaction pathway of yeast pyrophosphatase BIOCHEMISTRY 39 13931-13938, 2000
DOI:10.1021/bi000895s

Loo BM, Darwish K, Vainikka S, Saarikettu J, Vihko P, Hermonen J, Goldman A, Alitalo K, Jalkanen M Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4 International Journal of Biochemistry and Cell Biology 32 489-497, 2000
DOI:10.1016/S1357-2725(99)00145-4
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Kapat A, Jaakola VP, Heimo H, Liitti S, Heikinheimo P, Glumoff T, Goldman A Production and purification of recombinant human (alpha 2)C2 adrenergic receptor using Saccharomyces cerevisiae BIOSEPARATION 9 167-172, 2000
DOI:10.1023/A:1008150412294

Salminen A, Efimova IS, Parfenyev AN, Magretova NN, Mikalahti K, Goldman A, Baykov AA, Lahti R Reciprocal effects of substitutions at the subunit interfaces in hexameric pyrophosphatase of Escherichia coli. Dimeric and monomeric forms of the enzyme. J Biol Chem 274 33898-33904, 1999
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Leppänen VM, Merckel MC, Ollis DL, Wong KK, Kozarich JW, Goldman A Pyruvate formate lyase is structurally homologous to type I ribonucleotide reductase. Structure 7 733-744, 1999
DOI:10.1016/S0969-2126(99)80098-7
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Sivula T, Salminen A, Parfenyev AN, Pohjanjoki P, Goldman A, Cooperman BS, Baykov AA, Lahti R Evolutionary aspects of inorganic pyrophosphatase. FEBS Lett 454 75-80, 1999
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Heikinheimo P, Goldman A, Jeffries C, Ollis DL Of barn owls and bankers: a lush variety of alpha/beta hydrolases. Structure 7 R141-R146, 1999
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Leppänen VM, Nummelin H, Hansen T, Lahti R, Schäfer G, Goldman A Sulfolobus acidocaldarius inorganic pyrophosphatase: structure, thermostability, and effect of metal ion in an archael pyrophosphatase. Protein Sci 8 1218-1231, 1999
DOI:10.1110/ps.8.6.1218
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Baykov AA, Hyytia T, Turkina MV, Efimova IS, Kasho VN, Goldman A, Cooperman BS, Lahti R Functional characterization of Escherichia coli inorganic pyrophosphatase in zwitterionic buffers EUROPEAN JOURNAL OF BIOCHEMISTRY 260 308-317, 1999
DOI:10.1046/j.1432-1327.1999.00181.x

Hansen T, Urbanke C, Leppanen VM, Goldman A, Brandenburg K, Schafer G The extreme thermostable pyrophosphatase from Sulfolobus acidocaldarius: Enzymatic and comparative biophysical characterization ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 363 135-147, 1999
DOI:10.1006/abbi.1998.1072

Efimova IS, Salminen A, Pohjanjoki P, Lapinniemi J, Magretova NN, Cooperman BS, Goldman A, Lahti R, Baykov AA Directed mutagenesis studies of the metal binding site at the subunit interface of Escherichia coli inorganic pyrophosphatase Journal of Biological Chemistry 274 3294-3299, 1999
DOI:10.1074/jbc.274.6.3294
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Leppänen VM, Parast CV, Wong KK, Kozarich JW, Goldman A Purification and crystallization of a proteolytic fragment of Escherichia coli pyruvate formate-lyase. Acta Crystallogr D Biol Crystallogr 55 531-533, 1999
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Schell U, Helin S, Kajander T, Schlomann M, Goldman A Structural basis for the activity of two muconate cycloisomerase variants toward substituted muconates PROTEINS-STRUCTURE FUNCTION AND GENETICS 34 125-136, 1999
DOI:10.1002/(SICI)1097-0134(19990101)34:1<125::AID-PROT10>3.0.CO;2-Y

Tuominen V, Heikinheimo P, Kajander T, Torkkel T, Hyytiä T, Käpylä J, Lahti R, Cooperman BS, Goldman A The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications. J Mol Biol 284 1565-1580, 1998
DOI:10.1006/jmbi.1998.2266
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Vollmer MD, Hoier H, Hecht HJ, Schell U, Groning J, Goldman A, Schlomann M Substrate specificity of and product formation by muconate cycloisomerases: an analysis of wild-type enzymes and engineered variants APPLIED AND ENVIRONMENTAL MICROBIOLOGY 64 3290-3299, 1998

Pohjanjoki P, Lahti R, Goldman A, Cooperman BS Evolutionary conservation of enzymatic catalysis: quantitative comparison of the effects of mutation of aligned residues in Saccharomyces cerevisiae and Escherichia coli inorganic pyrophosphatases on enzymatic activity. Biochemistry 37 1754-1761, 1998
DOI:10.1021/bi971771r
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Velichko IS, Mikalahti K, Kasho VN, Dudarenkov VY, Hyytiä T, Goldman A, Cooperman BS, Lahti R, Baykov AA Trimeric inorganic pyrophosphatase of Escherichia coli obtained by directed mutagenesis Biochemistry 37 734-740, 1998
DOI:10.1021/bi9714823
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Heikinheimo P, Tuominen V, Lahti R, Cooperman BS, Goldman A The three metal ion mechanism of inorganic pyrophoshatases Protein Engineering 10 62-, 1997

Fabrichniy IP, Kasho VN, Hyytiä T, Salminen T, Halonen P, Dudarenkov VY, Heikinheimo P, Chernyak VY, Goldman A, Lahti R, Cooperman BS, Baykov AA Structural and functional consequences of substitutions at the tyrosine 55-lysine 104 hydrogen bond in Escherichia coli inorganic pyrophosphatase Biochemistry 36 7746-7753, 1997
DOI:10.1021/bi9629844
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Tishkoff SA, Clark AG, Dietzsch E, Goldman A, Speed WC, BonneTamir B, Kidd JR, Calafell F, Pakstis AJ, Jenkins T, Kidd KK Global patterns of linkage disequilibrium and modern human origins. AMERICAN JOURNAL OF HUMAN BIOLOGY 9 165-165, 1997

Heikinheimo P, Lehtonen J, Baykov A, Lahti R, Cooperman BS, Goldman A The structural basis for pyrophosphatase catalysis. Structure 4 1491-1508, 1996
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Heikinheimo P, Pohjanjoki P, Helminen A, Tasanen M, Cooperman BS, Goldman A, Baykov A, Lahti R A site-directed mutagenesis study of Saccharomyces cerevisiae pyrophosphatase. Functional conservation of the active site of soluble inorganic pyrophosphatases. Eur J Biochem 239 138-143, 1996
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Salminen T, Teplyakov A, Kankare J, Cooperman BS, Lahti R, Goldman A An unusual route to thermostability disclosed by the comparison of Thermus thermophilus and Escherichia coli inorganic pyrophosphatases. Protein Sci 5 1014-1025, 1996
DOI:10.1002/pro.5560050604
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Kankare J, Salminen T, Lahti R, Cooperman BS, Baykov AA, Goldman A Structure of Escherichia coli inorganic pyrophosphatase at 2.2 A resolution. Acta Crystallogr D Biol Crystallogr 52 551-563, 1996
DOI:10.1107/S0907444996000376
View abstract

Kankare J, Salminen T, Lahti R, Cooperman BS, Baykov AA, Goldman A Crystallographic identification of metal-binding sites in Escherichia coli inorganic pyrophosphatase. Biochemistry 35 4670-4677, 1996
DOI:10.1021/bi952637e
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Volk SE, Dudarenkov VY, Kapyla J, Kasho VN, Voloshina OA, Salminen T, Goldman A, Lahti R, Baykov AA, Cooperman BS Effect of E20D substitution in the active site of Escherichia coli inorganic pyrophosphatase on its quaternary structure and catalytic properties BIOCHEMISTRY 35 4662-4669, 1996
DOI:10.1021/bi952636m

Baykov AA, Hyytia T, Volk SE, Kasho VN, Vener AV, Goldman A, Lahti R, Cooperman BS Catalysis by Escherichia coli inorganic pyrophosphatase: pH and Mg<sup>2+</sup>dependence Biochemistry 35 4655-4661, 1996
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Glumoff T, Helin S, Mazur P, Kozarich JW, Goldman A Crystallization and preliminary crystallographic analysis of 3-carboxy-cis,cis-muconate lactonizing enzyme from Neurospora crassa. Acta Crystallogr D Biol Crystallogr 52 221-223, 1996
DOI:10.1107/S0907444995010018
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Goldman A, Salminen T, Teplyakov A, Cooperman B, Lahti R AN UNUSUAL ROUTE TO THERMOSTABILITY IN PYROPHOSPHATASES, 1996
DOI:10.1107/S0108767396090289

Baykov AA, Dudarenkov VY, Kapyla J, Salminen T, Hyytia T, Kasho VN, Husgafvel S, Cooperman BS, Goldman A, Lahti R Dissociation of hexameric Escherichia coli inorganic pyrophosphatase into trimers on His-136->Gln or His-140->Gln substitution and its effect on enzyme catalytic properties JOURNAL OF BIOLOGICAL CHEMISTRY 270 30804-30812, 1995

Goldman A How to make my blood boil. Structure 3 1277-1279, 1995
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Helin S, Kahn PC, Guha BL, Mallows DG, Goldman A The refined X-ray structure of muconate lactonizing enzyme from Pseudomonas putida PRS2000 at 1.85 A resolution. J Mol Biol 254 918-941, 1995
DOI:10.1006/jmbi.1995.0666
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Heikinheimo P, Salminen T, Lahti R, Cooperman B, Goldman A New crystal forms of Escherichia coli and Saccharomyces cerevisiae soluble inorganic pyrophosphatases. Acta Crystallogr D Biol Crystallogr 51 399-401, 1995
DOI:10.1107/S0907444994010784
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VELICHKO IV, VOLK SE, DUDARENKOV VY, MAGRETOVA NN, CHERNYAK VY, GOLDMAN A, COOPERMAN BS, LAHTI R, BAYKOV AA COLD LABILITY OF THE MUTANT FORMS OF ESCHERICHIA-COLI INORGANIC PYROPHOSPHATASE FEBS LETTERS 359 20-22, 1995
DOI:10.1016/0014-5793(95)00003-R

Salminen T, Käpylä J, Heikinheimo P, Kankare J, Goldman A, Heinonen J, Baykov AA, Cooperman BS, Lahti R Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis? Biochemistry 34 782-791, 1995
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KAPYLA J, HYYTIA T, LAHTI R, GOLDMAN A, BAYKOV AA, COOPERMAN BS EFFECT OF D97E SUBSTITUTION ON THE KINETIC AND THERMODYNAMIC PROPERTIES OF ESCHERICHIA-COLI INORGANIC PYROPHOSPHATASE BIOCHEMISTRY 34 792-800, 1995
DOI:10.1021/bi00003a012

Kankare J, Neal GS, Salminen T, Glumoff T, Glumhoff T [corrected to Glumoff T, Cooperman BS, Lahti R, Goldman A The structure of E.coli soluble inorganic pyrophosphatase at 2.7 A resolution. Protein Eng 7 823-830, 1994
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HOIER H, SCHLOMANN M, HAMMER A, GLUSKER JP, CARRELL HL, GOLDMAN A, STEZOWSKI JJ, HEINEMANN U CRYSTAL-STRUCTURE OF CHLOROMUCONATE CYCLOISOMERASE FROM ALCALIGENES-EUTROPHUS JMP134 (PJP4) AT 3 ANGSTROM RESOLUTION ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 50 75-84, 1994
DOI:10.1107/S090744499300900X

DENESYUK AI, LUNDELL J, GOLDMAN A, ZAVYALOV VP, KORPELA T STRUCTURAL REPEATS IN CYCLOSPORINE-A BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 197 1438-1442, 1993
DOI:10.1006/bbrc.1993.2638

Camacho NP, Smith DR, Goldman A, Schneider B, Green D, Young PR, Berman HM Structure of an interleukin-1 beta mutant with reduced bioactivity shows multiple subtle changes in conformation that affect protein-protein recognition. Biochemistry 32 8749-8757, 1993
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OLLIS DL, CHEAH E, CYGLER M, DIJKSTRA B, FROLOW F, FRANKEN SM, HAREL M, REMINGTON SJ, SILMAN I, SCHRAG J, SUSSMAN JL, VERSCHUEREN KHG, GOLDMAN A THE ALPHA/BETA-HYDROLASE FOLD PROTEIN ENGINEERING 5 197-211, 1992
DOI:10.1093/protein/5.3.197

SUSSMAN JL, HAREL M, FROLOW F, OEFNER C, GOLDMAN A, TOKER L, SILMAN I ATOMIC-STRUCTURE OF ACETYLCHOLINESTERASE FROM TORPEDO-CALIFORNICA - A PROTOTYPIC ACETYLCHOLINE-BINDING PROTEIN SCIENCE 253 872-879, 1991
DOI:10.1126/science.1678899

Sanderson MR, Freemont PS, Rice PA, Goldman A, Hatfull GF, Grindley ND, Steitz TA The crystal structure of the catalytic domain of the site-specific recombination enzyme gamma delta resolvase at 2.7 A resolution. Cell 63 1323-1329, 1990
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Rice PA, Goldman A, Steitz TA A helix-turn-strand structural motif common in alpha-beta proteins. Proteins 8 334-340, 1990
DOI:10.1002/prot.340080407
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GOLDMAN A, OLLIS DL, STEITZ TA CRYSTAL-STRUCTURE OF MUCONATE LACTONIZING ENZYME AT 3 A RESOLUTION JOURNAL OF MOLECULAR BIOLOGY 194 143-153, 1987
DOI:10.1016/0022-2836(87)90723-6

RUSSO MW, GUYER CA, GOLDMAN A, STAROS JV A MODEL FOR THE EGF RECEPTOR KINASE CONTAINING MULTIPLE TRANSMEMBRANE ALPHA-HELICES BIOPHYSICAL JOURNAL 51 A36-A36, 1987

ENGELMAN DM, STEITZ TA, GOLDMAN A IDENTIFYING NONPOLAR TRANSBILAYER HELICES IN AMINO-ACID-SEQUENCES OF MEMBRANE-PROTEINS ANNUAL REVIEW OF BIOPHYSICS AND BIOPHYSICAL CHEMISTRY 15 321-353, 1986
DOI:10.1146/annurev.bb.15.060186.001541

Goldman A, Ollis D, Ngai KL, Steitz TA Crystal structure of muconate lactonizing enzyme at 6.5Å resolution Journal of Molecular Biology 182 353-355, 1985
DOI:10.1016/0022-2836(85)90352-3
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ENGELMAN DM, GOLDMAN A, STEITZ TA THE IDENTIFICATION OF HELICAL SEGMENTS IN THE POLYPEPTIDE-CHAIN OF BACTERIORHODOPSIN METHODS IN ENZYMOLOGY 88 81-88, 1982

STEITZ TA, GOLDMAN A, ENGELMAN DM QUANTITATIVE APPLICATION OF THE HELICAL HAIRPIN HYPOTHESIS TO MEMBRANE-PROTEINS BIOPHYSICAL JOURNAL 37 124-125, 1982